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http://dx.doi.org/10.5483/BMBRep.2019.52.5.055

Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP 131, in cervical cancer  

Kim, Dong Hyun (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Kim, Hye-Min (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Huong, Pham Thi Thu (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Han, Ho-Jin (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Hwang, Joonsung (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Cha-Molstad, Hyunjoo (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Lee, Kyung Ho (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Ryoo, In-Ja (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Kim, Kyoon Eon (Department of Biochemistry, College of Natural Science, Chungnam National University)
Huh, Yang Hoon (Center for Electron Microscopy Research, Korea Basic Science Institute)
Ahn, Jong Seog (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Kwon, Yong Tae (Protein Metabolism Medical Research Center, Department of Biomedical Sciences, College of Medicine, Seoul National University)
Soung, Nak-Kyun (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Kim, Bo Yeon (Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Publication Information
BMB Reports / v.52, no.5, 2019 , pp. 342-347 More about this Journal
Abstract
Methylation is a primary epigenetic mechanism regulating gene expression. 5-aza-2'-deoxycytidine is an FDA-approved drug prescribed for treatment of cancer by inhibiting DNA-Methyl-Transferase 1 (DNMT1). Results of this study suggest that prolonged treatment with 5-aza-2'-deoxycytidine could induce centrosome abnormalities in cancer cells and that CEP131, a centrosome protein, is regulated by DNMT1. Interestingly, cancer cell growth was attenuated in vitro and in vivo by inhibiting the expression of Cep131. Finally, Cep131-deficient cells were more sensitive to treatment with DNMT1 inhibitors. These findings suggest that Cep131 is a potential novel anti-cancer target. Agents that can inhibit this protein may be useful alone or in combination with DNMT1 inhibitors to treat cancer.
Keywords
Anti-cancer; Centrosome; CEP131; DNMT1;
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Times Cited By KSCI : 2  (Citation Analysis)
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