Browse > Article
http://dx.doi.org/10.5142/JGR.2003.27.4.165

Penile Blood Change after Oral Medication of Korean Red Ginseng in Erectile Dysfunction Patients  

Choi, Hyung-Ki (From the Department of Urology, Yongdong Severance Hospital, Urological Science Institute Yonsei University College of Medicine)
Choi, Yeong-Jin (From the Department of Urology, Yongdong Severance Hospital, Urological Science Institute Yonsei University College of Medicine)
Kim, Jang-Hwan (From the Department of Urology, Yongdong Severance Hospital, Urological Science Institute Yonsei University College of Medicine)
Publication Information
Journal of Ginseng Research / v.27, no.4, 2003 , pp. 165-170 More about this Journal
Abstract
The clinical efficacies of Korean Red Ginseng for improving sexual function has been reported only by self-reporting questionnaires.AVS-Penogram is a method evaluating natural penile blood flow changes by Gamma-camera after intravenous injection of Techmetium 99$\^$m/-RBC and also stimulating by erotic video tape. To more objectively evaluate the efficacies of Korean Red Ginseng for erectile function, we applied AVS-Penogram as a objective diagnostic tool. AVS-Penogram studies were done in 28 patients with erectile dysfunction after administration of Red Ginseng(19) or placebo(9) group. The pattern of AVS-Penogram before medication were normal type in 4, impossible in 2, unstable in 20, delayed in 1, and mixed in 1. The unstable type were the most prevalent observed in 71.4% of all patients. The patterns of AVS-penogram were 2.2. 13.1 in Red Ginseng group, while in placebo group normal 2, unstable 7. After 4 weeks in Red Ginseng group, there were 3 cases of improved penogram findings, while only 1 in placebo group. There were no statistical significancies in the type of penogram changes on both group. But the maximum radioactivity were improved in 11 patients(57.9%) in Red Ginseng group, while 2(22.2%) in placebo group. There were statistical significancies in comparing the maximal radioactivity of penogram on both group. These AVS-Penogram findings shows, encouraging results of by increased penile blood flow Korean Red Ginseng our medication. Further study is more needed to reconfirm these results by more concentrated active formulations of sapanonin St other active ginsenosides. These promising results will lead to develop a new remedy for erectile dysfunction by Korean Red Ginseng
Keywords
Gingseng; efficacy; impotence;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Chung, W . S. Chung, and Choi, H. K. : Erotic erection versus nocturnal erection. J. Ural. 143, 294-297 (1990)
2 Shirai, M.: Differential diagnosis between functional and organic impotence by radioisotope penogram loading with visual sexual stimulation. Japanese J.Urol. 64, 786-792 (1973)
3 Shirai, M., Nakamura, M. and Ishii, N. : Determination of intrapenial blood volume using 99m-Tc laveled autologous red blood cells. Tohoku J. Exp. Med. 120,3 77-383 (1976)
4 Ishii, N. and Shirai, M. : Report 12: A screening method of organic impotence for the penothermocurve. Japanese J. Urol. 74, 640-648 (1983)
5 Hah, J. S., Kang, B. S. and Kang, D. H. : Effect of panax ginseng alcohol extract on cardiovascular system. Yonsei Med. J .19, 11-15 (1978)
6 Huh, K.,Jang, B. S. and Park, J. M. : Protective effect of ginseng on bromobenzene-induced hepatotoxicity in mice. Koryo Insam Hakhoechi. 12, 114 (1988)
7 Huh, K., Lee, T. K., Park, J. M. and Shin, U. S. : Preventive effect of ginseng butanol fraction against acetyldehydeinduced acute toxicity. Koryo Insam hakhoechi. 13, 5 (1989)
8 남기열 : 성기능 장애에 대한 효능 in 한국인삼연초연구원. 최신고려인삼(성분 및 효능편), 천일인쇄사, 대전，pp. 152-153 (1996)
9 Morales, A. and Heaton, P. W. : The medical tretment of impotence : An update. World J. Urol. 8 : 80 (1990)
10 Shiao, P.- J., Liu, S. P., Hsieh, J. T. and Chiu, T. Y. : The effect of oral Trazodone in impotence : A perliminary report. Proceding of the 4th Biennial Asia-Pacific Meeting on Impotence. Bali, Indonesia. PP. 131, (1993)
11 Choi, H. K., Seong, D. H. and Rha, K. H. : Clinical efficacy of Korean red ginseng for erectile dysfunction. Int. J. Impotence Res. 7, 181-186 (1995)
12 최형기，최영진，나군호，최영득 : 국제 발기능측정설문지 (IIEF)-률 이용한 발기부전환자에서의 홍삼효능 평가, 고려인 삼학회지 25(3), 112-117 (2001)
13 최영득，신종성，최형기 : 고려인삼의 토끼 음경 해면체 평활근에 대한 작용. 고려인삼학회지 20, 133-138 (1996)   과학기술학회마을
14 민영기，최형기, 임포텐스환자에서 방사성동위원소를 이용 한 시청각자극 검사 3000례 의 분석. 대한비뇨회지 35, 1001-1006 (1994)
15 Kim, N., Azadozoi, K. M., Goldstein, I. and Tejada, I. S. : A nitric oxide-like factor mediate nonadrenergic-noncholinergic neurogenic relaxationof penile corpus cavernosum snooth muscle. J. Clin. Invest. 88, 112-118 (1991)
16 정희창，서준규.: Total saponin이 음경발기에 미치는 효과: 기존의 음경발기 유발 약물과 비교 연구. 대한비뇨회지 38, 866-872 (1997)
17 Kim, N. D., Kang, S. Y. and Schini, V. B.: Ginsenosides evoke endothelium- dependent vascular relaxationin rat aorta. Gen. Pharmacol. 25, 1071- 1077 (1994)
18 안태영，김건석，김청수，박태한, 박평섭 : 인삼이 토끼 음경 해변체 평활큰의 이완작용에 미치는 영향. 고려인삼학회지 20, 339-343 (1996)
19 김형지，이길호，김제종.: 가토 음경해면체평활근의 이완에 있어서 인삼사포닌의 효과에 대한 생체외 실험 연구. 대한 비뇨회지 39, 443-449 (1998)
20 최형기，김철수, : 시청각자극에 의한 음경혈류의 변화에 관 한 연구. 대한비뇨회지 29, 459-463 (1988)
21 김종현，최형기.: AVS-Penogram 의 세분유형에 대한 고찰. 대한비뇨회지 33, 105-114 (1992)
22 장수기, 최형기 . 야간발기와 시청각자극 발기의 비교관찰. 대한비뇨회지 29, 142-147 (1988)
23 최영득, 박진아，최형기，남기열 : 토끼와 흰쥐 음경해면체 이 완작용에 미치는 홍삼사포닌 분획별 효과. 고려인삼학회지 23, 13-20 (1999)
24 최영득，마상열，신종성，최형기 : 고려인삼 복용이 토끼 및 흰쥐의 음경해면체 평활근에 미치는 효과. 고려인삼학회지 21 , 98-103 (1997)