• Journal of Periodontal and Implant Science
• /
• v.51 no.6
• /
• pp.386-397
• /
• 2021

Purpose: MicroRNAs (miRNAs) are epigenetic post-transcriptional regulators that modulate gene expression and have been identified as biomarkers for several diseases, including cancer. This study aimed to systematically review the relationship between miRNAs and periodontal disease in humans, and to evaluate the potential of miRNAs as diagnostic and prognostic biomarkers of disease. Methods: The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (reference number CRD42020180683). The MEDLINE, Scopus, Cochrane Library, Embase, Web of Science, and SciELO databases were searched for clinical studies conducted in humans investigating periodontal diseases and miRNAs. Expression levels of miRNAs across the different groups were analysed using the collected data. Results: A total of 1,299 references were identified in the initial literature search, and 23 articles were finally included in the review. The study designs were heterogeneous, which prevented a meta-analysis of the data. Most of the studies compared miRNA expression levels between patients with periodontitis and healthy controls. The most widely researched miRNA in periodontal diseases was miR-146a. Most studies reported higher expression levels of miR-146a in patients with periodontitis than in healthy controls. In addition, many studies also focused on identifying target genes of the differentially expressed miRNAs that were significantly related to periodontal inflammation. Conclusions: The results of the studies that we analysed are promising, but diagnostic tests are needed to confirm the use of miRNAs as biomarkers to monitor and aid in the early diagnosis of periodontitis in clinical practice.

• The Journal of Health Technology Assessment
• /
• v.6 no.2
• /
• pp.123-132
• /
• 2018

Objectives: Maternal morbidity and mortality are important healthcare issues. However there have been few studies on cost of illness (COI) from maternal disorders. This study aimed to estimate the COI due to maternal disorders in Korea. Methods: By reviewing previous studies and consulting expert we determined the scope of maternal disorders. We operationally defined maternal disorders as maternal hemorrhage, maternal sepsis, hypertensive disorders of pregnancy, obstructed labor, and abortion for maternal disorders. The reference period of this study is the year 2015. Main source of data were the National Health Insurance Service claims data, cause of death statistics from the Korea National Statistical Office, and the Korea Health Panel study. We classified the total costs into direct and indirect costs. The direct costs cover healthcare costs and non-healthcare costs. The indirect costs consist of productivity losses due to morbidity and premature death. Results: The cost of maternal disorders in 2015 was 229.7 billion won. The direct and indirect costs of maternal disorders were 165.2 billion won and 64.5 billion won respectively. The largest cost item for maternal disorders was healthcare cost (138.3 billion won, 60.2%). By age groups, the COI in 30-39 years old women were the highest (165.1 billion won, 71.9%). Abortion was the disorder with the highest COI among maternal disorders (71.9 billion won, 31.3%). Conclusion: The COI due to maternal disorders in Korea is quite substantial. Economic burden of maternal disorder increased when being compared with the year 2012 data despite the continued low birth rate in Korea. Therefore, it is necessary to continuously monitor the social costs of the maternal disorders in Korea.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.41 no.4
• /
• pp.42-49
• /
• 2018

Pilot Aptitude Research Equipment (PARE) is a simulator developed to measure or research pilot aptitude and train for student pilots. Design of an ergonomic PARE operation console is required to operate the equipment effectively. This study carried out five steps : (S1) operator questionnaire survey, (S2) anthropometric design formula development, (S3) usability evaluation, (S4) improvement design, and (S5) validation considering both Physical User Interface (PUI) and Graphic User Interface (GUI) of PARE operation console. The operator questionnaire surveyed needs for each PUI and GUI part of the console from two PARE actual operators. In terms of PUI, the anthropometric design formula was developed by using design variables, body dimensions, target population characteristics, and reference posture related to the PARE console. In terms of GUI, the usability evaluation was conducted by three usability testing experts with a 7-point scale (1 : very low, 4 : neutral, 7 : very high) on GUI of the PARE operation console by seven usability criteria. The improved PARE operation console was designed to reflect the optimal values of design variables calculated from design formula, the results from usability testing, and the operator's needs. The improvement effect was observed by 20 people who had experience with the PARE operation console. As a result of the validation, monitor visibility and cockpit visibility for the improved PUI design and visibility and efficiency for the improved GUI design were significantly increased by more than 90% respectively. The improved design of the PARE operation console in this study can contribute to enhance operation performance of the PARE.

• Nuclear Engineering and Technology
• /
• v.51 no.4
• /
• pp.1091-1097
• /
• 2019

After the Fukushima accident in 2011, there has been increased public concern about radioactive contamination of water resources through fallout in neighboring countries. However, there is still no available initial response system that can promptly detect radionuclides. The purpose of this research is to develop the most efficient gamma spectrometer to monitor radionuclides in an aquatic environment. We chose a thallium-doped sodium iodide (NaI(Tl)) scintillator readout with a silicon photo multiplier (SiPM) due to its compactness and low operating voltage. Three types of a scintillation detector were tested. One was composed of a scintillator and a photomultiplier tube (PMT) as a reference; another system consisted of a scintillator and an array of SiPMs with a light guide; and the other was a scintillator directly coupled with an array of SiPMs. Among the SiPM-based detectors, the direct coupling system showed the best energy resolution at all energy peaks. It achieved 9.76% energy resolution for a 662 keV gamma ray. Through additional experiments and a simulation, we proved that the light guide degraded energy resolution with increasing statistical uncertainty. The results indicated that the SiPM-based scintillation detector with no light guide is the most efficient design for monitoring radionuclides in an aquatic environment.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2014.10a
• /
• pp.725-728
• /
• 2014

Continue to have an increasingly violent crimes against children every year, and as you know all seriousness is classified as a felony. However, efforts to reduce the underlying crime is low. Therefore, it is necessary to solve this problem, the security system. Is to protect the children and adults that exist that can pose a threat to children to identify and monitor tracking method in this paper. Was based on a Korean standard body size of a person, such as keys, arm length, leg length, head vertical length, head width proposed method. Also, separate the adults and children through the comparison of the reference value, the ratio and the ratio of the number of pixels of the detected object, the proposed method. Processing speed is fast because it detects only a specific object region in the entire image in the handling method in the proposed method the five nine minutes. The advantage is to enable comparison of the specific object, through which there is.

• Membrane and Water Treatment
• /
• v.10 no.1
• /
• pp.1-11
• /
• 2019

The Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report (AR5) predicted that recent extreme hydrological events would affect water quality and aggravate various forms of water pollution. To analyze changes in water quality due to future climate change, input data (precipitation, average temperature, relative humidity, average wind speed and sunlight) were established using the Representative Concentration Pathways (RCP) 8.5 climate change scenario suggested by the AR5 and calculated the future runoff for each target period (Reference:1989-2015; I: 2016-2040; II: 2041-2070; and III: 2071-2099) using the semi-distributed land use-based runoff processes (SLURP) model. Meteorological factors that affect water quality (precipitation, temperature and runoff) were inputted into the multiple linear regression analysis (MLRA) and artificial neural network (ANN) models to analyze water quality data, dissolved oxygen (DO), biological oxygen demand (BOD), chemical oxygen demand (COD), suspended solids (SS), total nitrogen (T-N) and total phosphorus (T-P). Future water quality prediction of the Anseongcheon River basin shows that DO at Gongdo station in the river will drop by 35% in autumn by the end of the $21^{st}$ century and that BOD, COD and SS will increase by 36%, 20% and 42%, respectively. Analysis revealed that the oxygen demand at Dongyeongyo station will decrease by 17% in summer and BOD, COD and SS will increase by 30%, 12% and 17%, respectively. This study suggests that there is a need to continuously monitor the water quality of the Anseongcheon River basin for long-term management. A more reliable prediction of future water quality will be achieved if various social scenarios and climate data are taken into consideration.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.43 no.4
• /
• pp.161-167
• /
• 2020

In the process of cutting large aircraft parts, the tool may be abnormally worn or damaged due to various factors such as mechanical vibration, disturbances such as chips, and physical properties of the workpiece, which may result in deterioration of the surface quality of the workpiece. Because workpieces used for large aircrafts parts are expensive and require strict processing quality, a maintenance plan is required to minimize the deterioration of the workpiece quality that can be caused by unexpected abnormalities of the tool and take maintenance measures at an earlier stage that does not adversely affect the machining. In this paper, we propose a method to indirectly monitor the tool condition that can affect the machining quality of large aircraft parts through real-time monitoring of the current signal applied to the spindle motor during machining by comparing whether the monitored current shows an abnormal pattern during actual machining by using this as a reference pattern. First, 30 types of tools are used for machining large aircraft parts, and three tools with relatively frequent breakages among these tools were selected as monitoring targets by reflecting the opinions of processing experts in the field. Second, when creating the CNC machining program, the M code, which is a CNC auxiliary function, is inserted at the starting and ending positions of the tool to be monitored using the editing tool, so that monitoring start and end times can be notified. Third, the monitoring program was run with the M code signal notified from the CNC controller by using the DAQ (Data Acquisition) device, and the machine learning algorithms for detecting abnormality of the current signal received in real time could be used to determine whether there was an abnormality. Fourth, through the implementation of the prototype system, the feasibility of the method proposed in this paper was shown and verified through an actual example.

• Geomechanics and Engineering
• /
• v.27 no.6
• /
• pp.537-550
• /
• 2021

There are various technical problems need to be solved in the construction process of pre-setting an isolation wall into a double lane in the outburst prone mine. This study presents a methodology that pre-setting an isolation wall into a double lane without a coal pillar. This requires the excavation of two small section roadways to dig a wide section roadway, followed by construction of the separation wall. During this process the connecting lane is reserved. In order to ensure the stability of the separation wall, the required bearing capacity of the isolation wall is 4.66 MN/m and the deformation of the isolation wall is approximately 25 cm. To reduce the difficulty of implementing support the roadway is driven by 5 m/d. After the construction of the separation wall, the left side coal wall is brushed 1.5 m to make the width of the gas roadway reach 2.5 m and the roadway support utilizes anchor rod, ladder beam, anchor cable beam and net configuration. During construction, the concrete pump and removable self-propelled hydraulic wall mold are used to pump and pour the concrete of the isolation wall. In the process of mining, the stress distribution of coal body and isolation wall is detected and measured on site. The results demonstrate that the deformation of the surrounding rock of roadway and separation of roof in the roadway is small. The stress of the bolt and anchor cable is within equipment tolerance validating their selection. The roadway is well supported and the intended goal is achieved. The methodology can be used for reference for similar mine gas control.

• Journal of Korean Society for Quality Management
• /
• v.50 no.3
• /
• pp.617-634
• /
• 2022

Purpose: This paper introduces Pohang University of Science Technology (POSTECH) advanced metering infrastructure (AMI) and Open Innovation Big Data Center (OIBC) platform and analysis results of electricity consumption data collected via the AMI in POSTECH campus. Methods: We installed 248 sensors in seven buildings at POSTECH for the AMI and collected electricity consumption data from the buildings. To identify the amounts and trends of electricity consumption of the seven buildings, electricity consumption data collected from March to June 2019 were analyzed. In addition, this study compared the differences between the amounts and trends of electricity consumption of the seven buildings before and after the COVID-19 outbreak by using electricity consumption data collected from March to June 2019 and 2020. Results: Users can monitor, visualize, and download electricity consumption data collected via the AMI on the OIBC platform. The analysis results show that the seven buildings consume different amounts of electricity and have different consumption trends. In addition, the amounts of most buildings were significantly reduced after the COVID-19 outbreak. Conclusion: POSTECH AMI and OIBC platform can be a good reference for other universities that prepare their own microgrid. The analysis results provides a proof that POSTECH needs to establish customized strategies on reducing electricity for each building. Such results would be useful for energy-efficient operation and preparation of unusual energy consumptions due to unexpected situations like the COVID-19 pandemic.

• Animal Bioscience
• /
• v.36 no.3
• /
• pp.417-428
• /
• 2023

Objective: Few studies have genetically monitored chickens over time, and no research has been conducted on ducks. To ensure the sustainable management of key duck breeds, we used microsatellite markers to monitor Brown Tsaiya ducks over time genetically. Methods: The second, fourth, sixth to eighth generations of the Brown Tsaiya duck selected for feeding efficiency and control lines were included in this study to investigate the genetic variations, effective population size, population structure and the differentiation between populations over time with 11 microsatellite markers derived from Brown Tsaiya duck. Results: The results showed there were a slight decrease in the genetic variations and an increase in within-population inbreeding coefficient (F_IS) in both lines, but no consistent increase in F_IS was observed in each line. The effective population size in the second and eighth generations was 27.2 for the selected line and 23.9 for the control line. The change in allele richness showed a downward trend over time, and the selected line was slightly lower than the control line in each generation. The number of private alleles (N_p) in the selected line were higher than in the control line. Moderate differentiation was observed between the second and eighth generations in the selected line (F_ST = 0.0510) and the control line (F_ST = 0.0606). Overall, differentiation tended to increase with each generation, but genetic variation and structure did not change considerably after six generations in the two lines. Conclusion: This study provides a reference for poultry conservation and helps to implement cross-generation genetic monitoring and breeding plans in other duck breeds or lines to promote sustainable management.