• 한국공간구조학회논문집
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• 제17권2호
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• pp.53-62
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• 2017

This study aims to establish a seismic resistance performance evaluation method that makes sure to secure the seismic resistance performance of the existing mid-low story reinforced concrete structures. This study focuses on the development of the seismic resistance performance evaluation method for the overall seismic resistance performance evaluation on the buildings by applying fuzzy theory. This seismic resistance performance evaluation method considers the mutual relations among the type of force, the type of member, the type of story, and the states of deterioration of the buildings. The total seismic resistance performance index from this method was calculated by the intensity weight of each evaluation item, fuzzy measure, fuzzy integration. Moreover, the evaluation methodology was established in this study to identify the performance level of the Immediate Occupancy, Life Safe, Collapse Prevention by applying the fuzzy theory.

• Nuclear Engineering and Technology
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• 제39권2호
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• pp.149-160
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• 2007

The IAEA launched the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) and developed the INPRO Methodology to provide guidelines and to assess the characteristics of a future innovative nuclear energy system in areas such as safety, economics, waste management, and proliferation resistance. The proliferation resistance area of the INPRO Methodology is reviewed here, and modifications for further improvements are proposed. The evaluation metrics including the evaluation parameters, evaluation scales and acceptance limits are developed for a practical application of the methodology to assess the proliferation resistance. The proliferation resistant characteristics of the DUPIC fuel cycle are assessed by applying the modified INPRO Methodology based on the developed evaluation metrics and acceptance criteria. The evaluation procedure and the metrics can be utilized as a reference for an evaluation of the proliferation resistance of a future innovative nuclear energy system.

• Geomechanics and Engineering
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• 제1권1호
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• pp.17-34
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• 2009

There has been growing agreement that geotechnical reliability-based design (RBD) is necessary for establishing more advanced and integrated design system. In this study, resistance factors for LRFD pile design using CPT results were investigated for axially loaded driven piles. In order to address variability in design methodology, different CPT-based methods and load-settlement criteria, popular in practice, were selected and used for evaluation of resistance factors. A total of 32 data sets from 13 test sites were collected from the literature. In order to maintain the statistical consistency of the data sets, the characteristic pile load capacity was introduced in reliability analysis and evaluation of resistance factors. It was found that values of resistance factors considerably differ for different design methods, load-settlement criteria, and load capacity components. For the total resistance, resistance factors for LCPC method were higher than others, while those for Aoki-Velloso's and Philipponnat's methods were in similar ranges. In respect to load-settlement criteria, 0.1B and Chin's criteria produced higher resistance factors than DeBeer's and Davisson's criteria. Resistance factors for the base and shaft resistances were also presented and analyzed.

• 한국도로학회논문집
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• 제16권1호
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• pp.31-39
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• 2014

PURPOSES : Surface treatment material for pavement preventive maintenance should be inspected field applicability. This study(Part II) aimed to checkup coating characteristics and performance analysis using lab and field tests. The hydrophobic - low viscosity filling material for pavement preventive maintenance is presented in Part I, which is a series of companion study. METHODS : Relative comparison between general asphalt mixtures and surface treatment asphalt mixtures are analyzed and measured for the field application such as indirect tensile strength ratio(TSR), abrasion resistance, crack propagation resistance, temperature resistance, coating thickness, permeability resistance and skid resistance in terms of british pendulum number(BPN). RESULTS : It is found that TSR, crack propagation resistance and permeability resistance is increased as against uncoated asphalt specimen. Abrasion resistance and temperature resistance is secured from the initial coating thickness point of view, which is about 0.2~0.3mm. Skid resistance on the surface treatment pavement is satisfied with the BPN criteria of national highway because of exposed aggregate and crack sill induced pavement deterioration and damage cracks. CONCLUSIONS : The hydrophobic - low viscosity surface treatment material for pavement preventive maintenance is validated on field applicability evaluation based on quantitative analysis of coating thickness and performance analysis using lab and field tests.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2017년도 추계 학술논문 발표대회
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• pp.143-144
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• 2017

Due to the recent depletion of natural resources and global warming, a passive house type building exterior system has been developed and applied. For this purpose, we developed a building exterior thermal resistance performance evaluation system and verify the feasibility of this system for evaluation of passive house building system.

• Journal of Ginseng Research
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• 제48권3호
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• pp.298-309
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• 2024

Background: 20(S)-ginsenoside Rh2(GRh2), an effective natural histone deacetylase inhibitor, can inhibit acute myeloid leukemia (AML) cell proliferation. Lactate regulated histone lactylation, which has different temporal dynamics from acetylation. However, whether the high level of lactylation modification that we first detected in acute promyelocytic leukemia (APL) is associated with all-trans retinoic acid (ATRA) resistance has not been reported. Furthermore, Whether GRh2 can regulate lactylation modification in ATRA-resistant APL remains unknown. Methods: Lactylation and METTL3 expression levels in ATRA-sensitive and ATRA-resistant APL cells were detected by Western blot analysis, qRT-PCR and CO-IP. Flow cytometry (FCM) and APL xenograft mouse models were used to determine the effect of METTL3 and GRh2 on ATRA-resistance. Results: Histone lactylation and METTL3 expression levels were considerably upregulated in ATRA-resistant APL cells. METTL3 was regulated by histone lactylation and direct lactylation modification. Overexpression of METTL3 promoted ATRA-resistance. GRh2 ameliorated ATRA-resistance by downregulated lactylation level and directly inhibiting METTL3. Conclusions: This study suggests that lactylation-modified METTL3 could provide a promising strategy for ameliorating ATRA-resistance in APL, and GRh2 could act as a potential lactylation-modified METTL3 inhibitor to ameliorate ATRA-resistance in APL.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2011년도 춘계 학술논문 발표대회 1부
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• pp.7-10
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• 2011

In this study, evaluation system of impact resistance performance is proposed. Compressive strength of concrete is 40, 60 and 80MPa. It evaluate impact resistance performance to use projectile 6, 7 and 8mm size. As a result, safety performance is more higher when the compressive strength is increased in. Compared with Hughes's formula, evaluation system of impact resistance performance is appropriated.

• 한국구조물진단유지관리공학회 논문집
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• 제27권6호
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• pp.79-85
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• 2023

미끄럼방지포장은 도로의 부속물로서 도로 및 교통 특성으로 인해 미끄럼저항을 충분히 확보하지 못한 곳이나 도로선형의 변화가 심한 구간에서 포장의 미끄럼저항을 높여 자동차의 안전한 주행을 도모하기 위한 시설이라고 명시하고 있다. 특히, 눈, 비, 블랙아이스와 같은 기상 악천후 상황에서 미끄럼방지포장의 미끄럼저항성능은 도로교통 및 운전자의 안전에 큰 영향을 미친다. 하지만 현재 미끄럼저항성능을 측정하는 데 주로 사용되는 BPN은 시험 면적이 0.009 m²에 불과하여 전체 포장면에 대한 대표성을 나타내기 어렵기 때문에 미끄럼방지포장 유지관리를 위한 신뢰성 있는 미끄럼저항성능 평가방법이 필요한 실정이다. 본 연구에서는 지침 및 표준 조사를 통하여 BPN, SN, GN 시험의 미끄럼저항 성능평가 방법을 비교하고 현장 미끄럼저항 성능평가에 적용하고자 하였다. 또한, 미끄럼방지포장의 체계적인 유지관리를 위하여 미끄럼방지포장재 미끄럼저항 성능평가 Test-bed 및 실도로 실증 현장에 미끄럼저항성능이 다른 미끄럼방지포장을 설치하여 성능평가방법(BPN, SN, GN)별 미끄럼저항성능을 비교하였다. 실험결과, SN과 GN은 미끄럼저항성능이 비슷한 경향으로 나타났으며, GN은 BPN × 0.01 과 유사하게 도출되었다.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2023년도 가을학술발표대회논문집
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• pp.221-222
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• 2023

In this study, the performance evaluation of waterproof sealant materials applied to the outer wall of PC apartment houses was conducted. The sealant for PC members must have resistance to movement, and since it is exposed to outside air, weather resistance and water resistance are required.

• Journal of Microbiology and Biotechnology
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• 제31권5호
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• pp.733-739
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• 2021

Acinetobacter strains are widely present in the environment. Some antimicrobial-resistant strains of this genus have been implicated in infections acquired in hospitals. Genetic similarities have been reported between Acinetobacter strains in nosocomial infections and those isolated from foods. However, the antimicrobial resistance of Acinetobacter strains in foods, such as meat, remains unclear. This study initially aimed to isolate Campylobacter strains; instead, strains of the genus Acinetobacter were isolated from meat products, and their antimicrobial resistance was investigated. In total, 58 Acinetobacter strains were isolated from 381 meat samples. Of these, 32 strains (38.6%) were from beef, 22 (26.5%) from pork, and 4 (4.8%) from duck meat. Antimicrobial susceptibility tests revealed that 12 strains were resistant to more than one antimicrobial agent, whereas two strains were multidrug-resistant; both strains were resistant to colistin. Cephalosporin antimicrobials showed high minimal inhibitory concentration against Acinetobacter strains. Resfinder analysis showed that one colistin-resistant strain carried mcr-4.3; this plasmid type was not confirmed, even when analyzed with PlasmidFinder. Analysis of the contig harboring mcr-4.3 using BLAST confirmed that this contig was related to mcr-4.3 of Acinetobacter baumannii. The increase in antimicrobial resistance in food production environments increases the resistance rate of Acinetobacter strains present in meat, inhibits the isolation of Campylobacter strains, and acts as a medium for the transmission of antimicrobial resistance in the environment. Therefore, further investigations are warranted to prevent the spread of antimicrobial resistance in food products.