• 산업경영시스템학회지
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• 제8권11호
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• pp.45-56
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• 1985

This thesis studies the order release scheduling by lead time offsetting technique in MRP system. MRP is the process of working backward from the scheduled completion dates of end products or major assemblies to determine the dates and quantities when the various component parts and materials are to be ordered. It aims getting the right quantity of component parts to the right places at the right time with a schedule that puts each parts or subassembly into stock shortly ahead of the need for that parts or subassembly. The planned order release point of a item can be easily decided when the scheduled completion date and planned lead time is certain and known before by lead time offsetting technique in MRP system.

• Coupled systems mechanics
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• 제11권6호
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• pp.543-556
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• 2022

Delamination of multilayered inhomogeneous beam that exhibits non-linear relaxation behavior is analyzed in the present paper. The layers are inhomogeneous in the thickness direction. The dealamination crack is located symmetrically with respect to the mid-span. The relaxation is treated by applying a non-linear stress-straintime constitutive relation. The material properties which are involved in the constitutive relation are distributed continuously along the thickness direction of the layer. The delamination is analyzed by applying the J-integral approach. A time-dependent solution to the J-integral that accounts for the non-linear relaxation behavior is derived. The delamination is studied also in terms of the time-dependent strain energy release rate. The balance of the energy is analyzed in order to obtain a non-linear time-dependent solution to the strain energy release rate. The fact that the strain energy release rate is identical with the J-integral value proves the correctness of the non-linear solutions derived in the present paper. The variation of the J-integral value with time due to the non-linear relaxation behavior is evaluated by applying the solution derived.

• Archives of Pharmacal Research
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• 제12권2호
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• pp.88-93
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• 1989

In order to obtain some informations about the effect of molecular weight on the release rate of drug from drug carrier, two types of poly-L-glutamic acid (PLGA)-cytarabine (ara-C) conjugates, PLGA-ara-C:I and PLGA-ara-C:II, were synthesized using two types of PLGA having different average molecular weight, 43,000 and 77,800, respectively. The PLGA-ara-C conjugates were synthesized by mixed anhydride method and found to be covalently linked. Both types of conjugates charged negatively at biological pH. The pH-dependent release rate of ara-C was observed in both cases, and the release rate was accelerated in basic, acidic conditions (the k values were 0.015 $day^{-1}$ at pH 7.0, 0.024 $day^{-1}$ at pH 5.0, and 0.059 $day^{-1}$ at pH 9.0 in the case of PLGA-ara-C:I) and in the presence of pretense. The time required for the release of 16.5% of ara-C from PLGA-ara-C:I were 8 hr and 144 hr in the presence and absence of protease, respectively. Although both types of conjugates showed similar drug substitution ratio, they showed different release rates. Between the two types of conjugates, PLGA-ara-C:II showed the faster release rate (0.030 vs 0.042 $day^{-1}$ in pH 7.4 phosphate buffer solution at $37^{\circ}C$) and the smaller activation energy for the release of drug (12.5 vs 7.7 Kcal/mol) than PLGA-ara-C:I. The characteristic effect of molecular weight on the release rates of PLGA-ara-C conjugates suggests that the drug release rate might be effectively controlled over a prolonged period of time by the combined use of the different types of PLGA-ara-C conjugates having different molecular weights.

• 한국가스학회지
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• 제16권4호
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• pp.44-51
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• 2012

대부분의 산업시설이 유해물질을 다루고 있기 때문에 산업시설의 사고발생은 막대한 물적, 인적 피해를 발생시키므로 안전관리, 중대형 사고 예방 및 위험 예측 등이 중요시 되고 있다. 특히, 유해물질 누출사고는 누출물질, 저장시설, 대기 상태에 따라 유독가스의 확산 속도와 범위가 달라지므로 이를 모사하는 대기확산 시스템이 이용되어왔다. 모사에 기반하는 대기확산 시스템은 산업시설 구조물 설계 단계에서 주로 사용되며 누출 사고 시 즉각적인 처리와 대응이 어렵다. 실시간 대기정보 데이터를 이용한 연구 및 사례는 존재하지만 시스템의 성능저하 및 전문적 지식의 결여로 신속한 처리 및 대응이 미흡하였다. 본 논문은 에너지 플랜트 환경에서 특수성과 효율성을 강화하여 유해화학물질 누출로 인한 대기확산범위를 즉각적으로 산출하고 누출 시점 및 지점을 지능형 알고리즘으로 결정함으로써 사고예방형 실시간 지능형 대기확산 시스템을 구현한다.

• Journal of Pharmaceutical Investigation
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• 제29권4호
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• pp.343-348
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• 1999

The purpose of this study is to prepare the controlled release adhesive patch containing naproxen. Pressuresensitive adhesive (PSA)-type patch was fabricated by casting of polyisobutylene (PIE.) and mineral oil in toluene. Membrane-controlled release (MCR)-type patch was prepared by the attachment of the controlled release membrane on the PSAtype patch. The membrane was mainly composed of Eudragit, polyethylene glycol(PEG) and glycerin. The drug release profile and skin permeation test with various patches were evaluated in vitro. The release of naproxen from PIE-based PSAtype patch with various loading doses fitted Higuchi's diffusion equation. However, the permeation of naproxen through hairless mouse skin from PSA-type patch followed zero-order kinetics. In MCR-type patch, thickness of controlled release membrane affected on the drug release rate highly. In the composition of membrane, the release rate was decreased as the ratio of Eudragit increased. The drug release from the MCR-type patch followed zero order kinetics. The permeation of naproxen through hairless mouse skin from MCR-type patch showed lag time for the intial release period and didn't fit the zero-order kinetics

• The Korean Journal of Physiology and Pharmacology
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• 제6권2호
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• pp.81-85
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• 2002

Conventional views of synaptic transmission generally overlook the possibility of 'postfusional-control' the regulation of the speed or completeness of transmitter release upon vesicular fusion. However, such regulation often occurs in non-neuronal cells where the dynamics of fusion-pore opening is critical for the speed of transmitter release. In case of synapses, the slower the transmitter release, the smaller the size and rate-of-rise of postsynaptic responses would be expected if postsynaptic neurotransmitter receptors were not saturated. This prediction was tested at hippocampal synapses where postsynaptic AMPA-type glutamate receptors (AMPAR) were not generally saturated. Here, we found that the small miniature excitatory postsynaptic currents (mEPSCs) showed significantly slower rise times than the large mEPSCs when the sucrose-induced mEPSCs recorded in cyclothiazide (CTZ), a blocker for AMPAR desensitization, were sorted by size. The slow rise time of the small mEPSCs might result from slow release through a non-expanding fusion pore, consistent with postfusional control of neurotransmitter release at central synapses.

• 대한안전경영과학회지
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• 제2권4호
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• pp.33-43
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• 2000

The consequence analysis for the unconfined vapor cloud explosion(UVCE) accident by the continuous release of butane vapor was performed and effects of process parameters on consequences were analyzed in standard conditions. For the case of continuous release(87.8 kg/s) of butane vapor at 8 m elevated height in the debutanizing process of tile naphtha cracking plant operating at 877 kPa ＆ 346.75 K, we found that combustion ranges of dispersed vapor estimated by HMP model were 11.2~120.2 m and overpressures estimated by TNT equivalency model at 200 m were about 37.35~55.1 kPa. Also, overpressures estimated by Model UVCE I based on advective travel time to $X_{LFL}$ were smaller than those estimated by Model UVCE IIbased on real travel time between $X_{UFL}$ and $X_{LFL}$. At the same time, damage intensities at 200 m and effect ranges by overpressure could be predicted. Furthermore, simulation results showed that effects of operating pressures on consequences were larger than those of operating temperatures and results of accidents were increased with increasing operating pressures. At this time, sensitivities of overpressures for UVCE accident by the continuous release were about 5 kPa/atm.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2012년도 학술발표회
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• pp.35-35
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• 2012

Most grid-based distributed hydrologic models are complex in terms of data requirements, parameter estimation and computational demand. To address these issues, a simple grid-based hydrologic model is developed in a geographic information system (GIS) environment using storage-release concept. The model is named GIS Storage Release Model (GIS-StoRM). The storage-release concept uses the travel time within each cell to compute howmuch water is stored or released to the watershed outlet at each time step. The travel time within each cell is computed by combining the kinematic wave equation with Manning's equation. The input to GIS-StoRM includes geospatial datasets such as radar rainfall data (NEXRAD), land use and digital elevation model (DEM). The structural framework for GIS-StoRM is developed by exploiting geographic features in GIS as hydrologic modeling objects, which store and process geospatial and temporal information for hydrologic modeling. Hydrologic modeling objects developed in this study handle time series, raster and vector data within GIS to: (i) exchange input-output between modeling objects, (ii) extract parameters from GIS data; and (iii) simulate hydrologic processes. Conceptual and structural framework of GIS StoRM including its application to Pleasant Creek watershed in Indiana will be presented.

• 산업경영시스템학회지
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• 제9권13호
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• pp.29-32
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• 1986

A decision procedure to determine when computer software should be released after testing is described. This paper extends optimum release policies minimizing the total expected software cost with a scheduled software delivery time under reliability requirement constraint. Such cost considerations enable us to make a release decision as to when transfer a software system from testing phase to operational phase. The underlying model is software reliability growth model described by a nonhomogeneous poisson process. It is assumed that the penalty cost function due to delay for a scheduled software delivery time is linearly proportional to time. Numerical examples are shown to illustrate the results.

• Korean Journal of Hydrosciences
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• 제4권
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• pp.11-19
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• 1993

The peak flood discharge at a downstream station and the flood travel time between a pair of dams due to a specific flood release from the upper reservoir are computed using a hydraulic river channel routing method. The study covered the whole large reservoir system in the Han River, Korea. The computed flood discharges and the travel times between dams were correlated with the duration and the magnitude of flood release rate at the upstream reservoir, and hence a multiple regression model is proposed for each river reach between a pair of dams. The peak flood discharge at a downstream location can be converted to the peak flood stage by a rating curve. Hence, the proposed regression model could be used to forecast the peak flood stage at a downstream location and the flood travel time between dams using the information on the flood travel time, release rate and duration from the upper dam.