Background: Platinum based concurrent chemo-radiation is the de-facto standard of care in the non-surgical management of locally-advanced head and neck cancer of squamous origin. Three-weekly single agent cisplatin at 100 $mg/m^2$ concurrent with radical radiotherapy has demonstrated consistent improvement in loco-regional control and survival. This improvement is however at the cost of considerable hematologic toxicity and poor overall compliance. The routine use of this regime is improbable in developing countries with limited resources. We therefore aimed to determine the safety and efficacy of an alternative regime of weekly cisplatin and concurrent radiotherapy in such patients. Materials and Methods: January-05 and April-12, 188 patients of locally-advanced head and neck cancer of squamous origin were treated with concurrent weekly-cisplatin at $35mg/m^2$ and conventional radiotherapy 60-66Gy/30-33 fractions/5days per week. Results: Overall, 95% patients received planned doses of RT while 74% completed within the stipulated overall treatment time of <50 days. Eighty-two percent received at-least 5 weekly cycles. Grade-III/IV mucositis was seen in 58%/9% respectively, which resulted in mean weight loss of 9.2% from a pre-treatment mean of 54.5 kg. Grade-III hematologic toxicity-0.5%; grade II nephrotoxicity-2.5% and grade III emesis-3% were also seen. Grade-III/IV subcutaneous toxicity-10%/1% and grade-III/IV xerostomia-10%/0% were observed. Complete responses at the primary site, regional nodes and overall disease were seen in 86%, 89% and 83% patients respectively. The median and 5-years disease-free survival were 26 months and 39.4% respectively, while the median and overall survival were 27 months and 41.8% respectively. Conclusions: Weekly-cisplatin at 35 $mg/m^2$ when delivered concurrently with conventional radical RT (at-least 66y/33 fractions) in locally-advanced head and neck cancer is well tolerated with minimal hematologic and neprologic toxicity and can be routinely delivered on an out-patient basis. It is an effective alternative to the standard 3-weekly cisplatin especially in the context of developing countries.
This study has been conducted as a basic research for developing efficient ways of managing Korean National Parks by finding differences via the comparison of present management systems of national parks in Korea and Japan. The survey was conducted through telephone interviews and direct interviews with staffs of related organizations as well as related literature study. In result, it is found that Japanese national parks have a numerical standard of minimum area, with less staff than Korea, and larger designated areas are being managed. Management organizations of both countries are divided as main and commission. In Korea, 6 staff in Natural Resources Division under Ministry of Environment are managing main organization, and in Japan, 53 staff of 3 divisions(National Park Division, Natural Environment Management Division, General Affairs Division) are taking charge of it. Moreover, General Affairs Division, dividing whole country into 11 blocks, manages 11 units of natural preservation offices, 12 branch offices, and 67 units of nature preservation management offices. In case of commission, Foundation of Natural Park Beautification & Management in Japan has a headquarter and 20 branch offices with 54 staff who are only doing site management, while in Korea, the National Parks Management Corporation has a headquarter and 25 offices with 748 staff carrying out main office jobs and site management side by side. From the differences in both countries, we could suggest efficient measures for our national park management as follows: \circled1 introduction of numerical value as criteria for national park designation, \circled2 review of use zone, \circled3 division of the national park management office into site office and regional office, with dividing works and re-posting staff, \circled4 enlargement of park management division in Department of Environment, \circled5 National Park authority becomes a national public servant
We investigated appearance tidal time and line of spats blood cockle, Tegillarca granosa. And we observed appearance individual numbers and shell growth of spats blood cockle, T. granosa on the several tidal lines and time for the highly valued aquaculture business. Most of the blood cockle spats distributed on the $2{\sim}3 $ hours tidal line. The shell growth was high on the $1{\sim}3$ hours tidal line. But we found small amount of spats on the $5{\sim}6$ hours tidal line. The shell length of spats became $4.7{\pm}1.0 mm$ in December, $5.2{\pm}1.2 mm$ in January, $5.4{\pm}0.9 mm$ in May, $8.5{\pm}0.8mm$ in June, $12.6{\pm}1.1 mm$ in July, $16.0{\pm}2.1 mm$ in August, $18.6{\pm}1.4 mm$ in September and $20.3{\pm}1.3 mm$ in October. As well, we could reconfirm of newly appearance blood cockle spats in the next October.
Journal of Korean Society for Geospatial Information Science
/
v.21
no.2
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pp.71-83
/
2013
Recently frequencies and scales in natural disasters have been significantly increased and enlarged and that leads to increase interests on preventing disasters. As natural disasters occur, it is difficult to fulfill the scale of natural disasters using ordinary stocks in a local government. Thus, it is necessary to establish a system that commonly uses protection resources according to regional characteristics in order to rapidly implement labor mobilization and equipment distribution based on the damage of natural disasters. In this study, regional characteristics in Korea provinces are analyzed and 'a way of composing a local government consortium for common disaster responses' is proposed. First, a disaster map that represents the amount of damage for each local government published in the disaster yearbook from 2002 to 2011 is produced using GIS. Then, the whole land is divided into five different sections according to administrative regions and that are divided into 12 clusters again based on the geographical and humanistic characteristics and the analysis of the scale of damage in typhoons and heavy rainfalls. Finally, disaster protection base stations for each region are selected. The data of analyzing disaster damages may be used as a reference material for establishing disaster prevention plans.
This study suggests the invigoration strategies of commercial and business functions for regeneration of old inner city as city center by examining Dangjin County which is a typical example of the local small-and-medium city where old inner city had declined as the city grew. I conducted a conjoint analysis in terms of important introduction functions and city regeneration directions for the invigoration. The results upon this are as follows. First, low-density of commercial and business places and the utilization of historical and cultural resources instead of the high-density mixed-use development should be considered. Second, It is important to promote regional specialized business and facilities rather than to attract new industry(high-tech industry) for activating local economy. Third, specific and practical countermeasures for resettlement of low-incomes and for maintenance of existing business zone should be established. Fourth, in terms of the maintenance and management, regulation on illegal commercial transactions, improvement of public spaces, and securement of user safety should be considered. Fifth, in terms of consolidation of functions, easier accessibility using public transportations, advertising and promotion of the city, and holding a number of events should be contemplated. Sixth, supporting for business activities and for establishing guides for design of old inner city should be needed. Seventh, public institutions should play a role as a bridge between local residences and experts for balanced regional development.
Journal of the Korean Association of Geographic Information Studies
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v.11
no.2
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pp.38-50
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2008
The site-specific seismic responses and corresponding seismic hazards are influenced mainly by the subsurface geologic and geotechnical dynamic characteristics. To estimate reliably the seismic responses in this study, a geotechnical information system (GTIS) within GIS framework was developed by introducing new concepts, which consist of the extended area containing the study area and the additional site visit for acquiring surface geo-knowledge data. The GIS-based GTIS was built for Gyeongju area, which has records of abundant historical seismic hazards reflecting the high potential of future earthquakes. At the study area, Gyeongju, intensive site investigations and pre-existing geotechnical data collections were performed and the site visits were additionally carried out for assessing geotechnical characteristics and shear wave velocity ($V_S$) representing dynamic property. Within the GTIS for Gyeongju area, the spatially distributed geotechnical layers and $V_S$ in the entire study area were reliably predicted from the site investigation data using the geostatistical kriging method. Based on the spatial geotechnical layers and $V_S$ predicted within the GTIS, a seismic zoning map on site period ($T_G$) from which the site-specific seismic responses according to the site effects can be estimated was created across the study area of Gyeongju. The spatial $T_G$ map at Gyeongju indicated seismic vulnerability of two- to five-storied buildings. In this study, the seismic zonation based on $T_G$ within the GIS-based GTIS was presented as regional efficient strategy for seismic hazard prediction and mitigation.
Korean Journal of Agricultural and Forest Meteorology
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v.6
no.2
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pp.85-93
/
2004
In recent years, technology has advanced so much, especially in the developed world, such that its application in development activities may be lagging behind. The lag between technological advances and its application affects agrometeorological science as well. This paper discusses technological advances that may be better used to communicate agrometeorological information. It is important to bear in mind that technological advances are only channels of communication that may be used to speed up the transference of information from the source to the user. The paper begins with a review of the definitions of 'communication' to put the discussion into context. After reviewing several papers, in simple terms, communication can be defined as the sharing of meaning. The paper also looks at operational communications channels and comes to a conclusion that operational communications channels are pretty much universal irrespective of the development level of a country, although some are more easily accessible in some parts of the world than others. The common communications channels include: newspapers, farming papers, radio, television, fax, email, mobile phones (SMS) and Internet web sites. As part of technological advances, mobile phones are becoming increasingly useful all over the world. In order to make better use of this technology, it is important far those that will use this technology to understand how the technology works, not necessarily in detail, but to be able to operate the technology and obtain the data they need. When it comes to constraints, communication of agrometeorological information requires a substantial amount of resources and it is generally expensive especially when sophisticated models must be operated.
Bivalves collected by a dredge in Yeongil Bay of Gyeongsangbuk-Do Province, Korea in May, 2010 and August, 2010 were 2 species including Dostinorbis japonicus and Scapharca broughtonii. The total abundance of bivalves were 1,703 inds. and 140.9 kg. Among them, the abundance of D. japonicus were 1,198 inds. and 76.1 kg. And the abundance of S. broughtonii were 505 inds. and 64.8 kg. The shell length by bivalves species were 25.76-67.88 mm (mean, 58.08 mm) in D. japonicus and 46.82-113.74 mm (mean, 76.86 mm) in S. broughtonii consisting mainly of recruitment group. By regional abundance comparison, the bivalves abundance collected in the outside harbor was 1,332 inds. and 105.4 kg, which was much more than that of the inside harbor indicating 371 inds. and 35.5 kg. In terms of size, the bivalves collected in the outside harbor were 49.49-67.88 mm (mean, 58.47 mm) in D. japonicus and 48.21-113.74 mm (mean, 77.48 mm) in S. broughtonii, which were larger than those of the inside harbor. The yearly biomass of the main commercial target species, S. broughtonii by swept area method (SAM) was estimated up to 242.1 tons. However, considering the regional differences of bivalves between the inside harbor and the outside harbor by abundance and size comparison, it might have been overfished to bivalves in the inside harbor.
The regional distributions and relative frequencies of some gastrointestinal endocrine cells in the 8 portions (fundus, pylorus, duodenum, jejunum, ileum, cecum, colon and rectum) of the gastrointestinal tract of ICR mouse (ICR) with immunohistochemical method using 7 types of specific antisera against somatostatin, serotonin, glucagon, cholecystokinin (CCK)-8, secretin, pancreatic polypeptide (PP) and gastrin. In this study, somatostatin-, serotonin-, glucagon-, CCK-8-, secretin- and gastrin-immunoreactive (IR) cells were identified. Most of these IR cells in the intestinal portion were generally spherical or spindle in shape (open-typed cell) while cells showing round in shape (close-typed cell) were found in the stomach regions occasionally. Their relative frequencies were varied according to each portion of gastrointestinal tract. Somatostatin-IR cells were demonstrated throughout whole gastrointestinal tract except for large intestine. Serotonin-IR cells were detected throughout whole gastrointestinal tract and they were most predominant endocrine cell types in this species of mouse. Glucagon-IR cells were restricted to the fundus and rectum with moderate and a few frequencies, respectively. CCK-8-IR cells were observed in the pylorus, duodenum and ileum with numerous, moderate and rare frequencies, respectively. Secretin-IR cells were restricted to the duodenum and ileum with a few and rare frequencies, respectively. Gastrin-IR cells were restricted to the pylorus with numerous frequency. However, no PP-IR cells were found in this study. In conclusion, some peculiar distributional patterns of gastrointestinal endocrine cells were found in the ICR mouse compared to those of other mammals.
This study attempted to do a research on whether local festivals contributed to local economic vitalization in an empirical aspect focusing on Almedalen's case of Sweden has not been discussed in Korea. For this, by analyzing Gotland's sociocultural and economic aspects into 3 steps and evaluating them, the study tried to derive policy implications for benchmarking Almedalen in Korea in the future. As a result of analyzing the economic effect of Almedalen in Sweden into 3 steps, it was shown that in the analysis of resources in Step 1, Almedalen positively affected tourist allurement based on Gotland's beautiful natural landscape. In the evaluation of operation in Step 2, according to the result of examining an increase in population and stabilization with a valuation index related to the activation of local economy, Gotland was steadily seeing a new inflow of population, due to which it can be confirmed that local income increases as various jobs are being created. Finally, as a result of examining the improvement in local image in Step 3, it was shown that as diverse members from all walks of life participated in Gotland's festival, external communication became flexible and the opportunity of social participation increased, which positively affected local image. Based on the study results, the policy implications for benchmarking Almedalen, Sweden's local festival, are as follows: First, selecting an appropriate place for attracting the participation of various people is needed. Second, local festivals should be places for communication to exchange opinions, not specific institute-oriented unilateral provision of information. Third, while advancing local festivals for nonprofit, the efforts to make positive changes in local image are needed.
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