• Tuberculosis and Respiratory Diseases
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• 제68권1호
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• pp.10-15
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• 2010

Background: Lung cancer is the most common cause of cancer mortality in Korea. The TNM stage at presentation in patients with non-small cell lung cancer (NSCLC) has the greatest impact on prognosis. Patients who undergo a complete resection for NSCLC are likely to develop recurrent and/or metastatic disease. There are several factors influencing the development of recurrence. We explored risk factors of recurrence in patients with stages I and II NSCLC, who had undergone curative resection. Methods: We reviewed patients who had complete surgical resection as definitive treatment for stage I or II. Patients followed up for more than 36 months. We evaluated several factors which might have relationship with recurrence, such as patient's demographic factors, TNM staging, pathologic finding, tumor markers and surgical technique. Results: A total of 75 patients were enrolled for analysis, of whom 58 were men and 17 were women with mean age of 61 (range, 37 to 76) years. The average size of tumors was 3.9 cm (0.7 to 10 cm). There were 64 patients with stage I NSCLC and 11 with stage II NSCLC. Among 64 patients with stage I NSCLC, 35 patients showed recurrences whereas 8 patients have recurred in stage II NSCLC. Grade of differentiation of tumor was closely related to the recurrence. Seventy-five percent of patients who had poor tumor differentiation experienced a recurrence. In contrast, 3 patients of twelve had recurrences, who revealed differentiation in their tissue (p<0.05). Conclusion: Tumor differentiation could be a predictive factor for tumor recurrence in patients who have undergone curative resection for stage I or II NSCLC.

• 대한골관절종양학회지
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• 제6권2호
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• pp.82-87
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• 2000

종양성 석회증은 칼슘과 인산의 대사장애 없이 관절주위의 연부조직에 석회성분의 침착을 일으키는 질환으로 그 원인은 정확히 알려져 있지 않으며, 발생빈도는 매우 드물며 주로 흑인에서 발생한 예들이 보고되어 있으나 황인종에서 수 차례 재발되어 보고된 예는 아직 없다. 이에 저자들은 우측 슬관절과 대퇴부에 발생하여 수 차례 재발된 종양성 석회증 1예를 경험하였기에 문헌고찰과 함께 보고하고자 한다. 21세 여자 환자로서 우측 슬관절과 대퇴부 후방의 종괴를 주소로 내원하였으며 과거력상 14년 전부터 타 병원에서 4차례에 걸쳐 생검 및 제거술을 실시하였으나 재발을 반복하였다. 치료로서 제거 가능한 종괴의 철저한 변연 절제술을 시행하였으며 조직학적 소견상 종양성 석회증으로 진단되었던 예이었다. 술 후 24개월 이상 추시 관찰하여 현재까지 재발의 소견이 없었다. 저자들은 황인종에서 발생빈도가 드문 재발된 종양성 석회증 1예를 보고하는 바이다.

• Journal of Chest Surgery
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• 제38권10호
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• pp.705-709
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• 2005

배경: 염증성 폐질환에 의해 발생한 객혈을 폐절제술로 치료한 후 임상 결과를 분석해보고자 한다 대상 및 방법 : 1995년 1월부터 2004년 5월까지 양성 폐질환에 의해 객혈이 발생하여 폐절제술로 치료한 총 45명의 환자를 대상으로 하여 수술 후 이환율에 미치는 술 전 요소들과 수술 후 객혈의 재발 요인들을 분석하였다. 환자의 평균 나이는 47.1세였고 평균 추적기간은 $35\pm34$개월이었다. 결과: 수술 후 조기 사망은 2명$(4.4\%)$이었다. 술 후 합병증은 8명의 환자에게서 발생하였다. 술 전 또는 술 중에 수혈이 이루어진 그룹에서 수술 후 합병증 발생률이 높았다(p=0.002). 특히 파괴성 폐결핵 환자에게서 술 전 및 술 중 수혈 가능성이 높았고(p=0.001)수술 전에 의의 있게 많은 양의 객혈이 발생하였으며(p=0.002) 전폐절제술이 시행될 가능성이 많았고(p=0.039) 수술 후 합병증의 빈도가 높았다(p=0.015). 전폐절제술을 시행한 환자에서 술 후 출혈로 인해 재수술의 시행이 많았다(p=0.047). 추적 관찰 중 5명의 환자에서 객혈이 재발하여 이 중 3명의 환자는 소실되었고 2명의 환자는 간헐적인 혈액흔적 가래(blood tinged sputum) 양상이 지속되고 있다. 위 2명의 환자는 결핵의 재발로 현재 치료 중이다. 걸론 수술 후 이환율을 높이는 질환으로 파괴성 폐결핵을 들 수 있으며 염증성 폐질환으로 인한 전폐절제술은 술 후 출혈에 대한 각별한 주의를 요한다. 향후 보다 많은 증례를 통해 수술 후 객혈의 재발에 대한 심도 있는 연구가 필요할 것이다.

• Journal of Chest Surgery
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• 제36권3호
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• pp.175-181
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• 2003

원발성 흉벽종양은 흉부의 연조직이나 뼈 또는 연골에서 다양하게 발생할 수 있는 종양으로서 전체 원발성 종양의 약 l∼2%를 차지한다. 수술적 절제술은 만성 궤양이나 심한 통증이 있는 환자에서 효과적인 치료법이며 조직학적 진단 및 수술방법에 따라서 장기생존이 가능할 수 있다. 대상 및 방법: 1976년 9월부터 2001년 3월까지 원발성 흉벽종양을 가진 125명(양성종양 86명, 악성종양 39명) 의 환자에서 수술적 절제술을 시행하여 수술결과와 예후에 영향을 미치는 요소들을 해석하고자 하였다. 결과: 양성종양은 수술적 치료로 재발 없이 완전 치료가 되었으며 악성종양은 대부분 광범위 절제술을 시행하였으며 환자에 따라 수술 후 보조요법을 병행하였다. 양성종양 중 신경초종이 가장 많았으며 악성종양은 악성섬유성조직구종이 가장 많은 빈도를 보였다. 악성종양의 경우 3년 생존율이 76.0%, 10년 생존율이 60.5%이었다. 수술과 관련된 사망은 없었으며 외래 추적 중 사망한 환자의 원인은 원격 전이에 의한 장기부전 이었으며 11명에서 재발하였다. 안전거리 절제면을 4 cm 이상과 미만으로 구분하였을 때 두 군간의 생존율에 차이가 없었다. 결론: 양성종양의 경우 수술적 치료로 재발 없이 완치가 가능하였으며 악성종양도 비교적 좋은 장기생존율을 나타내었다. 안전거리 4 cm는 예후에 미치는 영향은 발견할 수 없었으나 재발 시에는 예후가 좋지 않았다.

• Journal of Chest Surgery
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• 제40권12호
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• pp.843-850
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• 2007

배경: 흉부 식도암에서 Ivor-Lewis수술이 널리 이용되어 왔으나 최근 3구역 절제술로 보다 좋은 성적들이 보고되고 있다. 식도 편평세포암 환자에서 Ivor-Lewis수술의 유용성을 알아보고자 한다. 대상 및 방법: 1994년 9월부터 2004년 8월까지 식도암으로 절제술을 받은 273명의 환자 중 편평세포암으로 다른 원발성 암이 없고 Ivor-Lewis수술로 완전절제가 가능하였던 172명을 대상으로 술 후 합병증, 조기 및 장기성적, 재발양상을 후향적인 방법으로 분석하였다. 결과: 술 후 병기는 I기 40명(23%), IIA기 48명(27%), IIB기 18명 (10%), III기 55명(33%), IVA 5명(3%), IVB 6명(4%)이었다. 수술과 관련된 사망은 172명의 환자 중 7명(4%)에서 발생하였으며 술 후 합병증은 32명(18%)에서 발생하였고 55명(32%)에서 재발하였다. 전체 환자의 5년 생존율은 48%였는데, 병기별 5년 생존율은 I기 85.6%, IIA기 47.6%, IIB기 65%, III기 22.8%, IV기 0%였다. 종양의 위치에 따른 5년 생존율은 상흉부가 26.5%로 중흉부와 하흉부 52.4%에 비해 낮았으나 통계적 유의성은 없었다. 결론: 이상의 결과로 식도 편평세포암 환자에서 Ivor-Lewis수술의 적용은 비교적 만족할 만한 결과를 얻었으며, 상흉부 식도암인 경우에는 통계적 유의성은 없었으나 중 하 흉부식도암에 비해 낮은 5년 생존율을 보여 3구역 림프절절제술로의 전환도 고려해야 할 것으로 생각된다.

• The Journal of Korean Physical Therapy
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• 제17권2호
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• pp.22-37
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• 2005

This study was performed to investigate LBP(low-back pain) prevalence rate and its related factors inphysical therapists. A self-administered questionnaire survey was conducted to 522 physical therapists in Daegu and Gyeongsangbuk. The LBP prevalence rate for recent 6 months was $61.7\%$. According to age, the prevalence rate was highest in the group aged 24 or less for both male and female physical therapistis. For male physical therapists , it was higher in smokers and drivers, but for female ones, it was not in a significant relationship with smoking and driving. According to work experience, the prevalence rates of those who had been working for less than one year were the highest, and those who had been working at hospitals and clinics were $69.1\%$, significantly high. According to therapy techinque, the prevalence rate related ti PNF was $71.6\%$, the highest and to occupational therapy was $34.3\%$, the lowest. According to working environment for six months, in both male and female physical therapists. LBP prevalence rate was in a statistically significant relationship with work hours during the day, night and weekend duties, repetitive works, motions that bend or twist the waist, the number of patients per day, the number of time to help patients per day, the number of time to carry medical equipment per day and the length of time to work standing. The rate was also higher when physical therapists fekt nire stress from their work. According to the result of multiple logistic regression analysis, male was in a significant relationship with work experience and motions that bend or twist the waist and female was in a significant relationship with work hours during the night and weekend duties, the number of time to help patients per day, motions that bena or twist the waist, actions taken to protect the waist. As for the developmental pattem of LBP in the group of physical therapists with LBP for six moths, $15.7\%$ of them had LBP for first time, $42.3\%$ had recurred LBP, and $42.0\%$ had chronic LBP. As for the causes of LBP, $51.7\%$ said that it was because they worked in the same posture for a long time, and as for how to treat LBP, 48.8% said that they treated themselvs or got help from their co-wokers. The results presented above suggest that physical therapists are exposed to high risk of LBP caused form occupational activities. Therefire, it is necessary to improve working environment to reduce the occurrence of LBP and to develop education programs for preventing the occurrence and recurrence of LBP.

• 대한골관절종양학회지
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• 제1권2호
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• pp.205-209
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• 1995

A desmoid tumor is a locally aggressive growth of connective tissue origin which infiltrates the surrounding tissue and has a marked tendency for recurrence. And so it was also called as an aggressive fibromatosis, musculofascial fibromatosis or fibrosarcoma etc. Thirteen cases of desmoid tumor was treated since 1980, and their retrospective study was done with 79 months of follow-up after initial surgical excision. The female was involved in 12 cases(one male) with the age ranged from 7-50 years, average 28 years, and seven patients in third decade. A slowly growing mass was excised on average 4 months after first notice of the mass, but their margins are not demarcated clearly in most cases. Wide excision in 12 cases was done, but wide excision and saphenous vein graft was performed in one case because of invasion of posterior tibial artery by tumor mass. The tumor was found on extraabdominal region in 8 cases(61.5%) but 5 cases in abdominal wall(38.5%). The recurrence rate was high(6/13, 46.2%), and 11 times in 6 patients were recurred(average 1.8 times), within 27 months of initial excision. Six cases of recurrence were treated with wide excision again in 3 cases, wide excision combined with radiotherapy(4,000-6,000cGy) in 4 cases and wide excision with chemotherapy in one case. During the follow-up for average 21 months after treatment, no recurrences are found. Tumor remission periods without recurrence are average 67 months in all, and 11 years in longest case. Histologically it was very mimic with fibrosarcoma but could be differentiated with Trichrome stain, and their findings are not changed after recurrence.

• Journal of Korean Neurosurgical Society
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• 제30권4호
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• pp.501-508
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• 2001

Objectives : Hemifacial spasm is painless uncommon disorder characterized by involuntary paroxysmal movement on one side of face. It is known that hemifacial spasm is mainly due to pulsatile compression by vessels at the root exit zone(REZ) of the facial nerve. Microvascular decompression at REZ of the facial nerve has become the standard treatment modality for hemifacial spasm. The authors have analized patients with hemifacial spasm treated with microvascular decompression to evaluate operation result and clinical course after operation. Patients and Methods : From 1992 to 1999, 41 patients with hemifacial spasm underwent this operation. Retrospective analysis of operation results and clinical recovery patterns was done. The length of observation had been more than 6 months in all cases. Results : The ratio of male to female was 1:1.4, and age at operation ranged from 24 to 66 years. Their mean age was 47.6 years and the mean preoperative duration of symptoms was 7.2 years. Most common offending vessels were AICA in 18 cases(48%) and second most common were PICA in 13 cases(31.7%). The rest of them were 3 case in vertebral artery, and 7 cases(13%) in multiple offending vessels. Patterns of improvement after surgery could be divided into 4 clinical types. There was complete recovery in 3 days after operation in 24 cases(58.6%, Immediate complete recovery). There was complete recovery in 3 days after operation, and symptom was recurred partially, which was gradually subsided in 2 weeks after operation in 4 cases(9.8%, Delayed complete recovery type I). There was partial recovery after operation and symptom was compretely disappeared gradually in 6 months after operation in 7 cases(17.1%, Delayed complete recovery type II). Finally, there was partial recovery after operation, and symptom was somewhat remained after 6 months later(14.5%, Delayed partial recovery). Conclusion : In conclusion, microvascular decompression for hemifacial spasm is a safe and reliable treatment modality with good results of improvement and there are 4 recovery patterns in clinical course after operation in our series. Therefore, follow-up observation after microvascular decompression is necessary to evaluate the operative results and complication, especially in the delayed resolved cases.

• Journal of Korean Neurosurgical Society
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• 제30권4호
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• pp.522-527
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• 2001

37세 남자 환자로 경련발작을 주소로 본원에 내원하였고, 조직검사상 뇌실외 신경세포종으로 진단 받았으며, 방사선 치료를 받고 퇴원하였다. 11년후 언어장애, 우측 편마비를 주소로 다시 내원 하였다. 뇌 전산화 단층촬영과 뇌 자기공명영상에서 좌측 두정엽과 측두엽에 종양 크기의 증가, 뇌부종 및 석회화가 동반된 소견을 보여 종양 절제술을 시행 받았다. 조직검사상에서 1987년 처음 입원 시에는 투명세포질을 가진 작은 원형세포와 원섬유가 풍부하고 가유두상 양상을 보이는 중심 신경세포종으로 진단되었다. 그러나, 1998년 두 번째 조직 검사상에서 대부분의 종양세포는 심한 이형성을 보이는 신경교세포로 구성되었으며, 유사분열, 다형성핵 등이 관찰되었고, 면역염색상 glial fibrillary acidic protein에서 양성을 보였다. 일부에서는 작고 둥근 세포들의 군집이 보였으며, synaptophysin에 양성을 보였다. 중심 신경세포종은 젊은 성인에서 호발하고 주로 측뇌실이나 제 3 뇌실의 몬로공 주위에서 발생하는 비교적 드문 종양으로, 신경교 분화를 보이는 경우는 있으나 악성분화를 보이는 경우와 뇌실외 발생은 드물다. 본 교실에서는 11년전 중심 신경세포 종으로 진단 받은 후 악성 신경교 분화를 보이는 뇌실외 신경세포종을 경험하였기에 보고한다.

• Journal of Korean Neurosurgical Society
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• 제29권2호
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• pp.222-230
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• 2000

Purpose : Resection of the epileptogenic zone in the parietal and occipital lobes may be relevant although only few studies have been reported. Methods : Eight patients with parietal epilepsy and nine patients with occipital epilepsy were included for this study. Preoperatively, all had video-EEG monitoring with extracranial electrodes, MRI, 3D-surface rendering of MRI using Allegro(ISG Technologies Inc., Toronto, Canada), and PET scans. Sixteen patients underwent invasive recording with subdural grid. Eight had parietal resection including the sensory cortex in two. Seven had partial occipital resection. Two underwent total unilateral occipital lobectomy. The extent of the resection was made based mainly on the data of invasive EEG recordings, MRI, and 3D-surface rendering of MRI, not on the intraoperative electrocorticographic findings as usually done. During resection, electrocortical stimulation was performed on the motor cortex and speech area. Results : Out of eight patients with parietal epilepsy, three had sensory aura, two had gustatory aura, and two had visual aura. Six of nine patients with occipital epilepsy had visual auras. All had complex partial seizures with lateralizing signs in 15 patients. Four had quadrantopsia. One had mild right hemiparesis. Abnormality in MRI was noticed in six out of eight parietal epilepsy and in eight out of nine occipital epilepsy. 3D-surface rendering of MRI visualized volumetric abnormality with geometric spatial relationships adjacent to the normal brain, in all of parietal and occipital epilepsy. Surface EEG recording was not reliable in localizing the epileptogenic zone in any patient. The subdural grid electrodes can be implanted on the core of the structural abnormality in 3D-reconstructed brain. Ictal onset zone was localized accurately by subdural grid EEGs in 16 patients. Motor cortex in nine and sensory speech area in two were identified by electrocortical stimulation. Histopathologic findings revealed cortical dysplasia in 10 patients ; tuberous sclerosis was combined in two, hamartoma and ganglioglioma in one each, and subpial gliosis in six. Eleven patients were seizure free at follow-up of 6 months to 37 months(mean 19.7 months) after surgery. Seizures recurred in two and were unchanged in one. Six produced transient sensory loss and one developed hemiparesis and tactile agnosia. One revealed transient apraxia. Two patients with preoperative quadrantopsia developed homonymous hemianopsia. Conclusion : This study suggests that surgical treatment was relevant in parietal and occipital epilepsies with good surgical outcome, without significant neurologic sequelae. Neuroimaging studies including conventional MRI, 3Dsurface rendering of MRI were necessary in identifying the epileptogenic zone. In particular, 3D-surface rendering of MRI was very helpful in presuming the epileptogenic zone in patients with unidentifiable lesion in the conventional MRI, in planning surgical approach to lesions, and also in making a decision of the extent of the epileptogenic zone in patients with identifiable lesion in conventional MRI. Invasive EEG recording with the subdural grid electrodes helped to confirm a core of the epileptogenic zone which was revealed in 3D-surface rendered brain.