• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2015년도 춘계 종합학술대회 논문집
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• pp.125-126
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• 2015

According to the provisions of the United Nations, the proportion was 65 years of age or older population is 7% more than in the total population aged society. Due to the rapid decrease fertility and medical technologies and the improvement of living standards, the average life expectancy has emerged as an aging society. In the case of our country, and in 2011 the proportion of the population aged 65 and over 11.4%, the future is even faster aging rate is expected to launch in 2026, the super aged society. The days went by relying on caring for personal piety. Nursing crime is often due to the patriarchal family culture and afford. To care for patients with severe human or plant in the home, not to assume that society. Expanding the scope of long-term care insurance service person and the family burden reduced through measures to apply for health insurance, nursing care can prevent crime.

• Archives of Pharmacal Research
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• 제23권5호
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• pp.513-517
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• 2000

Enterohepatic recycling of estrogen after oral administration of 1 mg non-radioactive estriol was studied in fourteen women selected as the control subjects and ten infertile women in whom the infertility was appearing to be of endocrine origin. The extent of enterohepatic recycling of estriol ($E_3$) during the early follicular phase of menstrual cycle was assessed by monitoring during 48 h the urinary excretion of its two major metabolites i.e; estriol 16 $\alpha$-glucuronide ($E_3-16$$\alpha-G$) and estriol-3 glucuronide ($E_3$-3-G). The change in urinary level of $E_3$-3-G with respect to ($E_3-16$$\alpha-G$G was considered to reflect the extent of enterohepatic recycling of estriol. Lower values of urinary output of both metabolites in the infertile women as compared with the control subjects and the urinary excretion profile of both metabolites during 48 h after estriol ingestion reveal that the reduced extent of enterohepatic recycling could possibly be one of the factors which contribute towards the incidence of infertility in women.

• 한국임상수의학회지
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• 제24권2호
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• pp.292-294
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• 2007

말에서 자궁내막생검기술은 저하된 번식력과 관련된 자궁내막의 변화상을 관찰하고 자궁치료의 효과를 체크하는데 있어 중요한 산과적 기술이라 할 수 있다. 13세령의 더러브레드종의 암말은 오랜 동안 임신에 실패하였으며 이로 인해 차후의 임신가능성 진단을 위하여 자궁내막생검 의뢰를 받았다. 조직 생검을 통해서 이 말이 앞으로 성공적인 임신과 출산을 할 확률은 10-50%로 진단되었다.

• 한국인구학
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• 제11권1호
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• pp.32-49
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• 1988

The social conditions in Koreas until 1950s were similar to the model phenomena of low level eqilibrium trap which was named by Prof. Nelson, with the continuation of high population growth rate and low economic growth rate. To escape from the trap, Korean government adopted two different policies, one is economic development plans and the other is family planning programs. Theses policies were successful in both increasing the national products and decreasing the population growth rate. In 1985 per capita GNP increased to over two thousand dollars, fertility rate reduced to replacement level(2.1) and unemployment rate was stabilized at 4 percent level. From various prospects, we were successfully escaped from the Malthusian trap and many economists, who studied developed countries, belive that population growth has positive effects on technological progress, economies of scale, specialization, individual attitude on work, and economic growth. Therefore we need to reexamine the anti-natalistic population policy of Korea in this situation.

• 한국동물생명공학회지
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• 제37권3호
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• pp.209-212
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• 2022

Benign prostatic hyperplasia (BPH) is frequently observed in intact middle-aged or older male dogs with symptoms ranging from asymptomatic to various symptoms such as urination, dyschezia, dysuria, tenesmus, and intermittent serosanguinous or clear serous exudate. A 4-year-old, intact male Welsh corgi with symptoms of intermittent hematuria and serosanguinous exudate at the urethral opening was diagnosed with BPH and intraprostatic hematocyst through ultrasonographic examination and cytology test. The dog was internationally adopted for reproductive purposes and needed to undergo BPH treatment while maintaining fertility. Thus, 2.5 mg finasteride was administered orally once a day for treatment option and therapeutic effects were observed, including loss of clinical symptoms and reduced prostate and intraparenchymal cyst size.

• 한국토양비료학회지
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• 제19권1호
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• pp.63-69
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• 1986

1. 각(各) 비종(肥種)의 시비수준별(施肥水準別) 잎중 양분함량(養分含量)은 질소(窒素)의 경우 증비(增肥)할수록 비옥지(肥沃地), 척박지(瘠薄地)에서 모두 증가(增加)하였으며, 인산(燐酸)은 증비(增肥)에 관계없이 비옥도간(肥沃度間), 시비수준간(施肥水準間)에 함량차이(含量差異)가 없었고, 가리(加里)의 경우에는 비옥지(肥沃地)가 척박지(瘠薄地)보다 동일시비수준(同一施肥水準)에서 칼륨함량(含量)이 다소 높았으나 척박지(瘠薄地)는 변화폭(變化幅)이 작았다. 2. 질소질비료(窒素質肥料)의 증비(增肥)는 특히 비옥(肥沃)한 경작지(耕作地)일수록 수확엽(收護葉)의 성숙(成熟)을 지연(遲延)시켰으며, 생육후기(生育後期)의 지나친 질소흡수(窒素吸收)는 니코틴함량(含量)을 증가(增加)시킴과 동시에 환원당함량(還元糖含量)을 저하(低下)시킴으로써 품질지수(品質指數)(환원당(還元糖)/니코틴비(比); Coulson계수(係數))도 낮아졌다. 3. 토양(土壤)의 비옥도(肥沃度)와 관계없이 잎담배중 질소함량(窒素含量)이 높아짐에 따라 니코틴함량(含量)도 비례(比例)하여 증가(增加)되었으나 니코틴함량(含量)의 점증(漸增)에 따라 환원당함량(還元糖含量)은 점감(漸減)하는 부(負)의 관계가 인정(認定)되었으며, 잎담배중 니코틴함량(含量)이나 환원당함량(還元糖含量)은 척박지(瘠薄地)에서보다 비옥지(肥沃地)에서 전반적으로 더 높았다. 4. 니코틴함량(含量)과 잎담배등급감정가격(等級鑑定價格)과는 부(負)의 상관(相關), 환원당함량(還元糖含量)과는 고도(高度)의 정상관(正相關)을 보임으로써 잎담배등급감정가격(等級鑑定價格)을 근거(根據)로 한 품질지수(品質指數)는 화학성분(化學成分)에 의한 품질측정치(品質測定値)와 매우 밀접한 관련이 있는것으로 인정(認定)되었다.

• Clinical and Experimental Reproductive Medicine
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• 제45권3호
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• pp.135-142
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• 2018

Objective: To prospectively evaluate the efficacy and safety of a fixed early gonadotropin-releasing hormone (GnRH) antagonist protocol compared to a conventional midfollicular GnRH antagonist protocol and a long GnRH agonist protocol for in vitro fertilization (IVF) in patients with polycystic ovary syndrome (PCOS). Methods: Randomized patients in all three groups (early antagonist, n = 14; conventional antagonist, n = 11; long agonist, n = 11) received 21 days of oral contraceptive pill treatment prior to stimulation. The GnRH antagonist was initiated on the 1st day of stimulation in the early antagonist group and on the 6th day in the conventional antagonist group. The GnRH agonist was initiated on the 18th day of the preceding cycle. The primary endpoint was the number of oocytes retrieved, and the secondary endpoints included the rate of moderate-to-severe ovarian hyperstimulation syndrome (OHSS) and the clinical pregnancy rate. Results: The median total number of oocytes was similar among the three groups (early, 16; conventional, 12; agonist, 19; p= 0.111). The early GnRH antagonist protocol showed statistically non-significant associations with a higher clinical pregnancy rate (early, 50.0%; conventional, 11.1%; agonist, 22.2%; p= 0.180) and lower incidence of moderate-to-severe OHSS (early, 7.7%; conventional, 18.2%; agonist, 27.3%; p= 0.463), especially among subjects at high risk for OHSS (early, 12.5%; conventional, 40.0%; agonist, 50.0%; p= 0.324). Conclusion: In PCOS patients undergoing IVF, early administration of a GnRH antagonist may possibly lead to benefits due to a reduced incidence of moderate-to-severe OHSS in high-risk subjects with a better clinical pregnancy rate per embryo transfer. Further studies with more subjects are required.

• Asian-Australasian Journal of Animal Sciences
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• 제27권10호
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• pp.1417-1425
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• 2014

The selection of morphologically normal spermatozoa is critical to obtain high breeding performances in boar breeding farms and artificial insemination (AI) centers. Parameters for the selection of semen mainly include total sperm motility, concentration, and morphology. However, these primary parameters are often not reliable for discriminating between normal and abnormal, non-fertilizable spermatozoa. The present study was designed to compare the motion characteristics, fertilization ability using in vitro fertilization (IVF), and acrosome formation of the semen from boars having low (boar number 2012) and normal (boar number 2004 and 2023) breeding performances. The ultimate goal was to identify additional simple and easy criteria for the selection of normal sperm. There was no significant difference between boar 2004 and boar 2023 sperm total motility in computer assisted sperm analysis. However, boar number 2012 semen presented a significantly reduced population of rapid moving spermatozoa and an increased population of slow moving spermatozoa compared to boar numbers 2004 and 2023. Analysis of detailed motion characteristics revealed that sperm from boar number 2012 had significantly reduced motility in progressiveness, average path velocity, straight-line velocity (VSL), curvilinear velocity (VCL), straightness, and linearity. The assessment of the fertilizing ability by IVF also showed that sperm from boar number 2012 showed a fertility rate of 3.4%, whereas sperm from boar number 2023 had a fertility rate of 75.45%. Interestingly, most of the sperm nuclei were found on the peripheral area of the oocytes, suggesting that the sperm from boar number 2012 lacked penetration ability into the oocyte zonapellucida. The acrosome formation analysis using Pisum sativum agglutinin staining demonstrated that the sperm from boar number 2012 had a defect in acrosome formation. Consequently, primary parameters for selecting semen before AI such as motility are not sufficient to select normal and fertilizable spermatozoa. In conclusion, the present study suggests that the acrosome staining and detailed motion characteristics such as progressiveness, VCL, and VSL should be included in determining semen quality together with primary parameters for successful AI and high breeding performance in the swine industry.

• 한국작물학회지
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• 제33권2호
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• pp.138-145
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• 1988

수도에 있어서 일대잡종 품종의 육종적 이용을 전제로 잡종종자생산을 극대화하기 위한 적합한 양친의 배치법을 구명하고자 웅성불임친으로 V20A/Iri 342$^{*8}$ 과, Iri342를 화분친으로 하여 출수기 풍향에 따라 2처리(남↔북, 동↔남), 재식밀도 4 처리(10$\times$15, 15$\times$15, 20$\times$15, 25$\times$15cm), 화분친의 재식열수 4처리(1, 2, 3, 4열) 및 CMS의 재식열수 4처리(1, 2, 3, 4열)를 두고 자연교잡 증대를 위한 인위적 처리를 가하지 않은 상태에서 각 처리별 증식용 종자 생산량을 검토하였다. 그 결과는 다음과 같다. 1 출수기의 풍향과 수직으로 재식한 구가 다른구에 비하여 재식밀도 및 재식열수에 관계없이 종자 생산량이 많았으며 평균 46.9% 증가하였다. 2. 10$\times$15cm까지는 재식밀도가 높을수록 증수되었다. 최고 수량은 81.2kg/ha에 불과하였다. 그러나 수량의 변이가 구내의 개체간에서도, 동일 처리내의 반복구간에서도 비교적 컸다. 3. 환분친의 연속 재식열수가 많을수록 임실율은 높았으나 10a당 절대 수량은 화분친 1열 재식에서 가장 많았다. 4 CMS의 연속 재식열수가 적을수록 임실율은 높았으나 10a당 절대 수량은 CMS 4열 재식에서 가장 많았다. 5. 따라서 종자 생산량과 화분친의 수량 및 농작업과 관련하여 20$\times$15cm나 25$\times$15cm의 재식밀도로 하여 화분친 1열에 CMS 4열을 출수기 풍향과 수직이 되도록 재식하는 것이 가장 효율적인 것으로 생각한다.

• Molecules and Cells
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• 제26권6호
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• pp.558-565
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• 2008

Although the fertilizing ability of spermatozoa is greatly reduced after freezing, complete understanding of alterations induced by cryopreservation has not been elucidated. The present study evaluates the effects of cryopreservation on the $Ca^{2+}$ handling of boar spermatozoa using several sperm activators. Intracellular $Ca^{2+}$ signals from single spermatozoa were measured using confocal $Ca^{2+}$ imaging of unfrozen samples and of other spermatozoa after having been frozen. Elevation of the external $K^{2+}$ concentration elicited a three times larger $Ca^{2+}$ increase in fresh spermatozoa than in cryopreserved spermatozoa. Caffeine elicited $Ca^{2+}$ transients with some oscillations in the fresh spermatozoa, but not in the thawed spermatozoa. Depletion of the $Ca^{2+}$ store with thapsigargin induced a rapid rise in $Ca^{2+}$ in the control but generated a smaller increase of $Ca^{2+}$ after thawing. Exposure to progesterone induced a biphasic rise of the $Ca^{2+}$ level in the fresh spermatozoa only. Sperm viability was reduced by cryopreservation. Resting $Ca^{2+}$ levels in fresh and cryopreserved spermatozoa were similar. Longer incubation (2.5 h) of thawed spermatozoa partly recovered the $Ca^{2+}$ response to the interventions. These results suggest that cryopreservation reduces the responsiveness of spermatozoa to depolarization, modulators of the internal $Ca^{2+}$ store and progesterone in terms of the $Ca^{2+}$ signal, thus providing a possible mechanism for reduced fertility observed in cryopreserved boar spermatozoa.