• Journal of Microbiology and Biotechnology
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• v.27 no.1
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• pp.179-188
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• 2017

White-rot basidiomycetes are the organisms that decompose lignin most efficiently, and Trametes villosa is a promising species for ligninolytic enzyme production. There are several publications on T. villosa applications for lignin degradation regarding the expression and secretion of laccase and manganese peroxidase (MnP) but no reports on the identification and characterization of lignin peroxidase (LiP), a relevant enzyme for the efficient breakdown of lignin. The object of this study was to identify and partially characterize, for the first time, gDNA, mRNA, and the corresponding lignin peroxidase (TvLiP) protein from T. villosa strain CCMB561 from the Brazilian semiarid region. The presence of ligninolytic enzymes produced by this strain grown in inducer media was qualitatively and quantitatively analyzed by spectrophotometry, qPCR, and dye fading using Remazol Brilliant Blue R. The spectrophotometric analysis showed that LiP activity was higher than that of MnP. The greatest LiP expression as measured by qPCR occurred on the $7^{th}$ day, and the ABSA medium (agar, sugarcane bagasse, and ammonium sulfate) was the best that favored LiP expression. The amplification of the TvLiP gene median region covering approximately 50% of the T. versicolor LPGIV gene (87% identity); the presence of Trp199, Leu115, Asp193, Trp199, and Ala203 in the translated amplicon of the T. villosa mRNA; and the close phylogenetic relationship between TvLiP and T. versicolor LiP all indicate that the target enzyme is a lignin peroxidase. Therefore, T. villosa CCMB561 has great potential for use as a LiP, MnP, and Lac producer for industrial applications.

• The Korean Journal of Pain
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• v.19 no.1
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• pp.81-86
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• 2006

Background: Complex regional pain syndrome (CRPS) is a painful and disabling disease, yet the diagnosis of this can be difficult to confirm by purely objective measures. Therefore, we performed three-phasic bone scans and thermography as a work up in order to determine their predictive value and usefulness for making the diagnosis of CRPS. Methods: 44 patients who had been diagnosed with CRPS type-1, according to the modified criteria, were evaluated. All the patients were examined by performing a three-phasic bone scan and thermography as part of a work-up for diagnostic confirmation. The diffuse increased tracer uptake in the delayed image (phase III) was estimated by the positive findings. The findings were considered positive for CRPS if the thermographic findings showed temperature asymmetries between the affected and non- affected extremities of more than $1.00^{\circ}C$ Results: A review of the three-phasic bone scan for 44 patients indicated that 16 patients (36.4%) had diffusely positive scans, and thermographic abnormalities were noted in 35 of 44 patients (79.5%). Conclusions: The use of thermography in clinical settings can play an important role in the diagnosis of CRPS. However, a three-phasic bone scan alone cannot provide a completely accurate diagnosis, so it is imperative that the three-phasic bone scan data be integrated with the clinical evaluation and the other relevant tests.

• Journal of Korean Tunnelling and Underground Space Association
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• v.4 no.4
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• pp.277-286
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• 2002

Most of the problems in dealing with the tunnel construction are the uncertainties and complexities of the stress conditions and rock strengths in ahead of the tunnel excavation. The limitations on the investigation technology, inaccessibility of borehole test in mountain area and public hatred also restrict our knowledge on the geologic conditions on the mountainous tunneling area. Nevertheless an extensive and superior geophysical exploration data is possibly acquired deep within the mountain area, with up to the tunnel locations in the case of alternative design or turn-key base projects. An appealing claim in the use of artificial neural networks (ANN) is that they give a more trustworthy results on our data based on identifying relevant input variables such as a little geotechnical information and biological learning principles. In this study, error back-propagation algorithm that is one of the teaching techniques of ANN is applied to presupposition on Rock Mass Ratings (RMR) for unknown tunnel area. In order to verify the applicability of this model, a 4km railway tunnel's field data are verified and used as input parameters for the prediction of RMR, with the learned pattern by error back propagation logics. ANN is one of basic methods in solving the geotechnical uncertainties and helpful in solving the problems with data consistency, but needs some modification on the technical problems and we hope our study to be developed in the future design work.

• Journal of the Korean Society for information Management
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• v.32 no.1
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• pp.23-41
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• 2015

This study worked on the qualitative analysis about nomenclature East Sea by the record type in researches related to East Sea shown in the scientific journals. Here in this study, the way of marking is classified as three: 'sole notation of East Sea', 'sole notation of Sea of Japan', and 'simultaneous notation of both'. Based on a total of 4,192 selections from Web of Science DB, the analysis was followed up for change in time series by the notation type, notation type according to the nation that authors belong to, difference in research topic, impact factor, collaboration in research, and co-authorship network. The result turned out in this work that the sole notation of Sea of Japan accounted for the largest portion. It also showed that the rates of sole notation of East Sea and simultaneous notation have kept increasing continuously since the 1990s. Hub nations regarding the research of East Sea is five including Japan, Russia, Korea, USA, and China. In the case of sole notation of Sea of Japan, active collaboration studies are performed in USA, Russia, and China with a focus in Japan. In the case of sole notation of East Sea and simultaneous use, the research rate is relatively high in USA and Japan with a focus in Korea. As to the co-authorship network in the sole notation of Sea of Japan, sort of a "giant component" among different groups has been set up and through which the collaborative works are actively underway. However, it was found that the research of sole notation of East Sea is dispersed into small groups on the base of relevant individual institution.

• Journal of Biosystems Engineering
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• v.43 no.1
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• pp.72-80
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• 2018

Purpose: A modern greenhouse consists of various Information and Communications Technology (ICT) components e.g., sensor nodes, actuator nodes, gateways, controllers, and operating softwarethat communicate with each other. The interoperability between these components is an essential characteristic for any greenhouse control system. A greenhouse control system could not work unless the components communicate via common interfaces. The TTAK.KO-06.0288 is an interface standard consisting of four parts. Notably, TTAK.KO-06.0288-Part3, which describes the interface between a greenhouse operating system (GOS) and a greenhouse control gateway (GCG), is the core standard of TTAK.KO-06.0288. The objectives of this study were to analyze the TTAK.KO-06.0288-Part3 standard, to suggest alternative solutions for identified issues, and to develop a library as a proof of the alternative solutions. Methods: The "data field" was analyzed using a comparative analysis method, since it is a data transmission unit of TTAK.KO-06.0288-Part3. It was compared with other parts of TTAK.KO-06.0288 in terms of definition, format, size, and possible values. Although TTAK.KO-06.0288-Part1 and TTAK.KO-06.0288-Part2 do not use a "data field," they have a similar data structure. That structure was compared with the "data field" of TTAK.KO-06.0288-Part3. Results: Twenty-one issues were identified across four categories: inter-standard issues, intra-standard issues, operational issues, and misprint issues. Since some of the issues can raise interoperability problems, 16 alternative solutions were suggested. In order to prove the alternative solutions, an open-source communication library called libtp3 was developed. The library passed 14 unit tests and was adapted to two research. Conclusions: Although TTAK.KO-06.0288-Part3 is an interface standard for communication between a GOS and a GCG, it might not communicate between different implementations because of the identified issues in the standard. These issues could be solved by the alternative solutions, which could be used to revise TTAK.KO-06.0288. In addition, a relevant organization should develop a program for compatibility testing and should pursue test products for smart greenhouses.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4787-4793
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• 2014

Background: Many cancer patients experience poor pain control due to various factors, including misconceptions regarding the use of opioid analgesics. For management of cancer pain, interventions involving education of both patients and physicians have been attempted. Objectives: This review aimed to assess the current evidence of the benefits of education for the management of cancer pain. Methods: We searched the Medline, EMBASE, Cochrane library, and major Korean databases to identify relevant studies. We included most study designs, but excluded case series. The primary outcomes were pain intensity and quality of life (QoL). Two reviewers assessed the risk of bias using the Cochrane's tool for RCT and Risk of Bias Assessment tool for Non-randomized Studies (RoBANS) for non-randomized studies, independently. Results: After extensive searches, 3,324 publications were screened, and 32 studies were selected. The education interventions used in the included studies included a wide variety of education methods, but the most common method was a booklet produced for patients. Regardless of the education method used, the results of the meta-analysis were as follows. The SMDs of the most severe, average, and current pain in the RCTs were significant. The SMD of worst, average, and current pain were -0.34 (-0.55, -0.13), -0.40 (-0.64, -0.15), and -0.79 (-1.35, -0.23). In the non-randomized studies, the effects on average pain were significant, but those on worst and current pain were not. Conclusions: Education intervention reduced the pain of cancer patients. Therefore, patient education could be considered to be an effective method of cancer pain management. However, our data should be interpreted with caution, and studies using standardized protocols are needed to confirm these observations.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9731-9737
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• 2014

Large scale secular registry or surveillance systems have been accumulating vast data that allow mathematical modeling of cancer incidence and mortality rates. Most contemporary models in this regard use time series and APC (age-period-cohort) methods and focus primarily on predicting or analyzing cancer epidemiology with little attention being paid to implications for designing cancer registry, surveillance or evaluation initiatives. This research models age-specific cancer incidence rates using logistic growth equations and explores their performance under different scenarios of data completeness in the hope of deriving clues for reshaping relevant data collection. The study used China Cancer Registry Report 2012 as the data source. It employed 3-parameter logistic growth equations and modeled the age-specific incidence rates of all and the top 10 cancers presented in the registry report. The study performed 3 types of modeling, namely full age-span by fitting, multiple 5-year-segment fitting and single-segment fitting. Measurement of model performance adopted adjusted goodness of fit that combines sum of squred residuals and relative errors. Both model simulation and performance evalation utilized self-developed algorithms programed using C# languade and MS Visual Studio 2008. For models built upon full age-span data, predicted age-specific cancer incidence rates fitted very well with observed values for most (except cervical and breast) cancers with estimated goodness of fit (Rs) being over 0.96. When a given cancer is concerned, the R valuae of the logistic growth model derived using observed data from urban residents was greater than or at least equal to that of the same model built on data from rural people. For models based on multiple-5-year-segment data, the Rs remained fairly high (over 0.89) until 3-fourths of the data segments were excluded. For models using a fixed length single-segment of observed data, the older the age covered by the corresponding data segment, the higher the resulting Rs. Logistic growth models describe age-specific incidence rates perfectly for most cancers and may be used to inform data collection for purposes of monitoring and analyzing cancer epidemic. Helped by appropriate logistic growth equations, the work vomume of contemporary data collection, e.g., cancer registry and surveilance systems, may be reduced substantially.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.36
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• pp.87-109
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• 2007

This Comment explores the ICSID case of CMS Gas Transmission Company v. Argentine Republic, awarded on May 12, 2005. The Part II of this Comment first describes the relevant facts of the case including the some background for readers' understanding and the Part III summaries the claimant's requests and the decisions rendered by the Arbitral Tribunal in the Award. At Part IV, the Comment addresses the issue of determinating laws applicable to the merits of dispute in case that the parties of the case have not chosen a governing law, and at Part V, takes a close look into three main issues of (i) the indirect expropriation of the investment, (ii) the breach of fair and equitable treatment and (iii) the protections under umbrella clauses. In this CMS case, we see first that while the Tribunal affirmed that any indirect expropriation can occur from incidental interference depriving the foreign investor of the use or reasonable-to-be-expected economic benefit even if not necessarily to the obvious benefit of the host State, the Tribunal denied the occurrence of indirect expropriation in this case by holding that the Government of Argentina has not breached the standard of protection laid down in the Treaty. Secondly, however, regarding the issue of fair and equitable treatment, we see that the Tribunal, finding Argentina's breach of obligations, affirmed that the foreign investor can expect the host State to act in a consistent manner, free from ambiguity and totally transparently in its relations with the foreign investor, which can give the foreign investor certain degree of foreseeability. Thirdly and finally, we see that, on base of the effect of the umbrella clause, the Tribunal recognized the obligation of the host State undertaken not to freeze the tariff regime or subject it to price controls and not to alter the basic rules governing contracts between the foreign investor and the host State without the first's written consent. However, the protection under the umbrella clause is available only when there is a specific breach of rights and obligations under BIT or a violation of contract rights protected under BIT.

• The Journal of the Korea Contents Association
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• v.18 no.7
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• pp.28-37
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• 2018

It is necessary to produce and maintain interior lighting design reasonably and actively. Based on the lighting design applicable to interior design, the purpose of this study is to take into consideration the public design of public facilities installed in neighborhood parks and thereby to suggest a module-type variable interior lighting product design for reasonable use. To achieve that, relevant studies were reviewed to find the basic concepts of a module and the best cases of interior lighting applicable to interior design. To draw a new concept of the lighting design to which the concept of a module is applied, this study suggested the design direction for practical product development and a module-type design featuring easy process, product storage, assembly, and management, analyzed the reasonable maintenance direction for the development of lighting design, and proposed a case of design development applicable to the development of a new product design. Through cognitive strategy process, the design was made. This process, as a conceptual strategy, included the step of interior environment analysis, the step of lighting maintenance, the step of variable mechanism, and the step of emotional activation. These steps were connected with formative beauty of design so as to suggest a MLD(Module Lamp Design) strategy. In this way, this study tried to connect humans' free application for a space to a module product and to apply humans' visual approach and free conceptual value to MLD cognitive strategy design process for development.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.8
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• pp.370-378
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• 2020

The Construction Operations Building Information Exchange (COBie) collects and documents a large amount of information from different paths in one place during design and construction projects. This documented information is readily available as a means of continuously transferring data to the facility management systems used by building engineers. In this process, the COBie Worksheet, an open standard form, is used to input the information by simplifying the list required by the user. As a result, COBie was developed to improve dramatically how relevant information is obtained and updated to support operations, maintenance, and asset management at the design and construction stages. On the other hand, to use COBie, a great deal of manual work is required for information linkage and quality inspection with heterogeneous data models. These issues become obstacles to COBie-based facility management system development. This study analyzed the COBie information system and defined the framework for simpler operating maintenance information from BIM (Building Information Modeling). Moreover, the rules for facility management information submission, quality inspection, role definition of framework components, and information linkage were derived. COBie DB schema and support data linkages could be generated effectively based on the proposed framework in prototype development.