• Proceedings of the Korean Society of Computer Information Conference
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• 2021.07a
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• pp.117-122
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• 2021

In order to reveal the co-research relationship with key research institutes in the computer field in Korea, which have high competitiveness in the ICT field, this paper analyzes the co-author network of research institutes based on the papers of Korean journals. For this study, 15 computer journals published in Korea were selected and collected for the past 5 years. In addition, authors, affiliated institutions, and country information were extracted from the papers, and experimental data were produced using institutional identification data and SNA analysis techniques. Through this, statistical analysis was performed on researchers, research institutes, and countries, and the centrality of research institutes was measured through co-authored network analysis and visualized as a map. The results of the research that analyzed the co-author relationship based on the papers in computer science journals published in Korea are as follows. First, the status of co-author relations among researchers was statistically analyzed in detail. The number of authors, the number of co-authors, and statistics by co-authoring countries, as well as the ratio of co-authored research by institution and the ratio of co-authored by country were revealed. The co-authoring status of papers in English journals was analyzed separately to compare and analyze characteristics. Second, the centrality of each individual was measured through the co-authored network analysis of the identified researchers, institutions and countries affiliated with the institution, and the frequency of connection between data by level was identified. In addition, the co-authorization network between research institutes was visualized and presented as a map so that the overall view of the co-authoring network was presented, and the connection frequency between the institutes was checked. It is possible to recommend a research partner based on the co-authoring behavior of Korean computer researchers and the co-authoring relationship between major research institutes. For this, additional research is needed to analyze the subject areas of each institution.

• Journal of Contemporary Eastern Asia
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• v.15 no.1
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• pp.27-40
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• 2016

This study uses a network approach to investigate the structural characteristics of sub-organizations within public research institutes in order to obtain their implications for organizational structures. We construct a network based on research similarities between sub-organizations because sub-organizations generally build their own research portfolios. We examine how sub-units are organized based on their structural features. The structural features are compared between three public research institutes in different countries: the Korean the Government-funded Research Institutes (GRIs), the Max-Planck-Gesellschaft in Germany, and the National Laboratories (NLs) in the United States. The structural comparison helps to identify organizational characteristics and to differentiate between them. We found little common ground in the research areas between the GRIs because individual sub-organizations have distinct research portfolios. Therefore, the organizational hierarchy of research in the GRIs is less matured than it is in other public research institutes. This study suggests that the GRIs need to establish integrated strategies in order to strengthen the common knowledge base.

• Journal of Technology Innovation
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• v.16 no.1
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• pp.141-163
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• 2008

Technology transfer from public research institutes is receiving an ever increasing importance in today's fast growing economy. Many factors have been cited as influencing the transfer performance. This study is focused on the strategy of institutes which is characterized by technology strategic factors and organizational/institutional factors. Methodologically, the technology strategy is represented by the information contained in applied patents, and the performance of technology transfer is indicated by the number of licensing contracts and royalty income. To further improve the contribution of public research institutes through technology transfer, I argue that individual institutes become more specialized in specific field and become more open to collaboration. It is also recommended that public research institutes gather together since it is easy to form the consortium of technology licensing office and it is not necessary to be located near the industrial field.

• STI Policy Review
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• v.3 no.1
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• pp.117-138
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• 2012

Governments around the world place great hopes in innovation in their search for new sources of growth and for responses to grand challenges, such as climate change, new or re-emerging infectious diseases, accelerating urbanisation, ageing, food security, and availability of clean water. However they must devise their relevant support policies -- including through sponsored research within public research institutes -- taking into account that innovation processes are currently undergoing a major transformation. New innovation patterns include a broadening scope of relevant activities, a growing importance but changing nature of scientific roots of technological development, a stronger demand-pull, the emergence of new local and national STI powerhouses, and the rise of more open and globalised innovation networks. They translate into new opportunities but also constraints for policies to enhance the contribution of public research institutes to national innovation performance. The article derives the main policy implications regarding the desirable evolution of the mission, research focus, as well as the funding and steering of public research institutes, with a special reference to Korea.

• Proceedings of the KSAR Conference
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• 2004.06a
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• pp.215-215
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• 2004

Human papillomavirus type 16 (HPV16) has been known as a major causative factor for the development of uterine cervical carcinomas. To investigate the in vivo activity of HPV16 expressed in squamous epithelia, transgenic mice harboring HPV16 E6/E7 with human keratin 14 (hK14) promoter were generated. Grossly, hK14 driven HPV16 E6/E7 transgenic mice exhibited multiple phenotypes, including wrinkled skin that was apparent prior to the appearance of hair in neonates, thickened ears, and loss of hair in adults. (omitted)

• STI Policy Review
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• v.1 no.1
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• pp.63-92
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• 2010

Recent years have seen an intensified discussion in many OECD countries about the role and mission of public research in the innovation system. This discussion takes place in quite specific national contexts, but should benefit from international experience. However, whereas voluminous literatures address the changing governance methods, organizational forms and missions of universities, much less attention has been devoted to developing a common understanding of the challenges faced by non-university public research institutions. The main goals of this paper is to contribute to clarifying the nature of these challenges, outlines possible policy answers and draws some implications for Korea. In the first section, the paper uses available internationally comparable indicators to review trends in the contribution of government research institutes (GRIs) to R&D and innovation activities. In the second section, the paper identifies the current major changes in the dynamics of innovation that may call for further adjustments in the positioning, organization and steering of public research institutes. Finally, the paper outlines some strategic objectives and orientations for the reform of public research institutes as part of the broader agenda of the Korean innovation strategy.

• Archives of Pharmacal Research
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• v.28 no.12
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• pp.1350-1357
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• 2005

Nuclear factor kappa B (NF-$\kappa$B) regulates the expression of multiple cytokines, chemokines, and cell adhesion molecules that are involved in the pathogenesis of asthma. We investigated the anti-asthmatic effects and the mechanism of action of DA-9201, an extract of the black rice, in a mouse model of asthma. Mice immunized with ovalbumin (OVA) were administered with DA-9201 (30, 100 or 300 mg/kg) or dexamethasone (DEXA, 3 mg/kg) for 2 weeks and challenged with aerosolized OVA during the last 3 days. Anti-asthmatic effects were assessed by means of enhanced pauses, level of total lgE and Th2 cytokines in plasma or bronchoalveolar lavage fluid (BALF), the percentage of eosinophils in BALF, and histopathological examination. The expression of NF-$\kappa$B in nuclear and cytoplasmic fraction and its DNA-binding activity in lung tissues were analyzed by means of Western blotting and electrophoretic gel mobility shift assay (EMSA), respectively. DA-9201 significantly reduced airway hyperrespon-siveness (AHR), total lgE level in plasma and BALF, IL-4, IL-5, and IL-13 levels in BALF, and the percentage of eosinophils in BALF. Tissue inflammation was significantly improved by DA­9201 treatment. In addition, DA-9201 dramatically suppressed the expression of NF-$\kappa$B and its DNA-binding activity. These results suggest that DA-9201 may be useful for the treatment of asthma and its efficacy is related to suppression of NF-$\kappa$B pathway.

• World Technopolis Review
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• v.6 no.2
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• pp.113-129
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• 2017

Universities are considered important actors and drivers of socio-economic development in the regional innovation eco-system. This article investigates the role Kenyan universities and research institutes play in the development of regional innovation eco-system in the context of triple and Quadruple helices. A model involving Government, Industry, Universities and Society (Public) linkages in the regional innovation eco-system and with Information and Communication Technology as an enabler is used as a framework for analysing the nature of linkages in Kenya. The article uses literature review and case study methods to examine how universities and research institutes can spur the development of the innovation eco-systems. The research question is: what is the role of Kenyan universities and research institutes in spurring innovation ecosystems? Six cases of Kenyan universities and research institutes are considered in the light of Government Policy on Science, Technology and Innovation (STI) which is underpinned in Kenyan constitution 2010. The study contributes to the understanding of how deep collaboration among universities, government, research institutes, Science Cities, local, regional, national and international players spurs the creation of world-class innovation ecosystems which can contribute to regional development in developing countries like Kenya.

• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.44-44
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• 2003

In previous reports, pVPSV.IGR2.1 transgenic mouse were described that brain tumor and lymphoma by reason of Vasopressin-SV40 T antigen. In this study, we produced pVPSV.IGR3.6 transgenic mouse that used pVPSV.IGR3.6 vector. Expression of transgene was vary different in transgenic mouse. We obtained 6 transgenic mouse line, moreover they had died at the age of 2~6 weeks without transmitting the transgene to their offspring, and had tumorigenesis on same location with pVPSV.IGR2.1 transgenic mouse. Only a founder mouse was investigated for expression of fusion gene. Here we extended this transgenic approach to the study of tumor progression. From the mouse, we confirmed brain tumor cell, after then cultured for investigate characterization. In this report, we demonstrate that reduction of survival rate in transgenic mouse fused vasopressin gene length, acquisition of brain tumor cell, composition with astrocyte cells and neuronal cells. Finally, cells had no change with increase of passage.

• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.45-45
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• 2003

Human papillomavirus type 16(HPV16) has been known to the major factor for the development of uterine cervical carcinomas. We have extended these studies to investigate the in vivo activities of HPV-16 E6/E7 when expressed in squamous epithelia of transgenic mice. Grossly, hK14HPV16E6/E7 transgenic mice had multiple phenotypes, including wrinkled skin that was apparent prior to the appearance of hair on neonates, thickened ears, and loss of hair in adults. In the transgenic mice, the wrinkled skin phenotype on the body and legs died at the age of 3∼4 weeks. Histological analysis of demonstrated that E6/E7 causes epidermal hyperplasia in multiple transgenic lineages with high penetrance. This epithelial hyperplasia was characterized by an expansion of the proliferating compartment and an expansion of the keratinocyte and was associated with hyperkeratosis. These transgenic mice expressed E6/E7 transgene mainly in skin, heart, pancreas and kidney. Hyperplasia was found at the skin. The enzyme activities of GR, GPx and CuZnSOD were measured from the transgene cause keratinocyte at the skin. The specific enzyme activities were significantly higher in transgenic mice skin compared to the normal mice skin. Thus these transgenic mice may be useful for the develpment of antioxidant enzymes or other therapies for HPV-associated hyperkeratosis.