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Biometry of width between labial transitional line angles in anterior teeth: an observational study

  • Wen, Chao;Ye, Hongqiang;Chen, Hu;Zhou, Yongsheng;Huang, Mingming;Sun, Yuchun
    • The Journal of Advanced Prosthodontics
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    • v.14 no.1
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    • pp.1-11
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    • 2022

  • PURPOSE. The maximum width between the mesial and distal labial transitional line angles, described as "esthetic width" herein, could significantly influence the visual perception of the teeth and smile. This study aimed to conduct biometric research on esthetic width and to explore whether regular distribution exists in the esthetic width of human teeth. MATERIALS AND METHODS. A total of 4,264 maxillary and mandibular anterior teeth were measured using the Geomagic studio software program. The proportions of maxillary to mandibular homonymous teeth and proportions between the adjacent teeth were calculated. Bilateral symmetry and the correlation between the esthetic and mesiodistal widths were both accounted for during the measurement procedures. RESULTS. The mean esthetic widths were 6.773 ± 0.518 mm and 4.329 ± 0.331 mm for maxillary and mandibular central incisors, respectively, 5.451 ± 0.487 mm and 5.008 ± 0.351 mm for maxillary and mandibular lateral incisors, respectively, and 3.340 ± 0.353 mm and 5.958 ± 0.415 mm for maxillary and mandibular canines, respectively. Except for the mandibular canines, no significant difference in esthetic width was found among homonymous teeth from the same jaw. A high linear correlation was found between the esthetic and mesiodistal widths of the same tooth, except for the maxillary canines. Esthetic width proportions among different tooth categories showed some regular patterns, which were similar to those of the mesiodistal width. CONCLUSION. Esthetic width is regularly distributed among the teeth in the Chinese population. This could provide an important reference for anterior dental restorations and dimension recovery in esthetic reconstruction of anterior teeth.

  • https://doi.org/10.4047/jap.2022.14.1.1 인용 PDF KSCI

Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP 131, in cervical cancer

  • Kim, Dong Hyun;Kim, Hye-Min;Huong, Pham Thi Thu;Han, Ho-Jin;Hwang, Joonsung;Cha-Molstad, Hyunjoo;Lee, Kyung Ho;Ryoo, In-Ja;Kim, Kyoon Eon;Huh, Yang Hoon;Ahn, Jong Seog;Kwon, Yong Tae;Soung, Nak-Kyun;Kim, Bo Yeon
    • BMB Reports
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    • v.52 no.5
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    • pp.342-347
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    • 2019

  • Methylation is a primary epigenetic mechanism regulating gene expression. 5-aza-2'-deoxycytidine is an FDA-approved drug prescribed for treatment of cancer by inhibiting DNA-Methyl-Transferase 1 (DNMT1). Results of this study suggest that prolonged treatment with 5-aza-2'-deoxycytidine could induce centrosome abnormalities in cancer cells and that CEP131, a centrosome protein, is regulated by DNMT1. Interestingly, cancer cell growth was attenuated in vitro and in vivo by inhibiting the expression of Cep131. Finally, Cep131-deficient cells were more sensitive to treatment with DNMT1 inhibitors. These findings suggest that Cep131 is a potential novel anti-cancer target. Agents that can inhibit this protein may be useful alone or in combination with DNMT1 inhibitors to treat cancer.

  • https://doi.org/10.5483/BMBRep.2019.52.5.055 인용 PDF KSCI