• 말소리와 음성과학
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• 제7권3호
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• pp.183-191
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• 2015

This study evaluated the effect of the therapeutic methods between vocal function exercise(VFE), which has been used for the patients with presbyphonia in the precedent studies and laryngeal calibration technique($SKLCT^{(R)}$), which is designed by the author. We identified 58 patients who was been diagnosed as presbylaryngis by laryngoscopic examinations. 21 patients were underwent voice therapy using $SKLCT^{(R)}$, 20 patients were taken VFE, and the control group of 17 patients were not taken any voice therapy. All subjects received the therapy, ranging from seven to nine sessions, and were evaluated the voice change on pretherapy and posttherapy. The grade of hoarseness, roughness, and breathiness voice were reduced on perceptual judgments after $SKLCT^{(R)}$, but only grade of hoarseness was reduced after the VFE. Jitter, Shimmer, NHR were reduced and MPT were increased after the $SKLCT^{(R)}$(p<.05), while Jitter and SFF were reduced after the VFE. Frequency and intensity range were increased significantly on the posttest performance after taking voice therapy by the $SKLCT^{(R)}$, on the other hand only intensity range was increased after VFE. Especially, we can find the significant change that glottic gap and supraglottic compressions was reduced in most of patients after the $SKLCT^{(R)}$, but there's no changes in the group of VFE and control group. In the study, we can suggest that the $SKLCT^{(R)}$ may be useful in improving the voice qualities and laryngeal function of presbyphonia.

• 천문학회보
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• 제37권2호
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• pp.118.2-118.2
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• 2012

In particle-in-cell (PIC) simulation studies related to ion-ion two-stream instability, a reduced ion-to-electron mass ratio is often employed to save computation time. But it was not clearly verified how electrons dynamics are coupled with the slower evolution of ion-ion interactions under the external electric field. We have studied the ion beam driven instability using a 1D electrostatic PIC code by comparing different rescaling of parameter with real ion mass from the reference simulation with reduced ion mass. As the external electric field is stronger, the excited unstable mode range was more sensitively affected by the system size with the real mass ratio than the reduced ion mass. The results show that the reduced mass ratio should be used cautiously in PIC code as the electron dynamics can modify the ion instabilities. Additionally we found the formation of electron flat-top distribution in the final saturation stage. Simulation results show that in the early phase electrostatic solitary waves are quasi-periodically formed, but later they are fully dissipated resulting in heated, flat-top distributions. New electron beam components are occasionally formed. These are a consequence of the interaction with solitary wave structures. We parametrically investigate the development of electron phase space distributions for various drift speeds of ion beams and temperature ratios between ions and electrons

• Structural Engineering and Mechanics
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• 제55권5호
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• pp.979-999
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• 2015

This paper proposes a novel reliability analysis method which computes reliability index, most probable point and probability of failure of uncertain systems more efficiently and accurately with compared to Monte Carlo, first-order reliability and response surface methods. It consists of Initial and Simulation steps. In Initial step, a number of space-filling designs are selected throughout the variables space, and then in Simulation step, performances of most of samples are estimated via interpolation using the space-filling designs, and only for a small number of the samples actual performance function is used for evaluation. In better words, doing so, we use a simple interpolation function called "reduced" function instead of the actual expensive-to-evaluate performance function of the system to evaluate most of samples. By using such a reduced function, total number of evaluations of actual performance is significantly reduced; hence, the method can be called Reduced Function Evaluations method. Reliabilities of six examples including series and parallel systems with multiple failure modes with truncated and/or non-truncated random variables are analyzed to demonstrate efficiency, accuracy and robustness of proposed method. In addition, a reliability-based design optimization algorithm is proposed and an example is solved to show its good performance.

• Molecules and Cells
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• 제43권3호
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• pp.304-311
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• 2020

Methionyl-tRNA synthetase (MRS) is essential for translation. MRS mutants reduce global translation, which usually increases lifespan in various genetic models. However, we found that MRS inhibited Drosophila reduced lifespan despite of the reduced protein synthesis. Microarray analysis with MRS inhibited Drosophila revealed significant changes in inflammatory and immune response genes. Especially, the expression of anti-microbial peptides (AMPs) genes was reduced. When we measured the expression levels of AMP genes during aging, those were getting increased in the control flies but reduced in MRS inhibition flies age-dependently. Interestingly, in the germ-free condition, the maximum lifespan was increased in MRS inhibition flies compared with that of the conventional condition. These findings suggest that the lifespan of MRS inhibition flies is reduced due to the down-regulated AMPs expression in Drosophila.

• 한국세라믹학회지
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• 제52권5호
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• pp.389-394
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• 2015

Direct reduced iron was made using an electric furnace. The reduction ratio of direct reduced iron varied depending on the grade of iron ore. Coal played an important role as a reducing agent in making the direct reduced iron. The coal must contain a suitable amount of volatile components having high calorie values and low impurity content. In this study, oxidized pellets were directly reduced using anthracite as a reductant in an electric furnace. Direct reduction behaviors of hematite and magnetite pellets were confirmed in a coal-based experiment. Reduction behaviors were demonstrated by analyzing the chemical compositions, measuring the reducibility, and observing the phase changes and microstructure. The superior reducibility of hematite pellets can be ascribed to their high effective diffusivity, which is due to their high porosity. The quickly after reducing for 40min and achieves a high value at the end of the reduction.

• 대한기계학회논문집A
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• 제30권9호
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• pp.1062-1069
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• 2006

Reduction schemes approximate the lower eigenvalues that represent the global behavior of the structures. But, they are not efficient to be applied to large-scaled problems because these schemes require considerable amount of computing time in constructing reduced one from the original large-scaled systems. In addition, the selection of the primary degrees of freedom might be localized to cause the excessive emphasis of the lower mode or lost of the important modes. In the present study, a new reduction method combined with the subdomain method is proposed. For the construction of the final reduced system the system of each domain subdivided into primary, slave and interface degrees of freedom. It is remarkably efficient and accurate comparable to full-scale system. Numerical examples demonstrate that the proposed method saves computational cost effectively and provides a reduced system which predicts accurate eigen-pairs of global system.

• 한국자동차공학회논문집
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• 제21권2호
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• pp.37-44
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• 2013

Generally, a reduced chemical mechanism of n-heptane is used as chemical fuel of a 3-D diesel engine simulation because diesel fuel consists of hundreds of chemical components and various chemical classes so that it is very complex and large to use for the calculation. However, the importance of fuel in a 3-D simulation increases because detailed fuel characteristics are the key factor in the recent engine research such as homogeneous charged compression ignition engine. In this study, normal paraffin, iso paraffin and aromatics were selected to represent diesel characteristics and n-dodecane was used as a representative normal paraffin to describe the heavy molecular weight of diesel oil (C10~C20). Reduced kinetics of iso-octane and toluene which are representative species of iso paraffin and aromatics respectively were developed in the previous study. Some species were selected based on the sensitivity analysis and a mechanism was developed based on the general oxidation scheme. The ignition delay times, maximum pressure and temperature of the new reduced n-dodecane chemical mechanisms were well matched to the detailed mechanism data.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.278.1-278.1
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• 2013

Among the prerequisites for stable neural interfacing are the long-term stability of electrical performance of and the excellent biocompatibility of conducting materials in implantable neural electrodes. Reduced graphene oxide offers a great potential for a variety of biomedical applications including biosensors and, particularly, neural interfaces due to its superb material properties such as high electrical conductivity, decent optical transparency, facile processibility, and etc. Nonetheless, there have been few systematic studies on the graphene-based neural interfaces in terms of biocompatibility of electrode materials and long term stability in electrical characteristics. In this research, we prepared the primary culture of rat hippocampal neurons directly on reduced graphene oxide films which is chosen as a model electrode material for the neural electrode. We observed that the viability of primary neuronal culture on the present structure is minimally affected by nanoscale graphene flakes below. These results implicate that the multilayer films of reduced graphene oxides can be utilized for the next-generation neural interfaces with decent biocompatibility and outstanding electrical performance.

• Advances in Energy Research
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• 제4권3호
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• pp.213-221
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• 2016

The main purpose of this work is to test the validation of use of a four step reaction mechanism to simulate the laminar speed of hydrogen enriched methane flame. The laminar velocities of hydrogen-methane-air mixtures are very important in designing and predicting the progress of combustion and performance of combustion systems where hydrogen is used as fuel. In this work, laminar flame velocities of different composition of hydrogen-methane-air mixtures (from 0% to 40% hydrogen) have been calculated for variable equivalence ratios (from 0.5 to 1.5) using the flame propagation module (FSC) of the chemical kinetics software Chemkin 4.02. Our results were tested against an extended database of laminar flame speed measurements from the literature and good agreements were obtained especially for fuel lean and stoichiometric mixtures for the whole range of hydrogen blends. However, in the case of fuel rich mixtures, a slight overprediction (about 10%) is observed. Note that this overprediction decreases significantly with increasing hydrogen content. This research demonstrates that reduced chemical kinetics mechanisms can well reproduce the laminar burning velocity of methane-hydrogen-air mixtures at lean and stoichiometric mixture flame for hydrogen content in the fuel up to 40%. The use of such reduced mechanisms in complex combustion device can reduce the available computational resources and cost because the number of species is reduced.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제25권4호
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• pp.196-220
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• 2021

This study formulates a new geometric parameterization scheme to effectively address numerical analysis subject to the variation of the fiber radius of a square unit cell. In particular, the proposed mesh-morphing approach may lead to a parameterized weak form whose bilinear and linear forms are affine in the geometric parameter of interest, i.e. the fiber radius. As a result, we may certify the reduced basis analysis of a square unit cell model for any parameters in a predetermined parameter domain with a rigorous a posteriori error bound. To demonstrate the utility of the proposed geometric parameterization, we consider a two-dimensional, steady-state heat conduction analysis dependent on two parameters: a fiber radius and a thermal conductivity. For rapid yet rigorous a posteriori error evaluation, we estimate a lower bound of a coercivity constant via the min-θ method as well as the successive constraint method. Compared to the corresponding finite element analysis, the constructed reduced basis analysis may yield nearly the same solution at a computational speed about 29 times faster on average. In conclusion, the proposed geometric parameterization scheme is conducive for accurate yet efficient reduced basis analysis.