• Journal of the Korean Institute of Gas
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• v.11 no.2 s.35
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• pp.15-24
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• 2007

For consequence analysis at a gas explosion by vessel release, release rates, demage areas of facilities, and fatality areas were estimated and analyzed at various conditions(release materials, temperatures, pressures, and vessel types) by using the release scenario of API-581 BRD. Simulation results showed that release rates and consequences in the vessel release were higher than those in the pipe release, and the order of release rates and damage areas was as follows; tank>reactor>drum> column.

• Magazine of the Korean Society of Agricultural Engineers
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• v.30 no.2
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• pp.95-104
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• 1988

This study refers to the development of a hydrologic model simulating daily inflow and release rates for inigation reservoirs. A daily - based model is needed for adequate operation of an irrigation reservoir sufficing the water demand for paddy fields which is closely related to meteorological conditions. And the objective of this study is to develop a reservoir release rate model and then to calibrata the parameters. The release rates model considers daily water demands , water supply for transplanting, minmum release for maintaining canal flow, and maxirnun and regular flooding depth for determining effective rainfall on paddy fields. Each of the factors in the model was regarded as a lumped pararuter representing the average condition of a whole irrigated area. The water demand was estimated form the potential evapotranspiration by Penman method, the effective rainfall, and the infiltration on paddy fields. The release model was found to be capable of adequately simulating daily reservoir releases based on meteorological data.

• Journal of Pharmaceutical Investigation
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• v.19 no.4
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• pp.173-178
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• 1989

Drug release rates from copolymer hydrogels were controlled by their hydrophilic-hydrophobic balances. As a model copolymer hydrogel, poly(acrylamide-co-styrene) was synthesized at different monomer composition. Release mechanisms of propranolol-HCI from the copolymer matrices were investisated. Swelling rates of the copolymer hydrogels retarded as their hydrophobicity increased. Swelling kinetics of the copolymer hydrogels regulated drug release rates via polymer relaxation controlled release mechanisms. Zero order drug release could thus be achieved within certain periods.

• Magazine of the Korean Society of Agricultural Engineers
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• v.30 no.3
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• pp.95-105
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• 1988

This study refers to the development of a hydrologic model simulating daily inflow and release rates for irrigation reservoirs. A daily - based model is needed for adequate operation of an irrigation reservoir sufficing the water demand for paddy fields which is closely related to meteorological conditions. And the objective or this study is to develop a Daily Irrigation Reservoir Operation Model(DIROM) combining the inflow and the release models which depicts the daily water level fluctuations of an irrigation reservoir, and to evaluate the applicability of the model. DIROM was applied to four reservoirs and daily water levels were simulated and compared to the observed data. The model behaviour was also compared with that of a ten - day based model, Reservoir Operation Study(ROS) which has been applied for determining the design capacity of reservoirs. Various combinations of measured and simulated inflow and release rates for tested reservoirs were used to define the daily water level fluctuations. Simulated release rates and measured inflow data resulted in larger errors, and simulated inflow and release rates produced the smallest errors in water level comparison. Two resevoir operation models, DIROM and ROS were applied to the same reservoir and the simulation results compared. The computational errors of DIROM ware smaller than those of ROS, and DIROM was more sensitive to meteorological conditions. DIROM demonstrated its potenial applicability in water management and operation.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.21 no.4
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• pp.391-399
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• 2008

In this paper, we further generalize the work of Lin and Abel to the case of the first and the second order derivatives of energy release rates for two-dimensional, multiply cracked systems. The direct integral expressions are presented for the energy release rates and their first and second order derivatives. The salient feature of this numerical method is that the energy release rates and their first and second order derivatives can be computed in a single analysis. It is demonstrated through a set of examples that the proposed method gives expectedly decreasing, but acceptably accurate results for the energy release rates and their first and second order derivatives. The computed errors were approximately 0.5% for the energy release rates, $3\sim5%$ for their first order derivatives and $10\sim20%$ for their second order derivatives for the mesh densities used in the examples. Potential applications of the present method include a universal size effect model and a probabilistic fracture analysis of cracked structures.

• Nuclear Engineering and Technology
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• v.26 no.1
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• pp.78-89
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• 1994

The radionuclide release rates from the engineered barrier composed of concrete structure and clay-based backfill in a low and intermediate level waste repository were assessed. Four types of release pathway were considered, and the contribution of each pathway to the total release were analyzed. To quantify the effect of uncertainties of input parameter values on the assessment of radionuclide release rates, the Latin Hypercube sampling method was used, and the resulting release rate distribution were determined through a goodness-of-fit test. Finally, the ranges of maxi-mum release rates ore estimated statistically with a confidence level of 95%.

• Journal of Pharmaceutical Investigation
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• v.27 no.3
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• pp.225-231
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• 1997

For the effective administration of naloxone, we attempted to investigate the naloxone sustained-release implants. Using the biodegradable polymer, poly[(diethyl glutamate)-co-(ethyl glycinate)phosphazenes](PGGP), the implantable devices containing naloxone hydrochloride(NLX HCl) and naloxone base(NLX) were prepared. The release rates of NLX and NLX HCl were compared. Influences of NLX contents on release rates were examined. For pharmacokinetic studies, NLX and NLX HCl loaded devices were implanted subcutaneously in rabbits and then the plasma concentrations of NLX were determined by HPLC(ECD). NLX-containing devices were implanted with various doses and pharmacokinetic parameters according to dose were calculated. The relative bioavailabilities were evaluated and compared. Incorporation of NLX in the polymer leaded to a slow release. There were no differences of release rates based on drug contents. In pharmacokinetic parameters determined in 216 hours, NLX loaded devices resulted in enhanced bioavailability with the higher AUC (p<0.01) than NLX HCl loaded devices and MRT was significantly (p<0.05) increased. This result demonstrates that NLX is more suitable for sustained release devices than NLX HCl. Therefore it is anticipated that the effective concentrations of naloxone could be maintained for longer periods and bioavailabilities could be improved by naloxone sustained-release implants, with varying drug base/hydrochloride.

• Journal of Pharmaceutical Investigation
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• v.36 no.6
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• pp.393-399
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• 2006

This study was aimed to design, formulate and characterize the moisture-activated patches containing acyclovir for antiviral action. Gel intermediates for film-type patches were prepared with mucoadhesive polymer, viscosity builders, enhancers and acyclovir. Patches containing acyclovir were characterized by in vitro measurement of drug release rates through a cellulose barrier membrane, and of drug flux through the hairless mouse skin. Film-type patches obtained were uniform in the thickness and showed a mucoadhesive property when contacted with moisture. The formulation was optimized, which consisted of $Cantrez^{\circledR}$ AN-169(2%), $Kollidon^{\circledR}$ VA 64(1%), $Natrosol^{\circledR}$(1%), hydroxypropyl-$\beta$-cyclodextrin(1%) and dimethylsulfoxide(0.5%). Release rates of acyclovir patches increased dose-dependently. The addition of terpenes such as d-limonene or cineole increased release rates of acyclovir, but decreased permeation rates. The permeation rates were enhanced by 2 and 2.5 times by the addition of glycyrrhizic acid ammonium salt and sodium glycocholate, respectively, compared with that of no enhancer. These results suggest that it may be feasible to deliver acyclovir through the skin or gingival mucosa from the moisture-activated patches.

• Journal of Korean Society on Water Environment
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• v.25 no.5
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• pp.742-749
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• 2009

To examine the characteristics of the nutrient release from the sediments in two reservoirs, Lake Paldang and Lake Cheungpyeung, we analyzed physical and chemical properties of the sediments and calculated the nutrient release rates from the sediments. The particle properties of sediments in Lake Paldang changed from silt to sand after summer rainy season, especially in the water area of the Kyeungan River where the water depth was shallow and the width of river was narrow. The sediments in Lake Cheungpyeung had higher contents of silt and clay than in Lake Paldang, and the particle size was not much different before and after rainfall. The release rates of nutrients in two lakes varied with the kind of nutrients and the season. The release rates of DTN and ${NH_4}^+-N$ in Lake Paldang were faster in spring than autumn. But the Lake Cheungpyeung showed similar values of release rates before and after summer rainy season. ${NO_3}^--N$ and phosphorous were not released from sediments or were absorbed into sediments all the time in two lakes. Compared with other lakes, the sediments of two lakes consisted of bigger particles and had a lower organic matters content than other lake-type reservoirs. Due to the short hydraulic retention time and no stratification throughout the year in Lake Paldang and Lake Cheungpyeung, the release rates of nutrients from sediment in these reservoirs were lower than other lakes and this seems to be a typical characteristic of river-type reservoirs.

• Archives of Pharmacal Research
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• v.12 no.3
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• pp.186-190
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• 1989

The release rates of methotrexate (MTX) from MTX-human serum albumin (HSA) conjugate, and 5-fluorouracil (5-FU) from 5-FU acetic acid (AA)-HSA conjugate were determined after incubation of the conjugates in various conditions. The concentrations of 5-FU released from the conjugate increased monoexponentially, however those of MTX increased biexponentially in all studies. It indicated that there are two distinct types of MTX-HSA linkage, weakly and tightly bound linkages. The release rates of 5-FU were lower than those of MTX in all studies indicating that the bond of 5-FU-AA-HSA conjugate is very stable, which is supported by the higher value of activation energy (39. 9 vs 10. 7 Kcal/mole) using Arrhenius equation. The release rates of MTX and 5 -FU from the conjugates increased with incubation temperatures. Proteolytic enzyme and liver homogenates accelerated significantly the release rates of MTX and 5-FU. Approximately 1.30 and 22.0% of MTX were released after 12 hours of incubation in the absence and presence of protease, respectively. The corresponding values for 5-FU were released after 12 hours of incubation with rat liver homogenates which were diluted 6 times with phosphate buffer of pH 6.0. The MTX-HSA and 5-FU-AA-HSA conjugates were very stable in rat plasma.