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http://dx.doi.org/10.14348/molcells.2019.0273

Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila  

Suh, Yoon Seok (Metabolism and Neurophysiology Research Group, Korea Research Institute of Bioscience & Biotechnology (KRIBB))
Yeom, Eunbyul (Metabolism and Neurophysiology Research Group, Korea Research Institute of Bioscience & Biotechnology (KRIBB))
Nam, Jong-Woo (Department of Biological Sciences, Inha University)
Min, Kyung-Jin (Department of Biological Sciences, Inha University)
Lee, Jeongsoo (Metabolism and Neurophysiology Research Group, Korea Research Institute of Bioscience & Biotechnology (KRIBB))
Yu, Kweon (Metabolism and Neurophysiology Research Group, Korea Research Institute of Bioscience & Biotechnology (KRIBB))
Publication Information
Molecules and Cells / v.43, no.3, 2020 , pp. 304-311 More about this Journal
Abstract
Methionyl-tRNA synthetase (MRS) is essential for translation. MRS mutants reduce global translation, which usually increases lifespan in various genetic models. However, we found that MRS inhibited Drosophila reduced lifespan despite of the reduced protein synthesis. Microarray analysis with MRS inhibited Drosophila revealed significant changes in inflammatory and immune response genes. Especially, the expression of anti-microbial peptides (AMPs) genes was reduced. When we measured the expression levels of AMP genes during aging, those were getting increased in the control flies but reduced in MRS inhibition flies age-dependently. Interestingly, in the germ-free condition, the maximum lifespan was increased in MRS inhibition flies compared with that of the conventional condition. These findings suggest that the lifespan of MRS inhibition flies is reduced due to the down-regulated AMPs expression in Drosophila.
Keywords
anti-microbial peptides; Drosophila; lifespan; methionyl-tRNA synthetase;
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