• Toxicological Research
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• v.8 no.2
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• pp.265-272
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• 1992

Effects of repeated physical exercise on the carbon tetrachloride ($CCl_4$) hepatotoxicity were examined in adult female rats. Rats were introduced into a cylindrical rotating cage and forced to exercise for 1 hr each day, 6days/week, for 5 consecutive weeks at a speed starting from 10m/min, increased by 1m/min per day until the speed reached 27m/min. Significantly less body weight gain was observed in the exercise group suggesting that physical fitness had been induced in these animals. Eighteen hours following termination of the last exercise bout rats were treated with $CCl_4$(2 mmol/kg.ip). The $CCl_4$-induced heptotoxicity was significantly potentiated in the repeated exercise group compared to the resting sedentary animals as determined by changes in serum sorbitol dehydrogenase (SDH), glutamic oxaloacetic transaminase(GOT), glutamic pyruvic transaminase (GPT), and glucose-6-phosphatase(G-6-Pase) activities when measured 24hrs following the $CCl_4$ treatment. Hepatic drug metabolizing activity was determined in order to elucidate the underlying mechanism of potentiating action of the $CCl_4$ hepatotoxicity induced by repeated physical exercise. Repeated exercise increased the hepatic microsomal cytochrome P-450 contents and aminopyrine N-demethylase activity. The results suggest that the potentiation of $CCl_4$ hepatotoxicity by repeated exercise is associated with induction of the mixed function oxidase (MFO) enzyme system mediating the metabolism of $CCl_4$ to its active metabolite(s).

• Korean Journal of Exercise Nutrition
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• v.24 no.4
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• pp.15-23
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• 2020

[Purpose] Lactate is a principal energy substrate for the brain during exercise. A single bout of high-intensity interval exercise (HIIE) can increase the blood lactate level, brain lactate uptake, and executive function (EF). However, repeated HIIE can attenuate exercise-induced increases in lactate level and EF. The lactate levels in the brain and blood are reported to be correlated with exercise-enhanced EF. However, research is yet to explain the cause-and-effect relationship between lactate and EF. This study examined whether lactate consumption improves the attenuated exercise-enhanced EF caused by repeated HIIE. [Methods] Eleven healthy men performed two sets of HIIE, and after each set, 30 min were given for rest and examination. In the 2^nd set, the subjects consumed experimental beverages containing (n = 6) and not containing (n = 5) lactate. Blood, cardiovascular, and psychological variables were measured, and EF was evaluated by the computerized color-word Stroop test. [Results] The lactate group had a higher EF (P < 0.05) and tended to have a higher blood lactate level (P = 0.082) than the control group in the 2^nd set of HIIE. Moreover, blood lactate concentration was correlated with the interference score (i.e., reverse score of EF) (r = -0.394; P < 0.05). [Conclusion] Our results suggest that the attenuated exercise-enhanced EF after repeated HIIE can be improved through lactate consumption. However, the role of lactate needs to be elucidated in future studies, as it can be used for improving athletes' performance and also in cognitive decline-related clinical studies.

• Toxicological Research
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• v.18 no.3
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• pp.215-226
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• 2002

Acute or repeated physical exercise affects a large number of physiological parameters including hemodynamics, respiration, pH, temperature, gastrointestinal function and biotransformation, which determine the pharmacokinetics of drugs and chemicals. The rate and the amount of a chemical reaching the active site are altered by physical exercise, which results in significant changes in pharmacolosical/toxicological activity of the chemical. This aspect of physical exercise has vast implication in therapeutics and in safety evaluation, particularly for chemicals that have a low margin of safety. However there appears to be a wide inter- and intraindividual variation in the effects of physical exercise depend-ing on the duration, intensity and type of exercise, and also on the properties of each chemical. It is suggested that more studies need to be done to determine which factor(s) plays a major role in the disposition of chemicals in human/animals performing physical exercise. Certain chemicals induce severe toxicity due to metabolic conversion to reactive intermediate metabolites. it is suggested that repeated exercise may enhance the free radical scavenging system by increasing the activity of antioxidant enzymes. This area of research remain to be explored to elucidate the interaction of exercise and chemical on the antioxidant system.

• Physical Therapy Rehabilitation Science
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• v.10 no.2
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• pp.90-97
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• 2021

Objective: The purpose of this study was to find out how the back instability during clam exercise (CE) causes changes in pelvic rotation and hip joint abductor muscle activity, and to find out the effects with different methods of application of pressure biofeedback. Design: Comparative study using repeated measures. Methods: Each subjects performed the clam exercise (CE) without pressure biofeedback, the clam exercise with pressure biofeedback applied to the back (CE-PBU to back), and the clam exercise with pressure biofeedback applied to the side (CE-PBU to side). The amount of pelvic rotation was measured using myomotion. And the muscle activity of the muscle gluteus medius and the tensor fasciae latae was measured using EMG device. One-way repeated measures ANOVA followed by the Bonferroni post test were used to compare the EMG activity in each muscle and pelvic rotation angle during the CE, CE-PBU to back, CE-PBU to side. Results: The amounts of pelvic rotation was the lowest in CE-PBU to back (p< 0.05) and the ratio of muscle activity of the muscle gluteus / tensor fasciae latae was the highest in CE-PBU to back (p< 0.05). Conclusions: It is thought that, in order to stabilize the waist-pelvis and increase hip joint muscle strength in subjects with back instability, applying clam exercise with pressure biofeedback applied to the lower back is effective in improving waist-pelvic movements and selectively strengthening the muscle gluteus medius.

• Journal of the Korean Society of Physical Medicine
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• v.6 no.2
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• pp.189-197
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• 2011

Purpose: Trunk muscle weakness in the children with cerebral palsy can lead to postural and alignment problems, breathing difficulties, and so on. Therefore, children with cerebral palsy can benefit from exercises that strengthen the muscles in their trunks. The purpose of this study was to investigate the effects of trunk muscle strengthening exercise on functional gross movement and balance ability in children with spastic diplegic cerebral palsy. Methods: We used single group repeated measure design in 8 children(four males, four females; aged 6~12 years; mean 8.3 years) with diplegia. The functional gross motor outcome measured by using the GMFM and balance ability of all children was measured by pediatric balance scale. All participants were alternately received trunk strengthening exercise and neurodevelopment treatment for 40 minutes twice per week during 8 weeks. Results: Significant and clinical meaningful improvement in functional gross motor and balance ability were shown. Conclusion: The results indicate that trunk strengthening exercise has a positive effect on both functional gross motor and balance ability in children with spastic diaplegic cerebral palsy.

• Journal of Korean Physical Therapy Science
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• v.24 no.1
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• pp.69-78
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• 2017

Background: The purpose of the present study is to report the effect of muscle performance on knee flexion and extension by chin in exercise. Methods: This study was Participated in 10 healthy subjects. For conducting the chin-in exercise, subjects are lay down with supine position. Using the rounded towel, subjects was performed contraction of longus colli and longus capatis muscle by push the towel. Chin-in exercise was conducted 3 times a day, 4 times a week for 4 weeks. By using the Biodex system4, We measured absolute muscle strength, relative muscle strength, total exercise quantity and average rate of production in knee flexion and extension. The data was analyzed by the repeated-measure ANOVA for comparing before, after exercise 2 weeks, after exercise 4 weeks changes of factors. Results: After chin-in exercise, there was significant difference of before, after 2 weeks and 4weeks results in absolute muscle strength, relative muscle strength, total exercise quantity, average rate of production, agonist/antagonist ratio(p<.05). Conclusion: As a results of this study, chin-in exercise may help to improve muscle ability of knee joint activation and knee joint action performance.

• Journal of the Korean Society of Physical Medicine
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• v.13 no.3
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• pp.11-17
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• 2018

PURPOSE: The purpose of this study was to identify the effect of abdominal stabilization exercise with Stabilizer and Gymball. METHODS: The participants were divided randomly into 2 groups each of 20 participants in the gymball exercise group and 20 participants in the exercise group. The changes of respiratory muscle activity between the two groups were measured three times a week for 4 weeks. The activity of rectus abdominis and internal oblique was measured using surface EMG to measure respiratory muscle activity. The training was repeated five sets, and one set was repeated 6 times with one 10 second exercise and 5 second rest. RESULTS: The results of the study showed that there was a significant difference in the amount of respiratory accessory muscle activation, inspiratory pressure, respiratory minute volume at the experimental group with stabilizer and control group with gymball exercise. Between-group difference was statistically significant only for rectus abdominis muscle activation. CONCLUSION: Both the stabilizer and the gymball exercises were effective in improving the respiratory rate but there was no difference between the two groups. Also, when comparing activity of muscle in both group, both groups were effective in improving and more effective than improvement of muscular activity of stabilizer in muscle of stabilizer.

• PNF and Movement
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• v.11 no.2
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• pp.87-93
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• 2013

Purpose : The purpose of this study was to investigate the effects of closed chain breathing exercise on thorax circumference increase and ROM of shoulder rotation for cervical vertebral cord injury patient's. Methods : 12 cervical vertebral cord injury patients volunteer to participate in this study. closed chain breathing exercise group of 4 subjects performed exercise three time a week. The deep breathing exercise group and general exercise group of 4 subjects performed exercise three time a week. We analyaed the descriptive statistics and $3{\times}2$ repeated measures ANOVA by SPSS 12.0 for window. Results : In comparison of rotation of shoulder ROM between pre and post value, the increase of rotation ROM of shoulder was significant in the closed chain breathing exercise group(p<.05). Conclusion : The closed chain breathing exercise helped to increased rotation ROM of shoulder.

• The Journal of Korean Physical Therapy
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• v.20 no.1
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• pp.11-16
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• 2008

Purpose: This study was undertaken to compare the signal characteristics of surface electromyography (EMG) between progressive resistive increase exercise (PRIE) and progressive resistive decrease exercise (PRDE). Methods: Forty healthy male subjects were randomly assigned to either the PRIE group or the PRDE group. Subjects participated in the PRIE and PRDE methods, with 10 RM for each subject. EMG activity was recorded from the rectus femoris muscle. Outcome data were collected for both groups pre-exercise, immediately post-exercise, then at 5 and 10 minutes post-exercise. Repeated measures 2-way ANOVA was used to determine the statistical difference of the root mean square (RMS) in EMG activity. Results: We showed that RMS values, when compared with pre-exercise, were decreased immediately after exercise and were increased at 5 and 10 minutes after exercise (p<0.05). The RMS values were not significantly different between the two groups (p>0.05). Conclusion: These results can indicate that both the PRIE and PRDE protocols will be improve strength with equivalent efficacy. Further studies are needed to address exercise duration, frequency of exercise sessions, and rest times than the PRIE and PRDE protocols with regard to the changes in strength improvement without a large amount of muscle fatigue.

• Journal of East-West Nursing Research
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• v.10 no.1
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• pp.41-52
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• 2004

Purpose: The purpose of this research was to compare the effects of Danjeon Breathing exercise and walking exercise on blood lipids, physical symptoms and hemoglobin of middle-aged women to determine which of these two exercises was more beneficial. Methods: The Danjeon breathing exercise group(20) took health management counseling and performed an eighty-minute Danjeon breathing exercise three times a week for 12 weeks while the walking exercise group(25) took health management counseling and performed a walking exercise seven hours per week for 12 weeks. The control group(20) received only health management counseling. The groups were homogeneous on age, religion, marital status, education, profession, monthly income per household, menopause, smoking, drinking, fat intake and cholesterol intake. Likewise, the groups were homogeneous on total cholesterol, HDL-cholesterol,atherogenic index, hemoglobin and physical symptoms. The collected data were analyzed by using the SPSS PC program and $x^2$-test, ANOVA, repeated measures of ANOVA and LSD. Results: 1. Total cholesterol of the Danjeon breathing exercise group and the walking exercise group were lower than that of the control group. 2. HDL- cholesterol of the Danjeon breathing exercise group and the walking exercise group were not higher than that of the control group. 3. Atherogenic index of the Danjeon breathing exercise group was lower than that of the control group, but atherogenic index of the walking exercise group was not lower than that of the control group. 4. Hemoglobin of the Danjeon breathing exercise group and the walking exercise group were not higher than that of the control group. 5. Physical symptom score of the Danjeon breathing exercise group was lower than those of the walking exercise group and the control group, but Physical symptom score of the walking exercise group was not lower than that of the control group. Conclusion: Danjeon breathing exercise and walking exercise are effective for decreasing total cholesterol of middle-aged women. Danjeon breathing exercise is more effective for decreasing atherogenic index and physical symptoms of middle-aged women than walking exercise.