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Review of Red Ginseng in terms of Mechanisms for Pharmacodynamics and Toxicity (홍삼의 약리와 독성 기전에 대한 고찰)

  • Park, Yeong-Chul;Lim, Jung-Dae;Kim, Jong-Bong;Lee, Sundong
    • The Journal of Korean Medicine
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    • v.33 no.3
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    • pp.200-230
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    • 2012
  • Objectives: Ginseng, Panax ginseng C. A., white ginseng, has been used for thousands of years in Traditional Korean Medicine. Red ginseng can be made by a steaming process of white ginseng changing a variety of ginsenosides and ingredients such as dencichine. This article reviews red ginseng for mechanisms for pharmacodynamics and toxicity based on the content of ginseng's active ingredients, ginsenoside changed by steaming. Methods: The following electronic databases were searched: PubMed, Science Direct and Chinese Scientific Journals full text database (CQVIP), and KSI (Korean Studies Information) from their respective inceptions to June 2012. Results: Compared with unsteamed ginseng, the content of ginsenosides Rg2, Rg3, Rg5, Rh1, Rh2 and Rk1 called red ginseng-specific ginsenosides increased after the steaming process. Different ginsenosides have shown a wide variety of effects such as lowering or raising blood sugar and blood pressure or stimulating or sedating the nervous system. Especially, the levels of Rg2, Rg3, Rg5, Rh1, Rh2 and Rk1 were increased by the steaming process, showing a variety of pharmacodynamics in biological systems. Also, various processing methods such as puffing and fermentation have been developed in processing crude ginseng or red ginseng, affecting the content of ginseng's ingredients. The safety issue could be the most critical, specifically, on changed ginseng's ingredients such as dencichine. The level of dencichine was significantly reduced in red ginseng by the steaming process. In addition, the possible toxicity for red ginseng was affected by cytochrome P450, a herbal-drug interaction. Conclusions: The variety of pharmacological and toxicological properties should be changed by steaming process of Panax ginseng C. A., white ginseng. Even if it is not sure whether the steaming process of white ginseng would be better pharmacologically, it is sure that steaming reduces the level of dencichine causing a lower toxicity to the nervous system.

Penile Blood Change after Oral Medication of Korean Red Ginseng in Erectile Dysfunction Patients (발기부전환자에서 홍삼 복용후의 음경혈류와 발기력 변화)

  • Choi, Hyung-Ki;Choi, Yeong-Jin;Kim, Jang-Hwan
    • Journal of Ginseng Research
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    • v.27 no.4
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    • pp.165-170
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    • 2003
  • The clinical efficacies of Korean Red Ginseng for improving sexual function has been reported only by self-reporting questionnaires.AVS-Penogram is a method evaluating natural penile blood flow changes by Gamma-camera after intravenous injection of Techmetium 99$\^$m/-RBC and also stimulating by erotic video tape. To more objectively evaluate the efficacies of Korean Red Ginseng for erectile function, we applied AVS-Penogram as a objective diagnostic tool. AVS-Penogram studies were done in 28 patients with erectile dysfunction after administration of Red Ginseng(19) or placebo(9) group. The pattern of AVS-Penogram before medication were normal type in 4, impossible in 2, unstable in 20, delayed in 1, and mixed in 1. The unstable type were the most prevalent observed in 71.4% of all patients. The patterns of AVS-penogram were 2.2. 13.1 in Red Ginseng group, while in placebo group normal 2, unstable 7. After 4 weeks in Red Ginseng group, there were 3 cases of improved penogram findings, while only 1 in placebo group. There were no statistical significancies in the type of penogram changes on both group. But the maximum radioactivity were improved in 11 patients(57.9%) in Red Ginseng group, while 2(22.2%) in placebo group. There were statistical significancies in comparing the maximal radioactivity of penogram on both group. These AVS-Penogram findings shows, encouraging results of by increased penile blood flow Korean Red Ginseng our medication. Further study is more needed to reconfirm these results by more concentrated active formulations of sapanonin St other active ginsenosides. These promising results will lead to develop a new remedy for erectile dysfunction by Korean Red Ginseng

A Study on the Interior of Blood Donation Houses of the Korean Red Cross - Improvement Advice based on Recent Changes around Seoul Area - (적십자사 헌혈의 집 실내공간의 실태분석에 따른 개선 방안에 관한 연구 - 서울지역을 중심으로 -)

  • Han Myoung-Heum
    • Korean Institute of Interior Design Journal
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    • v.14 no.6 s.53
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    • pp.140-147
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    • 2005
  • For a safe and stable supply of blood in Korea, 'Blood Donation Houses' are springing up all over Korea to advertise and improve the awareness on blood donations. This research will conduct a study on such blood donation centers, their conditions and problems. It will furthermore provide solutions to raise the level of comfort to donators and help nurses for a better working environment. The research will be conducted in 'Blood Donation Houses' that were established by 4 centers of the Korean Red Cross in Seoul after 1993. Any houses that are temporary (containers, buses, smaller than 15 pyung) were excluded from this study. In order to investigate changes of these houses, the ones analyzed and recorded in the 2002 data were used as a basis for comparison. A total of 16 houses were selected for this study. 5 houses were closed after the initial study of 2002, and 6 houses were not available for research upon above mentioned criteria, leaving 9 houses from the original 2002 data. 7 additional houses were opened after 2002, which were included in this study. The research was conducted by a close study of written materials on the historical and theoretical viewpoint of blood donations, as well as visits to the actual Blood Donation Houses. The conclusion will offer solutions to necessary functional and working space, and lighting in such houses on the basis of above analyzed theoretical and practical data.

The Correlation of Racing Performance with Pre-Race Blood Values in Thoroughbred Horses

  • Lee, Young-woo;Shim, Seung-tae;Song, Hee-eun;Hwang, Hye-shin;Seo, Jong-pil;Lee, Kyoung-kap
    • Journal of Veterinary Clinics
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    • v.35 no.5
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    • pp.190-194
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    • 2018
  • Recently, the horse racing industry in Korea has developed rapidly with good betting turnover. One of the most important factors in enhancing the performance of racehorses is the study of equine exercise physiology. This study was performed to analyze the results of pre-race blood test on race day and evaluate its correlation with the race performance in Thoroughbred racehorses. Twenty-one, healthy 3- to 6-year-old Thoroughbred horses were used to collect blood samples and hematological and biochemical measurements were performed. Results were analyzed to identify its correlation with racing performance. Analysis of hematological profile of pre-race blood of the racehorses revealed that red blood cell indices including RBC, Hb, and PCV levels were elevated. Additionally, levels of AP, AST, and GGT were also elevated in pre-race blood of horses on race day. RBC, Hb, and PCV levels of high performance racehorses were significantly lower than those of low class racehorses. Moreover, the analysis of correlation between blood test results and racing ability-related categories have shown negative correlations for rating, placing strike rate, prize money per race, RBC, Hb, and PCV and positive correlations for G3F and PCV. Additionally, AST value was positively correlated to prize money per race. Thus, the results of this study show that red blood cell indices and AST are good parameters for evaluating racing performance of horses before the race.

The correlation of the skin color to the blood circulation on the face of Korean female between the ages of 30 and 45 (30${\sim}$40대 한국 여성의 안색과 혈행의 상관성 연구)

  • Kim, Eun-Joo;Roh, Ho-Sik;Kim, Su-Jong;Moon, Eun-Jeong;Kim, Duck-Hee;Kim, Han-Kon;Cho, Ga-Young
    • Journal of the Korean Institute of Oriental Medical Informatics
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    • v.14 no.2
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    • pp.73-79
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    • 2008
  • Objectives : We investigated the correlation of the skin color to blood circulation on the face of Korean female by noninvasive-skin measuring devices. Methods : Korean female(37.47${\pm}$3.66 years, n=36) aged 30-45 years were participated in this study. We measured the skin color of the face with Spectrophotometer CM2600d (Minolta, Japan) and the skin blood flow with Laser Doppler Imaging-Periscan PIM II (Perimed AB, Sweden). The skin color and blood circulation of three groups (30-35 years, 36-40 years, 41-45 years) divided on age were analyzed by paired-t test and regression analysis. Results : The L* values of the skin were decreased and the a* values were increased significantly with age. This means that the more age increase, the more the skin is dark and red. But the skin blood flow was not significantly different with age and skin color. Conclusions : In the oriental medicine, It was reported that the face of the female over 35 years is changed gradually haggard and the blood circulation is decreased. In our study, the blood circulation was not changed and the skin color was dark and red with increasing the age. We think this symptom resulted from the better nutrition than the past, the change of the blood-quality and this changes were too sensitive to be measured by Laser Doppler Imaging system.

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Effects of Puffed and Fermented Red Ginseng on Blood Glucose-related Biomarkers in Streptozotocin-Induced Diabetic Rats (팽화발효홍삼이 Streptozotocin 유발 당뇨쥐의 혈당관련 지표에 미치는 영향)

  • Park, Ju-Hun;Sung, Ki-Seung;Kim, Sung-Soo;Shim, Gun-Sub;Han, Chan-Kyu
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.41 no.5
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    • pp.630-637
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    • 2012
  • This study was performed to investigate the effects of puffed and fermented red ginseng on blood glucose-related biomarkers in streptozotocin-induced diabetic rats. Male Sprague-Dawley diabetic rats were orally injected with 0.85% NaCL as a diabetic control (DC), 300 mg/kg general red ginseng (RG), 300 mg/kg puffing red ginseng fermented by mixed strain culture of $Bifidobacterium$ $breve$ and $Lactobacillus$ $delbrueckii$ (BL), and 300 mg/kg puffing red ginseng fermented by $Enterococcus$ $faecalis$ (EF) for 5 weeks. The blood glucose level of group BL was significantly lower maintained than in groups DC and RG for the experimental period (p<0.05). It was also significantly lower than in groups DC, RG, and EF at the 5th week (p<0.05). In the oral glucose tolerance test, the blood glucose of group BL was maintained the lowest level (p<0.05), and the area under the blood glucose curve (AUC) was also significantly lower in group BL than in group DC (p<0.05). The fasting blood glucose and insulin levels after the experiment were significantly low in group BL (p<0.05), and the HOMA-IR was more significantly low in groups BL and EF than in group DC (p<0.05). Also, the HbA1c content of group BL was significantly low than in groups DC and RG (p<0.05). The serum TC level was significantly decreased in groups RG, BL, and EF than in group DC (p<0.05), and the LDL-C content was significantly low in group BL than in group DC (p<0.05). From the findings, it was shown that the puffed and fermented red ginseng made using a mixed strain culture of $B.$ $breve$ and $L.$ $delbrueckii$ could improve blood glucose-related biomarkers.

Effect of Korean Red Ginseng Extract on Blood Circulation in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Trial (건강한 지원자에서 홍삼농축액의 혈행 개선 효과: 무작위, 이중맹검, 위약-대조 시험)

  • Shin, Kyeong-Seob;Lee, Jung-Jin;Kim, Yeong-Il;Yu, Ji-Yeon;Park, Eun-Seok;Im, Ji-Hyun;You, Soon-Hyang;Oh, Ki-Wan;Lee, Myung-Koo;Wee, Jae-Joon;Kim, Young-Sook;Yun, Yeo-Pyo
    • Journal of Ginseng Research
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    • v.31 no.2
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    • pp.109-116
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    • 2007
  • Korean red ginseng has broad efficacious effects against hypertension, diabetes, nociception, and cancer, and it counteracts weakness. It has been reported that Korean red ginseng is able to normalize blood pressure, improve cholesterol and lower blood glucose levels. We have recently reported that Korean red ginseng extract (KRGE) significantly prevented rat carotid arterial thrombosis in vivo, and inhibited platelet aggregation ex vivo and in vitro in a dose-dependent manner. The purpose of this study was to examine the effects of KRGE on blood circulation in human by measuring ex vivo platelet aggregation, plasma coagulation and serum lipid profiles in healthy volunteers. Subjects were randomly divided into three groups (placebo-group, KRGE-low dose group, KRGE-high dose group). Administration of KRGE to subjects significantly inhibited ADP-induced platelet aggregations both in KRGE-low dose group from $72.79{\pm}20.53$ to $62.00{\pm}23.06%$ (p=0.0009), and in KRGE-high dose group from $75.14{\pm}21.86$ to $64.52{\pm}24.72%$ (p=0.0039), respectively. Administration of KRGE to subjects also significantly inhibited collagen-induced platelet aggregations both in KRGE-low dose group from $85.52{\pm}12.57$ to $79.62{\pm}20.47%$ (p=0.0916), and in KRGE-high dose group from $80.24{\pm}18.11$ to $70.31{\pm}25.93%$ (p=0.0565), respectively. Whereas, KRGE has no significant effects on coagulation system, such as prothrombin time (PT) and activated partial thromboplastin time (APTT), and serum lipid profiles, such as total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride. KRGE also has no significant effects on hematological and serum biochemical profiles. These results suggest that KRGE has a potential to improve blood circulation through antiplatelet activity in human, and KRGE intake may be beneficial for the individuals with high risks of thrombotic and cardiovascular diseases.

Influence of Burnout and Coping Type on Organizational Citizenship Behavior among Employees at Korean Red Cross Blood Center (소진 및 대처 유형이 조직시민행동에 미치는 영향 - 적십자 혈액원 직원을 대상으로 -)

  • Kim, Young-Mi;Lee, Key-Hyo;Kim, Won-Joong;Park, Young-Seok
    • Korea Journal of Hospital Management
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    • v.9 no.4
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    • pp.87-100
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    • 2004
  • The main objective of this paper is to investigate the burnout state, coping types, and their relationship with organizational citizenship behavior, and based on the investigation, to provide some reference materials for effective management of burnout and appropriate methods of coping. For this purpose, employees of Korean Red Cross Blood Center were selected as the subject of the research. Data for empirical analysis were obtained through mail survey using structured and self-administered questionnaire for 282 employees of five Red Cross Blood Centers across the nation. Following is the summary of the results: 1) Degree of organizational citizenship behavior was higher among the married, the forties in age, and the employees whose major reason for choosing to work at the Center was 'to help other people.' On the other hand, degree of burnout was higher among the single but lower among the forties in age and the employees who chose to work at the Center because of suitable abilities and interests. As for the types of coping, problem-oriented coping method was more frequently used by the married, older, relatively more-educated and higher-grade employees. 2) Among the three kinds of burnout, 'achievement burnout' was found to have the greatest influence on the organizational citizenship behavior, negatively affecting organizational citizenship behavior as a whole and all of its components except for 'sportsmanship.' Next was 'impersonality burnout,' which also had negative effect on organizational citizenship behavior as a whole, and altruism, conscientiousness and sportsmanship among the components. Finally, 'emotion burnout' appeared to have positive effect on altruism and courtesy but negative effect on sportsmanship. 3) Among the various types of coping, 'problem-oriented' and 'positive perspective' coping methods were found to positively influence overall organizational citizenship behavior, whereas 'stress dissolution' had negative effect. These results imply that special management, counselling and education are needed for sociodemographic groups with high burnout to utilize problem-oriented and positive perspective coping methods which are considered to have desirable effects in coping with burnout problems. In addition, some methods should be devised to prevent and manage the 'achievement burnout' that was found to have great negative influence on organizational citizenship behavior.

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A Simple Design of an Imaging System for Accurate Spatial Mapping of Blood Oxygen Saturation Using a Single Element of Multi-wavelength LED (혈중 산소 포화도의 정확한 공간 매핑을 위한 다중 파장 LED 단일소자를 활용한 이미징 시스템 설계)

  • Jun Hwan Kim;Gi Yeon Yu;Ye Eun Song;Chan Yeong Yu;Yun Chae Jang;Riaz Muhammad;Kay Thwe Htun;Ahmed Ali;Seung Ho Choi
    • Journal of Biomedical Engineering Research
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    • v.44 no.6
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    • pp.450-464
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    • 2023
  • Pulse oximetry, a non-invasive technique for evaluating blood oxygen saturation, conventionally depends on isolated measurements, rendering it vulnerable to factors like illumination profile, spatial blood flow fluctuations, and skin pigmentation. Previous efforts to address these issues through imaging systems often employed red and near-infrared illuminations with distinct profiles, leading to inconsistent ratios of transmitted light and the potential for errors in calculating spatial oxygen saturation distributions. While an integrating sphere was recently utilized as an illumination source to achieve uniform red and near-infrared illumination profiles on the sample surface, its bulkiness presented practical challenges. In this work, we have enhanced the pulse oximetry imaging system by transitioning illumination from an integrating sphere to a multi-wavelength LED configuration. This adjustment ensures simultaneous emission of red and near-infrared light from the same position, creating a homogeneous illumination profile on the sample surface. This approach guarantees consistent patterns of red and near-infrared illuminations that are spatially uniform. The sustained ratio between transmitted red and near-infrared light across space enables precise calculation of the spatial distribution of oxygen saturation, making our pulse oximetry imaging system more compact and portable without compromising accuracy. Our work significantly contributes to obtaining spatial information on blood oxygen saturation, providing valuable insights into tissue oxygenation in peripheral regions.

The Effects on the Blood Lipid Profiles and Body Fat by Long Term Administration of Red Ginseng Product (장기간 홍삼복방제 투여가 혈중 지질 및 체지방 변화에 미치는 영향)

  • Kim, Sung-Soo;Park, Ho-Yoon;Byun, Yong-Hyun;Hwang, Bu-Geun;Lee, Jae-Hyun;Shim, Young-Jae;Park, Chae-Kyu;Park, Myung-Han;Yang, Jai-Won
    • Journal of Ginseng Research
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    • v.26 no.2
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    • pp.67-73
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    • 2002
  • This study was done in order to evaluate the of effects on the blood lipid profiles, the body weight and body fat in 28 healthy female volunteers who had over 30% body fat by the long term intake of red ginseng product. Subjects were divided into four groups (placebo group n=7, red ginseng product group; n=7, exorcise group; n=7, exercise & red ginseng product group; n=7). Blood sampling and measuring of the body fat were taken by pre-treatment, 3 weeks, and after 12 weeks. Statistical techniques for data analysis were applied one-way ANOVA and repeated measures ANOVA. The 5% level of significance was used as the critical level for this study. In summary of results, total cholesterol, triglyceride and low density lipoproprotein cholesterol were reduced in three groups (red ginseng product group, p<0.001, exercise group, p<0.01 ; exercise & red ginseng product group, p<0.001) except placebo group. HDL-C was improved in three groups (red ginseng product group, p<0.05; exercise group, p<0.01; exercise & red ginseng product group, p<0.001) except placebo group. Body weight, percent body fat and body fat mass were reduced in three groups (red ginseng product group, p<0.01, exercise group, p<0.01 ; exercise & red ginseng product group, p<0.001) except placebo group. Finally, lean body mass was improved in three groups (red ginseng product group, p<0.05; exercise group, p<0.01; exercise & red ginseng product group, p<0.001) except placebo group.