• 한국가스학회지
• /
• 제11권2호통권35호
• /
• pp.15-24
• /
• 2007

용기누출로 인한 가스 폭발사고의 영향을 분석하기 위해 API-581 절차에서 제시된 누출 시나리오를 사용하여 누출물질, 온도, 압력 및 용기의 종류 등을 변화시키면서 누출속도, 장치피해영역 및 상해영역을 산출하였다. 그 결과, 용기누출에서 누출속도, 장치피해영역 및 상해영역은 배관누출에서보다 상당히 큰 값을 가지며, 그 크기는 탱크>반응기>드럼>탑의 순서로 나타났다.

• 한국농공학회지
• /
• 제30권2호
• /
• pp.95-104
• /
• 1988

This study refers to the development of a hydrologic model simulating daily inflow and release rates for inigation reservoirs. A daily - based model is needed for adequate operation of an irrigation reservoir sufficing the water demand for paddy fields which is closely related to meteorological conditions. And the objective of this study is to develop a reservoir release rate model and then to calibrata the parameters. The release rates model considers daily water demands , water supply for transplanting, minmum release for maintaining canal flow, and maxirnun and regular flooding depth for determining effective rainfall on paddy fields. Each of the factors in the model was regarded as a lumped pararuter representing the average condition of a whole irrigated area. The water demand was estimated form the potential evapotranspiration by Penman method, the effective rainfall, and the infiltration on paddy fields. The release model was found to be capable of adequately simulating daily reservoir releases based on meteorological data.

• Journal of Pharmaceutical Investigation
• /
• 제19권4호
• /
• pp.173-178
• /
• 1989

Drug release rates from copolymer hydrogels were controlled by their hydrophilic-hydrophobic balances. As a model copolymer hydrogel, poly(acrylamide-co-styrene) was synthesized at different monomer composition. Release mechanisms of propranolol-HCI from the copolymer matrices were investisated. Swelling rates of the copolymer hydrogels retarded as their hydrophobicity increased. Swelling kinetics of the copolymer hydrogels regulated drug release rates via polymer relaxation controlled release mechanisms. Zero order drug release could thus be achieved within certain periods.

• 한국농공학회지
• /
• 제30권3호
• /
• pp.95-105
• /
• 1988

This study refers to the development of a hydrologic model simulating daily inflow and release rates for irrigation reservoirs. A daily - based model is needed for adequate operation of an irrigation reservoir sufficing the water demand for paddy fields which is closely related to meteorological conditions. And the objective or this study is to develop a Daily Irrigation Reservoir Operation Model(DIROM) combining the inflow and the release models which depicts the daily water level fluctuations of an irrigation reservoir, and to evaluate the applicability of the model. DIROM was applied to four reservoirs and daily water levels were simulated and compared to the observed data. The model behaviour was also compared with that of a ten - day based model, Reservoir Operation Study(ROS) which has been applied for determining the design capacity of reservoirs. Various combinations of measured and simulated inflow and release rates for tested reservoirs were used to define the daily water level fluctuations. Simulated release rates and measured inflow data resulted in larger errors, and simulated inflow and release rates produced the smallest errors in water level comparison. Two resevoir operation models, DIROM and ROS were applied to the same reservoir and the simulation results compared. The computational errors of DIROM ware smaller than those of ROS, and DIROM was more sensitive to meteorological conditions. DIROM demonstrated its potenial applicability in water management and operation.

• 한국전산구조공학회논문집
• /
• 제21권4호
• /
• pp.391-399
• /
• 2008

본 논문에서는 다중 균열 구조물에서의 균열 진전에 따른 에너지 해방을 및 고차 미분값을 구할 수 있는 가상균열 진전법을 제시한다. 이 방법은 다중 균열 체계의 에너지 해방율과 고차 미분값이 단 한번의 해석으로 수행될 수 있는 장점이 있다. 예제에서 얻어진 해의 최대 오차는 에너지 해방율 0.2%, 일차 미분값 $2\sim3%$, 이차 미분값 $5\sim10%$이다 이 방법으로 구한 에너지 해방률의 미분값들은 파괴 확률을 구하거나, sire effect law에 적용될 수 있다.

• Nuclear Engineering and Technology
• /
• 제26권1호
• /
• pp.78-89
• /
• 1994

콘크리트 구조물과 점토성 되메움재로 구성된 중저준위 방사성폐기물처분장 인공방벽으로 부터의 핵종유출률이 평가되었다. 네 종류의 유출경로가 고려되었으며, 각 유출경로가 방사성핵종의 총유출률에 미치는 영향이 분석되었다. 입력변수 간의 불확실도가 핵종유출률 분석에 미치는 영향을 정량화하기 위해 Latin Hypercube 표본추출 방법이 이용되었으며, 그 결과 얻어진 유출률 분포는 적합도검증을 통하여 결정되었다. 마지막으로 최대유출률의 범위가 통계적방법에 의해 95% 신뢰도수준으로 추정되었다.

• Journal of Pharmaceutical Investigation
• /
• 제27권3호
• /
• pp.225-231
• /
• 1997

For the effective administration of naloxone, we attempted to investigate the naloxone sustained-release implants. Using the biodegradable polymer, poly[(diethyl glutamate)-co-(ethyl glycinate)phosphazenes](PGGP), the implantable devices containing naloxone hydrochloride(NLX HCl) and naloxone base(NLX) were prepared. The release rates of NLX and NLX HCl were compared. Influences of NLX contents on release rates were examined. For pharmacokinetic studies, NLX and NLX HCl loaded devices were implanted subcutaneously in rabbits and then the plasma concentrations of NLX were determined by HPLC(ECD). NLX-containing devices were implanted with various doses and pharmacokinetic parameters according to dose were calculated. The relative bioavailabilities were evaluated and compared. Incorporation of NLX in the polymer leaded to a slow release. There were no differences of release rates based on drug contents. In pharmacokinetic parameters determined in 216 hours, NLX loaded devices resulted in enhanced bioavailability with the higher AUC (p<0.01) than NLX HCl loaded devices and MRT was significantly (p<0.05) increased. This result demonstrates that NLX is more suitable for sustained release devices than NLX HCl. Therefore it is anticipated that the effective concentrations of naloxone could be maintained for longer periods and bioavailabilities could be improved by naloxone sustained-release implants, with varying drug base/hydrochloride.

• Journal of Pharmaceutical Investigation
• /
• 제36권6호
• /
• pp.393-399
• /
• 2006

This study was aimed to design, formulate and characterize the moisture-activated patches containing acyclovir for antiviral action. Gel intermediates for film-type patches were prepared with mucoadhesive polymer, viscosity builders, enhancers and acyclovir. Patches containing acyclovir were characterized by in vitro measurement of drug release rates through a cellulose barrier membrane, and of drug flux through the hairless mouse skin. Film-type patches obtained were uniform in the thickness and showed a mucoadhesive property when contacted with moisture. The formulation was optimized, which consisted of $Cantrez^{\circledR}$ AN-169(2%), $Kollidon^{\circledR}$ VA 64(1%), $Natrosol^{\circledR}$(1%), hydroxypropyl-$\beta$-cyclodextrin(1%) and dimethylsulfoxide(0.5%). Release rates of acyclovir patches increased dose-dependently. The addition of terpenes such as d-limonene or cineole increased release rates of acyclovir, but decreased permeation rates. The permeation rates were enhanced by 2 and 2.5 times by the addition of glycyrrhizic acid ammonium salt and sodium glycocholate, respectively, compared with that of no enhancer. These results suggest that it may be feasible to deliver acyclovir through the skin or gingival mucosa from the moisture-activated patches.

• 한국물환경학회지
• /
• 제25권5호
• /
• pp.742-749
• /
• 2009

To examine the characteristics of the nutrient release from the sediments in two reservoirs, Lake Paldang and Lake Cheungpyeung, we analyzed physical and chemical properties of the sediments and calculated the nutrient release rates from the sediments. The particle properties of sediments in Lake Paldang changed from silt to sand after summer rainy season, especially in the water area of the Kyeungan River where the water depth was shallow and the width of river was narrow. The sediments in Lake Cheungpyeung had higher contents of silt and clay than in Lake Paldang, and the particle size was not much different before and after rainfall. The release rates of nutrients in two lakes varied with the kind of nutrients and the season. The release rates of DTN and ${NH_4}^+-N$ in Lake Paldang were faster in spring than autumn. But the Lake Cheungpyeung showed similar values of release rates before and after summer rainy season. ${NO_3}^--N$ and phosphorous were not released from sediments or were absorbed into sediments all the time in two lakes. Compared with other lakes, the sediments of two lakes consisted of bigger particles and had a lower organic matters content than other lake-type reservoirs. Due to the short hydraulic retention time and no stratification throughout the year in Lake Paldang and Lake Cheungpyeung, the release rates of nutrients from sediment in these reservoirs were lower than other lakes and this seems to be a typical characteristic of river-type reservoirs.

• Archives of Pharmacal Research
• /
• 제12권3호
• /
• pp.186-190
• /
• 1989

The release rates of methotrexate (MTX) from MTX-human serum albumin (HSA) conjugate, and 5-fluorouracil (5-FU) from 5-FU acetic acid (AA)-HSA conjugate were determined after incubation of the conjugates in various conditions. The concentrations of 5-FU released from the conjugate increased monoexponentially, however those of MTX increased biexponentially in all studies. It indicated that there are two distinct types of MTX-HSA linkage, weakly and tightly bound linkages. The release rates of 5-FU were lower than those of MTX in all studies indicating that the bond of 5-FU-AA-HSA conjugate is very stable, which is supported by the higher value of activation energy (39. 9 vs 10. 7 Kcal/mole) using Arrhenius equation. The release rates of MTX and 5 -FU from the conjugates increased with incubation temperatures. Proteolytic enzyme and liver homogenates accelerated significantly the release rates of MTX and 5-FU. Approximately 1.30 and 22.0% of MTX were released after 12 hours of incubation in the absence and presence of protease, respectively. The corresponding values for 5-FU were released after 12 hours of incubation with rat liver homogenates which were diluted 6 times with phosphate buffer of pH 6.0. The MTX-HSA and 5-FU-AA-HSA conjugates were very stable in rat plasma.