• Journal of Korean Neurosurgical Society
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• v.49 no.1
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• pp.1-7
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• 2011

Objective: Glutamate is a key excitatory neurotransmitter in the brain, and its excessive release plays a key role in the development of neuronal injury. In order to define the effect of nimodipine on glutamate release, we monitored extracellular glutamate release in real-time in a global ischemia rat model with eleven vessel occlusion. Methods: Twelve rats were randomly divided into two groups: the ischemia group and the nimodipine treatment group. The changes of extracellular glutamate level were measured using microdialysis amperometric biosensor, in coincident with cerebral blood flow (CBF) and electroencephalogram. Nimodipine (0.025 ${\mu}g$/100 gm/min) was infused into lateral to the CBF probe, during the ischemic period. Also, we performed Nissl staining method to assess the neuroprotective effect of nimodipine. Results: During the ischemic period, the mean maximum change in glutamate concentration was $133.22{\pm}2.57\;{\mu}M$ in the ischemia group and $75.42{\pm}4.22\;{\mu}M$ (p<0.001) in the group treated with nimodipine. The total amount of glutamate released was significantly different (P<0.001) between groups during the ischemic period. The %cell viability in hippocampus was $47.50{\pm}5.64$ (p<0.005) in ischemia group, compared with sham group. But, the %cell viability in nimodipine treatment group was $95.46{\pm}6.60$ in hippocampus (p<0.005). Conclusion: From the real-time monitoring and Nissl staining results, we suggest that the nimodipine treatment is responsible for the protection of the neuronal cell death through the suppression of extracellular glutamate release in the 11-VO global ischemia model of rat.

• Journal of Environmental Science International
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• v.20 no.9
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• pp.1151-1163
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• 2011

The bed change analysis near the opening gate of a dam or weir to release deposited sediments have been conducted mostly using the numerical models. However, the use of unverified input parameters in the numerical model is able to produce the different results with natural and real conditions. Also, the bed changes near the opening gate of a dam or weir calculated with a numerical model could be varied depending on the geometry extent included the downstream area with supercritical flow in the model. In addition, the different time steps could provide different results in the bed change calculation, even though other conditions such as input parameters, geometries, and total simulation time were same. Therefore, in this study, hydraulic experiments were performed to validate the eddy viscosity coefficient which is the one of important input parameters in the RMA2 model and relevant to variation of simulation results. The bed changes were calculated using the SED2D model based on flow results calculated in the RMA2 model with the verified and selected eddy viscosity coefficient and also compared with experimental results. The bed changes near the opening gate were underestimated in the numerical model comparing with experimental results except only the numerical case without the modeling section of sediment release pipe and downstream area where the supercritical flow was produced. For the simulation of minimum time steps, different shapes of scour hole were produced in numerical and physical modeling.

• Archives of Pharmacal Research
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• v.20 no.6
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• pp.555-559
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• 1997

The three different batches of an oral sustained release melatonin (MT) delivery system were prepared by aqueous-based fluid-bed coating of the sugar spheres for the evaluation of in vitro release characteristics and plasma concentration profiles in human subjects. The MT contents in 20% coated sugar spheres of three batches (B1, B2 and B3) were $3.3{\pm}0.08$, $2.4{\pm}0.1$ and $2.5{\pm}0.13$ mg per gram of coated sugar spheres, respectively. The release profiles of three different batches had a very similar fashion. However, the release profiles of three different batches had a very similar fashion. However, the release half-lives $(T_{50%})$ of MT from B1, B2 and B3 was $3.70{\pm}0.2$, $5.2{\pm}0.2$ and $4.9{\pm}0.07h$, respectively. Plasma concentration profiles of sustained release 0.2mg melatonin-loaded sugar spheres containing 10% immediate release melatonin in gelatin capsules (B1 and B2) were then evaluated in human subjects. The in vivo plasma concentration profies of the two batches (B1 and B2) were very similar each other and located between the physiological endogenous ranges. The time to reach the peak concentration $(T_max)$ was more advanced in case of B1 when compared to B2. However, there was no statistically significant difference in the maximum concentration $(C_max)$ and the area under the curve (AUC) between B1 and B2. The AUC of melatonin-loaded sugar spheres containing 10% and 20% immediate release MT in human subjects had a good linearity between dose and AUC, regardless of the fraction of immediate release MT, indicating the first order elimination process of MT within these doses. The current oral sustained release MT delivery system may be utilized to treat circadian rhythm disorders if it is proven to be more clinically useful when compared to immediate release MT.

• Journal of the Korean Institute of Gas
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• v.20 no.5
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• pp.104-111
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• 2016

Recently, the quantities of chemical material are increasing in chemical industries. At that time, release accident is increasing due to aging of equipment, mechanical failure, human error, etc. and industrial complexes found community properties in a specific area. For that matter, chemical release accident can lead to hight probability of large disaster. There is a need to analyze the boundaries optimal sensor placement calculated by selecting release scenarios through release condition and wether condition in a chemical process for release detection and response. This paper is to investigate chlorine release accident scenarios using COMSOL. Through accident scenarios, a numerical calculation is studied to determine optimized sensor placement with weight of detection probability, detection time and concentration. In addition, validity of sensor placement is improved by robustness analysis about unpredicted accident scenarios. Therefore, this verifies our studies can be effectively applicable on any process. As mention above, the result of this study can help to place mobile sensor, to track gas release based concentration data.

• Korean Journal of Applied Biomechanics
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• v.27 no.2
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• pp.117-124
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• 2017

Objective: The purpose of this study was to examine the effect of changes in degrees of freedom of the fingers (i.e., the number of the fingers involved in tasks) on the task performance during force production and releasing task. Method: Eight right-handed young men (age: $29.63{\pm}3.02yr$, height: $1.73{\pm}0.04m$, weight: $70.25{\pm}9.05kg$) participated in this study. The subjects were required to press the transducers with three combinations of fingers, including the index-middle (IM), index-middle-ring (IMR), and index-middle-ring-little (IMRL). During the trials, they were instructed to maintain a steady-state level of both normal and tangential forces within the first 5 sec. After the first 5 sec, the subjects were instructed to release the fingers on the transducers as quickly as possible at a self-selected manner within the next 5 sec, resulting in zero force at the end. Customized MATLAB codes (MathWorks Inc., Natick, MA, USA) were written for data analysis. The following variables were quantified: 1) finger force sharing pattern, 2) root mean square error (RMSE) of force to the target force in three axes at the aiming phase, 3) the time duration of the release phase (release time), and 4) the accuracy and precision indexes of the virtual firing position. Results: The RMSE was decreased with the number of fingers increased in both normal and tangential forces at the steady-state phase. The precision index was smaller (more precise) in the IMR condition than in the IM condition, while no significant difference in the accuracy index was observed between the conditions. In addition, no significant difference in release time was found between the conditions. Conclusion: The study provides evidence that the increased number of fingers resulted in better error compensation at the aiming phase and performed a more constant shooting (i.e., smaller precision index). However, the increased number of fingers did not affect the release time, which may influence the consistency of terminal performance. Thus, the number of fingers led to positive results for the current task.

• Journal of Pharmaceutical Investigation
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• v.30 no.4
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• pp.241-246
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• 2000

To develop a sustained-release preparation containing ketorolac tromethamine, two sustained-release pellet formulations were evaluated with a pharmacokinetic study as compared with a conventional commercial tablets (10 mg $Tarasyn^{TM}$, Roche Korea Ltd.). Two sustained-release formulations were as follows; formulation A was composed of an inner layer containing 75% of drug coated with $Eudragit^{TM}$ RS 100 membrane and an outer layer containing 25% of drug mixed with $Eudragit^{TM}$ NE30D, and formulation B was composed of only an inner layer containing 100% of drug coated with $Eudragit^{TM}$ RS 100 membrane. The dissolution test was performed for two formulations. In case of conventional tablets, 2.5 mg of drug per a dose was administered orally into male Albino rabbit (2.0-2.3 kg of body weight) 3 times at intervals of 4 hours. In case of two sustained formulations, 7.5 mg of drug was administered once orally. Blood samples were withdrawn periodically after the administration, and the blood concentration was determined by HPLC. The conventional tablets showed very high peak-trough fluctuation between administered doses, but two sustained formulations showed less fluctuation. Formulation A with the loading dose showed the time to reach minimum effective concentration (MEC) i.e. the onset time was less than 20 min, while Formulation B had more than 1 hr of the onset time. Formulation A had the more constant plasma level than formulation B. However, formulation B had a time lag, so the plasma level was less than MEC for an initial period of 1 hr. In formulation A, the plasma level was maintained within the therapeutic window $(0.3-5\;{\mu}g/ml)$ for a long period. Formulation A was thought to be an ideal sustained-release formulation for ketorolac tromethamine oral delivery system.

• Journal of the Korean Society of Hazard Mitigation
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• v.11 no.2
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• pp.147-156
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• 2011

The purpose of multipurpose reservoir operation in flood season is to reduce the peak flood at a control point by utilizing flood control storage or to minimize flood damage by controlling release and release time. Therefore, the most important thing in reservoir operation for flood season is to determine the optimal release and release time. In this study, goal programming is used for the optimal reservoir operation in flood season. The goal programming minimizes a sum of deviation from the target value using linear programming or nonlinear programming to obtain the optimal alternative for the problem with more than two objectives. To analyze the applicability of goal programming, the historical storm data are utilized. The goal programming is applied to the reservoir system operation as well as single reservoir operation. Chungju reservoir is selected for single reservoir operation and Andong and Imha reservoirs are selected for reservoir system operation. The result of goal programming is compared with that of HEC-5. As a result, it was found that goal programming could maintain the reservoir level within flood control level at the end of a flood season and also maintain flood discharge within a design flood at a control point for each time step. The goal programming operation is different from the real operation in the sense that all inflows are assumed to be given in advance. However, flood at a control point can be reduced by calculating the optimal release and optimal release time using suitable constraints and flood forecasting system.

• Journal of Radiation Protection and Research
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• v.28 no.3
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• pp.239-245
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• 2003

Every nuclear power plant measured concentrations of tritium in groundwater and surface water around the plants periodically. It was not easy to predict the tritium concentration only with these measurement data in case of various release scenarios. KAERI developed a new approach to find the relationship between the tritium release rate and tritium concentration in the environment. The approach was based upon a dynamic compartment model. In this paper the dynamic compartment model was modified to predict the tritium behavior more accurately. The mechanisms considered for the transfer of tritium between the compartments were evaporation, groundwater flow, infiltration, runoff, and hydrodynamic dispersion. Time dependent source terms of the compartment model were introduced to refine the release scenarios. Also, transfer coefficients between the compartments were obtained using realistic geographical data. In order to illustrate the model various release scenarios were developed, and the change of tritium concentration in groundwater and surface water around the nuclear power plants was estimated.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2014.06a
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• pp.260-261
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• 2014

In the present study analysed the physico chemical properties and distribution of heavy metal and also analysed the changes of heavy metal distribution by resuspension and properties of heavy metal release into sea water. From the experimental result showed sediment resuspension plays an important role in the release of heavy metals in coastal environment. Heavy metal release percentage was high in different mixing time of resuspension and different amounts of sediment due to resuspension of particulate matter.

• Journal of Pharmaceutical Investigation
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• v.35 no.3
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• pp.151-155
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• 2005

A drug delivery system(DDS) for practically insoluble meloxicam was developed and evaluated by dissolution study. A novel DDS is two layered system, where the first layer is consisted of gas-forming agent for an immediate release and the second layer is composed of metolose SR(HPMC) for sustained release. This bilayered tablets were manufactured by using manual single punch machine. The results of dissolution study showed an initial burst release followed by sustained release for the experimental period time. From a pharmaceutical point of view, the designed DDS for meloxicam would be informative system in terms of poorly soluble analgesic medicines.