• Advances in aircraft and spacecraft science
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• v.8 no.1
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• pp.1-15
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• 2021

Mars exploration demands aerodynamic computations for a proper design of missions of spacecraft carrying instruments and astronauts to Mars. Both Computational Fluid Dynamics (CFD) and Direct Simulation Monte Carlo (DSMC) method play a key role for this purpose. To the author's knowledge, the altitude separating the fields of applicability of CFD and DSMC in Mars atmosphere entry is not yet clearly defined. The limitations in using DSMC at low altitudes are due to technical limitations of the computer. The limitations in using CFD at high altitudes are due to thermodynamic non-equilibrium. Here, this problem is studied in Mars atmosphere entry, considering the Mars Pathfinder capsule in the altitude interval 40-80 km, by means of a DSMC code. Non-equilibrium is quantified by the relative differences between translational temperature and: rotational (θt-r), vibrational (θt-v), overall (θt-ov) temperatures, anisotropy is quantified by the relative difference between the translational temperature component along x and those along y (θx-y) and along z (θx-z). The results showed that θt-r, θt-v, θx-y, θx-z are almost equivalent. The altitude of 45 km should be the limit altitude for a proper use of a CFD code and the altitude of 40 km should be the limit altitude for a reasonable use of a DSMC code.

• Clinical and Experimental Reproductive Medicine
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• v.49 no.3
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• pp.196-201
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• 2022

Objective: This prospective consecutive study investigated the variation in sperm DNA fragmentation (SDF) in multiple semen samples from patients with cancer. Methods: Eighty-one patients with various cancers underwent multiple semen collections on 3 consecutive days for sperm cryopreservation prior to cancer treatment. A commercial Halosperm kit was used to measure SDF. Within- and between-subject coefficients of variation were estimated via random-effects analysis of variance to assess the consistency of semen parameters and SDF. Intraclass correlation coefficients (ICCs) were calculated to assess the magnitude of the between-subject component of variance relative to the total variance. Results: The volume of semen in the day-2 and day-3 samples was significantly lower compared with the day-1 sample. Most parameters showed high ICC values, suggesting that within-subject fluctuations were small relative to the between-subject variability. The highest ICC values were identified for the SDF (ICC, 0.68; 95% confidence interval [CI], 0.45-0.84) and semen volume (ICC, 0.67; 95% CI, 0.45-0.84). Conclusion: Our findings showed that repeated ejaculates from patients with cancer had stable SDF levels.

• Korean Journal of Exercise Nutrition
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• v.24 no.2
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• pp.38-46
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• 2020

[Purpose] This study aimed to investigate the effects of leucine-enriched essential amino acid (LEAA) supplementation on muscle fatigue and the level of inflammatory cytokines in wheelchair basketball players after a basketball game and interval training. [Methods] Of the ten recruited wheelchair basketball players (aged 34.5±8.9 years; lean body mass of 34.3±10.0 kg) who had spinal cord injury (SCI) and had undergone amputation, nine participated in the final test. These nine athletes received LEAA supplements (3 times 4.0 g/day) or placebo treatment in a double-blind, randomized, crossover study. We measured variables related to muscular fatigue and inflammatory response before the intense exercise and 4 days after recovery. [Results] The significant effect of LEAA supplementation was inhibition of circulating IL-6 levels in the LEAA-treated group compared with the placebo group (P < .05). However, no changes were observed in the TNF-α and creatinine kinase levels. Moreover, analysis of variance analysis showed no significant difference in the relative values of muscle soreness. However, the effect size analysis with Cohen's d reported a significant improvement in the relative values of whole body and back muscle soreness. [Conclusion] Our results revealed that LEAA supplementation before and after intense exercise could help reduce muscle soreness and IL-6 levels in wheelchair basketball players.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4493-4497
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• 2014

Background: Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) can predict the clinical response to tyrosine kinase inhibitor (TKI) therapy. However, EGFR mutations may be different in primary tumors (PT) and metastatic lymph nodes (MLN). The aim of this study was to compare EGFR mutations between PT and the corresponding MLN in NSCLC patients, and provide some guidelines for clinical treatment using TKI therapy. Materials and Methods: A systematic review and meta-analysis was performed with several research databases. Relative risk (RR) with the 95% confidence interval (CI) were used to investigate the EGFR mutation status between PT and the corresponding MLN. A random-effects model was used. Results: 9 publications involving 707 patients were included in the analysis. It was found that activation of EGFR mutations identified in PT and the corresponding MLN was 26.4% (187/707) and 19.9% (141/707), respectively. The overall discordance rate in our meta-analysis was 12.2% (86/707). The relative risk (RR) for EGFR mutation in PT relative to MLN was 1.33 (95%CI: 1.10-1.60; random-effects model). There was no significant heterogeneity between the studies ($I^2$=5%, p=0.003). Conclusions: There exists a considerable degree of EGFR mutation discrepancy in NSCLC between PT and corresponding MLN, suggesting that tumor heterogeneity might arise at the molecular level during the process of metastasis.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.9
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• pp.1846-1855
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• 2015

In this paper, a precise relative positioning with TD(time differenced) carrier phase measurements from a low-cost GNSS(Global Navigation Satellite System) receiver is proposed and analysed. The proposed method is using carrier phase measurement from a single GNSS receiver that reference receiver is not required and stand alone positioning is possible. TD operation removes the troublesome integer ambiguity resolution problem, and if the time interval is short, other error, such as, ionospheric, tropospheric delay and ephemeris error are effectively eliminated. The error analysis of the proposed method shows that a precise and positioning with carrier phase is possible. The implemented system is evaluated using a real car experiments. The results show that the horizontal positioning error was less than 3m during 10 minutes experiments, which is 4 times more precise than the results of normal code based absolute positioning.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.4
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• pp.867-872
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• 2009

Peak expiratory flow rate(PEF) is one of the most important diagnostic parameters in spirometry. PEF occurs in a very short duration during the forced expiratory maneuver, which could lead to measurement error due to non-ideal dynamic characteristic of the transducer. In such case the initial slope of the flow rate signal determines the accuracy of the measured PEF. The present study considered this initial slope as a parameter to compensate PEF. The 26 standard flow rate signals recommended by the American Thoracic Society(ATS) were flown through the air flow transducer followed by simultaneous measurements of PEF and maximum transducer output$(N_{PEF})$. $N_{PEF}$-PEF satisfied a quadratic equation in general, however, two signals (ATS #2 and #26) having large initial slopes deviated from the fitting equation to a significant degree. The relative error was found to be in a linear relationship with the initial slope, thus, $N_{PEF}$ was appropriately compensated to provide accurate PEF with mean relative error less than only 1%. The 99% confidence interval of the mean relative error was less than a half of the error limit of 5% recommended by ATS. Therefore, PEF can be very accurately determined by compensating the transducer output based on the initial slope, which should be a useful technique for air flow transducer calibration.

• Genomics & Informatics
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• v.18 no.3
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• pp.27.1-27.12
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• 2020

The prevalence of early-onset type 2 diabetes (EOT2D) is increasing in Asian countries. Genome-wide association studies performed in European and various other populations have identified associations of numerous variants with type 2 diabetes in adults. However, the genetic component of EOT2D which is still unexplored could have similarities with late-onset type 2 diabetes. Here in the present study we aim to identify the association of variants with EOT2D in South Indian population. Twenty-five variants from 18 gene loci were genotyped in 1,188 EOT2D and 1,183 normal glucose tolerant subjects using the MassARRAY technology. We confirm the association of the HHEX variant rs1111875 with EOT2D in this South Indian population and also the association of CDKN2A/2B (rs7020996) and TCF7L2 (rs4506565) with EOT2D. Logistic regression analyses of the TCF7L2 variant rs4506565(A/T), showed that the heterozygous and homozygous carriers for allele 'T' have odds ratios of 1.47 (95% confidence interval [CI], 1.17 to 1.83; p = 0.001) and 1.65 (95% CI, 1.18 to 2.28; p = 0.006) respectively, relative to AA homozygote. For the HHEX variant rs1111875 (T/C), heterozygous and homozygous carriers for allele 'C' have odds ratios of 1.13 (95% CI, 0.91 to 1.42; p = 0.27) and 1.58 (95% CI, 1.17 to 2.12; p = 0.003) respectively, relative to the TT homozygote. For CDKN2A/2B variant rs7020996, the heterozygous and homozygous carriers of allele 'C' were protective with odds ratios of 0.65 (95% CI, 0.51 to 0.83; p = 0.0004) and 0.62 (95% CI, 0.27 to 1.39; p = 0.24) respectively, relative to TT homozygote. This is the first study to report on the association of HHEX variant rs1111875 with EOT2D in this population.

• Korean Journal of Exercise Nutrition
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• v.25 no.2
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• pp.26-32
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• 2021

[Purpose] This study aimed to analyze the prevalence of hypertension according to the body mass index (BMI) and relative handgrip strength (RHGS) among elderly individuals in Korea. [Methods] We analyzed the data of 44,183 Korean elderly individuals over 65 years old (men: n = 15,798, age = 73.31 ± 5.04 years, women: n = 28,385, age = 72.14 ± 5.04 years) obtained from the Korean National Fitness Assessment in 2019. All the participants were categorized into three groups according to the BMI and RHGS; additionally, one-way ANOVA and logistic regression analysis were performed. [Results] Overweight (men: 1.16 odds ratio [OR] 1.06-1.26, 95% confidence interval [CI]; women: 1.15 OR, 1.07-1.23 95% CI) and obese (men: 1.54 OR, 1.42-1.66 95% CI; women: 1.44 OR, 1.36-1.53 95% CI) elderly individuals showed a higher prevalence of hypertension than elderly individuals with normal weight, after controlling for age. In men, a lower RHGS was associated with a higher prevalence of hypertension after controlling for age (weak RHGS: 1.09 OR, 1.00-1.17 95% CI; middle RHGS: 1.21 OR, 1.12-1.31 95% CI vs. strong RHGS). [Conclusion] A higher BMI was associated with the prevalence of hypertension in the elderly Korean population. In addition, a lower RHGS was associated with the prevalence of hypertension in elderly Korean men.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.711-716
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• 2003

This study considers the implementation issues of the inter-vehicle communication system for the vehicle platoon experiments via a testbed. The testbed, which consists of three scale vehicles and one RCS(remote control station), is developed as a tool for functions evaluation between simulation studies and full-sized vehicle researches in the previous study. The cooperative communication of the vehicle-to-vehicle or the vehicle-to-roadside plays a key role for keeping the relative spacing of vehicles small in a vehicle platoon. The static platoon control, where the number of vehicles remains constant, is sufficient for the information to be transmitted in the suitably fixed interval, while the dynamic platoon control such as merge or split requires more flexible network architecture for the dynamical coordination of the communication sequence. In this study, the wireless communication device and the reliable protocol of the flexible network architecture are implemented for our testbed, using the low-cost, ISM band transceiver and the 8-bit microcontroller.

• Proceedings of the KSME Conference
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• 2001.06e
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• pp.499-505
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• 2001

The objective of the paper was to measure the pressure drop and to investigate the recirculation region of the conical orifices used in Kwang-yang Iron & Steel Company. The flow field with water used as a working fluid was the turbulent flow for Reynolds number of $2{\times}10^4$. The effective parameters for the pressure drop and the recirculation region were the conical orifice's inclined angle (${\theta}$) against the wall, the interval(L) between orifices, the relative angle of rotation(${\alpha}$) of the orifices, the shape of the orifice's hole(circle, rectangle, triangle) having the same area. It was found that the shape of the orifice's hole affected the pressure drop and the flow field a lot, But the other parameters did not make much differences to the pressure drop. The PISO algorithm with FLUENT code was employed.