Inhibition of HIV-1 Protease by isoflavonoids from Erythrina senegalensis

  • Lee, Ji-Suk (Research Group of Pain and Neuroscience in vision 2000 Project, East-West Medical Research Institutes, Kyung Hee University) ;
  • Ma , Chao-Mei (Research Group of Pain and Neuroscience in vision 2000 Project, East-West Medical Research Institutes, Kyung Hee University) ;
  • Hattori Masao (Research Group of Pain and Neuroscience in vision 2000 Project, East-West Medical Research Institutes, Kyung Hee University) ;
  • Oh, Won-Keun (Research Group of Pain and Neuroscience in vision 2000 Project, East-West Medical Research Institutes, Kyung Hee University) ;
  • Ahn, Jong-Seog (Research Group of Pain and Neuroscience in vision 2000 Project, East-West Medical Research Institutes, Kyung Hee University) ;
  • Kim, Yong-Hae (Research Group of Pain and Neuroscience in vision 2000 Project, East-West Medical Research Institutes, Kyung Hee University) ;
  • Tanyi Mbaforj (Research Group of Pain and Neuroscience in vision 2000 Project, East-West Medical Research Institutes, Kyung Hee University) ;
  • Wandji Jean (Research Group of Pain and Neuroscience in vision 2000 Project, East-West Medical Research Institutes, Kyung Hee University) ;
  • Tanee FomumZ (Research Group of Pain and Neuroscience in vision 2000 Project, East-West Medical Research Institutes, Kyung Hee University)
  • Published : 2002.10.01

Abstract

Eight compounds were isolated from the MeOH extracts of Erythrina senegalensis for HIV-1 protease inhibitors. Their structures were elucidated as eight isoflavonoids by spectroscopic analysis. These compounds showed dose dependent inhibitory activities on HIV-l protease with $IC_{50}$ values from 0.5 to 30.0 ${\mu}$M. (omitted)

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