• Journal of the Korean Geographical Society
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• v.49 no.3
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• pp.405-422
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• 2014

Two important issues in hedonic model are to specify accurate model and delineate submarkets. While the former has experienced much improvement over recent decades, the latter has received relatively little attention. However, the accuracy of estimates from hedonic model will be necessarily reduced when the analysis does not adequately address market segmentation which can capture the spatial scale of price formation process in real estate. Placing emphasis on improvement of performance in hedonic model, this paper tried to segment real estate markets in Gangnam-gu and Jungrang-gu, which correspond to most heterogeneous and homogeneous ones respectively in 25 autonomous districts of Seoul. First, we calculated variable coefficients from mixed geographically weighted regression model (mixed GWR model) as input for clustering, since the coefficient from hedonic model can be interpreted as shadow price of attributes constituting real estate. After that, we developed a spatially constrained data-driven methodology to preserve spatial contiguity by utilizing the SKATER algorithm based on a minimum spanning tree. Finally, the performance of this method was verified by applying a multi-level model. We concluded that submarket does not exist in Jungrang-gu and five submarkets centered on arterial roads would be reasonable in Gangnam-gu. Urban infrastructure such as arterial roads has not been considered an important factor for delineating submarkets until now, but it was found empirically that they play a key role in market segmentation.

• Journal of the Korean Geographical Society
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• v.49 no.3
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• pp.390-404
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• 2014

This study analysed the job-housing balance using the number of employees and workers data, and investigated the relationship between job-housing ratio and commuting trip in the Seoul metropolitan area. Between 2005-2010, in the central business district which functioned as urban center, the number of employees were reduced and population growth slowed. Meanwhile, the suburbanization of employment and population has advanced as the employment and population moved from Seoul to Gyeonggi-do. As the increasement of workers compared to the employees became prominent, the excess workers increased significantly. The size of excess workers acted as a factor which reduced the job-housing ratio. Job-housing imbalance worsened in Gyeonggi-do especially. While in many regions, job-housing imbalance improved in clerical, sales, and professional job sectors, but in some regions, the job-housing imbalance worsened in simple labor job and service job sectors. The number of jobs which job-housing imbalance was eased increased in the employment center. The more the job-housing ratio is high, the lower the degree of self-sufficiency of commuting trip and the proportion of internal commuters. In business centers where the number of employees exceed the number of workers, the job-housing ratio and the proportion of commuting trips coming from other regions showed decreasing trend together. The results bear important implications for regional labour market plans considering the spatial mismatch between jobs and housing.

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.4
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• pp.270-274
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• 2016

The effect of the rib angle-of-attack on heat transfer in the convergent channel with ${\vee}/{\wedge}$-shaped ribs was examined experimentally. Four differently angled ribs (a = $30^{\circ}$, $45^{\circ}$, $60^{\circ}$, and $90^{\circ}$) were placed to only the one sided wall. The ribbed wall was manufactured with a fixed rib height (e) of 10 mm and rib spacing (p)-to-height (e) ratio of 10. The convergent channel had a length of 1,000 mm and a cross-sectional areas of $100mm{\times}100mm$ at inlet and $50mm{\times}100mm$ at exit. The measurement was conducted for the Reynolds numbers ranging from 22,000 to 75,000. The results show that the Nusselt number is generally higher at higher Reynolds number and that an angle-of-attack of $45^{\circ}$ at the ${\wedge}$-shaped rib produces the greatest Nusselt number.

• The Journal of the Korea Contents Association
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• v.14 no.10
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• pp.306-314
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• 2014

It has been known that cruise tourism adds value in the local industry and its impacts on regional economy are tremendous. From this point of view, identifying services provided by a cruise ship port, cruise tourists' satisfaction, and their behavioral intentions are significant issues at cruse destinations. The main purpose of this study was to identify significant service factors at the cruise ship port that have an influence on cruise tourists' satisfaction and loyalty in Jeju Island. To achieve the study purpose, a structured survey questionnaire was developed on the basis of reviewing related literatures. The survey was conducted through personal interviews at the Jeju Cruise Ship Port. In total, 386 useable samples were collected during the period from September 11 to October 29, 2012. According to the factor analysis using 15 attributes related to services at a cruise ship port, three service factors were extracted: (1) infra-services, (2) shore excursion services, and (3) attributes affecting the selection of shore excursions. Regression analyses indicated that two service factors(shore excursion services and attributes affecting the selection of shore excursions) significantly influence cruise tourists' satisfaction and loyalty. Findings in this study may be insightful and useful information to marketers or managers at cruise ship ports.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3785-3792
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• 2015

The CCAAT/enhancer-binding protein-alpha (CEBPA) is a transcriptional factor that plays a crucial role in the control of proliferation and differentiation of myeloid precursors. This gene was recognized as the target of genetic alterations and were associated with clinical complexity among AML. We here analyze the frequency and types of CEBPA mutations and polymorphisms in a de novo AML patients from South India and tried to find out associations of these variations with different clinical parameters and the prognostic significance in AML. Study was carried out in 248 de novo AML patients, cytogenetic analysis was performed from the bone marrow samples and was karyotyped. PCR-SSCP analysis and sequencing was performed for the detection of CEBPA gene variations. All the statistical analysis was performed using SPSS 17 (statistical package for social sciences) software. Pearson Chi-square test, Mann-Whitney U test, Kaplan-Meier survival analysis and log rank tests were performed. CEBPA mutations were detected in 18% and CEBPA polymorphisms were detected in 18.9% of AML cases studied. Most of the mutations occured at the C terminal region. Polymorphisms were detected in both N and C terminal region. with most common being, c.584_589dup ACCCGC and c.690G>T. A significant association was not observed for the mutation and polymorphism with respect to clinical and laboratory parameters. Survival advantage was observed for the mutated cases compared to non mutated cases, especially for the normal karyotype groups. Polymorphisms has no effect on the survival pattern of AML patients. CEBPA mutation and polymorphisms were observed with similar frequency and was identified in all the FAB subtypes as well as in cytogenetic risk groups in our study population, but CEBPA mutations alone confer a prognostic value for NK AML patients.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6311-6318
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• 2012

Background: HER2/neu overexpression due to gene amplification is an important factor in breast cancer, modifying the sensitivity to anti-HER2 monoclonal antibody therapy. The clinical significance of HER2 expression in non small cell lung carcinoma (NSCLC) is currently under evaluation. The tumor suppressor gene PTEN negatively regulates the HER2/PI3K/Akt signalling pathway. The purpose of this study was to evaluate the role of simultaneous alteration in HER2 and PTEN protein expression in relation to biological behaviour of NSCLCs. Materials and Methods: Protein expression was determined by immunohistochemistry in sixty-one (n=61) NSCLC cases along with CISH for HER2 gene analysis and detection of chromosome 17 aneuploidy. Patients were followed-up for a period of 34 to 41 months after surgery. Results: HER2 overexpression (2+/3+score) was detected in 17 (27.9%) patients while loss of PTEN expression was observed in 24 (39.3%) cases, low expression in 29 (47.6%) and overexpression in 8 (13.1%). Simultaneous HER2 overexpression and PTEN low/loss of expression were correlated with metastasis (71.4% vs 36.2% p=0.03). Analysis in the subgroup of 22 patients of pTNM stage III with lymph node status N1 or N2 revealed that there was a relationship between the number of positive regional lymph node groups and simultaneous deregulation of the two genes (p=0.04). Multivariate analysis determined that HER2 overexpression was associated with an increasing risk of developing metastases (OR: 4.3; 95%CI: 1.2-15.9; p: 0.03) while PTEN overexpression was associated with lower risk (OR: 0.1; 95%CI: 0.1, 1.0; p: 0.05). Conclusions: Simultaneous HER2/PTEN deregulation is a significant genetic event that leads to a more aggressive phenotype of NSCLC.

• Korean Journal of Environment and Ecology
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• v.27 no.6
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• pp.757-764
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• 2013

This study was conducted to determine factors causing urban temperature rises in a mixed urban and rural city in Korea. The study site was Miryang City. For this study, temperature changes over a 36 year period from 1974 to 2010, as well as changes made in the urban environment of the city were examined. Changes in the urban environment included data pertaining to both urban development and changing land use, as well as the changing lifestyle patterns of the populace. The study showed that a rise in the average annual temperature and the average annual mean-maximum temperature were statistically significant and the greatest determining factor for the temperature rise was a corresponding decrease in arable land. The study also showed that the decrease in cultivated land was directly and significantly related to an expansion of regional urbanization. There is a direct relationship between the decrease in cultivated land and an increase in the annual-mean-maximum temperature compared with annual-mean temperature. This increase can be explained as arable land works as an "island" of cooler temperatures in the hottest times of the day. A decrease of $1km^2$ of arable land is expected to cause an increase of $0.08^{\circ}C$ of annual-maximum-mean temperature and $0.06^{\circ}C$ of annual-mean temperature.

• Korea journal of population studies
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• v.23 no.2
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• pp.39-77
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• 2000

The paper examines non-agricultural occupations of Korean immigrants in the Russian Far East from 1860s to 1930s. First of all, theoretical perspectives regarding immigrants\` job selection and positions in the labor market such as cultural theory, segmented labor market theory, human capital theory, and ethnic enclave theory were reviewed and then how these theories can be applied to various jobs of Korean immigrants including mining, fishing, small business, service, and miscellaneous jobs was studied. Next. this article points out that those theories cannot explain both supply and demand sides of migration simultaneously, suggesting the need to integrate two sides of migration. In order to fill out this gap in the literature, this paper suggests the integrative approach which combines supply side and demand side of migration. According to this model, several factors in the non-agricultural jabs which were affecting Korean immigration in the Russian Far East. were identified and discussed in relation with existing theoretical perspectives. Finally this paper concludes that, in order to understand Koran migration in the Russian Far East properly, we have to take into consideration simultaneously both supply-sided factors of immigration including farming-oriented characteristics of Koreans, Korean socio-economic problems preceding immigration, and self-dependent tendencies of Korean immigrants and demand-side factor like the Russian migration policy to the immigrants and various regional situations in the Russian Far East.

• Journal of Korea Spatial Information System Society
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• v.9 no.3
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• pp.17-24
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• 2007

The noise problem is one of the major problems associated with large cities and is considered important factor not only in maintenance but also in development of cities. Accordingly, the noise map is being increasingly used in city planning and design. However, the existing two-dimensional noise maps only show regional, planar distribution of noise. This study presented a method to build a data model for analyzing and visualizing noise levels at fine scale considering the vertical distribution of noise in a building. By expanding the 2D topology concept used in conventional GIS to 3D, it suggested a 3D GIS data model that makes 3D spatial queries, analyses and visualization possible and applied the proposed approach to building a 3D noise information system. By building and testing the system, the study showed different functionalities including 3D spatial queries and 3D visualization of noise levels varying temporally or according as the height of sound-proof walls. In each case, the population exposed to noise was quantitatively computed to illustrate the potential in the areas of city planning and design.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.12
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• pp.5081-5086
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• 2016

Background: Pathological factors, based mainly on immunohistochemistry (IHC) and histological differentiation, are mostly used to differentiate breast cancer (BC) subtypes. Our present aim was to describe the characteristics and survival of a relapsing BC patient cohort based on clinico-pathologic subtypes determined for the primary tumors. Methods: We used a clinico- pathological definition of BC subtypes based on histological grade (HG), estrogen receptor (ER), progesterone receptor (PgR),and epidermal growth factor receptor type 2 (HER2) expression assessed by IHC. We determined variables associated with loco-regional recurrence (LRR), second primaries (SP), systemic recurrence (SR) and post-recurrence survival (PRS). Results: Out of 1,702 patients, 240 (14%) had an event defined as recurrence. Those with recurrent disease were significantly younger than those without,and were initially diagnosed at more advanced stages, with larger tumors, greater lymph nodal involvement and higher HG. With a median follow up of 61 months (1-250), 4.6% of patients without recurrence and 56.6% of patients with an event defined as recurrence had died. The median PRS for the LRR group was 77 months; 75 months for those who developed a SP and 22 months for patients with an SR (p <0.0001). In SR cases, the median PRS was shorter for ER- tumors than for ER+ tumors (15 vs. 26 months, respectively; p = 0.0019, HR 0.44; CI: 0.25-0.44). Conclusions: Subtype, defined through classic histopathologic parameters determined for primary tumors, was found to eb related to type of recurrence and also to prognosis after relapse.