The Usefulness of Three-phase Bone Scan and Thermography for Making the Diagnosis of CRPS-I

제1형 복합부위 통증증후군의 진단에서 적외선 체열측정과 3상 골스캔의 유용성

  • Park, Sang Hyun (Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Bundang Hospital) ;
  • Lee, Pyung Bok (Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Bundang Hospital) ;
  • Lim, Yun Hee (Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Bundang Hospital) ;
  • Lee, Seung Yoon (Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Bundang Hospital) ;
  • Choi, In Yong (Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Bundang Hospital) ;
  • Lee, Sang Jin (Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Bundang Hospital) ;
  • Oh, Yong Seok (Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Bundang Hospital)
  • 박상현 (서울대학교 의과대학 마취과학교실, 분당서울대학교병원 마취통증의학과) ;
  • 이평복 (서울대학교 의과대학 마취과학교실, 분당서울대학교병원 마취통증의학과) ;
  • 임윤희 (서울대학교 의과대학 마취과학교실, 분당서울대학교병원 마취통증의학과) ;
  • 이승윤 (서울대학교 의과대학 마취과학교실, 분당서울대학교병원 마취통증의학과) ;
  • 최인용 (서울대학교 의과대학 마취과학교실, 분당서울대학교병원 마취통증의학과) ;
  • 이상진 (서울대학교 의과대학 마취과학교실, 분당서울대학교병원 마취통증의학과) ;
  • 오용석 (서울대학교 의과대학 마취과학교실, 분당서울대학교병원 마취통증의학과)
  • Received : 2006.04.14
  • Accepted : 2006.06.08
  • Published : 2006.06.30

Abstract

Background: Complex regional pain syndrome (CRPS) is a painful and disabling disease, yet the diagnosis of this can be difficult to confirm by purely objective measures. Therefore, we performed three-phasic bone scans and thermography as a work up in order to determine their predictive value and usefulness for making the diagnosis of CRPS. Methods: 44 patients who had been diagnosed with CRPS type-1, according to the modified criteria, were evaluated. All the patients were examined by performing a three-phasic bone scan and thermography as part of a work-up for diagnostic confirmation. The diffuse increased tracer uptake in the delayed image (phase III) was estimated by the positive findings. The findings were considered positive for CRPS if the thermographic findings showed temperature asymmetries between the affected and non- affected extremities of more than $1.00^{\circ}C$ Results: A review of the three-phasic bone scan for 44 patients indicated that 16 patients (36.4%) had diffusely positive scans, and thermographic abnormalities were noted in 35 of 44 patients (79.5%). Conclusions: The use of thermography in clinical settings can play an important role in the diagnosis of CRPS. However, a three-phasic bone scan alone cannot provide a completely accurate diagnosis, so it is imperative that the three-phasic bone scan data be integrated with the clinical evaluation and the other relevant tests.

Keywords

References

  1. Stanton-Hicks M, Janig W, Hassenbusch S, Haddox JD, Boas R, Wilson P: Reflex sympathetic dystrophy; changing concepts and taxonomy. Pain 1995; 63: 127-33 https://doi.org/10.1016/0304-3959(95)00110-E
  2. Wasner G, Schattschneider J, Bindet A, Baron R: Complex regional pain syndrome; diagnostic, mechanisms, CNS involvement and thetapy. Spinal Cord 2003; 41: 61-75 https://doi.org/10.1038/sj.sc.3101404
  3. Galer BS, Bruehl S, Harden RN: IASP diagnostic criteria for complex regional pain syndrome; a preliminary empirical validation study. International Association for the Study of Pain. Clin J Pain 1998; 14: 48-54 https://doi.org/10.1097/00002508-199803000-00007
  4. Oyen WJ, Arntz IE, Claessens RM, Van der Meer JW, Corstens FH, Goris RJ: Reflex sympathetic dystrophy of the hand; an excessive inflammatory response? Pain 1993; 55: 151-7 https://doi.org/10.1016/0304-3959(93)90144-E
  5. Gellman H, Nichols D: Reflex sympathetic dystrophy in the upper extremity. J Am Acad Orthop Surg 1997; 5: 313-22 https://doi.org/10.5435/00124635-199711000-00003
  6. Rommel O, Malin JP, Zenz M, Janig W: Quantitative sensory testing, neurophysiological and psychological examination in patients with complex tegional pain syndrome and hemisensory deficits. Pain 2001; 93: 279-93 https://doi.org/10.1016/S0304-3959(01)00332-3
  7. Mailis A, Wade J: Profile of Caucasian women with possible genetic predisposition to reflex sympathetic dystrophy; a pilot study. Clin J Pain 1994; 10: 210-7 https://doi.org/10.1097/00002508-199409000-00007
  8. Chelimsky TC, Low PA, Naessens JM, Wilson PR, Amadio PC, O'Brien PC: Value of autonomic testing in reflex sympathetic dystrophy. Mayo Clin Proc 1995; 70: 1029-40
  9. Allen G, Galer BS, Schwartz L: Epidemiology of complex regional pain syndrome: a retrospective chatt teview of 134 patients. Pain 1999; 80: 539-44 https://doi.org/10.1016/S0304-3959(98)00246-2
  10. Hogan QH, Abram SE: Neural blockade for diagnosis and prognosis. A review. Anesthesiology 1997; 86: 216-41 https://doi.org/10.1097/00000542-199701000-00026
  11. Holdet LE, Cole LA, Myetson MS: Reflex sympathetic dystrophy in the foot; clinical and scintigraphic criteria. Radiology 1992; 184: 531-5 https://doi.org/10.1148/radiology.184.2.1620860
  12. Kozin F, Soin JS, Ryan LM, Carrera GF, Wortmann RL: Bone scintigraphy in the reflex sympathetic dystrophy syndrome. Radiology 1981; 138: 437-43 https://doi.org/10.1148/radiology.138.2.7455127
  13. Davidoff G, Werner R, Cremer S, Jackson MD, Ventodlla C, Wolf L: Predictive value of the three-phase technetium bone scan in diagnosis of reflex sympathetic dystrophy syndrome. Arch Phys Med Rehabil 1989; 70: 135-7
  14. Sarikaya A, Sarikaya I, Pekindil G, Firat MF, Pekindil Y: Tech-netium-99m sestamibi limb scintigraphy in post-traumatic reflex sympathetic dystrophy: preliminary results. Eur J Nucl Med 2001; 28: 1517-22 https://doi.org/10.1007/s002590100615
  15. Mailis A, Meindok H, Papagapiou M, Pham D: Alterations of the thtee-phase bone scan after sympathectomy. Clin J Pain 1994; 10: 146-55 https://doi.org/10.1097/00002508-199406000-00009
  16. Uematsu S, Jankel WR, Edwin DH, Kim W, Kozikowski J, Rosen-baum A, et al: Quantification of thetmal asymmetry. Part 2: Application in low-back pain and sciatica. J Neurosurg 1988; 69: 556-61 https://doi.org/10.3171/jns.1988.69.4.0556
  17. Uematsu S: The new study on steteographic displays. Rinsho Hoshasen 1983; 28: 329-31
  18. Feldman F: Thermography of the hand and wtist: practical applications. Hand Clin 1991; 7: 99-112
  19. Btuehl S, Lubenow TR, Nath H, Ivankovich O: Validation of thermography in the diagnosis of teflex sympathetic dystrophy. Clin J Pain 1996; 12: 316-25 https://doi.org/10.1097/00002508-199612000-00011