• 한국발생생물학회지:발생과생식
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• 제7권1호
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• pp.35-40
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• 2003

성선자극호르몬 분비호르몬은 시상하부에서 분비되며, 포유동물의 생식에 중추적인 역할을 담당한다. 골든 햄스터는 계절적으로 번식하는 포유동물이며, 생식 활동은 광주기(하루 중 낮의 길이)에 의해 결정된다. 장주기(12.5 시간 이상의 빛)는 생식 능력을 유지시키지만, 단주기(12시간 이하의 빛)는 생식 기능을 억제한다. 성선자극호르몬 분비호르몬과 광주기의 상호 관계를 자세히 조사하기 위하여 랫트 성선자극호르몬 분비호르몬 cDNA를 포함하는 벡터를 여러 농도로 골든 햄스터의 수컷에 주입하고 단주기에 유지하여 생식 활동을 개별적으로 조사하였다. 벡터를 고농도로 처리한 그룹의 골든 햄스터는 기타 실험 그룹에 비해 정소 퇴화가 의미있게(P<0.05) 가속되었다. GnRH의 맥동적 분비가 생식 능력을 유지하는 관점에서 보면, GnRH-cDNA를 포함하는 벡터는 GnRH를 일정하게 고농도로 분비했다고 사료된다. 이 결과는 GnRH를 포함하는 벡터가 뇌하수체 전엽을 desensitization시켜 정소 퇴화를 가속시켰음을 암시한다.

• Animal cells and systems
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• 제5권3호
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• pp.217-224
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• 2001

The present study examines the expression and regulation of gonadotropin-releasing hormone (GnRH) and its receptor (GnRH-R) mRNA levels during mouse ovarian development. A fully processed, mature GnRH mRNA together with intron-containing primary transcripts was expressed in the immature mouse ovary as determined by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). The size of ovarian GnRH mRNA was similar to that of hypothalamus, but its amount was much lower than that in the hypothalamus. Quantitative RT-PCR procedure also revealed the expression of GnRH-R mRNA in the ovary, but the estimated amount was a thousand-fold lower than that in the pituitary gland. We also examined the regulation of ovarian GnRH and GnRH-R mRNA levels during the follicular development induced by pregnant mare's serum gonadotropin (PMSG) and/or human chorionic gonadotropin (hCG). Ovarian luteinizing hormone receptor (LH-R) mRNA was abruptly increased st 48 h after the PMSG administration and rapidly decreased to the basal level thereafter. Ovarian GnRH mRNA level was slightly decreased at 48 h after the PMSG administration, and then returned to the basal value. GnRH-R mRNA level began to increase at 24 h after the PMSG treatment, decreased below the uninduced basal level at 48 h, and gradually increased thereafter. HCG administration did not alter ovarian GnRH mRNA level, while it blocked the PMSG-induced increase in GnRH mRNA level. Taken together, the present study demonstrates that the expression of GnRH and GnRH-R mRNA are regulated by gonadotropin during follicular development, suggesting possible intragonadal paracrine roles of GnRH and GnRH-R in the mouse ovarian development.

• 한국농공학회논문집
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• 제63권1호
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• pp.89-102
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• 2021

Soils in agricultural lands contain large amount of organic matter and nutrients due to the injected fertilizers and manure. During heavy rain, surface water and base runoff pollutants flows into a nearby stream or lake with eroded soil from agricultural lands. On the other hands, agricultural lands near the lake are inundated due to the increase of the water level in the lake, leading to organic matter and nutrient release from the inundated soil. In this study, releasing rates of nutrient salts and organic substances were analyzed for the soil in the agricultural land, where cultivation activities has been carried out and periodically flooded, to account for the possibility of contamination from the inundated agricultural land in reservoir areas The experiment results have shown that COD was released from the soil in anaerobic conditions, and T-P was released in both anaerobic and aerobic conditions. However, in the case of T-N, it was found that the runoff by soil was not made before the rainfall occurred, and when the soil was impound due to rainfall, the elution occurred under the aerobic conditions. Through the results of this study, it was possible to account for the effect of flooded agricultural lands on the water quality in the lake, and this could be reflected in an efficient agricultural non-point pollution management policy. In order to determine the precise releasing rate for each agricultural land, it is believed that the leaching experiment for paddy fields and grasslands are needed.

• 디지털융복합연구
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• 제18권4호
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• pp.55-65
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• 2020

본 연구에서는 냉동·냉장창고의 서비스품질 향상을 위한 요인을 도출하고, 냉동·냉장화물을 취급하는 화주사 및 운영사의 서비스품질 향상에 대한 인식차이를 분석한다. 이를 바탕으로 IPA분석(Importance-Performance Analysis)분석을 활용하여 냉동·냉장화물 서비스품질 향상을 위한 개선방안을 제시하는 것을 목적으로 한다. 연구결과 총 15개 분석요인을 도출하였으며, 독립표본 T-test 결과, 화주사와 운영사 간의 품질향상을 위한 인식에는 차이가 없다는 것을 확인하였다. 또한 IPA분석 결과, 최우선 투자영역에 온·습도유지, 가변적 보관공간 확보, 입·출고 정시성, 정보서비스 제공 등 4개의 요인이 도출되었다. 한편 재고관리 서비스능력, 입출고 정시성, 화물을 안정적으로 보관할 수 있는 능력의 경우 시급한 개선이 필요한 것으로 분석되었다. 본 연구는 서비스 품질향상을 위한 실무적인 개선점을 제시하였다는 점에서 산업적인 시사점을 갖는다.

• 대한한의학방제학회지
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• 제25권4호
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• pp.553-574
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• 2017

The purpose of this study is to find out effects of prescriptions according to the formula, manipulation of Rhei Rhizoma, configuration. The following results were reached through investigations on the prescriptions using Rhei Rhizoma as a main component. Objectives : Analysis of prescriptions According to the formula : Liquid Extract Prescriptions were used widely on three parts to treat fever and damp heat in the interior organs. Powder Prescriptions were taken with hot water, thin porridge, tea etc. to treat damp heat, congestion of phlegm, acute episodes. Liquid Mixed Pill treat congestion of QI, damp heat, phlegm. Honey Mixed Pill treat accumulated fever, distension, acute excessive fever. Paste Pill treat blood stagnation, excessive toxic-fever, epidemic diseases. External Application treat inflammation by injury, swelling due to severe fever by internal damage. Methods : Analysis of prescriptions According to the manipulation of Rhei Rhizoma : Prescriptions including Liquor processed Rhei Rhizoma treat excessive toxic-fever, congestion of phlegm, blocking orifices on the upper side. Steamed Rhei Rhizoma strengthen effects of making evacuate and cooling of heat. Processed Rhei Rhizoma with vinegar strengthen effects of removing blood stagnation by activating blood movement, releasing gathering. Results : Analysis of prescriptions According to the Composition of Rhei Rhizoma : 41% of the total prescriptions were on the area of less than 20%. In case of lower groups show increased frequency of combination with Pharbitidis Semen, Persicae Semen, Scutellariae Radix and manipulation of baking, steaming, roasting. In case of higher groups show increased frequency of treating excess syndrome, critical illness, acute severe illness, and using proccesed Rhei Rhizoma with vinegar. Treatment of damp heat on the liver and gallbladder, disorder of the spleen and stomach is done mostly by prescriptions on the area of less than 30%. Conclusions : Rhei Rhizoma-Coptidis Rhizoma pair treat damp heat, heat toxins in blood, and Constipation caused by excessive heat. Rhei Rhizoma-Glycyrrhizae Radix pair relieve effects of Rhei Rhizoma passing blocked feces, removing the poison, activating blood movement, releasing gathering with the effects of Glycyrrhizae Radix relaxing tension by harmonizing Middle. Rhei Rhizoma-Magnoliae Cortex pair are used to treat damp heat in middle area, excessive heat in the stomach and intestine. Rhei Rhizoma-Pharbitidis Semen pair act on both blood system and QI system treating edema, damp, stagnation, heat toxins, feces. Rhei Rhizoma-Persicae Semen pair treat blood stagnation with fever on blood system.

• Ocean and Polar Research
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• 제31권4호
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• pp.305-318
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• 2009

A marine ranching project in Tongyoung was established in 1998, lasting 9 years to 2006. Project activities included the deployment of artificial reefs, the release of young fishes like jacopever and rockfish, and input/output control for specific marine ranching areas in Tongyoung. This report focuses on the economic feasibility of the project in hindsight. Analysis concentrates on three aspects; (a) direct economic benefits, such as increasing effects of fisheries income and savings in harvesting costs, (b) indirect benefits, including increasing effects of recreational fishing and saving R&D costs, and (c) costs, including releasing and purchasing costs of artificial reef and juvenile fish, R&D costs, maintenance costs and harvesting costs. Results show that NPV=4.7 billion won, IRR=8.55% and B/C ratio=1.286 under Scenario 1, which considers the saving effects of R&D costs, and NPV=0.9 billion won, IRR=6.03% and B/C ratio=1.11 under Scenario 2, which does not consider the saving effects of R&D costs, based on 5.5% of the social rate of discount. According to sensitivity analysis, the economic feasibility is very sensitive to the recapture rate.

• 국제초고층학회논문집
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• 제3권4호
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• pp.243-254
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• 2014

In this study, a demolition analysis code using the adaptively shifted integration (ASI)-Gauss technique, which describes structural member fracture by shifting the numerical integration point to an appropriate position and simultaneously releasing the sectional forces in the element, is developed. The code was verified and validated by comparing the predicted results with those of several experiments. A demolition planning tool utilizing the concept of a key element index, which explicitly indicates the contribution of each structural column to the vertical load capacity of the structure, is also develped. Two methods of selecting specific columns to efficiently demolish the whole structure are demonstrated: selecting the columns from the largest index value and from the smallest index value. The demolition results are confirmed numerically by conducting collapse analyses using the ASI-Gauss technique. The numerical results suggest that to achieve a successful demolition, a group of columns with the largest key element index values should be selected when explosives are ignited in a simultaneous blast, whereas those with the smallest should be selected when explosives are ignited in a sequence, with a final blast set on a column with large index value.

• 보건행정학회지
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• 제11권3호
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• pp.121-150
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• 2001

This study was conducted to investigate provider's behavior change after releasing the information on the Cesarean section rate. Claims data filed at the National Health Insurance Corporation was used for this analysis and the focus of this study was the change of cesarean rate after the public disclosure of information. Average rates of the year 1999 and 2000 were compared, on the institutional basis, and range and coefficient of variation were estimated. For the last decade, Cesarean section rate has been increased dramatically. Clinical or demographic factors could not adequately explain the increase. Instead, nonclinical factors, such as financial incentive, physician's convenience, practice characteristics, etc., were more significant in explaining the increasing rate. Providers' behavior was significantly affected by the public release of information: after the release, average rate was decreased by 10.2%, and variations were also decreased. In particular, the extent of decrease was explained mainly by nonclinical factor rather than clinical ones. The results suggest that disseminating practice information to providers and consumers could contribute to reducing unnecessary medical service.

• 한국생산제조학회지
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• 제21권2호
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• pp.259-266
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• 2012

In this study, the temperature distributions are analyzed on the air flow according to the position of fan inside computer main frame by CFD simulation. In case that ventilation hole is existed at the side of computer frame, the air with lower temperature can be circulated near CPU radiant thermal panel. In case of installation with fan at the side panel, the temperature of air flow becomes lowest. The efficiency of thermal emission at personal computer and its durability can be improved by releasing a lot of heat at air flow effectively inside computer frame according to this simulation result.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2006년도 추계학술대회논문집
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• pp.556-561
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• 2006

In this study, the failure of the automotive clutch disk was investigated. During the process of power transmission, clutch disk plates did repeated work of releasing and engaging the pressure plate. The effects of unbalance rotation in the abnormal vibration and torque amplitude under engaged state were measured from this experiment. In order to reduce the unbalance, a modified clutch disk shape was developed. With a three-dimensional model of the stopper pin, to predict fatigue fracture, finite element analysis was carried out and evaluated the improvement of the new clutch disk.