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Potential Role of Bioactive Phytochemicals in Combination Therapies against Antimicrobial Activity

  • Choudhury, Ananta
    • 대한약침학회지
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    • 제25권2호
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    • pp.79-87
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    • 2022
  • Since ancient times, plants have been a major source of novel drug molecules and have been used in the treatment of different infectious diseases. Secondary plant metabolites have miraculous healing properties and show potent therapeutic responses when used in combination drug therapy. The prime objective of this review is to summarize the concept of drug combination with special emphasis on the synergistic interactions between plant-derived bioactive phytochemicals with commercially available antimicrobial agents. The study also assesses the roles, importance, and applicability of phytochemicals in the management of different diseases. The review focuses on different aspects of combined antimicrobial activities, the possible mechanisms involved, and the current status of research in the field. The study was conducted based on an extensive literature survey that resulted in the following hypothesis: secondary metabolites derived from plants possess remarkable therapeutic activities. The study was designed as a systematic review that ensures unbiased and accurate representations of the relevant data and information. Jadad scale selection criteria were used for qualitative analysis of the articles to assess them based on the relevant secure score (minimum and maximum scores range between 1 and 5, respectively). Articles with secure scores > 3 were considered for the study. A comprehensive literature survey was conducted using resource databases including PubMed, Google Scholar, Bielefeld Academic Search Engine, Research Gate, Scopus, Medline, and Science Direct up to June 2019. This article contains concise information about the most commonly used bioactive phytochemicals with potent antifungal and antibacterial effects.

Management and Development Potential of the Wig Industry in the Beauty Tech Era

  • Eun-Jung SHIN;Ki Han KWON
    • 산경연구논집
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    • 제14권7호
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    • pp.27-38
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    • 2023
  • Purpose: The new technological innovation caused by the Fourth Industrial Revolution will bring about a major change in the scalp healthcare market and the wig industry. This review paper is an empirical analysis focusing on the development potential of the Korean beauty tech market and the wig industry. Research design, data and methodology: This review of the wig industry and consumer experience is an important literature review. The PRISMA flow chart was used. Beauty Tech; Beauty Industry; Wig Industry; Wig; Scalp Healthcare; was used as Keywords as records verified through database screening. A total of 513 references were finally selected through major journal search sites such as PubMed, Google Scholar, RISS, Scopus, and Research Gate. Among the selected references, a total of 52 papers were selected in the final stage from 2001 to 2022. Results: For the sustainable development of wig industry management, consumers' desire for new and convenient products should be secured through technologies related to the 4th industrial revolution, and creative thinking was presented throughout manufacturing, distribution, and customer service. Conclusions: Hair loss reduces the quality of life due to mental stress and affects social life. The continuous development of wig companies, such as information on wigs and quality improvement, should be supported.

Large Size and High Resolution Organic Light Emitting Diodes Based on the In-Ga-Zn-O Thin Film Transistors with a Coplanar Structure

  • Hong Jae Shin
    • 한국재료학회지
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    • 제33권12호
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    • pp.511-516
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    • 2023
  • Amorphous In-Ga-Zn-O (a-IGZO) thin film transistors (TFTs) with a coplanar structure were fabricated to investigate the feasibility of their potential application in large size organic light emitting diodes (OLEDs). Drain currents, used as functions of the gate voltages for the TFTs, showed the output currents had slight differences in the saturation region, just as the output currents of the etch stopper TFTs did. The maximum difference in the threshold voltages of the In-Ga-Zn-O (a-IGZO) TFTs was as small as approximately 0.57 V. After the application of a positive bias voltage stress for 50,000 s, the values of the threshold voltage of the coplanar structure TFTs were only slightly shifted, by 0.18 V, indicative of their stability. The coplanar structure TFTs were embedded in OLEDs and exhibited a maximum luminance as large as 500 nits, and their color gamut satisfied 99 % of the digital cinema initiatives, confirming their suitability for large size and high resolution OLEDs. Further, the image density of large-size OLEDs embedded with the coplanar structure TFTs was significantly enhanced compared with OLEDs embedded with conventional TFTs.

Developing Airport Safety Performance Indicators and Index - The Case of Incheon Airport Airside -

  • In Kie Na;Yu-Jin Choi
    • 한국항공운항학회지
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    • 제31권3호
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    • pp.103-118
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    • 2023
  • An indicator system is an effective way to monitor ongoing safety status. Current aviation safety measurements account for many qualitative technical and lagging indicators. Conversely, quantitative and leading indicators have only a tiny proportion. This research added more quantitative leading indicators and reviewed them to harmonize lagging and leading indicators to measure airport safety and provide an index. The South Korean national gate, Incheon International Airport's indicators, were applied as primary data to verify this research practically. Then, examples from International and national authorities were reviewed and extracted for use. Fifty-five safety specialists participated in the focus group discussion and three rounds of the Delphi survey. Finally, 51 sub-indicators were newly chosen. After this process, weights for each indicator could be assigned using the AHP (Analytical Hierarchy Process) to provide an integrated index. The result of the simulation with newly added indicators in the past five years (2020-2022) reliable trend showed in indicators and integrated index. Moreover, this allows monitoring the status of the details of indicators and holistic insight. This study considered that it is more suitable for a single company or service provider to use it according to the exact situation than in a macro- and general-purpose at the country or regional level.

무전해 식각법으로 합성한 Si 나노와이어 Field Effect Transistor 유연소자의 특성 (Electrical Properties of Flexible Field Effect Transistor Devices Composed of Si Nanowire by Electroless Etching Method)

  • 이상훈;문경주;황성환;이태일;명재민
    • 한국재료학회지
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    • 제21권2호
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    • pp.115-119
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    • 2011
  • Si Nanowire (NW) field effect transistors (FETs) were fabricated on hard Si and flexible polyimide (PI) substrates, and their electrical characteristics were compared. Si NWs used as channels were synthesized by electroless etching method at low temperature, and these NWs were refined using a centrifugation method to get the NWs to have an optimal diameter and length for FETs. The gate insulator was poly(4-vinylphenol) (PVP), prepared using a spin-coating method on the PI substrate. Gold was used as electrodes whose gap was 8 ${\mu}m$. These gold electrodes were deposited using a thermal evaporator. Current-voltage (I-V) characteristics of the device were measured using a semiconductor analyzer, HP-4145B. The electrical properties of the device were characterized through hole mobility, $I_{on}/I_{off}$ ratio and threshold voltage. The results showed that the electrical properties of the TFTs on PVP were similar to those of TFTs on $SiO_2$. The bending durability of SiNWs TFTs on PI substrate was also studied with increasing bending times. The results showed that the electrical properties were maintained until the sample was folded about 500 times. But, after more than 1000 bending tests, drain current showed a rapid decrease due to the defects caused by the roughness of the surface of the Si NWs and mismatches of the Si NWs with electrodes.

New Semiconducting Multi-branched Conjugated Molecules Bearing 3,4-Ethylene-dioxythiophene-based Thiophenyl Moieties for Organic Field Effect Transistor

  • Kim, Dae-Chul;Lee, Tae-Wan;Lee, Jung-Eun;Kim, Kyung-Hwan;Cho, Min-Ju;Choi, Dong-Hoon;Han, Yoon-Deok;Cho, Mi-Yeon;Joo, Jin-Soo
    • Macromolecular Research
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    • 제17권7호
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    • pp.491-498
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    • 2009
  • New $\pi$-conjugated multi-branched molecules were synthesized through the Homer-Emmons reaction using alkyl-substituted, 3,4-ethylenedioxythiophene-based, thiophenyl aldehydes and octaethyl benzene-l,2,4,5-tetrayltetrakis(methylene) tetraphosphonate as the core unit; these molecules have all been fully characterized. The two multi-branched conjugated molecules exhibited excellent solubility in common organic solvents and good self-film forming properties. The semiconducting properties of these multi-branched molecules were also evaluated in organic field-effect transistors (OFET). With octyltrichlorosilane (OTS) treatment of the surface of the $SiO_2$ gate insulator, two of the crystalline conjugated molecules, 7 and 8, exhibited carrier mobilities as high as $2.4({\pm}0.5){\times}10^{-3}$ and $1.3({\pm}0.5){\times}10^{-3}cm^2V^{-1}s^{-1}$, respectively. The mobility enhancement of OFET by light irradiation ($\lambda$ = 436 nm) supported the promising photo-controlled switching behavior for the drain current of the device.

장미 뿌리혹병 발생과 품종간 저항성 차이 (Occurrence of Crown Gall of Rose and Rose Cultivar-specific Resistance)

  • 한경숙;김원희;박종한;이중섭;서상태
    • 식물병연구
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    • 제12권2호
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    • pp.75-80
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    • 2006
  • 2003 년부터 2005 년까지 장미 주요 재배단지를 중심으로 뿌리혹병 발생을 조사한 결과 전지역에서 발생이 확인되었으며, 주로 토양재배보다는 양액재배되는 장미에서 발생이 더 심하였다. 뿌리혹병에 감염된 장미는 주로 지제부에 발생이 많았으며, 뿌리에 발생하여 생육이 부진해지는 피해를 나타내었다. 저항성 품종 선발에서는 '리틀 실버' 등 10 품종만이 저항성 품종으로 검정되었을 뿐 대부분이 감수성이었다. 특히 '골든게이트', '리틀마블', '로사로제티' 등은 매우 감수성이 높았다.

송야천 유역의 비점오염물질 유출 특성 및 오염기여율 분석 (Analysis of Characteristics of NPS Runoff and Pollution Contribution Rate in Songya-stream Watershed)

  • 강태성;유나영;신민환;임경재;박민지;박배경;김종건
    • 한국물환경학회지
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    • 제39권4호
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    • pp.316-328
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    • 2023
  • In this study, the characteristics of nonpoint pollutant outflow and contribution rate of pollution in Songya-stream mainstream and tributaries were analyzed. Further, water pollution management and improvement measures for pollution-oriented rivers were proposed. An on-site investigation was conducted to determine the inflow of major pollutants into the basin, and it was found that pollutants generated from agricultural land and livestock facilities flowed into the river, resulting in a high concentration of turbid water. Based on the analysis results of the pollution load data calculated through actual measurement monitoring (flow and water quality) and the occurrence and emission load data calculated using the national pollution source survey data, the S3 and S6 were selected as the concerned pollution tributaries in the Songya-stream basin. Results of cluster analysis using Pearson correlation coefficient evaluation and Density based spatial clustering of applications with noise (DBSCAN) technique showed that the S3 and S6 were most consistent with the C2 cluster (a cluster of Songya-stream mainstream owned area) corresponding to the mainstream of Songya-stream. The analysis results of the major pollutants in the concerned pollution tributaries showed that livestock and land pollutants were the major pollutants. Consequently, optimal management techniques such as fertilizer management, water gate management in paddy, vegetated filter strip and livestock manure public treatment were proposed to reduce livestock and land pollutants.

조선시대 한양 청계천 가산(假山)의 버드나무 수책(樹柵)에 관한 연구 (A Case Study on the Willow Tree Fence(樹柵) in Gasan(假山) of Cheonggyecheon, Hanyang in the Joseon Dynasty Period)

  • 심순희;김충식
    • 헤리티지:역사와 과학
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    • 제57권2호
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    • pp.118-141
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    • 2024
  • 본 연구는 고문헌(古文獻) 기록과 도상자료(圖像資料)를 조사·분석하여 조선시대 수해 방지를 위해 계획적으로 조성된 한양도성(漢陽都城) 내 청계천(淸溪川) 가산(假山)에 식재된 버드나무 수책(樹柵)에 대해 고찰하였다. 그동안 버드나무에 관련된 연구 사례는 있었으나 버드나무의 구체적인 활용사례와 그 역사적 배경을 조사·분석하여 그 원형적 가치를 파악하는 데 목적을 두고 진행된 연구는 찾아보기 어렵다. 이에 본 연구는 조선시대 청계천에 조성된 버드나무 수책의 사례를 확인하고 조성 배경과 지역적 특징을 조명함으로써 그 가치를 재해석하고자 하였다. 본 연구의 주요 내용은 다음과 같다. 조선시대의 수재(水災)는 제일 큰 위해 요소로 작용하였을 것으로 추정된다. 16~18세기 조선은 홍수로 인한 피해가 심각하였다. 영조 시기에 이르러서는 도성의 사산(四山)이 모두 민둥산이 되었는데, 이는 잦은 홍수의 원인이 되었다. 1760년(영조 36)에 영조는 준천사업(濬川事業)을 통해 장마 때마다 넘치는 청계천 바닥을 준설하고 오간수문 양안에 조성된 가산에 버드나무 수책을 조성하여 수해를 예방하고 토양의 유실을 방지하는 조치를 시행하였다. 영조 시기인 18세기 중반에 제작된 《광여도(廣輿圖)》 속의 <도성도(都城圖)>에는 오간수문(五間水門) 앞에 조성된 가산이 보이고, 『신증동국여지승람(新增東國輿地勝覽)』의 기록에서 1760년(영조 36)에 버들을 양쪽 가산에 심었다는 기록을 검증하였으며, 1770년(영조 46) 제작된 <한양도성도(漢陽都城圖)>를 통해 18세기 후반에는 오간수문 근처의 가산 위 버드나무가 숲을 이루어 우거졌던 사실도 확증하였다. 또한 『조선왕조실록(朝鮮王朝實錄)』이나 『승정원일기(承政院日記)』, 『일성록(日省錄)』 등의 고문헌 기록을 통해 청계천 준천사업과 버드나무 수책의 조성이 조선 전기인 15세기부터 조선 후기인 19세기 말까지 계속되었다는 사실을 확인하였다. 본 연구는 홍수 및 수해 방지는 물론 아름다운 경관을 형성하는데 큰 바탕이 되었던 조선시대 버드나무 수책의 조성사례와 그 활용성을 조사함으로써 버드나무가 고유한 문화유산이자 전통 경관자원이었음을 알리고, 버드나무의 역사적 의미를 되새기는 데 의의가 있다.

시화호 및 주변해역의 수질 특성 (Characteristics of Water Quality In the Shihwa Lake and Outer Sea)

  • 장정익;한인섭;김경태;나공태
    • 해양환경안전학회지
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    • 제17권2호
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    • pp.105-121
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    • 2011
  • 본 연구에서는 시화호의 수질 관리 정책 연구를 위한 최근의 수질 자료 확보를 목적으로 2010년에 시화호 내 외측 해역에서 수질 조사를 수행하였다. 시화호 표층수 수질항목들의 수평적 농도분포는 하천을 통한 담수 유업과 배수갑문을 통한 외해수 유입의 영향으로 인하여 반윌 및 시화 산단 얀근 상류지역에서는 높고 배수갑문으로 갈수록 낮아지는 경향을 나타냈다. 시화호 외해에서는 TN 및 TP가 소래포구에 가까운 곳에서 높은 농도를 나타내었으며, 전체적으로 시화호 내해보다는 상대적으로 낮은 농도를 나타내었다. 시화호 내측의 경우, 여름철 성층 형성 및 저층의 활발한 유기물 분해로 빈산소층이 발달되고 있었다. 수질항목들의 수직적 농도분포의 경우, 용존영양염, TN 및 TP는 표층보다 저층에서 높았지만, COD, 클로로필-a 및 POC는 이와 반대로 저층보다 표층에서 높은 분포를 나타냈다. 시화호 표층수에서 염분은 용존영양염과 양호한 음의 상관성을 보여 담수 기원의 영양염 공급이 확인되었고, 이에 의한 식물플랑크톤의 대증식으로 COD 및 POC가 높게 나타났다.