• Natural Product Sciences
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• 제22권4호
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• pp.263-269
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• 2016

Rhynchophylline (RP) is a major tetracyclic oxindole alkaloid of Uncariae Ramulus et Uncus which has been used to treat hypertension, seizures, pain and anxiety in the oriental countries. A recent report revealed that RP attenuated ischemia-induced neuronal damage and kainite-induced convulsions in animals. This study was performed to investigate whether RP enhances pentobarbital-induced sleep behaviors and modulates sleep architecture in mice. Locomotor activity was significantly inhibited by RP at 0.25 and 0.5 mg/kg, similar to 2 mg/kg diazepam (a benzodiazepine agonist) in mice. RP shortened sleep latency and increased total sleep time in a dose-dependent manner when administrated with pentobarbital (42 mg/kg, i.p.). RP also increased the number of sleeping mice and total sleep time by concomitant administration with the sub-hypnotic dosage of pentobarbital (28 mg/kg, i.p.). On the other hand, RP (0.25 mg/kg, p.o.) itself significantly inhibited sleep-wake cycles, prolonged total sleep time, and rapid eye movement in rats. In addition, RP also increased chloride influx in the primary cultured hypothalamic neuronal cells. In addition, we found that glutamic acid decarboxylase ($GAD_{65/67}$) was activated by RP. In conclusion, RP augments pentobarbital-induced sleeping behaviors, and can be a candidate for treating insomnia.

• 동의생리병리학회지
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• 제27권2호
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• pp.189-195
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• 2013

This study was designed to analyze the effects of methanol extracts and solvent fractions of the young branch of Prunus persica on scavenging activity of ROS, RNS and inhibiting activity of oxidative modification in human LDL induced by copper ion or free radical generator. The scavenging capacities of the fractions on DPPH radical, superoxide radical, nitric oxide and peroxynitrite were exhibited the highest in ethylacetate fraction, followed by butanol fraction. In the copper-induced LDL oxidative modification system, the highest antioxidant activity was revealed in ethylacetate fraction, and butanol fraction exhibited a similar activity. However, solvent fractions of the young branch of Prunus persica showed a relatively low antioxidant activity in the AAPH-mediated LDL oxidation. In addition, ethylacetate and butanol fractions also inhibited the copper-mediated LDL oxidation in the REM assay, which was comparable to that of the positive controls, including EDTA, ascorbic acid and BHT. Futhermore, a content of total phenolics in these two fractions was higher than that of the other fractions. These results indicated that ethylacetate and butanol fractions of the young branch of Prunus persica were useful for the prevention of the free radical- or metal ion-induced oxidative damages.

• 대한의용생체공학회:의공학회지
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• 제35권6호
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• pp.211-218
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• 2014

The objective of this research is to develop an automatic algorithm based on electrocardiogram (ECG) to estimate slow-wave sleep (SWS). An algorithm is based on 7 indices extracted from heart rate on ECG which simultaneously recorded with standard full night polysomnography from 31 subjects. Those 7 indices were then applied to independent component analysis to extract a feature that discriminates SWS and other sleep stages. Overall Cohen's kappa, accuracy, sensitivity and specificity of the algorithm to detect 30s epochs of SWS were 0.52, 0.87, 0.70 and 0.90, respectively. The automatic SWS detection algorithm could be useful combining with existing REM and wake estimation technique on unattended home-based sleep monitoring.

• 한국응용과학기술학회지
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• 제36권4호
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• pp.1050-1059
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• 2019

비결정성 영역에서의 유동단위의 고찰을 위하여 유동 파라메타와 결정크기로부터 폴리아미드 섬유고분자 물질의 자체확산, 홀 부피, 유동 열역학 파라메타 등을 계산하였다. 폴리아미드 섬유의 응력완화 실험은 용매기를 부착한 인장 시험기를 사용하여 여러 온도의 공기, 증류수, 산, 염기 용액에서 실행하였다. REM 모델의 이론적인 응력완화 식에 응력완화 실험 결과를 적용하여 여러 가지 유동 파라메타를 계산하였다. 이들 시료의 유동 파라메타는 완화 스펙트럼, 자체확산, 점도 및 유동 활성화 에너지와 직접적인 연관을 갖는 것으로 규명되었다.

• Journal of Welding and Joining
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• 제10권1호
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• pp.12-19
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• 1992

용접능률의 향상을 위한 대입열용접법의 적용은 과도한 입열량으로 인하여 용접부의 인성이 저 하한다는 점에서 그 적용에 주의를 요한다. 본 보에서는 대입열용접시 열영향부의 인성 저하의 원인과 그 대책을 강재의 측면에서 검토하였다. 고장력강을 용접하면 입열량이 증가함에 따라 오스테나이트 결정립이 조대화되고 상부 베이나이트와 도상 마르텐사이트가 생성되어 인성이 저하한다. 그 대책으로서는 용접 열싸이클과정중 안정한 질화물, 산화물등을 모재에 미세분산시켜 오스테나이트 결정립 성장을 억제하고, 페라이트, 펄라이트 변태를 촉진시킨다. 이러한 석출물의 형성을 위해서는 주로 Ti, Ca, REM, B등의 합금원소가 이용된다. 소입성이 높은 주질고장력 강에서는 석출물의 분산에 의한 페라이트의 변태 촉진 보다는 Mn, Ni, Cr, Mo, V등의 합금원 소를 첨가하여 소입성을 높여 인성이 우수한 하부 베이나이트 조직을 형성하든가, 탄소량을 저 감시켜 도상 마르텐사이트의 생성을 억제하므로서 인성을 확보한다. 현재 국내에서 제조되고 있는 대입열용접용강중 인장강도 50kgf/mm$^{2}$급강은 기본적으로 용접부 인성이 우수한 TMCP법으로 제조되며, Ti등을 첨가하여 석출물의 효과를 이용하고 N을 억제하여 기지의 인 성을 향상시키는 등의 방법을 병용하고 있다. 인장강도 60kgf/mm$^{2}$ 급강은 조질처리에 의하여 제조되며, 50kgf/mm$^{2}$급강과 같이 Ti, B등의 첨가에 의한 석출물의 효과를 이용 하고 있다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제4권1호
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• pp.173-178
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• 1993

기면증의 초발연령은 비교적 균일하여 15세 이전, 보통 30세이후에 발병하는 것으로 알려져있다. 저자는 기면증의 4대 증상인 주간의 과도한 졸리움, 탈력 발작, 수면마비 및 입면환각을 보이며 수면다원 검사에 의해 진단된 11세 남아를 경험하였기에 문헌고찰과 함께 이를 보고하고자 한다.

• 한국전자통신학회논문지
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• 제11권2호
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• pp.223-228
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• 2016

사람은 하루 7~8시간 잠자는 동안 20~30번 자세를 바꿈으로 해서 최적의 수면 활동을 유지하려 한다. 최적의 수면을 제공하기 위해서는 베개 내부에 코골이 습관은 물론이고 개인의 수면 패턴을 감지할 수 있는 Sensing시스템과 Sensor에서 출력되는 정보를 분석 가공하는 프로그램 및 정보를 제공하는 디스플레이 장치를 통해 파악된 각종 수면 데이터를 효과적으로 활용하기 위한 센싱 장치의 개발이 필요하다. 본 논문에서는 수면 중 인 사람의 뒤척임을 감지해 수면 패턴을 분석하고 분석된 자료를 바탕으로 수면 건강에 대한 적극적인 관리 할 수 있는 웰빙 베개를 개발하고자 한다.

• 대한한방소아과학회지
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• 제9권1호
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• pp.221-236
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• 1995

In order to investigate the anticonvulsive effect of Jinkyungondamtang, the experiment were performed in mice. After solid exract of Jinkyungondamtang was orally administered to mice, four types of convulsion were induced in mice by electric shock, strychnine, picrotoxin, and caffeine. Each of the time to elicit the convulsion and to die was observed. Results were as follows: 1. In the case of convulsion induced by electric shock, the lapse of the time to elicit convulsion and the time to die were delayed by oral administration of Jinkyungondam-tang(P<0.05, P<0.025). 2. The solid extracts of Jinkyungondamtang were revealed rem- arkable effect in delaying the time to die induced by stry-chnine (P<0.05). 3. By oral administration of Jinkyungondamtang, the lapse of the time to elicit convulsion and to die were delayed significantly to elicit convulsion inducing by picrotoxin (P<0.05, P<0.05). 4. Considerable prolongation of the lapse of the time to elicit the convulsion was observed in convulsion induced caffeine due to the anticonvulsive effects of Jinkyungondamtang (P<0.05).

• The Journal of Asian Finance, Economics and Business
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• 제7권9호
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• pp.75-84
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• 2020

The study investigates and measures the impact of financial restructuring on overall financial performance of commercial banks in Vietnam. Survey data for this research were collected from audited financial reports of 28 commercial banks in Vietnam, for the period from 2008 to 2018. In the study, we have built a model of econometric regression with the dependent variable being financial results measured through ROA and ROE. The research methods used include Pooled Ordinary Least Square Model (POLS), Fixed Effects Model (FEM), Random Effects Model (REM), and different Generalized Method of Moments (GMM). The results showed that the account payables restructuring and owners' equity restructuring are much needed. Increasing the owners' equity, decreasing the account payables would improve the overall financial performance, bad debts restructuring to decrease bad debts would also improve the financial performance as well. However, the financial restructuring in the period 2012-2015 and 2016-2018, indeed worsen the financial performance during those times. The findings of this study suggest that the evaluation of the financial performance after restructuring of commercial banks in Vietnam must be based on longer data. At the same time, it is necessary to examine differences between various banking groups to draw accurate conclusions on financial performance.

• The Journal of Asian Finance, Economics and Business
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• 제7권9호
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• pp.251-261
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• 2020

The paper examines the role of some determinants of economics, politics and institutions on the budget deficit volatility in some countries of the Association of South East Asian Nations (ASEAN) such as Indonesia, Thailand and Vietnam. The paper uses the fixed effects model (FEM) and the random effects model (REM) to investigate panel data of these countries in the period of 1990-2018. Moreover, the study also explores ordinary least square (OLS) to analyze time-series data for each country in the same period to make comparison among them. The economic data is collected from international financial statistics and world development indicators. The data on political variables are collected from International Country Risk Data Guide (ICRG). The empirical results both confirm that corruption and political stability are important indicators of budget deficit. Besides, the paper suggests authorities should pay more attention on improving the institutional setup of the economy in order to avoid high and unstable deficit. The findings offer new insight on the budget deficit in essence and suggest that the most important thing need to be done ahead is to strongly implement anti-corruption actions. By doing so, the status of budget deficit would be remarkably improved immediately.