• Clinical and Experimental Pediatrics
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• v.52 no.6
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• pp.725-729
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• 2009

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) with central nervous system (CNS) involvement is usually fatal unless stem cell transplant (SCT) is offered. However, SCT with conventional intensity conditioning is associated with high transplant-related mortality. We describe our experience with unrelated SCTs after reduced-intensity conditioning (RIC) for patients with EBV-HLH with progressive CNS disease. This approach was associated with minimal toxicities and might be an effective option in patients with EBV-HLH with progressive CNS disease. Moreover, the addition of rituximab to RIC appears to be safe and effective in suppressing EBV in the patients with EBV-HLH.

• Korean Journal of Clinical Pharmacy
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• v.22 no.2
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• pp.123-130
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• 2012

거대세포바이러스(Cytomegalovirus; CMV) 감염은 동종조혈모세포이식 환자의 주요 사망원인 중 하나이다. 용량감소전처치(Reduced-intensity conditioning; RIC)를 이용한 조혈모세포이식은 골수억제전처치(Myeloablative conditioning; MAC)에 비해 골수억제 및 면역억제가 적으므로 CMV 감염 발생율을 감소시킬 것이라 예상되었으나 예방적 면역억제요법, T세포 제거 약제의 사용 등으로 서로 상이한 결과가 보고되고 있다. 2007년 1월부터 2009년 12월까지 총 141명의 환자(MAC 113명, RIC 28명)가 동종조혈모세포이식을 받았으며, CMV 감염은 MAC 62.8%, RIC 57.1% (p = 0.310), CMV 질환은 각각 12.4%, 14.3% (p = 0.785)에서 발생하였다. CMV 감염/질환 발생빈도와 CMV 항원 혈증검사 지속기간, 초기/최고치, 생존율은 두 군간 유의한 차이가 없었다. CMV 감염 위험인자에 대한 다변량분석 결과, 환자가 고령일수록(HR 1.024, 95% CI 1.002-1.045; p = 0.031) 또는 grade 2 이상의 급성 이식편대숙주병이 발생한 경우에(HR 1.849, 95% CI 1.031-3.315; p=0.039) CMV 감염 발생 위험율이 유의하게 높았다. 결론적으로, 전처치요법 강도에 따른 CMV 감염의 발생빈도와 발현양상의 차이는 없었으나, 고령이거나 grade 2 이상의 급성 이식편대숙주병이 발생한 환자의 경우 CMV 감염 발생과 유의한 연관성을 보였다. 이상과 같은 결과에 비춰 봐서 CMV 질환이 대부분 이식 100일 이후에 발생한 점을 고려할 때, 이식 후 CMV 감염 발생 시 ganciclovir 선제요법과 함께 이들 환자들에게 지속적인 모니터링을 실시하는 것이 필요할 것으로 사료된다.

• International Journal of Air-Conditioning and Refrigeration
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• v.14 no.2
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• pp.76-83
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• 2006

An efficiency of a refrigeration cycle and a reliability of a compressor can be reduced if a refrigerant including excessive lubricating oil is exhausted from the compressor. Thus, the analysis of the oil behavior inside the compressor is required to prevent the problem. A tested rotary compressor with visualization windows has been manufactured. in this study to investigate the oil behavior using developed visualization techniques. The oil behaviors at various operating conditions have been quantified to obtain the relationship with the outlet pressure inside the compressor. Also, the effect of the operating conditions on the quantity of the exhausted oil from the rotary compressor has been investigated using a manufactured test model.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.21 no.9
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• pp.787-797
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• 2011

The noise in a vehicle is an important factor for customers purchasing a car. Particularly, reduction of the noise that is generated from HVAC(heating, ventilation and air conditioning) is very important since it has considerable effects on interior noise. In general, identification of noise source is crucial to reduce noise level. The complex acoustic intensity method is widely used to obtain the accurate measurement and identification of noise source. Therefore, in the previous study, noise source of HVAC was identified through experimental approach using the complex acoustic intensity method. In this study, we are intended to confirm reduced level of noise by comparing the result between before and after modification of cam curve that is based on identified noise source of HVAC. It is found out that noise source of HVAC are motor and cam area using the complex acoustic intensity method in the previous study. We performed experiments to compare noise level between before and after modification of cam curve. Especially, it can be seen that complex acoustic intensity method using both active and reactive intensity is vital in devising a strategy for comparison to noise level. Also, the vector flow of acoustic intensity was investigated to identify sound intensity distributions and energy flow in the near field of HVAC.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.17 no.8
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• pp.772-779
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• 2005

An efficiency of a refrigeration cycle and a reliability of a compressor can be reduced if a refrigerant including excessive lubricating oil is exhausted from the compressor. Thus, the analysis of the oil behavior inside the compressor is required to prevent the problem. A tested rotary compressor with visualization windows has been manufactured in this study to investigate the oil behavior using developed visualization techniques. The oil behaviors at various operating conditions have been quantified to obtain the relationship with the outlet pressure inside the compressor. Also, the effect of the operating conditions on the quantity of the exhausted oil from the rotary compressor has been investigated using a manufactured test model.

• Clinical and Experimental Pediatrics
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• v.50 no.7
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• pp.613-621
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• 2007

Hematopoietic stem cell transplantation (HSCT) has expanded and evolved substantially in the last decades to treat various malignant and nonmalignant diseases. However, the conditioning regimen can lead to transplantation related death by major organ dysfunction, severe infection and bleeding. In the allogeneic setting, graft versus host disease may also develop, making post-transplant management complex. To overcome these problems, new stem cell sources, stem cell mobilizing agents and new skills, nonmyeloablative stem cell transplantation including reduced intensity stem cell transplantation has been introduced in clinical practice, but problems remained so far. Recipients of stem cell transplant may be severely immunocompromised for many months after transplantation. Furthermore, long-term complications (endocrine, metabolic, relapse, second malignancies, etc) can develop. Pediatrician is open called on to participate in the evaluation and consideration of patients for possible transplant and long-term follow-up of HSCT patients. This review is intended as a basic overview of HSCT relevant to general pediatrician.

• Proceedings of the SAREK Conference
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• 2005.11a
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• pp.570-575
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• 2005

An efficiency of a refrigeration cycle and a reliability of a compressor can be reduced if a refrigerant including excessive lubricating oil is exhausted from a rotary compressor. Thus, the oil behavior inside the compressor should be analyzed to improve the efficiency. A tested rotary compressor has been manufactured with visualization windows at upper parts in this study to investigate the oil behavior using developed visualization techniques. Discharge pipe with level gage has been visualized to investigate discharged oil amount. The oil behaviors inside the compressor and discharging pipe at various operating conditions have been analyzed. The results of the visualization for the discharging pipe have been compared with those of the upper part to confirm the accuracy.

• Proceedings of the SAREK Conference
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• 2006.06a
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• pp.1043-1048
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• 2006

This paper aimed to verify and develop lighting design data for offices in Korea. It focused on a Korean standard office value relative to lighting density and the evaluation of lighting energy and cooling load. When planning indoor lighting design, we generally utilize the lighting density value which is set $14W/m^2$ by the ASHRAE/IES standard office value. However, the value is not appropriate to apply in Korea where higher efficiency lamps are more popular than others. For calculation of a proper lighting density of Korea, we analysed distribution curves of luminous intensity(2-lamp fluorescent lighting fixture with Parabolic) and derived the new lighting density $12.64W/m^2$ as Korea standard office value. In the simulation using this value, it was shown that lighting energy and cooling load could be reduced.

• Investigative Magnetic Resonance Imaging
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• v.19 no.2
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• pp.76-87
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• 2015

Purpose: There is an ongoing search for a stent material that produces a reduced susceptibility artifact. This study evaluated the effect of manganese (Mn) content on the MRI susceptibility artifact of ferrous-manganese (Fe-Mn) alloys, and investigated the correlation between MRI findings and measurements of Fe-Mn microstructure on X-ray diffraction (XRD). Materials and Methods: Fe-Mn binary alloys were prepared with Mn contents varying from 10% to 35% by weight (i.e., 10%, 15%, 20%, 25%, 30%, and 35%; designated as Fe-10Mn, Fe-15Mn, Fe-20Mn, Fe-25Mn, Fe-30Mn, and Fe-35Mn, respectively), and their microstructure was evaluated using XRD. Three-dimensional spoiled gradient echo sequences of cylindrical specimens were obtained in parallel and perpendicular to the static magnetic field (B0). In addition, T1-weighted spin echo, T2-weighted fast spin echo, and $T2^*$weighted gradient echo images were obtained. The size of the low-intensity area on MRI was measured for each of the Fe-Mn binary alloys prepared. Results: Three phases of ${\alpha}^{\prime}$-martensite, ${\gamma}$-austenite, and ${\varepsilon}$-martensite were seen on XRD, and their composition changed from ${\alpha}^{\prime}$-martensite to ${\gamma}$-austenite and/or ${\varepsilon}$-martensite, with increasing Mn content. The Fe-10Mn and Fe-15Mn specimens comprised ${\alpha}^{\prime}$-martensite, the Fe-20Mn and Fe-25Mn specimens comprised ${\gamma}+{\varepsilon}$ phases, and the Fe-30Mn and Fe-35Mn specimens exhibited a single ${\gamma}$ phase. The size of the low-intensity areas of Fe-Mn on MRI decreased relative to its microstructure on XRD with increasing Mn content. Conclusion: Based on these findings, proper conditioning of the Mn content in Fe-Mn alloys will improve its visibility on MR angiography, and a Mn content of more than 25% is recommended to reduce the magnetic susceptibility artifacts on MRI. A reduced artifact of Fe-Mn alloys on MRI is closely related to the paramagnetic constitution of ${\gamma}$-austenite and/or ${\varepsilon}$-martensite.

• Clinical and Experimental Pediatrics
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• v.55 no.7
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• pp.219-223
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• 2012

Since the first umbilical cord blood transplantation (CBT) in 1998, cord blood (CB) has now become one of the most commonly used sources of hematopoietic stem cells for transplantation. CBT has advantages of easy procurement, no risk to donor, low risk of transmitting infections, immediate availability and immune tolerance allowing successful transplantation despite human leukocyte antigen disparity. Several studies have shown that the number of cells transplanted is the most important factor for engraftment in CBT, and it limits the wide use of CB in adult patients. New strategies for facilitating engraftment and reducing transplantation-related mortality are ongoing in the field of CBT and include the use of a reduced-intensity conditioning regimen, double-unit CBT, ex vivo expansion of CB, and co-transplantation of CB and mesenchymal stem cells. Recently, the results of two international studies with large sample sizes showed that CB is an acceptable alternative source of hematopoietic stem cells for adult recipients who lack human leukocyte antigen-matched adult donors. Along with the intensive researches, development in banking process of CB will amplify the use of CB and offer the chance for cure in more patients.