• Parasites, Hosts and Diseases
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• v.50 no.4
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• pp.281-286
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• 2012

Helminthic infections afflict over 1.5 billion people worldwide, while Mycobacterium tuberculosis infects one third of the world's population, resulting in 2 million deaths per year. Although tuberculosis and helminthic infections coexist in many parts of the world, and it has been demonstrated that the T-helper 2 and T-regulatory cell responses elicited by helminths can affect the ability of the host to control mycobacterial infection, it is still unclear whether helminth infections in fact affect tuberculosis disease. In this review article, current progress in the knowledge about the immunomodulation induced by helminths to diminish the protective immune responses to bacille Calmette-Guerin vaccination is reviewed, and the knowledge about the types of immune responses modulated by helminths and the consequences for tuberculosis are summarized. In addition, recent data supporting the significant reduction of both M. tuberculosis antigen-specific Toll-like receptor (TLR) 2 and TLR9 expression, and pro-inflammatory cytokine responses to TLR2 and TLR9 ligands in individuals with M. tuberculosis and helminth co-infection were discussed. This examination will allow to improve understanding of the immune responses to mycobacterial infection and also be of great relevance in combating human tuberculosis.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.14 no.1
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• pp.63-78
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• 2016

To meet nuclear regulatory requirements, more than 95% individual radionuclides in the low- and intermediate-level radioactive waste inventory have to be identified. In this study, the radionuclide inventory has been estimated by taking the long-term radioactive waste generation, the development plan of disposal facility, and the new radioactive waste classification into account. The state of radioactive waste cumulated from 2014 was analyzed for various radioactive sources and future prospects for predicting the long-term radioactive waste generation. The predicted radionuclide inventory results are expected to contribute to secure the development of waste disposal facility and to deploy the safety case for its long-term safety assessment.

• Health Policy and Management
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• v.28 no.3
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• pp.226-232
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• 2018

The objectives of this study were to evaluate the current state of governance structure and management of the health system to achieve the goals of the health system in South Korea, and to propose reform plan. This study drew implications from the governance of United Kingdom, Germany, and Netherlands, based on the principle of health system proposed by World Health Organization. The presidency and the health ministry should make macroscopic decision-making. The government has to decentralize the enforcement by municipality to operate public health and national health insurance (NHI), and to distribute the centralized NHI fund by municipality. The front line health centers and community centers should provide integrated health and social services. The government has to establish diversified regulatory bodies to enhance both the patient-centered care and the efficiency and equity of health care, and to provide mechanisms for ensuring autonomy of providers. The governance of the health system should be composed of the centralization of macro decision-making, the decentralization of implementation by municipality, the integration of health and social services on the front line, and the well-balanced regulation and autonomy on both consumers and suppliers.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.24 no.68
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• pp.85-94
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• 2001

Most of customers want to know how to develop the computer system they want to get to use according to the their requirements. This study presents a Computer Integration management System for Quality (CISQ) model for system-integration organizations, which need to demonstrate their capability to consistently provide computer integrated system that meets customer satisfaction and applicable regulatory requirements. The Plan.Do.Check.Act(PDCA) cycle called by Doming wheel expresses the basic concept of continuous improvement action in order to emphasize on achieving business goal. It is useful for providing full competence of a system-integration organization to integrate management systems based on the international management system, and to take an advantage in its market. This study specifies International Certification Network Business Excellence Concept(IBEC) approach to ensure a harmonized integration of the variety of management systems and thereby produce synergy effect. The end part of this study specifies a Assessment Model including an assessment concept adding to the compliance audit according to the CISQ for the continuous improvement. A simple application on Failure Modes and Effects Analysis(FMEA) in testing phase in project life cycle has been done.

• Journal of Soil and Groundwater Environment
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• v.22 no.4
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• pp.33-48
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• 2017

An optimum disposal plan of disused sealed radioactive sources (DSRSs) should be established to ensure long-term disposal safety at the low- and intermediate-level radioactive waste (LILW) disposal facility in Gyeongju. In this study, an optimum disposal system was suggested and preliminary post-closure safety assessment was performed. The DSRSs disposal system was composed of a rock cavern and near surface disposal facilities at the Gyeongju LILW disposal facility. The assessment was conducted using GoldSim program, and probabilistic assessment and sensitivity analysis were implemented to evaluate the uncertainties in the input parameters of natural barriers. Deterministic and probabilistic calculations indicated that the maximum dose was below the regulatory limits ($0.1mSvyr^{-1}$ for the normal scenario, $1mSvyr^{-1}$ for the well scenario). It was concluded that the DSRSs disposal system would maintain environmental safety over a long-time. Moreover, the partition coefficient of Np in host rock, Darcy velocity in host rock, and density of the host rock were the most sensitive parameters in predicting exposure dose in the safety assessment.

• Corrosion Science and Technology
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• v.20 no.4
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• pp.189-195
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• 2021

A technology for designing and licensing a dedicated radiation shielding facility needs to be developed for safe and efficient operation an R&D center. Technology development is important for smooth operation of such facilities. Causes of damage to internal structures (such as baffle former bolt (BFB) of pressurized water reactor) of a nuclear power reactor should be analyzed along with prevention and countermeasures for similar cases of other plants. It is important to develop technologies that can comprehensively analyze various characteristics of internal structures of long term operated reactors. In high-temperature, high-pressure operating environment of nuclear power plants, cases of BFB cracks caused by irradiated assisted stress corrosion cracks (IASCC) have been reported overseas. The integrity of a reactor's internal structure has emerged as an important issue. Identifying the cause of the defect is requested by the Korean regulatory agency. It is also important to secure a foundation for testing technology to demonstrate the operating environment for medium-level irradiated testing materials. The demonstration testing facility can be used for research on material utilization of the plant, which might have highest fluence on the internal structure of a reactor globally.

• Journal of the Society of Naval Architects of Korea
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• v.59 no.6
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• pp.372-384
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• 2022

Total shipping accounts for 2.9 % of the annual average percentage of global anthropogenic GHG emissions. The International Maritime Organization implements EEDI (Energy Efficiency Design Index), Energy Efficiency eXisting-ship Index (EEXI), and Carbon Intensity Indicator (CII) as regulatory frameworks for shipping decarbonization. The Republic of Korea has enforced the Act on Development and Popularization of Greenship from 2020 and publicly announced the 1st national plan which was named 『2030 Greenship-K Promotion Strategy』 for the activation of a greenship market. The Greenship Certification Scheme is going on for the sustainability of Korean shipbuilding and shipping industries, to secure clean maritime environments, as well as to contribute to the national economy. Greenship Certification guarantees the credit of such eco-friendly technologies and products for shipping. The certification is going to be the basis of industrial competitiveness in coastal and international shipping. This study investigates an existing certification process, identifies the limitations, and proposes the process improved with several case studies. The improved certification scheme may have rationality for Net-zero with regard to climate alignment.

• Journal of Information Technology Services
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• v.22 no.1
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• pp.15-27
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• 2023

As the number of users of the Metaverse platform increases and virtual assets in the Metaverse can be converted into reality, various commercial trading activities are occurring within the Metaverse. Considering that users can earn profits through selling digital products and the profits can be converted into fiat money or virtual assets, the commerce activities within Metaverse are similar to existing e-commerce. However, due to the peculiarity of transactions performed in Metaverse platform, the current legal system is insufficient to apply to Metaverse commerce, and many researches have been conducted for this purpose. But, regulatory research on NFT(Non-Fungible Token) digital products that can be applied to all types of physical products is inadequate. Therefore, This study investigated the types of digital products commerce in Metaverse, investigated the issues of commerce transactions related to NFT digital products and the regulations related to them. Based on this, research results can be used as the development direction of NFT digital products trading and consideration of related policy to protect NFT digital products.

• Economic and Environmental Geology
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• v.49 no.4
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• pp.301-314
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• 2016

Disused Sealed Radioactive Sources (DSRSs) are stored temporally in the centralized storage facility of Korea Radioactive Waste Agency (KORAD) and planned to be disposed in the low- and intermediate-level radioactive waste (LILW) disposal facility in Gyeongju city. In this study, preliminary post-closure safety assessment was performed for DSRSs in order to draw up an optimum disposal plan. Two types of disposal options were considered, i.e. engineered vault type disposal and rock cavern type disposal which were planned to be constructed and operated respectively in LILW disposal facility in Gyeongju city. Assessment end-point was individual effective dose of critical group and calculated by using GoldSim code. In normal scenario, the maximum dose was estimated to be approximately $1{\times}10^{-7}mSv/yr$ for both disposal options. It meant that both options had sufficient safety margin when compared with regulatory limit (0.1 mSv/yr). Otherwise, in well scenario, the maximum dose exceeded regulatory limit of 1 mSv/yr in engineered vault type disposal and the exposure dose was mainly contributed by $^{226}Ra$, $^{210}Pb$ (daughter nuclide of $^{226}Ra$) and $^{237}Np$ (daughter nuclide of $^{241}Am$). For rock cavern type disposal, even though the peak dose satisfied regulatory limit, the exposure doses by $^{14}C$ and $^{237}Np$ were relatively high above 10% of regulatory limit. Therefore, it is necessary to exclude $^{14}C$, $^{226}Ra$ and $^{241}Am$ for two type of disposal options and additional management such as long-term storage and development of disposal container for those radionuclides should be performed before permanent disposal for conservative safety and security.

• Journal of the Korean Society of Marine Environment & Safety
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• v.18 no.6
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• pp.617-625
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• 2012

This study examines the current status and policy development of Carbon Dioxide Capture and Storage(CCS), which is a technology to mitigate climate change, in Korea and foreign countries. It also analyzes IEA CCS regulatory framework as a guideline and provides limitations and implications for marine geological storage in the Republic of Korea. Although CCS master plan is established at national level, related laws are not amended and detailed polices are not yet provided. Established 'Intergovernmental CCS committee' lacks its cooperative mechanism and flexibility. Only limited and segmented economic analyses are performed and funding for large scale of CCS project is not secured. In addition, information sharing is limited and public awareness activities are insufficient. Therefore, this paper provides some policy suggestions on establishing a legal framework based on the 'Marine Environmental Management Act', strengthening the role of intergovernmental CCS committee, conducting CCS economic analysis based on various scenarios, providing economic incentives and public participation strategies, and establishing a specialized agency for information sharing.