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Ddt Increase Aromatase Gene Expression and Activity in Leydig Cells

  • Lee, Kyung-Jin;Kim, Ji-Young;Shin, Dong-Weon;Cho, Young-Rhan;Jung, Kyung-Sik;You, Ho-Jin;Jeong, Hye-Gwang
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.10b
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    • pp.137-137
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    • 2003

  • Dichlorodiphenyltrichloroethane (DDT) is a widespread environmental pollutant. Earlier reports have demonstrated that DDT is an endocrine-active compound capable of affecting early-stage sexual differentiation in male rats. Experiments based on receptor binding affinity and receptor-mediated transcriptional activation have identified DDE as an androgen receptor antagonist.(omitted)

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Up-regulation of inducible nitric oxide synthase expression and inflammatory cytokines by collagen and gelatin in murine macrophages

  • Kim, Ji-Young;Lee, Kyung-Jin;Oh, Duk-Hee;Jung, Kyung-Sik;Shin, Dong-Weon;Cho, Young-Rhan;Jeong, Hye-Gwang
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.121.2-121.2
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    • 2003

  • Synthetic polymers, biological polymer such as collagen and gelatin are employed extensively as backbones in the construction of hydrogels or cell/tissue scaffoldings for various biomedical applications. In the present study, we investigated the effect of collagen and gelatin on the inducible nitric oxide synthase (iNOS) gene expression in the mouse macrophage cell line RAW 264.7. The production of nitric oxide and expression level of iNOS mRNA were induced by both of collagen and gelatin in dose-dependent manner. (omitted)

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Ircinin-1 from the Sponge Sarcotragus Species Induces of Cell Proliferation and Apoptosis in the Human Skin Cancer Cells

  • Choi, Hye-Joung;Yee, Su-Bog;Park, Hwa-Sun;Chung, Sang-Woon;Park, Sang-Eun;Jung, Jee-Hyung;Kim, Nam-Deuk
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.256.1-256.1
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    • 2002

  • We investigated the anti-proliferative effects of a new compound. ircinin-1. from the sponge Sarcotragus sp. on SK-MEL -2 human skin cancer cells. From the data of MTT assay, cell viability was decreased by ircinin-1 in a dose-dependent manner. We observed that the anti-proliferative effect of ircinin-1 was due to the induction of apoptosis, which was confirmed by observing the morphological changes. the increased ratio of pro-apoptotic protein Bax to anti-apoptotic protein Bcl-2, and cleavage of poly(ADP-ribose) polymerase protein, via activation of caspase-3. (omitted)

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