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Determinants of Reduced Bone Mass in Postmenopausal Women with Rheumatoid Arthritis (폐경 후 류마티스 관절염 여성의 골량감소 판별요인)

  • Lee, Eun-Nam
    • The Korean Journal of Rehabilitation Nursing
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    • v.2 no.2
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    • pp.193-205
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    • 1999
  • This study was carried out to identify the important risk factors for reduced bone mass of postmenopausal RA patients and to develop discriminant function which can classify postmenopausal RA patients with either reduced or normal bone mass. Through the literature review, individual characteristics such as age, body weight, height, age of menarche, duration of menopause, gravity, parity, and breast feeding period and factors of life style such as milk consumption exercise habit, alcohol intake, cigarette smoking, coffee consumpt ion , disease activity, corticosteroid therapy were identified as influencing factors of reduced bone mass in RA patients Sixty eight postmenopausal women with rheumatoid arthritis aged between 42 and 76 were selected among those who checked bone mineral density in lumbar spine and femur from october, 1998 to Apr il, 1999 at Dong-a university hospital in Pusan. Assessment of disease activity, duration of disease and corticosteroid therapy were made by the same rheumatologist and included Ritchie articular index, erythrocyte sedimentation rate, and C-reactive protein on measuring bone mineral density. Cumulative steroid dosage was calculated from the daily dosage multiplied by t h e number of days received. The information of other risk factor including health assessment score, individual characteristics and life style factors were collected by questionnaire. Bone mineral density(BMD) was measured using DXA at lumbar spine and femoral Ward's triangle. Discriminant function(regression equation) was developed for estimating the likelihood of the presence or absence of reduced bone mass. The results are as follows: Among the subjects, thirteen(19.1%) exhibited osteoporosis in lumbar spine and twenty four(35.3%) exhibited osteoporosis in femoral Ward's triangle. For lumbar spine, the variables significant were age, body weight, health assessment score, while for femoral Ward's triangle, age, body weight, duration of disease. But disease activity and corticosteroid therapy were not signigicant to distinguish reduced bone mass from normal bone mass. When the discriminant function was evaluated by comparing the observed out come with predicted out come, the discriminant function correctly classified 85.4% of patients with reduce bone mass and 63.0% of patients with normal bone mass in the lumbar spine and 100% of patients with reduced bone mass and 9.1% of patients with normal bone mass in the femoral Ward's triangle. In summary, we found that osteoporosis in postmenopausal women with RA is more evident at the femur than the lumbar spine. Also the important discriminant factors of reduced bone mass postmenopausal women with RA were age, body weight , duration of disease and health disability. In nursing situation, the efforts to improve of functional capacity of postmenopausal women with rheumatoid arthritis should be considered to prevent osteoporosis and fractures. Also we recommend those postmenopausal women with RA who are classified as a group of the reduced bone mass in the discriminant function should examine the bone mineral density to further examine the usefulness of this discriminant function.

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A study on the outcome of IDC (Incremental Dental Care) (계속구강건강관리(IDC) 성과에 관한 연구)

  • Cho, Min-Jung
    • Journal of Korean society of Dental Hygiene
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    • v.9 no.1
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    • pp.153-168
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    • 2009
  • This study was executed to find out the outcome of Incremental Dental Care from September to November, 2004. 40 visitors to oral health center were examined on the oral conditions every week, seven times during above-mentioned period. Various tests were practiced in order to check their oral conditions before and after IDC such as tooth-brushing method/frequency/duration, calculus index, PHP index, halitosis and dental caries activity. Question and answer sheets were presented to student dental hygienists and 40 visitors respectively after IDC program. Results obtained are as follows. 1. Rotation method of toothbrushing increased from 27.8% to 88.9%. for men and increased from 27.3% to 95% for women. 2. Toothbrushing frequency increased from 2.8 times to 3.0 times a day for men and increased from 2.6 times to 3.1 times for women. Toothbrushing duration increased from 2.3 minutes to 2.8 minutes for men and increased from 2.1 minutes to 2.9 minutes for women. 3. Calculus index reduced from 0.5 to 0.1 for men and reduced from 0.7 to 0 for women. PHP index reduced from 3.7 to 3.0 for men and reduced 3.2 to 1.7 for women. However, halitosis didn't mark any significant difference before and after IDC. 4. Saliva buffering capacity of medium plus showed no change for men(94.5%), however increased from 95.4% to 100% for women. Dental caries activity of medium plus in S.mutans reduced by 4.3 times(72.2% to 16.7%) for men and reduced by 2 times(36.4% to 18.1%) for women. LB test results reduced by 1.5 times(50% to 33.3%) for men and reduced by 2.5 times(50% to 18.1%) for women. Alban's test results reduced by 1.4 times(83.3% to 61.1%) for men and reduced by 1.2 times(81.8% to 68.2%) for women. 5. All participants including visitors and students realized the importance of IDC and expressed a great satisfaction with IDC program. In conclusion, it is considered very necessary that IDC program should be maintained and extended to whole country so as to enhance the peoples' oral health conditions.

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Effects of Amyda sinensis on Allergic Inflammation Mechanism related Atopy Dermatitis (별갑이 아토피 피부염에서의 알러지성 염증 반응에 미치는 영향)

  • Sim, Tae-Kyung;Ko, Dae-Kyoung;Kim, Hyun-Chang;Baek, Yeon-Jong;Lee, Jae-Seok;Yoo, Hwa-Seung
    • Journal of Haehwa Medicine
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    • v.20 no.1
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    • pp.69-83
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    • 2011
  • Objectives: This study aimed to investigate the effects of Amyda sinensis (AS) on allergic inflammation mechanism related atopy dermatitis. Methods: To investigate the effects of AS, We study inhibitory effect of AS on the levels of pro-inflammatory cytokines released from Raw264.7 cell stimulated with LPS (lipopolysaccaride), and EoL-1, THP-1, Jutkat cell stimulated with DP (Dermatophagoides pteronyssinus), and LPS indused acute inflammatory BALB/c mouse model. Result: AS reduced the levels of IL-$1{\beta}$ released from Raw264.7 cell stimulated with LPS at 20 ug/ml, 5 ug/ml concentration, and reduced the levels of IL-6 in a dose-dependent. AS significantly reduced the levels of MCP-1 released from EoL-1 cell stimulated with DP (Dermatophagoides pteronyssinus) at all the concentration, and significantly reduced the level of IL-8 at 0.1 ug/ml concentration. AS significantly reduced the levels of MCP-1 released from THP-1 cell stimulated with DP (Dermatophagoides pteronyssinus) at 1 ug/ml concentration, and reduced the level of IL-6 in a dose-dependent. AS significantly reduced the levels of IL-4 released from Jutkat cell stimulated with DP at all the concentration, and significantly reduced the level of IL-5 at 0.1 ug/ml. 1 ug/ml concentration,. and reduced the level of TNF-${\alpha}$ in a dose-dependent. AS significantly reduced the levels of TNF-${\alpha}$, IL-6, IL-$1{\beta}$, in LPS indused acute inflammatory BALB/c mouse model, in a dose-dependent. Conclusion: These result suggested that AS has suppressive effect on pro-inflammatory cytokines in various cell lines through the regulation of immune system. AS could be applied on the medicinal sources for treatment of immune abnormal diseases such as atopy dermatitis afterward.

The Effects of Lumbar Stabilizing Exercise on the Functional Recovery and the Range of Motion of Low Back Pain Patients (요부 안정화 운동이 요통환자의 기능회복과 가동범위에 미치는 영향)

  • Jung Yeon-Woo;Bae Sung-Soo
    • The Journal of Korean Physical Therapy
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    • v.16 no.1
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    • pp.157-182
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    • 2004
  • The purpose of this study was to evaluate effects of lumbar stabilizing exercise on the functional recovery and the range of motion of low back pain patients. The subjects were consisted of sixty patients who had non specific chronic low back pain(32 females. 28 males; mean aged 37.3) from 19 to 65 years of age(mean age : 37.3). All subjects randomly assigned to the lumbar stabilizing exercise group, the modalities treatment group, the manual treatment group. Lumbar stabilizing exercise group received manual treatment with lumbar stabilizing exercise for 30minutes, modalities treatment group received hot pack used thermal therapy for 20minutes and ICT used electrical therapy for 20minutes and US or MWD used deep thermal therapy for 15minutes, manual treatment group received modalities treatment with therapeutic massage for 10minutes and joint mobilization or manipulation for 10minutes per day and three times a week during 4 weeks period. The Multilevel Roland-Morris Disability Questionnaire(MR-MDQ) was used to measure functional disability level. Visual Analogue Scale(VAS) was used to measure subjective pain level. Remodified Schober test(RST) was used to measure forward flexion range of motion of lumbar segment. Finger-to-Floor test(F-T-FT) was used to measure forward flexion range of motion of full spine of low back pain patients. All measurements of each patients were measured at pre-treatment and 4 week post-treatment. The results of this study were summarized as follows : 1. The MR-MDQ of lumbar stabilizing exercise group, modalities treatment group, and manual treatment group was significantly reduced between pre-treatment and post-treatment(p<.05). 2. The VAS of lumbar stabilizing exercise group, modalities treatment group, and manual treatment group was significantly reduced between pre-treatment and post-treatment(p<.05). 3. The RST of lumbar stabilizing exercise group, modalities treatment group, and manual treatment group was significantly reduced between pre-treatment and post-treatment(p<.05). 4. The F-T-FT of lumbar stabilizing exercise group, modalities treatment group, and manual treatment group was significantly reduced between pre-treatment and post-treatment(p<.05). 5. The results of analyzed effects of MR-MDQ, RST, F-T-FT were significantly reduced (p<.05), but VAS wasn't significantly reduced(p>.05) between treatment type of lumbar stabilizing exercise group and modalities treatment group and manual treatment group according to pre-treatment and post-treatment. 6. The results of LSD post-hoc to find difference between treatment type of lumbar stabilizing exercise group and modalities treatment group and manual treatment group according to pre-treatment and post-treatment that MR-MDQ was significantly reduced stabilizing exercise group than modalities treatment group(p<.05), and VAS wasn't significantly reduced all treatment group(p>.05), and RST was significantly reduced stabilizing exercise group than modalities treatment group(p<.05), and F-T-FT was significantly reduced stabilizing exercise group than modalities treatment group and manual treatment group (p<.05).

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Properties of Cholesterol-reduced Butter and Effect of Gamma Linolenic Acid Added Butter on Blood Cholesterol

  • Jung, Tae-Hee;Kim, Jae-Joon;Yu, Sang-Hoon;Ahn, Joungjwa;Kwak, Hae-Soo
    • Asian-Australasian Journal of Animal Sciences
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    • v.18 no.11
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    • pp.1646-1654
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    • 2005
  • The present study was carried out to develop cholesterol-reduced and gamma linolenic acid (GLA)-added butter and to examine the changes in chemical and sensory properties, and cholesterol lowering effect of GLA addition. The cholesterol removal rate reached 93.2% by $\beta$-cyclodextrin in butter before GLA addition. The thiobarbituric acid value of cholesterol-reduced and GLA-added butter increased slowly up to 4 week and plauteaued thereafter. TBA value was significantly increased with 2% GLA addition, compared with no GLA addition. The production of short-chain free fatty acids (FFA) increased with storage in all treatments. From 4 weeks storage, the amount of short-chain FFA in 2% GLA-added group was significantly higher than those in other groups. Among sensory characteristics, color, greasiness and overall acceptability were mostly affected by GLA addition, however, the rancidity value of 2% GLA addition was significantly different from those of control and GLA-unadded and cholesterol-reduced butter at 0, 6 and 8 week storage. Among groups, no difference was found in texture in all storage periods. The smallest increase of total blood cholesterol in rats was found in the group fed 2% GLA-added and cholesterol-reduced butter for 8 week, compared with that in controls. The present results showed the possibility of cholesterol-reduced and GLA-added butter development without much difference in chemical, rheological and sensory properties, and indicated a slow increase effect on blood total cholesterol in rats.

On the nonlinear structural analysis of wind turbine blades using reduced degree-of-freedom models

  • Holm-Jorgensen, K.;Staerdahl, J.W.;Nielsen, S.R.K.
    • Structural Engineering and Mechanics
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    • v.28 no.1
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    • pp.107-127
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    • 2008
  • Wind turbine blades are increasing in magnitude without a proportional increase of stiffness for which reason geometrical and inertial nonlinearities become increasingly important. Often these effects are analysed using a nonlinear truncated expansion in undamped fixed base mode shapes of a blade, modelling geometrical and inertial nonlinear couplings in the fundamental flap and edge direction. The purpose of this article is to examine the applicability of such a reduced-degree-of-freedom model in predicting the nonlinear response and stability of a blade by comparison to a full model based on a nonlinear co-rotating FE formulation. By use of the reduced-degree-of-freedom model it is shown that under strong resonance excitation of the fundamental flap or edge modes, significant energy is transferred to higher modes due to parametric or nonlinear coupling terms, which influence the response and stability conditions. It is demonstrated that the response predicted by such models in some cases becomes instable or chaotic. However, as a consequence of the energy flow the stability is increased and the tendency of chaotic vibrations is reduced as the number of modes are increased. The FE model representing the case of infinitely many included modes, is shown to predict stable and ordered response for all considered parameters. Further, the analysis shows that the reduced-degree-of-freedom model of relatively low order overestimates the response near resonance peaks, which is a consequence of the small number of included modes. The qualitative erratic response and stability prediction of the reduced order models take place at frequencies slightly above normal operation. However, for normal operation of the wind turbine without resonance excitation 4 modes in the reduced-degree-of-freedom model perform acceptable.

A Dynamic Condensation for Tall Buildings with Active Tuned Mass Damper (능동 동조질량감쇠의 고층빌딩 해석을 위한 동적압축법)

  • Jung, Yang-Ki;Qu, Zu Qing
    • Journal of the Earthquake Engineering Society of Korea
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    • v.10 no.2 s.48
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    • pp.21-29
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    • 2006
  • It is impractical to install sensors on every floor of a tall building to measure the full state vector because of the large number of degrees of freedom. This makes it necessary to introduce reduced order control. A kind of system reduction scheme (dynamic condensation method) is proposed in this paper. This method is iterative and Guyan condensation is looked upon as an initial approximation of the iteration. Since the reduced order system is updated repeatedly until a desired one is obtained, the accuracy of the reduced order system resulting from the proposed method is much higher than that obtained from the Guyan condensation method. An eigenvalue shilling technique is applied to accelerate the convergence of Iteration. Two schemes to establish the reduced order system by using the proposed method are also presented and discussed in this paper. The results for a tail building with active tuned mass damper show that the proposed method is efficient for the reduced order modelling and the accuracy is very close to exact only after two iterations.

Transition from Conventional to Reduced-Port Laparoscopic Gastrectomy to Treat Gastric Carcinoma: a Single Surgeon's Experience from a Small-Volume Center

  • Kim, Ho Goon;Kim, Dong Yi;Jeong, Oh
    • Journal of Gastric Cancer
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    • v.18 no.2
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    • pp.172-181
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    • 2018
  • Purpose: This study aimed to evaluate the surgical outcomes and investigate the feasibility of reduced-port laparoscopic gastrectomy using learning curve analysis in a small-volume center. Materials and Methods: We reviewed 269 patients who underwent laparoscopic distal gastrectomy (LDG) for gastric carcinoma between 2012 and 2017. Among them, 159 patients underwent reduced-port laparoscopic gastrectomy. The cumulative sum technique was used for quantitative assessment of the learning curve. Results: There were no statistically significant differences in the baseline characteristics of patients who underwent conventional and reduced-port LDG, and the operative time did not significantly differ between the groups. However, the amount of intraoperative bleeding was significantly lower in the reduced-port laparoscopic gastrectomy group (56.3 vs. 48.2 mL; P<0.001). There were no significant differences between the groups in terms of the first flatus time or length of hospital stay. Neither the incidence nor the severity of the complications significantly differed between the groups. The slope of the cumulative sum curve indicates the trend of learning performance. After 33 operations, the slope gently stabilized, which was regarded as the breakpoint of the learning curve. Conclusions: The surgical outcomes of reduced-port laparoscopic gastrectomy were comparable to those of conventional laparoscopic gastrectomy, suggesting that transition from conventional to reduced-port laparoscopic gastrectomy is feasible and safe, with a relatively short learning curve, in a small-volume center.

The Effects of Low-Intensity Ultrasound and Laser on Healing of Bone Fracture (저강도 레이저와 초음파의 동시 적용이 골절 치유 촉진에 미치는 효과)

  • Lee, Hyun-Kee
    • The Journal of Korean Physical Therapy
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    • v.15 no.4
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    • pp.331-372
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    • 2003
  • The purpose of study was to evaluate effects of low-intensity ultrasound and laser on healing of bone fracture. Twenty fracture patient were selected for this study(fourteen males, six females. mean aged 44.8) fracture area was humerus, tibia, forearm bones. The obtain result are as follows. 1. The result of this study were following that pain score was significantly reduced pre intervention compared with post intervention in male(P<.001). 2. The result of this study were following that pain score was significantly reduced pre intervention compared with post intervention in female(P<.001). 1. The result of this study were following that pain score was not appeared reduced pre intervention compared with post intervention in male and female(P<.001). 4. The result of this study were following that pain score was not appeared pre intervention compared with post intervention in male between age(P<.001). 5. The result of this study were following that pain score was not appeared pre intervention compared with post intervention in female between age (P<.001). 6. The result of this study were following that radiologic score was significantly reduced pre intervention compared with post intervention in male(P<.001). 7. The result of this study were following that radiologic score was significantly reduced pre intervention compared with post intervention in female(P<.001). 8. The result of this study were following that radiologic score was not appeared reduced pre intervention compared with post intervention in male and female(P<.001). 9. The result of this study were following that radiologic score was not appeared pre intervention compared with post intervention in male between ages(P<.001). 10. The result of this study were following that radiologic score was not appeared pre intervention compared with post intervention in female between ages(P<.001). 11. The result of this study were following that healing on fracture area was observed that reduced pre intervention compared with post intervention

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Synthesis and Electrochemical Characterization of Reduced Graphene Oxide-Manganese Oxide Nanocomposites

  • Lee, Yu-Ri;Song, Min-Sun;Lee, Kyung-Min;Kim, In-Young;Hwang, Seong-Ju
    • Journal of Electrochemical Science and Technology
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    • v.2 no.1
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    • pp.1-7
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    • 2011
  • Nanocomposites of reduced graphene oxide and manganese (II,III) oxide can be synthesized by the freeze-drying process of the mixed colloidal suspension of graphene oxide and manganese oxide, and the subsequent heat-treatment. The calcined reduced graphene oxide-manganese (II,III) oxide nanocomposites are X-ray amorphous, suggesting the formation of homogeneous and disordered mixture without any phase separation. The reduction of graphene oxide to reduced graphene oxide upon the heat-treatment is evidenced by Fourier-transformed infrared spectroscopy. Field emission-scanning electronic microscopy and energy dispersive spectrometry clearly demonstrate the formation of porous structure by the house-of-cards type stacking of reduced graphene oxide nanosheets and the homogeneous distribution of manganese ions in the nanocomposites. According to Mn K-edge X-ray absorption spectroscopy, manganese ions in the calcined nanocomposites are stabilized in octahedral symmetry with mixed Mn oxidation state of Mn(II)/Mn(III). The present reduced graphene oxide-manganese oxide nanocomposites show characteristic pseudocapacitance behavior superior to the pristine manganese oxide, suggesting their applicability as electrode material for supercapacitors.