Browse > Article
http://dx.doi.org/10.3345/kjp.2009.52.6.725

Unrelated stem cell transplantation after reduced-intensity conditioning plus rituximab for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with CNS involvement  

Baek, Hee Jo (Department of Pediatrics, Chonnam National University Hwasun Hospital)
Kook, Hoon (Department of Pediatrics, Chonnam National University Hwasun Hospital)
Han, Dong Kyun (Department of Pediatrics, Chonnam National University Hwasun Hospital)
Lee, Min-Cheol (Department of Pathology, Chonnam National University Hwasun Hospital)
Jeong, Tae Woong (Department of Radiology, Chonnam National University Hwasun Hospital)
Hwang, Tai Ju (Department of Pediatrics, Chonnam National University Hwasun Hospital)
Publication Information
Clinical and Experimental Pediatrics / v.52, no.6, 2009 , pp. 725-729 More about this Journal
Abstract
Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) with central nervous system (CNS) involvement is usually fatal unless stem cell transplant (SCT) is offered. However, SCT with conventional intensity conditioning is associated with high transplant-related mortality. We describe our experience with unrelated SCTs after reduced-intensity conditioning (RIC) for patients with EBV-HLH with progressive CNS disease. This approach was associated with minimal toxicities and might be an effective option in patients with EBV-HLH with progressive CNS disease. Moreover, the addition of rituximab to RIC appears to be safe and effective in suppressing EBV in the patients with EBV-HLH.
Keywords
Unrelated stem cell transplantation; Reduced-intensity conditioning; Rituximab; Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis; CNS involvement;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Imashuku S, Kuriyama K, Teramura T, Ishii E, Kinugawa N, Kato M, et al. Requirement for etoposide in the treatment of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. J Clin Oncol 2001;19:2665-73   ScienceOn
2 Cooper N, Rao K, Gilmour K, Hadad L, Adams S, Cale C, et al. Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis. Blood 2006; 107:1233-6   PUBMED   ScienceOn
3 Haddad E, Sulis ML, Jabado N, Blanche S, Fischer A, Tardieu M. Frequency and severity of central nervous system lesions in hemophagocytic lymphohistiocytosis. Blood 1997; 89:794-800   PUBMED   ScienceOn
4 Thompson PA, Allen CE, Horton T, Jones JY, Vinks AA, McClain KL, et al. Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2009;52:621-25   DOI   ScienceOn
5 Cooper N, Rao K, Goulden N, Webb D, Amrolia P, Veys P. The use of reduced-intensity stem cell transplantation in haemophagocytic lymphohistiocytosis and Langerhans cell histiocytosis. Bone Marrow Transplant 2008;42:S47-S50   DOI   ScienceOn
6 Lim WH, Russ GR, Coates PT. Review of Epstein-Barr virus and post-transplant lymphoproliferative disorder post- solid organ transplantation. Nephrology 2006;11:355-66   DOI   ScienceOn
7 Balamuth NJ, Nichols KE, Paessler M, Teachey DT. Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. J Pediatr Hematol Oncol 2007;29:569-73   DOI   ScienceOn
8 Cesaro S, Locatelli F, Lanino E, Porta F, Di Maio L, Messina C, et al. Hematopoietic stem cell transplantation for hemophagocytic lymphohistiocytosis: a retrospective analysis of data from the Italian Association of Pediatric Hematology Oncology (AIEOP). Haematologica 2008;93:1694-701   DOI   ScienceOn
9 Baker KS, Filipovich AH, Gross TG, Grossman WJ, Hale GA, Hayashi RJ, et al. Unrelated donor hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis. Bone Marrow Transplant 2008;42:175-80   DOI   ScienceOn
10 Ouachee-Chardin M, Elie C, de Saint Basile G, Le Deist F, Mahlaoui N, Picard C, et al. Hematopoietic stem cell transplantation in hemophagocytic lymphohistiocytosis: a single- center report of 48 patients. Pediatrics 2006;117:743-50   DOI   ScienceOn
11 Chung TW. CNS involvement in hemophagocytic lymphohistiocytosis: CT and MR findings. Korean J Radiol 2007;8:78- 81   DOI   ScienceOn
12 Horne A, Janka G, Maarten Egeler R, Gadner H, Imashuku S, Ladisch S, et al. Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis. Br J Haematol 2005;129:622-30   DOI   ScienceOn
13 Horne A, Trottestam H, Aricò M, Egeler RM, Filipovich AH, Gadner H, et al. Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosis. Br J Haematol 2008;140:327-35   DOI   ScienceOn
14 Jordan MB, Filipovich AH. Hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis: a journey of a thousand miles begins with a single (big) step. Bone Marrow Transplant 2008;42:433-7   DOI   ScienceOn