• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 Ⅲ
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• pp.1621-1624
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• 2003

As the entities participating Grid become larger, performance requirement for the LDAP-based GIS(Grid Information Service) goes beyond that provided by a stand-alone single LDAP server. This entails the exploration of distributed LDAP systems. This paper presents the performance evaluation respectively for a distribution-based and a replication-based LDAP model. The analysis is based on an analytic performance model for each distributed system which is obtained by applying the M/M/1 queuing model. The performance evaluation made to these analytic models reveals that the distribution-based and the replication-based model show a significant tradeoff in their performance with respect to the system size as well as the amount of system load.

• 보존과학회지
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• 제37권1호
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• pp.25-33
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• 2021

To extend the application of digital technology to the replication of artifacts, meticulous details of the process and the diversity of three-dimensional (3D) printing output materials need to be supplemented. Thus, in this study, a bronze mirror with Hwangbichangcheon inscription was digitalized by 3D scanning, converted into a voxel model, and virtual conservation treatment was performed using a haptic device. Furthermore, the digital mold of the bronze mirror completed by Boolean modeling was printed using a 3D sand-printer. Such contactless replication based on digital technology reflects the stability, precision, expressivity, collectivity, durability, and economic feasibility of artifacts. Its application can be further extended to cultural products as well as such areas as education, exhibition, and research. It is expected to be in high demand for metal artifacts that require casting. If empirical studies through experimental research on casting are supplemented in the future, it could extend the application of digital technology-based contactless replication methods.

• 대한공간정보학회지
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• 제5권2호
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• pp.193-205
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• 1997

대용량의 매핑 자료를 다수의 사용자들이 효율적으로 공유하는데는 클라이언트-서버 환경에서 복제 일관성을 위한 분산 모델 개발이 요구된다. 기존의 분산 모델은 각 사이트들의 사본간의 일관성을 강조했으나 GUI를 이용한 화면과 사본간의 일관성이 고려되지 못하여 매핑 시스템과 같은 장기 트랜잭션에는 적합하지 않다. 매핑자료의 특성상 분산 환경에서 트랜잭션들의 일관성을 유지하는데는 시간 지연이 많으므로 병행효율이 중요하다. 본 연구에서는 디스플레이 록을 이용하여 GUI 화면과 사본들 사이의 일관성을 지원한다. 매핑자료의 특성을 이용하여 낙관적 병행제어 기법과 일관성 모델을 개선하여, 처리효율을 향상하는 일관성 모델을 제시한다.

• 인터넷정보학회논문지
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• 제6권1호
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• pp.73-84
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• 2005

ALTIBASE/sup TM/ 시스템은 메인 메모리를 주 저장장치로 사용하는 관계형 주기억장치 DBMS이다. 본 논문에서는 최근 데이터베이스 응용들의 요구사항으로 부각되고 있는 데이터베이스의 고가용성과 실시간 데이터베이스 시스템의 높은 트랜잭션 처리율을 동시에 보장하기 위하여 ALTIBASETM시스템의 구조 및 설계에 대하여 기술한다. 특히, 고가용성 보장을 위한 ALTIBASETM 시스템의 이중화 기능에 대하여 논의한다. 이중화 기법의 분류를 통해 다른 기법과의 비교를 하였으며, 이중화 관리를 위한 프로세스 구조 및 이중화 통신 모델, 프로토콜에 대하여 설명한다. 또한, 다양한 실험을 통하여 트랜잭션 처리율을 측정하였으며, 이중화 기능을 지원하기 위해 요구되는 오버헤드를 독립 시스템의 성능과 비교하여 측정하였다.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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• pp.14-14
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• 2003

Potato virus X (PVX), the type member of Potexvirus genus, is a flexuous rod-shaped virus containing a single-stranded (＋) RNA. Infection by PVX produces genomic plus- and minus-strand RNAs and two major subgenomic RNAs (sgRNAs). To understand the mechanism for PVX replication, we are studying the cis- and/or trans-acting elements required for RNA replication. Previous studies have shown that the conserved sequences located upstream of two major sgRNAs, as well as elements in the 5' non-translated region (NTR) affect accumulation of genomic and sg RNAs. Complementarity between sequences at the 5' NTR and those located upstream of two major sgRNAs and the binding of host protein(s) to the 5' NTR have shown to be important for PVX RNA replication. The 5 NTR of PVX contains single-stranded AC-rich sequence and stem-loop structure. The potential role(s) of these cis-elements on virus replication, assembly, and their interaction with viral and host protein(s) during virus infection will be discussed based on the data obtained by in vitro binding, in vitro assembly, gel shift mobility assay, host gene expression profiling using various mutants at these regions.

• Journal of Microbiology and Biotechnology
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• 제30권9호
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• pp.1412-1419
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• 2020

Human noroviruses (HuNoVs) are a leading cause of gastroenteritis outbreaks worldwide. However, the paucity of appropriate cell culture models for HuNoV replication has prevented developing effective anti-HuNoV therapies. In this study, first, the replication of the virus at various temperatures in different cells was compared, which showed that lowering the culture temperature from 37℃ significantly increased virus replication in Madin-Darby canine kidney (MDCK) cells. Second, the expression levels of autophagy-, immune-, and apoptosis-related genes at 30℃ and 37℃ were compared to explore factors affecting HuNoV replication. HuNoV cultured at 37℃ showed significantly increased autophagy-related genes (ATG5 and ATG7) and immune-related genes (IFNA, IFNB, ISG15, and NFKB) compared to mock. However, the virus cultured at 30℃ showed significantly decreased expression of autophagy-related genes (ATG5 and ATG7), but not significantly different major immune-related genes (IFNA, ISG15, and NFKB) compared to mock. Importantly, expression of the transcription factor FOXO1, which controls autophagy- and immune-related gene expression, was significantly lower at 30℃. Moreover, FOXO1 inhibition in temperature-optimized MDCK cells enhanced HuNoV replication, highlighting FOXO1 inhibition as an approach for successful virus replication. In the temperature-optimized cells, various HuNoV genotypes were successfully replicated, with GI.8 showing the highest replication levels followed by GII.1, GII.3, and GII.4. Furthermore, ultrastructural analysis of the infected cells revealed functional HuNoV replication at low temperature, with increased cellular apoptosis and decreased autophagic vacuoles. In conclusion, temperature-optimized MDCK cells can be used as a convenient culture model for HuNoV replication by inhibiting FOXO1 and providing adaptability to different genotypes.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 컴퓨터소사이어티 추계학술대회논문집
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• pp.3-6
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• 2003

In this paper, we conduct a performance analysis for the composite scheme that is obtained by combining the data distribution and the data replication schemes usually used for the implementation of distributed directory service systems. The analysis results reveal that the composite model is a viable option to overcome the performance trade-off between the data distribution and the data replication model. In this paper, we present the performance model developed for the composite model by appling queuing modelling. Using the performance model, performance values for a variety of system execution environments are suggested which enable us to bring an efficient design for high performance distributed directories.

• 한국산학기술학회논문지
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• 제14권5호
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• pp.2449-2456
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• 2013

컬럼-기반 데이터베이스 저장소는 우수한 입출력 성능으로 대용량 데이터 분석 시스템을 위한 매우 진보적인 모델이다. 전통적인 데이터 저장소는 빠른 쓰기 연산을 위하여 한 레코드의 속성들을 하드 디스크에 연속적으로 배치되어 있는 가로-지향 저장 모델을 활용하였다. 하지만 검색이 대부분인 데이터웨어하우스 시스템을 위해서는 월등한 판독 성능 때문에 컬럼-지향 저장소가 더 적합한 모델이 되고 있다. 또한 최근에는 MLC 플래시 메모리를 사용한 SSD가 고속 데이터 분석 시스템을 위한 적합한 저장 매체로 인식되고 있다. 본 논문에서는 고속 컬럼-지향 데이터 저장소 모델을 도입하고, 고속 컬럼-지향 데이터웨어하우스 시스템을 위한 교차 압축 이중화를 활용하는 새로운 저장소 관리 기법을 제안한다. 본 저장소 관리 기법은 두 개의 MLC SSD에 기반하며, 압축과 비압축된 세그먼트의 교차 이중화를 통하여 높은 CPU 및 입출력 부하에서도 우수한 저장 성능과 안정성을 얻는다. 성능 평가 결과를 통하여 본 저장소 관리 기법이 기존 기법보다 컬럼 세그먼트 갱신 처리치 및 그 응답시간 측면에서 더 우수함을 확인하였다.

• The Plant Pathology Journal
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• 제24권3호
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• pp.289-295
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• 2008

RNA-RNA interactions and the dynamic RNA conformations are important regulators in virus replication in several RNA virus systems and may also involved in the regulation of many important virus life cycle phases, including translation, replication, assembly, and switches in these important stages. The 5' non-translated region of Potato virus X(PVX) contains multiple cis-acting elements that facilitate various viral processes. It has previously been proposed that RNA-RNA interactions between various RNA elements present in PVX RNA genome are required for PVX RNA accumulation(Hu et al., 2007; Kim and Hemenway, 1999). This model was based on the potential base-pairing between conserved sequence elements at the upstream of subgenomic RNAs(sgRNAs) and at the 5' and 3' end of RNA genome. We now provide more evidence that RNA-RNA base-pairing between elements present at the 5' end and upstream of each sgRNA is required for efficient replication of genomic and subgenomic plus-strand RNA accumulation. Site-directed mutations introduced at the 5' end of plus-strand RNA replication defective mutant(${\Delta}12$) increasing base-pairing possibility with conserved sequence elements located upstream of each sgRNAs restored genomic and subgenomic plus-strand RNA accumulation and caused symptom development in inoculated Nicotiana benthamiana plants. Serial passage of a deletion mutant(${\Delta}8$) caused more severe symptoms and restored wild type sequences and thus retained possible RNA-RNA base-pairing. Altogether, these results indicate that the RNA element located at the 5' end of PVX genome involved in RNA-RNA interactions and play a key role in high-level accumulation of plus-strand RNA in vivo.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2010년도 춘계학술대회 논문집
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• pp.151-152
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• 2010