• 대한가정학회지
• /
• 제26권1호
• /
• pp.151-162
• /
• 1988

This study is mainly concerned with providing a basis for the T.V. ad. regulation toward child consumer. The objective of this study is to investigate the facors related to the level of understanding & trust toward T.V. ad. The samples are composed of 258 child consumers filtered by purposive sampling. The statistics used for data analysis are x-tes, T-test, and one-way ANOVA. The results are as follows: 1) The level of understanding indicates significant difference according to age, discriminent ability between T.V. ad. and T.V. program. 2) The level of understanding about persuasive intent indicates significant difference according to age, parent-child interaction. 3) The level of trust indicates significant difference according to age, parent-child interaction, purchasing experience, sex. 4) Attitude toward advertised product indicates significant difference according to level of understanding about persuasive intent, level of trust.

• Journal of Ginseng Research
• /
• 제40권1호
• /
• pp.9-17
• /
• 2016

Background: Alzheimer's disease (AD) is a progressive brain disease, for which there is no effective drug therapy at present. Ginsenoside Rg1 (G-Rg1) and G-Rg2 have been reported to alleviate memory deterioration. However, the mechanism of their anti-AD effect has not yet been clearly elucidated. Methods: Ultra performance liquid chromatography tandem MS (UPLC/MS)-based metabolomics was used to identify metabolites that are differentially expressed in the brains of AD mice with or without ginsenoside treatment. The cognitive function of mice and pathological changes in the brain were also assessed using the Morris water maze (MWM) and immunohistochemistry, respectively. Results: The impaired cognitive function and increased hippocampal $A{\beta}$ deposition in AD mice were ameliorated by G-Rg1 and G-Rg2. In addition, a total of 11 potential biomarkers that are associated with the metabolism of lysophosphatidylcholines (LPCs), hypoxanthine, and sphingolipids were identified in the brains of AD mice and their levels were partly restored after treatment with G-Rg1 and G-Rg2. G-Rg1 and G-Rg2 treatment influenced the levels of hypoxanthine, dihydrosphingosine, hexadecasphinganine, LPC C 16:0, and LPC C 18:0 in AD mice. Additionally, G-Rg1 treatment also influenced the levels of phytosphingosine, LPC C 13:0, LPC C 15:0, LPC C 18:1, and LPC C 18:3 in AD mice. Conclusion: These results indicate that the improvements in cognitive function and morphological changes produced by G-Rg1 and G-Rg2 treatment are caused by regulation of related brain metabolic pathways. This will extend our understanding of the mechanisms involved in the effects of G-Rg1 and G-Rg2 on AD.

• 한국콘텐츠학회논문지
• /
• 제12권8호
• /
• pp.123-135
• /
• 2012

콘텐츠의 디지털화와 네트워크의 광대역화로 인한 다매체 다채널 환경은 광고시장에도 많은 변화를 초래하고 있다. 콘텐츠 유통 윈도우로서의 플랫폼은 증가하고 있지만 이를 장악하는 미디어는 제작능력과 자본능력을 보유한 소수의 매체라는 점에서 증가하는 플랫폼을 통한 추가 광고의 수익은 대부분 이들 거대 독점 미디어에 쏠려 있는 것이 현실이다. 여기에 미디어렙 법안이 국회 본회의를 통과하면서 일부 미디어에 편중된 광고시장의 쏠림현상이 가속화될 전망이다. 이와 같은 현실에서 다양한 장르와 실험적인 도전으로 새로운 콘텐츠 제작과 유통의 성장이 예견되고 있는 유료방송시장이 직접적인 영향권에 놓일 전망이다. 따라서 본 연구는 유료방송광고시장의 확대를 위한 방법론과 대안을 제시하고자 한다. 연구의 결과, 간접광고와 가상광고, 광고금지 품목에 대한 개선방안이 제시되었고, 기업과 정부 차원에서 광고시장 확대를 위한 방법론이 제시되었다.

• 한국전자파학회논문지
• /
• 제23권8호
• /
• pp.976-984
• /
• 2012

Ad-hoc 네트워크는 음영지역, 재난지역, 전쟁 시와 같은 통신 인프라가 구축되기 어려운 상황에서 유용하게 사용될 수 있다. 그러나 음성 및 데이터 서비스 등과 같은 무선 서비스의 제공을 위해 많은 양의 네트워크 용량이 필요하게 되지만, 기존의 제한된 주파수 자원에 따른 주파수 부족 상황 및 주파수 자원 정책의 규제에 따라 원활한 주파수 사용이 어려운 상황이다. 이에 따라 높은 주파수 활용을 제공하는 인지 무선 시스템을 ad-hoc 네트워크에 적용하여 보다 다양하고 확장된 네트워크 서비스를 제공할 수 있다. 하지만 인지 무선 시스템을 통해 센싱한 1차 사용자의 유휴 대역을 모든 CR 사용자들이 공평하게 사용할 수 없다는 문제점이 있다. 이러한 문제점을 해결하고자 본 논문에서는 CDMA 방식의 다중 orthogonal sequence를 이용하여, 하나의 주파수 대역 내에서도 여러 명의 CR user가 간섭 없이 효율적인 주파수 대역을 활용할 수 있는 기법을 제안하였으며, 이를 통해 인지 무선 시스템에서의 성능 향상을 보여 준다.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
• /
• pp.259.3-260
• /
• 2003

Alzheimer's disease(AD) is the most common cause of senile dementia in elderly people and the causes of AD are currently not fully understood. However, AD is generally understood to be associated with reduced levels of acetylcholine in the brain as cholinergic neurons are lost and cholinergic neurotransmission declines. There are growing evidences that two types of cholinesterase(ChE), i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) both play important roles in the regulation of acetylcholine level in brain and thus may have a crucial role in the development and progression of AD. (omitted)

• Molecules and Cells
• /
• 제42권11호
• /
• pp.739-746
• /
• 2019

Significant knowledge about the pathophysiology of Alzheimer's disease (AD) has been gained in the last century; however, the understanding of its causes of onset remains limited. Late-onset AD is observed in about 95% of patients, and APOE4-encoding apolipoprotein E4 (ApoE4) is strongly associated with these cases. As an apolipoprotein, the function of ApoE in brain cholesterol transport has been extensively studied and widely appreciated. Development of new technologies such as human-induced pluripotent stem cells (hiPSCs) and CRISPR-Cas9 genome editing tools have enabled us to develop human brain model systems in vitro and readily manipulate genomic information. In the context of these advances, recent studies provide strong evidence that abnormal cholesterol metabolism by ApoE4 could be linked to AD-associated pathology. In this review, we discuss novel discoveries in brain cholesterol dysregulation by ApoE4. We further elaborate cell type-specific roles in cholesterol regulation of four major brain cell types, neurons, astrocytes, microglia, and oligodendrocytes, and how its dysregulation can be linked to AD pathology.

• BMB Reports
• /
• 제42권1호
• /
• pp.6-15
• /
• 2009

The most common genetic disorder Down syndrome (DS) displays various developmental defects including mental retardation, learning and memory deficit, the early onset of Alzheimer's disease (AD), congenital heart disease, and craniofacial abnormalities. Those characteristics result from the extra-genes located in the specific region called 'Down syndrome critical region (DSCR)' in human chromosome 21. In this review, we summarized the recent findings of the DYRK1A and RCAN1 genes, which are located on DSCR and thought to be closely associated with the typical features of DS patients, and their implication to the pathogenesis of neural defects in DS. DYRK1A phosphorylates several transcriptional factors, such as CREB and NFAT, endocytic complex proteins, and AD-linked gene products. Meanwhile, RCAN1 is an endogenous inhibitor of calcineurin A, and its unbalanced activity is thought to cause major neuronal and/or non-neuronal malfunction in DS and AD. Interestingly, they both contribute to the learning and memory deficit, altered synaptic plasticity, impaired cell cycle regulation, and AD-like neuropathology in DS. By understanding their biochemical, functional and physiological roles, we hope to get important molecular basis of DS pathology, which would consequently lead to the basis to develop the possible therapeutic tools for the neural defects in DS.

• 한국화재소방학회논문지
• /
• 제24권3호
• /
• pp.45-51
• /
• 2010

본 논문은 공기호흡기 사용실패 유형과 원인을 생산자에 대한 정부규제와 고객에 대한 정부규제의 문제점을 중심으로 분석한다. 전자의 경우 용기 및 공기호흡기의 안전검사 기준의 한계점 분석이고, 후자의 경우 사용자관리자의 유지관리 및 폐기처분 규정의 한계점 분석이다. 개선방안으로는 수거검사와 수집검사를 확대, 폐용기 처리 결과 감시확인 절차의 투명성 강화 등이 있다.

• BMB Reports
• /
• 제56권3호
• /
• pp.190-195
• /
• 2023

We propose a novel blood biomarker detection method that uses miRNA super-resolution imaging to enable the early diagnosis of Alzheimer's disease (AD). Here, we report a single-molecule detection method for visualizing disease-specific miRNA in tissue from an AD mice model, and peripheral blood mononuclear cells (PBMCs) from AD patients. Using optimized Magnified Analysis of Proteome (MAPs), we confirmed that five miRNAs contribute to neurodegenerative disease in the brain hippocampi of 5XFAD and wild-type mice. We also assessed PBMCs isolated from the whole blood of AD patients and a healthy control group, and subsequently analyzed those samples using miRNA super-resolution imaging. We detected more miR-200a-3p expression in the cornu ammonis 1 and dentate gyrus regions of 3 month-old 5XFAD mice than in wild-type mice. Additionally, miRNA super-resolution imaging of blood provides AD diagnosis platform for studying miRNA regulation inside cells at the single molecule level. Our results present a potential liquid biopsy method that could improve the diagnosis of early stage AD and other diseases.

• The Korean Journal of Physiology and Pharmacology
• /
• 제21권3호
• /
• pp.335-343
• /
• 2017

Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study, the therapeutic effect of Lactobacillus plantarum CJLP55 isolated from Kimchi was studied in AD-induced mice. Orally administered Lactobacillus strain, CJLP55, suppressed AD symptoms and high serum IgE levels. CJLP55 administration reduced the thickness of the epidermis, infiltration of mast cells and eosinophils into the skin lesion, enlargement of axillary lymph nodes, and increase in cell population in axillary lymph nodes. CJLP55 treatment decreased the production of type 2 cytokines, such as interleukin (IL)-4, IL-5, IL-10, IL-12, interferon (IFN)-${\gamma}$, and IL-6,which were stimulated by house dust mite extracts, in the axillary lymph node cells. Orally administered CJLP55 exhibited a therapeutic effect on house dust mite-induced AD in NC/Nga mice after onset of the disease by altering immune cell activation. The Lactobacillus strain, CJLP55, isolated from Kimchi, suppressed AD. Our results suggest its possible use as a potential candidate for management of AD.