Korean Journal of Exercise Nutrition (운동영양학회지)

한국운동영양학회
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Effects of leucine-enriched essential amino acid supplementation on muscular fatigue and inflammatory cytokines in wheelchair basketball players

  • An, Young Hwan (Department of Physical Education, Konkuk University) ;
  • Kim, Jisu (Department of Sports Medicine and Science in Graduate School, Konkuk University) ;
  • Kim, Hee-Jae (Physical Activity and Performance Institute, Konkuk University) ;
  • Lim, Kiwon (Department of Physical Education, Konkuk University)
  • Received : 2020.06.05
  • Accepted : 2020.06.26
  • Published : 2020.06.30
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Abstract

[Purpose] This study aimed to investigate the effects of leucine-enriched essential amino acid (LEAA) supplementation on muscle fatigue and the level of inflammatory cytokines in wheelchair basketball players after a basketball game and interval training. [Methods] Of the ten recruited wheelchair basketball players (aged 34.5±8.9 years; lean body mass of 34.3±10.0 kg) who had spinal cord injury (SCI) and had undergone amputation, nine participated in the final test. These nine athletes received LEAA supplements (3 times 4.0 g/day) or placebo treatment in a double-blind, randomized, crossover study. We measured variables related to muscular fatigue and inflammatory response before the intense exercise and 4 days after recovery. [Results] The significant effect of LEAA supplementation was inhibition of circulating IL-6 levels in the LEAA-treated group compared with the placebo group (P < .05). However, no changes were observed in the TNF-α and creatinine kinase levels. Moreover, analysis of variance analysis showed no significant difference in the relative values of muscle soreness. However, the effect size analysis with Cohen's d reported a significant improvement in the relative values of whole body and back muscle soreness. [Conclusion] Our results revealed that LEAA supplementation before and after intense exercise could help reduce muscle soreness and IL-6 levels in wheelchair basketball players.

Keywords

Acknowledgement

This paper was supported by the KU Research Professor Program of Konkuk University.

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