• Title/Summary/Keyword: RelA

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Method for Position Estimation of Network Entry Terminal based on DTDMA(Dynamic Time Division Multiple Access) (DTDMA 기반 초기 망가입 단말의 효율적 위치 추정 방법)

  • Seo, Nan Sol
    • Journal of the Korea Institute of Military Science and Technology
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    • v.15 no.5
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    • pp.623-629
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    • 2012
  • In this paper, we analysis the performance of position estimation when adopting Dynamic TDMA(DTDMA) in JTIDS RelNav. JTIDS RelNav is widely understood as a new navigation solution possibly capable to support or take cover of the role of conventional systems including INS or GPS no matter if they are working well or not. By maximizing the efficiency of radio resource management in MAC(Medium Access Control) layer we enhance the system performance without any replacement of hardware.

Functional Analysis of Fibroblastic Reticular Cells Derived from Mouse Lymph Node via Bidirectional Crosstalk with T Cells (T세포와 양방향 작용을 통한 마우스 림프절로부터 분리된 fibroblastic reticular cell의 기능적 분석)

  • Park, Sung Hee;Lee, Jong-Hwan
    • Journal of Life Science
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    • v.23 no.10
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    • pp.1199-1208
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    • 2013
  • Fibroblastic reticular cells (FRCs) form the structural backbone of the T zone provide a guidance path for immigrating T cells in the lymph node (LN). FRCs may contribute directly to developing T-cell biology in the LN and allow analyses of fundamental aspects of FRC biology related to T cells. FRCs inhibited T-cell apoptosis, and FRC culture supernatants strongly induced the expression of Bcl-xL in T cells against doxorubicin. Coculture of FRC and T cells resulted in rearrangements of the actin cytoskeleton, as well as global changes in the morphology of the FRCs. In addition, when cocultured, the T cells adhered to the FRC monolayer, and the membrane intercellular adhesion molecule (ICAM)-1 was slightly increased by day-dependent manner. In contrast, the expression of soluble ICAM-1 was dramatically increased in a day-dependent manner. Several chemokines, such as CCL5, CXCL1, CXCL5, CXCL16, CCL8, CXCL13, and ICAM-1, and MMPs were expressed in FRCs sensed by tumor necrosis factor (TNF) families. Nuclear factor kappa B ($NF{\kappa}B$)-RelA of the $NF{\kappa}B$ canonical pathway was translocated into FRC nuclear by $TNF{\alpha}$. In contrast, p52 proteolyzed from p100, a counterpart of RelB of the noncanonical $NF{\kappa}B$ pathway, accumulated in the peripheral FRC nucleus by agonistic anti-$LT{\beta}R$ antibody. In summary, we propose a model in which FRCs engage in bidirectional crosstalk to increase the efficiency of T-cell biology. This cooperative feedback loop may help to maintain tissue integrity and function during immune responses.

Inulin stimulates NO synthesis via activation of PKC-$\alpha$ and protein tyrosine kinase, resulting in the activation of NF-$textsc{k}$B by IFN-ν-primed RAW 264.7 cells

  • Koo, Hyun-Na;Hong, Seung-Heon;Kim, Hyung-Min
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 2003.11a
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    • pp.78-78
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    • 2003
  • Inulin, an active component of Chicorium intybus root, has been shown to stimulate the growth of bifidobacteria, and inhibit colon carcinogenesis. NO mediates a number of the host-defense functions of activated macrophages, including antimicrobial and tumoricidal activity. We examined the effect of inulin on the synthesis of NO in RAW 264.7 cells. Inulin alone had no effect, whereas inulin with IFN-ν synergistically increased the NO production and inducible NO synthase (iNOS) expression in RAW 264.7 cells. Synergy between IFN-ν and inulin was mainly dependent on inulin-induced TNF-${\alpha}$ secretion. Also, protein kinase C (PKC)-${\alpha}$ was involved in the inulin-induced NO production. Inulin-mediated NO production was inhibited by the protein tyrosine kinase (PTK) inhibitor, tyrphostin AG126. Since iNOS gene transcriptions have been shown to be under the control of the NF -$\kappa$B/Rel family of transcription factors, we assessed the effect of inulin on NF -$\kappa$B/Rel using an EMSA. Inulin produced strong induction of NF-$\kappa$B/Rel binding, whereas AP-l binding was slightly induced in RAW 264.7 cells. Inulin stimulated phosphorylation and degradation of I$\kappa$B-${\alpha}$. These results suggest that in IFN-ν-primed RAW 264.7 cells inulin might stimulate NO synthesis via activation of PKC-${\alpha}$ and PTK, resulting in the activation of NF-$\kappa$B.

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Design and implementation of protection and management system of digital contents based on MPEG-21 IPMP (MPEG-21 IPMP 기반 디지털 콘텐츠 보호 관리 시스템 설계 및 구현)

  • Ryu Kwang-Hee;Kim Yun-Ki;Kim Kwang-Yong;Kim Jae-Gon;Hong Jin-Woo;Jung Hoe-Kyung
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2006.05a
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    • pp.149-152
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    • 2006
  • The usage increase of digital contents required solution for protection technology and interoperability of system. MPEG proposed MPEG-21 Multimedia Frameworks. MPEG-21 IPMP is standard that provides the means to enable digital item and rights information to be persistently managed and protected across networks and devices. In this paper, MPEG-21 IPMP based system to protect digital contents designed by four structures of license server, production server, consumption server, tool sewer. License sewer create rights information document using the XML-based REL about multimedia contents of users. Production server makes a digital item by packaging multimedia resource and metadata, which is combined by REL information and IPMP information of multimedia resource. Consumption server takes care of the functions of players that use digital item, and tool server was implement to transmit for missing tool that night occur in all procedures.

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Robust Fuzzy Logic Current and Speed Controllers for Field-Oriented Induction Motor Drive

  • El-Sousy, Fayez F.M.;Nashed, Maged N.F.
    • Journal of Power Electronics
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    • v.3 no.2
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    • pp.115-123
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    • 2003
  • This paper presents analysis, design and simulation for the indirect field orientation control (IFOC) of induction machine drive system. The dynamic performance of the IFOC under nominal and detuned parameters of the induction machine is established. A conventional proportional plus integral-derivative (PI-D) two-degree-of-freedom controller (2DOFC) is designed and analysed for an ideal IFOC induction machine drive at nominal parameters with the desired dynamic response. Varying the induction machine parameters causes a degredation in the dynamic response for disturbance rejection and tracking performance with PI-D 2DOF speed controller. Therefore, conventional controllers can nut meet a wide range of speed tracking performance under parameter variations. To achieve high- dynamic performance, a proposed robust fuzzy logic controllers (RFLC) for d-axis rotor flux, d-q axis stator currents and rotor speed have been designed and analysed. These controllers provide robust tracking and disturbance rejection performance when detuning occurres and improve the dynamic behavior. The proposed REL controllers provide a fast and accurate dynamic response in tracking and disturbance rejection characteristics under parameter variations. Computer simulation results demonstrate the effectiveness of the proposed REL controllers and a robust performance is obtained fur IFOC induction machine drive system.

[6]-Gingerol Inhibits Phorbol Ester-Induce d Expression of Cyclooxygenase-2 in Mouse Skin: p38 MAPK and p65/RelA as Possible Molecular Targets

  • Kim, Sue-Ok;Chun, Kyung-Soo;Surh, Young-Joon
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.05a
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    • pp.95.1-95
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    • 2003
  • Ginger (Zingiber officinale Roscoe, Zingiberaceae) has a wide array of pharmacologic effects. Our previous studies have demonstrated that [6]-gingerol, a major pungent ingredient of ginger, inhibits mouse skin tumor promotion and anchorage-independent growth of cultured mouse epidermal cells stimulated with epidermal growth factor. In this study, we have investigated the molecular mechanisms underlying chemopreventive effects of [6]-gingerol on mouse skin carcinogenesis. Cyclooxygenase-2 (COX-2), a key enzyme in the formation of prostaglandins, has been recognized as a molecular target of many chemopreventive as well as anti-inflammatory agents. The murine COX-2 promoter contains several transcriptional elements, particularly those involved in regulating inflammatory processes. One of the essential transcription factors responsible for COX-2 induction is NF-kappa B. Topical application of [6]-gingerol inhibited the COX-2 expression through suppression of NF-kappa B activation in phorbol ester-treated mouse skin. [6]-Gingerol, through down-regulation of p38 MAPK, abrogated the DNA binding activity of NF-kappa B by blocking phosphorylation of p65/RelA at the Ser 536 residue. These findings suggest that [6]-gingerol exerts an anti-tumor promotional activity through inhibition of the p38 MAPK-NF-kappa B siganling cascade in mouse skin.

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Selection and implementation of Standard Functional Blocks for Radio Library in multi-mode mobile device (멀티모드 단말기의 라디오 라이브러리를 위한 표준 기능 블록의 선정 및 구현)

  • Jung, Ildo;Choi, Sengwon
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.12 no.3
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    • pp.125-132
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    • 2016
  • The European Telecommunication Standards Institute (ETSI) Technical Committee (TC) Reconfigurable Radio Systems (RRS) is standardizing the multi-mode Mobile Device (MD). The configuration of multi-mode MD is determined by the downloaded mobile communication standard software. In this paper, we introduce the Radio Library concept for multi-mode MD which is one of the key components of RRS standard. This paper also introduces the Standard Functional Block which is a part of Radio Library. A method for selecting efficiency SFBs for multi-mode MD is presented and a Radio Library is generated based on the selected SFBs. This paper also shows sample Standard Functional Block Set which included in Radio Library. In order to verify the compatibility of the generated Radio Library which was made by C language, we implement the LTE Rel-10 and Wi-Fi(802.11b) to show the efficiency of generating a mobile communication standard software based on the Radio Library. Then using the Prograph Visual Programming MartenTM 1.6.4, we compiled our LTE Rel-10 and Wi-Fi(802.11b) source code.

A Mathematical Equation Retrieval System Based on Formula Patterns Expressed in Korean (한글화된 수식 패턴을 이용한 수학식 검색 시스템)

  • Kim, Shin-Il;Yang, Seon;Ko, Young-Joong
    • Proceedings of the Korean Information Science Society Conference
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    • 2011.06a
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    • pp.233-236
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    • 2011
  • 일반적인 문서에 대한 정보 검색 연구는 활발히 진행되고 있으며, 일상 생활 속에서도 대중화되어 많이 사용되고 있다. 이에 따라 음성, 이미지 검색 등 특정 분야의 검색에 대한 연구도 활발히 진행되고 있지만, 수학식 검색에 대한 연구는 비교적으로 미비한 실정이다. 수학식 검색과 관련된 연구들은 대부분 MathML (Mathematical Markup Language), TeX 등으로 작성된 수학식을 대상으로 진행되었지만, 특정 언어나 별개의 수학 입력 툴들을 이용한 검색 방법은 일반 사용자들이 사용하기에는 쉽지 않다는 단점이 있다. 그래서, 본 논문에서는 일반 문서 검색과 마찬가지로, 수학식을 읽듯이 한글을 입력했을 때 색인어 추출 방법 및 검색 방법에 대해 제안한다. 실험을 위해서 수학 문제집에 나오는 1,432개의 수학식을 한글화 시켰고, 한글화된 결과에 대해 패턴 등을 추출하여 MRR (Mean Reciprocal Rank), $Rel_{EQ}$@N(Relevance evaluation at N)로 평가하였다. 100개의 한글 질의어에 대해 MRR@5로 계산된 수학식 검색 결과가 약 0.6 정도 되는 것을 확인할 수 있었고, 학습 데이터에 포함되지 않은 질의수학식 5개에 대해 $Rel_{EQ}$@5로 계산했을 때 평균 60% 의 정확률을 보였다.