• The Journal of Engineering Geology
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• v.31 no.4
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• pp.493-506
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• 2021

Liquefaction refers to a phenomenon in which excessive pore water pressure occurs when a dynamic load such as an earthquake rapidly acts on a loose sandy soil saturated with soil, and the ground loses effective stress and becomes liquefied. The indoor repeated test for liquefaction evaluation can be confirmed through the repeated triaxial compression test and the repeated shear test. In this regard, this study tried to confirm the liquefaction resistance strength according to the relative density and particle size distribution of sand using the repeated triaxial compression test. As a result of the experiment, it was confirmed that the liquefaction resistance strength increased as the relative density increased regardless of the soil classification, and the liquefaction resistance strength according to the particle size distribution of the sand was confirmed that the liquefaction resistance strength of the SP sample close to SW was significantly higher. In addition, as a result of analyzing 30% of fine powder compared to 0% of fine powder, as the relative density increased to 40~70%, the liquefaction resistance strength decreased by 5~20%, and the domestic weathered soil ground had a fine liquefaction resistance strength compared to Jumunjin standard sand. When the minute was 10%, it was measured to be 30% or more, and when the fine particle was 30%, it was measured to be less than 50%.

• Toxicological Research
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• v.16 no.2
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• pp.163-172
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• 2000

Recently, there is a worldwide concern that a great number of man-made chemicals have a hormone-like action both in humans and in animals. DECD is developing screening programs using validated test systems to determine whether certain substances may have an effect in humans. In the present study. the establishment oj repeated-dose toxicity test method was tried. Flutamide. an anti-androgenic agent. was administered by gavage to Sprague-Dawley rats for 28 days at dose levels of 0. 0.5. 3 and 18 mg/kg body weight (10-15 rats/sex/group) to examine the effects on general findings. especially reproductive and endocrine parameters. Clinical signs. body weights, food consumption, and sexual cycle were checked and measured. For the gross and microscopic examinations. 10 rats/sex/group were sacrificed at the end of dosing period and the remaining animals of control and high dose groups (5 each) were sacrificed after 14 days recovery. Examinations for hematology and clinical chemistry were carried out at necropsy. There were no treatment-related changes in clinical signs. body weights, food consumption. gross necropsy. hematology and clinical chemistry at all doses of both sexes. The period and regularity of sexual cycle were not adversely affected at all doses by the test agent. At 18 mg/kg. both decreased weights of prostate, seminal vesicle and epididymis in males and increased weights of spleen and thymus in females were observed. In addition, decreased number of spermatids and sperms. increased serum testosterone concentration and increased incidence (100%) of interstitial cell hyperplasia were seen in males. At 18 mg/kg of the recovery group. decreased prostate weight. reduced sperm count and increased incidence (20%) of interstitial cell hyperplasia in males and increased thymus weight in females were observed. At 3 mg/kg. reduced sperm count was found. There were no adverse effects on parameters examined at 0.5 mg/kg of both sexes. The results suggested that the potential target organs of flutamide may be accessory sexual glands including testes for males and spleen and thymus for females. Taken together. this test method was found to be a useful screening test system for endocrine disrupting chemicals.

• Computational Structural Engineering
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• v.5 no.1
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• pp.119-132
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• 1992

The objective of this study is to perform extensive parametric studies of the lateral-torsional buckling of short 1-beams under repeated loadings, and to gain a further insight into the lateral-torsional beam buckling problem. A one-dimensional geometrically (fully) nonlinear beam model is used, which includes superposed infinitesimal transverse warping deformation in addition to finite torsional warping deformation. A multiaxial cyclic plasticity model is also implemented to better represent cyclic metal plasticity in conjunction with a consistent return mapping algorithm. The general response for the lateral-torsional buckling of short I-beams under repeated loadings is examined through several parametric studies around the standard case : the material yield strength, the yield plateau, the strain hardening, the kinematic hardening, the residual stresses, the load eccentricity with respect to the shear center, the height of the load with respect to the cross-section of the beam, the location of the load along the length of the beam, the dimensions of the cross-section of the beam and the fixity of the supported end remote from the load.

• Journal of Korea Game Society
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• v.16 no.2
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• pp.7-16
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• 2016

In this paper, we propose a method for effectively detecting specific behavior. The proposed method detects outlying behavior based on the game players' characteristics. These characteristics are captured non-invasively in a general game environment and add keystroke based on repeated pattern. In this paper, cameras were used to analyze observed data such as facial expressions and player movements. Moreover, multimodal data from the game players was used to analyze high-dimensional game-player data for a detection effect of repeated behaviour pattern. A support vector machine was used to efficiently detect outlying behaviors. We verified the effectiveness of the proposed method using games from several genres. The recall rate of the outlying behavior pre-identified by industry experts was approximately 70%. In addition, Repeated behaviour pattern can be analysed possible. The proposed method can also be used for feedback and quantification about analysis of various interactive content provided in PC environments.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.1D
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• pp.33-39
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• 2012

More and more pavements are suffering from damage these days due to the below-zero winter temperatures and frequent snowfalls. From this research, the freeze-thawing mechanisms of pavements will be observed, and the freeze-thawing resistance of porous asphalt concrete mixture is to be evaluated according to various assessment methods. The investigation was conducted through applying rigid and flexible pavements to freeze-thawing resistance experiments, which include various experiments such as deformation rate measurements, Lottman tests, repeated cyclic freeze-thawing experiments, stripping resistance tests and so on. Test results revealed that the porous asphalt concrete had less deformations according to temperatures compared to dense-graded asphalt concrete due to the 20% void gap. In addition, according to the freeze-thawing repetition experiments which are effected by moisture, the porous asphalt concrete mixture showed superior resistance to repeated cyclic freeze-thawing compared to other asphalt concrete mixtures due to the drainage and the voids within the specimen.

• Toxicological Research
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• v.14 no.3
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• pp.393-400
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• 1998

As a series of safety studies on DA-3585, a recombinant human erythropoietin, its local irritancy was examined in rabbits after the following treatments; application into the conjunctival sac of the eye(single), subcutaneous injection (single and -day repeated)and intravenous injection (7-day repeated.)In addition, perivascular irritation of DA-3585 was investigated in mice. In the result of ocular irritation test, 10,000IU/ml solution of DA-3585 could be considered as a non-irritating material. The local irritation of DA-3585 by a single and 7-day repeated subcutaneous injection was negligible and not so much different from that of saline. In the vascular irritancy test, macro-and microscopic observations revealed that local irritation of DA-3585 was comparable to that of saline when injected into retroauricular vein of rabbits for 7 consecutive days. Furthermore the perivascular administration of DA-3585 upto the concentration of 10,000 IU/ml did not induce any morphological abnormalities at injection sites. The results obtained from the present study suggest that the local irritancy of DA-3585 is not different from that of saline when injected through intravenous or subcutaneous route for clinical practice.

• Journal of the Korean Society of Physical Medicine
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• v.9 no.4
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• pp.363-373
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• 2014

PURPOSE: The purpose of this study was of scale using auditory biofeedback training and kinging training on walking speed and weight bearing ratio in patients hemiplegia with stroke to determine of the effects of such training would be maintained even after stopping the intervention. METHODS: The 30 subject were classified into three groups : 12 times, 3 times a week receiving the control, the experimental group scale using auditory and kicking training for 4 weeks. In addition, all subjects in the control group and experimental groups received the same general exercise treatment 12 times, 3 times a week for 4 weeks, and underwent follow-up tests. The significance of differences between the control group and the experimental groups was analysis by repeated-ANOVA, Interaction time and groups was analysis by repeated-ANOVA. In case where there were differences, post-hot tests were conducted using repeated measure ANOVA. RESULTS: There were significant differences in 10 m walking speed and weight bearing ratio between the control group and experimental group after the performance of the scale using auditory training and kicking training. Scale using auditory biofeedback training 4 weeks was more effective than kicking training. After 8 weeks weight bearing ratio maintained on scale using auditory training. CONCLUSION: These finding suggest that the scale using auditory biofeedback training and kicking training has positive effects on hemiplegia with stroke.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.3
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• pp.1117-1121
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• 2011

The movable bracket structure, which is an apparatus for supplying electric power to a running electric locomotive, is applied by a repeated load during the passage of the electric locomotive. Such a repeated load becomes an excitation source that causes screws constituting the movable bracket structure to be loosened. This study was conducted on the causes and countermeasures of the bolt loosening caused by the repeated vibration using a computer simulation. As the result, a simulation model was constructed to enable the dynamic analysis of the movable bracket structure. It could be found that the principal excitation frequency range for the bolt loosening of the movable bracket structure was less than 200 Hz. In addition, the bolts are prevented from being loosened by increasing stiffness of H beams. The vibration mode of a lower band bracket is found to be triggered in a frequency range between 300 and 600 Hz. And the increase in stiffness of the lower band bracket exhibits the effect to avoid the bolt loosening at a frequency range of 200 Hz or more.

• The Journal of Korean Medicine
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• v.38 no.4
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• pp.55-61
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• 2017

Objectives: In order to accurately measure skin moisture and accumulate normal skin moisture data, analyzing the uncertainty of the skin moisture measurement and establishing standard reference data is essential. It helps to evaluate the skin's condition and has great significance in diagnosis and treatment. In this study, the traceability of the equipment and the uncertainty of the results were analyzed for their potential use in the field of Korean medicine. The data was collected measuring skin moisture on the sole of the foot. Methods: One professional measured the moisture of the adult male's foot 10 times following a determined protocol. The standard uncertainty of repeated measurements was calculated from the mean value of 10 repeated measurements. Ten trainee participants also measured the adult male's foot following a determined protocol. The standard uncertainty by tester was calculated from the value of repeated measurements. Results: As a result of analyzing the difference between the mean and standard uncertainties in both the expert and trainees, it was confirmed that the variance in this study did not satisfy the normal distribution. In addition, the Mann-Whitney U-test was carried out, and it was found that there was no significant difference in the measured values of the two groups. The authorized uncertainty of measurements and traceability of all the equipment was not confirmed. Conclusions: This paper establishes the basis for later measurement-equipment research to provide the objective indicators to approach the dryness of plantar skin from dehydration, the Korean medicine perspective.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.1
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• pp.89-97
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• 2013

Developing an animal model for a specific disease is very important in the understanding of the underlying mechanism of the disease and allows testing of newly developed new drugs before human application. However, which of the plethora of experimental animal species to use in model development can be perplexing. Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a very well known method to induce the symptoms of Parkinson's disease in mice. But, there is very limited information about the different sensitivities to MPTP among mouse strains. Here, we tested three different mouse strains (C57BL/6, Balb-C, and ICR) as a Parkinsonian model by repeated MPTP injections. In addition to behavioral analysis, endogenous levels of dopamine and tetrahydrobiopterin in mice brain regions, such as striatum, substantia nigra, and hippocampus were directly quantified by liquid chromatography-tandem mass spectrometry. Repeated administrations of MPTP significantly affected the moving distances and rearing frequencies in all three mouse strains. The endogenous dopamine concentrations and expression levels of tyrosine hydroxylase were significantly decreased after the repeated injections, but tetrahydrobiopterin did not change in analyzed brain regions. However, susceptibilities of the mice to MPTP were differed based on the degree of behavioral change, dopamine concentration in brain regions, and expression levels of tyrosine hydroxylase, with C57BL/6 and Balb-C mice being more sensitive to the dopaminergic neuronal toxicity of MPTP than ICR mice.