• 한국통신학회논문지
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• 제30권10A호
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• pp.912-921
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• 2005

Optical Burst Switched (OBS)는 If over WDM 망에서 테라비트 전송을 하기 위한 진보된 기술이다. OBS의 핵심 기술 중 하나는 데이터 버스트(DB : Data Burst)의 경쟁을 막기 위한 채널 스케쥴링 이다. OBS망에서 버스트의 제어패킷(CHP : Control Header Packet)과 데이터 버스트는 시간 간격(Time Gap)을 가지고 전송된다. 버스트 스위치 노드에 CHP가 도착하면 데이터 버스트을 위해 스케줄링 알고리즘을 사용하여 파장/채널(wavelength/channel)과 같은 자원을 예약하여 광전광(O/E/O)변환 없이 데이터 버스트를 전송해준다. 데이터 버스트를 위해 채널 스케줄링 과정에서 버스트간의 경쟁과 시간 간격이 발생되어 자원의 사용율과 버스트 손실 확률이 떨어진다. 기존에 제안된 방법들은 이러한 문제를 해결하기 위하여 많은 연구가 되어 지고 있다. 본 논문에서는 데이터 할당에서 발생되는 데이터간 간격과 데이터 손실에 중점을 두어 버스트 손실 확률과 자원 사용율을 극대화하기 위하여 버스트의 개방 시간)Release Time)을 이용한 채널 스케줄링 알고리즘 RTUC(Release Time Unscheduled Channel)을 제안한다. 시뮬레이션 결과 기존에 제안된 스케쥴링 알고리즘(LAUC, LAUC-VF)보다 버스트의 생존(Survival)과 효율적인 자원 사용 및 지연에서 개선된 성능을 확인하였다. 하지만, 로드가 적었을 경우 상대적으로 기존의 스케줄링 알고리즘보다 성능저하가 확인되었고, 로드가 증가했을 경우에는 데이터 손실 면에서 우수함을 확인하였다.

• 한국해양환경ㆍ에너지학회지
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• 제14권4호
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• pp.249-256
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• 2011

EFDC와 라그랑쥐 입자추적모델을 이용하여 조석주기별로 오염물질의 방출 시점이 다를 경우에 대한 마산만의 체류시간 및 해수교환율의 정량적 차이를 계산하였다. 체류시간은 만 전체에 대해 약 40일이었고 그 범위는 부도 남쪽 해역에서 약 20일 이하, 소모도 상부에 위치하는 마산만 내측에서는 약 100일 이상으로 나타났다. 이러한 체류 시간의 공간적 차이는 주로 조석잔차류와 만 내측으로부터의 거리에 영향을 받는 것으로 밝혀졌다. 만 전체 면적에 대한 체류시간의 평균값은 대조기 및 소조기에 각각 약 36일과 42일로 나타났다. 해수교환율은 30%가 되기까지 걸리는 시간이 입자 방류 시점에 따라 최소 약 65일부터 최대 105일까지 약 40일 이상 차이가 나는 것으로 계산되었다.

• Archives of Pharmacal Research
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• 제21권6호
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• pp.645-650
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• 1998

The dual drug-loaded alginate beads simultaneously containing drug in inner and outer layers were prepared by dropping plain (single-layered) alginate beads into $CaCl_2$ solution. The release characteristics were evaluated in simulated gastric fluid for 2 h followed by intestinal fluids thereafter for 12 h. The surface morphology and cross section of dual drug-loaded alginate beads was also investigated using scanning electron microscope (SEM). The poorlv water-soluble ibuprofen was chosen as a model drug. The surface of single-layered and dual drug-loaded alginate beads showed very crude and roughness, showing aggregated particles, surface cracks and rough crystals. The thickness of dual drug-loaded alginate beads surrounded by outer layer was ranged from about 57 to 329mcm. The distinct chasm between inner and outer layers was also observed. In case of single-layered alginate bead, the drug was not released in gastric fluid but was largely released in intestinal fluid. However, the release rate decreased as the reinforcing $Eudragit^{\circledR}$ polymer contents increased. When the plasticizers were added into polymer, the release rate largely decreased. The release rate of dual drug-loaded alginate beads was stable in gastric fluid for 2 h but largely increased when switched in intestinal fluid. The drug linearly released for 4 h followed by another linear release thereafter, showing a distinct biphasic release characteristics. There was a difference in the release profiles between single-layered and dual drug-loaded alginate beads due to their structural shape. However, this biphasic release profiles were modified by varying formulation compositions of inner and outer layer of alginate beads. The release rate of dual drug-loaded alginate beads slightly decreased when the outer layer was reinforced with $Eudragit^{\circledR}$ RS1OO polymers. In case of dual drug-loaded alginate beads with polymer-reinforced outer layer only, the initial amount of druc released was low but the initial release rate (slope) was higher due to more swellable inner cores when compared to polymer-reinforced inner cores. The current dual drug-loaded alginate beads may be used to deliver the drugs in a time dependent manner.

• Biomaterials and Biomechanics in Bioengineering
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• 제1권1호
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• pp.13-25
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• 2014

In the current study, a drug-eluting stent coated with biodegradable polymers and sirolimus was developed by using an ultrasonic nanocoater and characterized in aspects of surface smoothness and coating thickness. In addition, in vitro release profiles of sirolimus by changing top coating layer with different biodegradable polymers were investigated. Smooth surfaces with variable thickness could be fabricated by optimizing polymer concentration, flow rate, nozzle-tip distance, gas pressure, various solvents and ultrasonic power. Smooth surface could be generated by using volatile solvents (acetone, chloroform, and methylene chloride) or post-treating with solvent vapor. Coating thickness could be controlled by varying injection volume or polymer concentration, and higher concentration could reduce the coating time while obtaining the same thickness. The thickness measurement was the most effectively performed by a conventional cutting method among three different methods that were investigated in this study. Release profiles of sirolimus were effectively controlled by changing polymers for top layer. PLGA made the release rate 3 times faster than PDLLA and PLLA and all top layers prevented burst release at the initial phase of profiles. Our results will provide useful and informative knowledge for developing drug-eluting stents, especially coated with biodegradable polymers.

• Toxicological Research
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• 제14권3호
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• pp.333-339
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• 1998

Sambutoxin, a newly purified mycotoxin in Koea, caused hemorrhage in the stomach and intestine of rats. To elucidate the mechanism of hemorrhage, effects of sambutoxin on rabbit platelet aggregation were investigated. First of all, the effects of sambutoxin on the platelet aggregation response and ATP release from platelet by various appregating factors were investigated. And then the role of $Ca^{2+}$ on the platelet aggregation was investigated by flow cytometer. Finally, morphological effect of sambutoxin on platelet ultrastructure was examined by transmission electron microscope. Sambutoxin inhibited aggregation induced by ADP, collagen, thrombin, and arachidonic acid and decreased platelet activating factor-induced disaggregation time in a dose dependent manner. Sambutoxin also decreased thrombin and arachidonic acid-induced ATP release, but increased all factors induced $Ca^{2+}$ release. Sambutoxin showed severe ultrastructural changes of platelet such as appearance of disorganization debri of cellular organelle in intercellular space. Our results indicate that sambutoxin inhibitis rabbit platelet aggregation, and it may be party due to the decrease of ATP release. However, it is not clear whether the antiaggregating effect of sambutoxin is related to $Ca^{2+}$ increase.

• Journal of Pharmaceutical Investigation
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• 제27권1호
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• pp.71-77
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• 1997

With the aim of improving periodontal regeneration efficacy, as a biodegradable local drug delivery device, drug releasing chitosan beads were prepared. Chitosan beads were prepared through the formation of intermolecular or intramolecular ionic interaction bewteen chitosan and sodium tripolyphosphate and were loaded with flurbiprofen. The mean diameter of the beads was $250\;{\mu}m$. Drug loading efficiency was improved by regulating the pH of tripolyphosphate solution. The drug release kinetics mainly depended upon the hydrophobic properties of the flurbiprofen, that is, the release of flurbiprofen showed initial burst with rapid release for the first day followed by a levelling off of the release rate. However, the release rate could be controlled by the formulation factor including the pH, concentration of the tripolyphosphate solution, gelation time, drug contents. From these results, flurbiprofen loaded chitosan beads were anticipated as biodegradable local drug delivery devices for periodontal regeneneration.

• Journal of Pharmaceutical Investigation
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• 제35권6호
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• pp.445-451
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• 2005

As a selective ${\alpha}_{1A}-adrenoreceptor$ antagonist, tamsulosin has been used clinically for urinary obstructed patients with benign prostatic hyperplasia. The single and multi-layered pellets containing tamsulosin hydrochloride were prepared in an effort to control the drug release, avoiding dose-dependent side effects of tamsulosin hydrochloride upon oral administration. The drug release from multi-layered pellets was substantially controlled, compared with single layered pellets. The drug release from coated pellets with single or multi layer was affected by the nature of coating agent, the percentage of coating level and the presence of hydrophilic material in coating layer. In conclusion, the controlled release oral delivery system using multi-layered pellet is very useful for tamsulosin hydrochloride, resulting in improvement of patient compliance and therapeutic drug levels for a longer period of time.

• 상하수도학회지
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• 제13권2호
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• pp.89-94
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• 1999

In this study small glass columns with 2.5cm inner diameter and 24.5cm length were used as many as the sample numbers to study the effects of initial pH, temperature, dissolved oxygen concentration, and sediment depth on the release of phosphorus from lake sediment. No phosphorus release occurred at $10^{\circ}C$ with all pHs, and release rate at $25^{\circ}C$ was higher than that at $35^{\circ}C$ with pH 4 and reverse trends were observed at pH 7 and 10. Under all conditions, DO concentrations were decreased and equilibrium was obtained after 4-8 days when phosphorus release started and the Do concentrations were less than 1 mg/l. Sediment depth had little effect on phosphorus release rate. It was found that relation between released SRP(Soluble Reactive Phosphorus) concentration and time was zero order reaction and reaction rate coefficients were obtained. The amount of phosphorus release from lake sediment can be predicted by considering these k values.

• 한국염색가공학회지
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• 제9권2호
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• pp.41-49
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• 1997

To control free formaldehyde release from fabric finished with N-methylol compounds, resin finished cotton fabric was treated with resorcinol solution, dried and cured. Factors affecting to control formaldehyde release have been investigated. It was shown that the aftertreatment with resorcinol greatly suppressed the free formaldehyde release. Up to concentration of about 5% of resorcinol, the concentration of resorcinol effected on the control of free and evolved formaldehyde. And at high concentration of resorcinol, however, the concentration became rather insensitive to contol formaldehyde release. Addition of some salt catalysts such as ammonium chloride, zinc nitrate, sodium acetate and ammonium acetate, was effective in decreasing formaldehyde release. Considering the effect on the control of formaldehyde and crease recovery, ammonium acetate was concidered to be the best catalyst. It was observed that the optimum curing temperature for the resorcinol treatment was about 15$0^{\circ}C$, and that the curing time did not affected formaldehyde release over three minutes. Although the treatment of resorcinol had a little adverse effect on crease recovery of resin finished fabric, this effect could be negligible.

• Macromolecular Research
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• 제13권5호
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• pp.397-402
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• 2005

To explore the potential of shell crosslinked micelle (SCM) as a drug carrier, the drug release behavior of poly($\varepsilon$-caprolactone)-b-poly(acrylic acid) (PCL-b-PAA) SCMs was investigated. PCL-b-PAA was synthesized by ring opening polymerization of $\varepsilon$-caprolactone and atom transfer radical polymerization of tert-butyl acrylate, followed by selective hydrolysis of tert-butyl ester groups to acrylic acid groups. The resulting amphiphilic polymer was used to prepare SCMs by crosslinking of PAA corona via amidation chemistry. The drug release behavior of the SCMs was studied, using pyrene as a model drug, and was compared with that of non-crosslinked micelles, especially below the critical micelle concentration (CMC). When the shell layers were crosslinked, the drug release behavior of the SCMs was successfully modulated at a controlled rate compared with that of the non-crosslinked micelles, which showed a burst release of drug within a short time.