• Title/Summary/Keyword: Research Institutes

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Inhibition of HIV-1 Protease by isoflavonoids from Erythrina senegalensis

  • Lee, Ji-Suk;Ma , Chao-Mei;Hattori Masao;Oh, Won-Keun;Ahn, Jong-Seog;Kim, Yong-Hae;Tanyi Mbaforj;Wandji Jean;Tanee FomumZ
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.377.3-378
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    • 2002

  • Eight compounds were isolated from the MeOH extracts of Erythrina senegalensis for HIV-1 protease inhibitors. Their structures were elucidated as eight isoflavonoids by spectroscopic analysis. These compounds showed dose dependent inhibitory activities on HIV-l protease with $IC_{50}$ values from 0.5 to 30.0 ${\mu}$M. (omitted)

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A 40 Kb Genomic Deletion Including tmie (Transmembrane Inner Ear Protein) Gene Causes Deafness, Circling and Head Tossing in Circling Mice

  • Kyoung In Cho;Jeong Woong Lee;Eun Ju Lee;Sol Ha Hwang;Myoung Ok Kim;Sung Hyun Kim;Jun Hong Park;Boo Kyoung Jung;Hee Chul Kim
    • Proceedings of the KSAR Conference
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    • 2004.06a
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    • pp.226-226
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    • 2004

  • Circling (cir) mouse is a spontaneous mutant in the inner ear that was first reported in Korea. The mutation is transmitted by an autosomal recessive gene with 100 %- penetrance.. Homozygous mice are characterized by head-tossing, bi-directional circling behavior and deafness. Histologicalexamination of the inner ear reveals abnormalities of the region around the organ of Corti, spiral ganglion neurons, and outer hair cells. (omitted)

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