• Journal of Pharmaceutical Investigation
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• 제31권1호
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• pp.19-25
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• 2001

The purpose of this study was to use a ternary polymeric matrix system for high drug loading of a highly soluble drug for controlled release delivery. The controlled drug delivery of diltiazem HCl (solubility > 50% in water at $25^{\circ}C$) with high loading dose (the final loading dose of drug was 34%) from a ternary polymeric matrix (gelatin, pectin, HPMC) was successfully accomplished. This simple monolithic system with 240 mg drug loading provided near zero-order release over a 24 hour-period by which time the system was completely dissolved. The release kinetics of diltiazem HCl tablet with high loading dose from the designed ternary polymeric system was dependent on the ratios of HPMC : pectin binary mixture. The release rate increased as pectin : HPMC ratio were increased. Swelling behavior of the ternary system and the ionic interaction of formulation components with cationic diltiazem molecule appear to control drug diffusion and the release kinetics. Comparable release profiles between commercial product and the designed system were obtained. The binding study between gelatin with diltiazem HCl showed the presence of two binding sites for drug interaction with subsequent controlled diffusion upon swelling. This designed delivery system is easy to manufacture and drug release behavior is highly reproducible and offers advantages over the existing commercial product.

• 항공우주시스템공학회지
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• 제15권4호
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• pp.1-6
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• 2021

The non-explosive holding and release mechanism is used to prevent damage to the mission component caused by explosives when the deployment structure for Cube Satellites is separated. However, among the several types available, the non-explosive holding and release mechanism system using nylon wires depend on the nylon wire knot method and tightening power of the worker. Therefore, in this study, we conducted experiments with the operation of a new holding and release mechanism system by conceptualizing the Boa System Dial, which can provide a constant tightening force regardless of worker proficiency and deploying a imitational solar panel. In this study, the process of binding and unbinding with constant tension was recorded while applying the novel non-explosive holding and release mechanism using the Boa System Dial proposed. In addition, required advances are indicated for the application of the proposed system to actual Cube Satellites.

• 한국농공학회:학술대회논문집
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• 한국농공학회 2003년도 학술발표논문집
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• pp.539-542
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• 2003

In South Korea, flooding is controlled with large or small reservoirs scattered spatially over the territory. Because recent unexpected hard-rain events requires more flood control capacities, the pre-release system is considered with the most economical alternative. In this case time and volume of discharge should be determined by the simulation. But, existing pre-release simulation system has the problem of specificity. Therefore, GASS is considered to estimate the pre-release time and volume with different configurations of pre-release system. This paper shows that pre-release simulation system could be constructed with arranging GASAtmosphere, GASWatershed, Reservoir, Gate components using GASS. It is also shows that GASS could be used as a foundation for constructing pre-release simulation system that is easy to use and is flexible to reflect the changing configurations of reservoir systems.

• Journal of Mechanical Science and Technology
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• 제16권6호
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• pp.776-784
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• 2002

We have performed experimental studies for the improvements of pneumatic brake systems of freight trains. Currently, most of the freight trains operated by the Korean National Railroad have either empty-load or diaphragm type brake systems. In this study, appropriate methods that the air pressure characteristics in both type of brake systems are in accordance with each other have been investigated. We have also performed running tests using a 30 car-train set to design optimum capacity of a quick release valve. The test results show that the quick release valve is considerably effective in shortening the release time of the diaphragm type brake system. In the case of a normal brake application, the diaphragm type brake system with the quick release valve reduces the release time to 34% of that of the system without the quick release valve. This release time is almost equivalent to that of the empty-load type brake system. Accordance of braking performance in different types of brake systems in a train set is expected to prevent wheel flats and to reduce maintenance costs.

• Archives of Pharmacal Research
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• 제19권6호
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• pp.520-528
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• 1996

The involvement of the cyclic AMP (cAMP) effector system in the release of endogenous dopamine and acetylcholine from the rat neostriatum was assessed. Forskolin, an activator of adenylate cyclase, was used to enhance cAMP production, and the consequence of this enhancement on the spontaneous and potassium stimulated release of dopamine and acetylcholine was evaluated. Neostriatal slices were prepared from Fischer 344 rats and after a preincubation period the release of each endogenous neurotransmitter was measured from the same slice preparation. To measure acetylcholine release the slice acetylcholinesterase (AChE) activity was inhibited with physostigmine, but the release from slices with intact AChE activity was also determined (choline, instead of acetylcholine was detected in the medium). Under both conditions forskolin induced a significant dose-dependent increase in the potassium-evoked release of dopamine. In the same tissue preparations the release of neither acetylcholine (AChE inhibited) nor choline (AChE intact) was affected by forskolin. The results indicate that the CAMP second messenger system might be involved in neuronal mechanisms that enhance neostriatal dopamine release, but stimulation of this second messenger by forskolin does not further enhance neostriatal acetylcholine release.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.179-179
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• 1996

The involvement of the cyclic AMP (cAMP) effector system in the release of endogenous dopamine and acetylcholine from the rat neostriatum was assessed. Forskolin, an activator of adenylate cyclase, was used to enhance CAMP production, and the consequence of this enhancement on the spontaneous and potassium stimulated release of dopamine and acetylcholine was evaluated. Neostriatal slices were prepared from Fischer 344 rats and after a preincubation period the release of each endogenous neurotransmitter was measured from the same slice preparation. To measure acetylcholine release the slice acetylcholinesterase (AChE) activity was inhibited with physostigmine, but the release from slices with intact AChE activity was also determined (choline, instead of acetylcholine was detected in the medium). Under both conditions forskolin induced a significant dose-dependent increase in the potassium-evoked release of dopamine. In the same tissue preparations the release of neither acetylcholine (AChE inhibited) nor choline (AChE intact) was affected by forskolin. The results indicate that the cAMP second messenger system is involved ill neuronal mechanisms that enhance neuronal dopamine release, but stimulation of this second messenger by forskolin does not further enhance neostriatal acetylcholine release.

• 산업경영시스템학회지
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• 제13권22호
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• pp.1-6
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• 1990

This paper deals with software Release policy having a Fixed Operational period after a Software System is released. The underlying Software Reliability Growth is described by J-M Model Optimal of Software Release Time minimizing Total Expected Cost is Obtained.

• 대한기계학회논문집B
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• 제25권12호
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• pp.1739-1747
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• 2001

Experimental study has been conducted to clarify the pneumatic characteristics of brake system for freight train and enhance the performance of diaphragm valve. Empty-load and diaphragm valves are installed in pneumatic brake system for freight trains of KNR (Korean National Railroad). Experiments are conducted by using freight train and diesel locomotive in operation. From the experimental results. new quick release valve shortens release time after brake application. In case of normal brake application, the release time is shortened to 34% of the original diaphragm valve. Reducing the release time of pneumatic brake system will be helpful to assure brake-release application and save maintenance efforts like wheel grinding.

• International Journal of Air-Conditioning and Refrigeration
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• 제17권1호
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• pp.25-31
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• 2009

Supercooled type ice storage system with aqueous solution (or water) may have trouble with non-uniform release of supercooling even though it contributes to the simplicity of system and ecological improvement. The non-uniform release increases the instability of the system because it may cause an ice blockage in pipe or cooling part. In order to suppress the release of the supercooling, a cooling experiment was tried to an ethylene glycol(EG) 3 mass% solution corresponding with pressurization. Also, the frequency ratio of the release of the supercooling was measured to the pressurization from 101 to 505 kPa. At results, the frequency ratio of supercooling release tends to decrease as the pressure of the aqueous solution increased in each cooling rate. Moreover, it tends to decrease as the cooling rate of the solution decreased in each pressure.

• 디지털산업정보학회논문지
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• 제6권3호
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• pp.9-17
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• 2010

Decision problem called an optimal release policies, after testing a software system in development phase and transfer it to the user, is studied. The applied model of release time exploited infinite non-homogeneous Poisson process. This infinite non-homogeneous Poisson process is a model which reflects the possibility of introducing new faults when correcting or modifying the software. The failure life-cycle distribution used superposition which has various intensity, if the system is complicated. Thus, software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement becomes an optimal release policies. In a numerical example, after trend test applied and estimated the parameters using maximum likelihood estimation of inter-failure time data, estimated software optimal release time. Through this study, in terms of superposition model and simply model, the optimal time to using superposition model release the software developer to determine how much could count will help.