• Macromolecular Research
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• 제13권4호
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• pp.327-333
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• 2005

pH-sensitive hydrogels were studied as a drug carrier for the protection of insulin from the acidic environment of the stomach before releasing it in the small intestine. In this study, hydrogels based on poly(ethylene oxide) (PEO) networks grafted with methacrylic acid (MAA) or acrylic acid (AAc) were prepared via a two-step process. PEO hydrogels were prepared by ${\gamma}-ray $ irradiation (radiation dose: 50 kGy, dose rate: 7.66 kGy/h), grafted by either MAA or AAc monomers onto the PEO hydrogels and finally underwent irradiation (radiation dose: 520 kGy, dose rate: 2.15 kGy/h). These grafted hydrogels showed a pH-sensitive swelling behavior. The grafted hydrogels were used as a carrier for the drug delivery systems for the controlled release of insulin. Drug-loaded hydrogels were placed in simulated gastric fluid (SGF, pH 1.2) for 2 hr and then in simulated intestinal fluid (SIF, pH 6.8). The in vitro drug release behaviors of these hydrogels were examined by quantification analysis with a UV-Vis spectrophotometer.

• International Journal of Naval Architecture and Ocean Engineering
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• 제10권6호
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• pp.670-682
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• 2018

This paper presents the experimental and numerical investigation results of the response of low-temperature steel (LT-FH32 grade steel) beams under repeated impacts at room temperature and a single impact at a sub-zero temperature. After conducting tensile tests at room and sub-zero, repeated impact tests were conducted on two clamped single-beam models at room temperature, and single-impact tests of two other clamped single-beam models were conducted at $-50^{\circ}C$. The single and repeated impact tests were conducted by releasing a knife-edge striker using a drop testing machine. The permanent deflection of the model measured after each impact gradually increased with increasing number of impacts. Under the reduced temperature, the permanent deflection of the models slightly decreased. The numerical analyses were also performed to predict the damage response of the tested single-beam models. A comparison of the numerical prediction with those of experiments showed quite reasonable agreement.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권8호
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• pp.2923-2943
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• 2021

The double helix structure of DNA makes it diverse, stable and can store information with high density, and these characteristics are consistent with the requirements of molecular communication for transport carriers. In this paper, a specific structure of molecular communication system based on DNA length coding is proposed. Transmitter (Tx) adopts the multi-layer golden foil design to control the release of DNA molecules of different lengths accurately, and receiver (Rx) adopts an effective and sensitive design of nanopore, and the biological information can be converted to the electric signal at Rx. The effect of some key factors, e.g., the length of time slot, transmission distance, the number of releasing molecules, the priori probability, on channel capacity is demonstrated exhaustively. Moreover, we also compare the transmission capacity of DNA-based molecular communication (DNA-MC) system and concentration-based molecular communication (MC) system under the same parameter setting, and the peak value of capacity of DNA-MC system can achieve 0.08 bps, while the capacity of MC system remains 0.025 bps. The simulation results show that DNA-MC system has obvious advantages over MC system in saving molecular resources and improving transmission stability.

• Environmental Engineering Research
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• 제23권4호
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• pp.390-396
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• 2018

This study investigated the transformation of dissolved organic matter (DOM) in a free-water surface flow constructed wetland. Pyrolysis gas chromatography-mass spectrometry (Py-GC/MS) coupled with preparative high-performance liquid chromatography (prep-HPLC) was used to analyze the compositions of biopolymers (polysaccharides, amino sugars, proteins, polyhydroxy aromatics, lipids and lignin) in DOM according to the molecular size at three sampling points of the water flow: inflow, midflow, and outflow. The prep-HPLC results verified the decomposition of DOM through the decrease in the number of peaks from three to one in the chromatograms of the sampling points. The Py-GC/MS results for the degradable peaks indicated that biopolymers relating to polysaccharides and proteins gradually biodegraded with the water flow. On the other hand, the recalcitrant organic fraction (the remaining peak) in the outflow showed a relatively high concentration of aromatic compounds. Therefore, the ecological processes in the constructed wetland caused DOM to become more aromatic and homogeneous. This indicated that the constructed wetland can be an effective buffer area for releasing biochemically stable DOM, which has less influence on biological water quality indicators, e.g., biochemical oxygen demand, into an aquatic ecosystem.

• 지역사회간호학회지
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• 제32권2호
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• pp.140-149
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• 2021

Purpose: This study aimed to identify factors (biological, psychological, interpersonal, and contextual factors) associated with the weight bias internalization of the Korean girls in early adolescence. Methods: This study used a cross-sectional design. Data was collected from 233 girls aged 12~14 years with a self-reported questionnaire. With multiple regression analysis, the factors associated with the weight bias internalization of the girls in early adolescence were analyzed. Results: Of psychosocial factors, fear to fat (anti-fat attitude) (β=.43, p<.001) was associated with the weight bias internalization of the girls in early adolescence. In addition, attachment with teachers (β=-.11, p=.029) of an interpersonal factor and perceived socio-cultural pressure regarding weight control (β=.34, p<.001) of a contextual factor were associated with the weight bias internalization of the girls in early adolescence. Conclusion: For releasing the weight bias internalization of the girls in early adolescence, decreasing anti-fat attitude and socio-cultural pressure regarding weight control should be primarily required through social efforts including community and school based interventions.

• 한국발생생물학회지:발생과생식
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• 제26권3호
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• pp.107-115
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• 2022

Kisspeptins, products of KISS1 gene, are ligands of the G-protein coupled receptor (GPR54), and the kisspeptin-GPR54 signaling has an important role as an upstream regulator of gonadotropin releasing hormone (GnRH) neurons. Interestingly, extrahypothalamic expressions of kisspeptin/GPR-54 in gonads have been found in primates and experimental rodents such as rats and mice. Hamsters, another potent experimental rodent, also have a kisspeptin-GPR54 system in their ovaries. The presence of testicular kisspeptin-GPR54 system, however, remains to be solved. The present study was undertaken to determine whether the kisspeptin is expressed in hamster testis. To do this, reverse transcription-polymerase chain reactions (RT-PCRs) and immunohistochemistry (IHC) were employed. After the nest PCR, two cDNA products (320 and 280 bp, respectively) were detected by 3% agarose gel electrophoresis, and sequencing analysis revealed that the 320 bp product was correctly amplified from hamster kisspeptin cDNA. Modest immunoreactive (IR) kisspeptins were detected in Leydig-interstitial cells, and the weak signals were detected in germ cells, mostly in round spermatids and residual bodies of elongated spermatids. In the present study, we found the kisspeptin expression in the testis of Syrian hamster. Further studies on the local role(s) of testicular kisspeptin are expected for a better understanding the physiology of hamster testis, including photoperiodic gonadal regression specifically occurred in hamster gonads.

• 한방안이비인후피부과학회지
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• 제36권3호
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• pp.27-41
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• 2023

Objectives : The purpose of this study is to analyze the trends of Korean medicine treatment on postherpetic neuralgia. Methods : Domestic databases(OASIS, KISS, RISS, KISTI, NDSL, KMbase) were used to search case studies related to Korean medical treatment of postherpetic neuralgia. Total 9 studies were selected. Results : A total 15 prescriptions were used 22 times in 14 cases. Among them, Sipjeondaebo-tang(十全大補湯) was the most frequently prescribed. Total 91 herbs were used and they were classified as tonifying and replenishing medicine(補益藥), exterior-releasing medicine(解表藥) and blood-activating and stasis-dispelling medicine(活血祛瘀藥) in the order of mostly used. In 8 studies, in addition to herbal medicine treatment, other Korean medicine treatments such as acupuncture, pharmacopuncture, moxibusiton, cupping therapy and external agents were performed at the same time. Most frequently used acupoints were 足竅陰(GB44) and 商陽(LI1). Conclusions : This is the first study to analyze the trends of Korean medicine treatment for postherpetic neuralgia. Although there are some limitations, this study is thought to be helpful in the domestic treatment of postherpetic neuralgia in the future.

• Nuclear Engineering and Technology
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• 제56권1호
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• pp.283-291
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• 2024

Sodium cooled Fast Reactors (SFR) are built with several engineered safety features and hence a severe accident such as a core melt accident is hypothetical with a probability of <10^-6/ry. However, in case of such accidents, the mixture of the molten fuel and structural materials interacts with sodium. This phenomenon is known as Molten Fuel Coolant Interaction (MFCI) and results in fragmentation of the melt due to various instabilities. The fragmented particles settle as a debris bed on the core catcher at the bottom of the reactor vessel, and continue to generate decay heat. Characteristics of the debris particles play a vital role in heat transfer from the bed and need thorough investigation. The size, shape, and physical state of the debris depend on the associated fragmentation mechanism, superheating of the melt, and sodium temperature. Experiments have been conducted by releasing simulated corium, a molten mixture of alumina and iron generated by the aluminothermy process at ~2400 ℃ into liquid sodium, to study the fragmentation phenomena. After the experiment, the fragmented debris was retrieved and the particle size distribution was determined by sieve analysis. The debris was subjected to microscopic investigation for obtaining morphological characteristics. Based on the characteristics of debris, an attempt has been made to assess of fragmentation mechanism of simulated corium in sodium.

• Nuclear Engineering and Technology
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• 제55권11호
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• pp.4112-4119
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• 2023

This study employs the microshear test method to examine the local mechanical properties of narrow-gap welded joints, revealing the mechanical inhomogeneity by evaluating the microshear strength, stress-strain curves, and failure strain. On this basis, the influence of weld joints micromechanical inhomogeneity on the crack tip opening displacement (CTOD) fracture toughness is investigated. From the root weld layer to the cover weld layer, the fracture toughness at the center of the weld seam demonstrates an increasing trend, with the experimental and calculated CTOD values showing a good correspondence. The microproperties of the welded joints significantly impact the load-bearing capacity and fracture toughness. During the deformation process of the "low-matching" microregions, the plastic zone expansion is hindered by the surrounding microregion strength constraints, thus reducing the fracture toughness. In contrast, during the deformation of the "high-matching" microregions, the surrounding microregions absorb some of the loading energy, partially releasing the concentrated stress at the crack tip, which in turn increases the fracture toughness.

• 한국가스학회지
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• 제21권5호
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• pp.45-55
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• 2017

대부분의 가연성가스의 누출 및 화재/폭발 등의 실험은 큰 위험성이 있으며 실험을 진행할 수 있는 부지 선정에 큰 어려움이 있어 가급적 전산유동해석(CFD) 등의 간접적 방법을 많이 활용하였다. 그러나 2016년 10일 강원도 영월군에 에너지안전실증연구센터가 개소함에 따라 대규모/고압/초저온 등의 실험 뿐아니라 소규모 가연성 가스의 누출 및 검지 실험이 가능하게 되어 본 실험을 계획하였다. 본 실험에서는 가스센서를 교정하고 가스가 누출될 공간에 배치 후 LP가스를 누출시켜 가스센서에 검지된 값을 Contour map으로 가시화하였다. 또한 동일 조건으로 해석한 전산유동해석 결과값과 비교하여 LEL 25% 값의 실제 누출(28s, 최대 3.7m)의 차이점에 대해 분석하였다.