• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2883-2887
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• 2015

Background: The calcium-binding S100A4 protein is involved in epithelial to mesenchymal transition, oncogenic transformation, angiogenesis, cytoskeletal integrity, mobility and metastasis of cancer cells. This study aimed to clarify the roles of S100A4 in genesis and progression of glioma. Materials and Methods: S100A4 expression was examined by real-time RT-CPR and Western blot in glioma and paired normal brain tissue (n=69), and compared with clinicopathological parameters of tumors. In addition, glioma U251 cells transfected with an S100A4-expressing plasmid were examined for proliferation by MTT, apoptosis by Annexin V-FITC, and migration and invasion with Transwell chambers. Results: Increased S100A4 mRNA expression was found in gliomas, compared with paired non-tumor tissue (p<0.001). Gradual elevation of overexpression of S100A4 was observed with increasing glioma grade (p<0.001). Astrocytoma showed lower S100A4 mRNA expression than oligodendrogliomas, with glioblastomas having highest values (p<0.001). Similar results were obtained for S100A4 protein, a positive link being found between mRNA and protein expression in gliomas (p<0.001). There was higher growth, lower apoptosis, stronger migration and invasion of S100A4 transfectants than control and mock transfected cells (p<0.001). Conclusions: These findings indicate that up-regulated S100A4 expression is positively linked to pathogenesis, progression and histogenesis of glioma by modulating proliferation, apoptosis, migration and invasion.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.25 no.2
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• pp.88-97
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• 2016

Aesthetics can be affected by the interest and the trend of the time. There are the limits of the equipment and materials required for the times, aesthetic case is also considered necessary to overcome them and will introduce the following case in accordance with the patients demands and circumstances. I hope the further development of CAD/CAM by taking over the things have done in the analogue by utilizing the latest technology that is thought to challenge the current limit itself is important. Digital has the advantages in various perspectives. Especially, I am very interested in as related to "digital communication." In particular, when utilizing the data using intra oral scanner can easily direct converse about prosthesis between the dentist and the dental technician through a software program Now, as the digital communication affects the integrity of the prosthesis directly, I had a expectation of a new era for the prosthetic and aesthetics. In this case report, I would like to introduce direct and real digital communication through the following 2 parts.

• Journal of the Korean Society for Nondestructive Testing
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• v.31 no.1
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• pp.68-76
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• 2011

Acoustic emission(AE) has emerged as a powerful nondestructive tool to detect any further growth or expansion of preexisting defects or to characterize failure mechanisms. Recently, this kind of technique, that is an in-situ monitoring of inside damages of materials or structures, becomes increasingly popular for monitoring the integrity of large structures like a huge wind turbine blade. Therefore, it is required to find a symptom of damage propagation before catastrophic failure through a continuous monitoring. In this study, a new damage location method has been proposed by using signal mapping algorithm, and an experimental verification is conducted by using small wind turbine blade specimen; a part of 750 kW real blade. The results show that this new signal mapping method has high advantages such as a flexibility for sensor location, improved accuracy, high detectability. The newly proposed method was compared with traditional AE source location method based on arrival time difference.

• Membrane and Water Treatment
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• v.1 no.2
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• pp.121-137
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• 2010

This work presents inexpensive inorganic precursor formulations to yield submicron range symmetric ceramic microfiltration (MF) membranes whose average pore sizes were between 0.1 and $0.4{\mu}m$. Incidentally, the sintering temperature used in this work was about 800 to $950^{\circ}C$ instead of higher sintering temperatures ($1100^{\circ}C$) that are usually deployed for membrane fabrication. Thermogravimetric (TGA) and X-Ray diffraction (XRD) analysis were carried out to evaluate the effect of temperature on various phase transformations during sintering process. The effect of sintering temperature on structural integrity of the membrane as well as pore size distribution and average pore size were evaluated using scanning electron microscopy (SEM) analysis. The average pore sizes of the membranes were increased from 0.185 to $0.332{\mu}m$ with an increase in sintering temperature from 800 to $950^{\circ}C$. However, a subsequent reduction in membrane porosity (from 34.4 to 19.6%) was observed for these membranes. Permeation experiments with both water and air were carried out to evaluate various membrane morphological parameters such as hydraulic pore diameter, hydraulic permeability, air permeance and effective porosity. Later, the membrane prepared with a sintering temperature of $950^{\circ}C$ was tested for the treatment of synthetic oily waste water to verify its real time applicability. The membrane exhibited 98.8% oil rejection efficiency and $5.36{\times}10^{-6}\;m^3/m^2.s$ permeate flux after 60 minutes of experimental run at 68.95 kPa trans-membrane pressure and 250 mg/L oil concentration. Based on retail and bulk prices of the inorganic precursors, the membrane cost was estimated to be $220 /$m^2$ and $1.53 /$m^2$, respectively.

• Geomechanics and Engineering
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• v.23 no.5
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• pp.441-454
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• 2020

The tunnel collapse, large deformation of surrounding rock, water and mud inrush are the major geological disasters in soft rock tunnel construction. Among them, tunnel collapse has the most serious impact on tunnel construction. Current research backed theories have certain limitations in identifying the collapse risk of soft rock tunnels. Examining the Zhengwan high-speed railway tunnel, eight soft rock tunnel collapse influencing factors were selected, and the combination of indicator weights based on the analytic hierarchy process and entropy weighting methods was obtained. The results show that the groundwater condition and the integrity of the rock mass are the main influencing factors leading to a soft rock tunnel collapse. A comprehensive fuzzy evaluation model for the collapse risk of soft rock tunnels is being proposed, and the real-time collapse risk assessment of the Zhengwan tunnel is being carried out. The results obtained via the fuzzy evaluation model agree well with the actual situation. A tunnel section evaluated to have an extremely high collapse risk and experienced a local collapse during excavation, verifying the feasibility of the collapse risk evaluation model. The collapse risk evaluation model proposed in this paper has been demonstrated to be a promising and innovative method for the evaluation of the collapse risk of soft rock tunnels, leading to safer construction.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.5
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• pp.836-842
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• 2016

When an accident occurs in the nuclear power plant, the faulted information might mislead to the high possibility of aggravating the accident. At the Fukushima accident, the operators misunderstood that there was no core exposure despite in the processing of core damage, because the instrument information of the reactor water level was provided to the operators optimistically other than the actual situation. Thus, this misunderstanding actually caused to much confusions on the rapid countermeasure on the accident, and then resulted in multiplying the accident propagation. It is necessary to be equipped with the function that informs operators the status of instrument integrity in real time. If plant operators verify that the instruments are working properly during accident conditions, they are able to make a decision more safely. In this study, we have performed various tests for the fault detection sensitivity of an data-driven empirical model to review the usability of the model in the accident conditions. The test was performed by using simulation data from the compact nuclear simulator that is numerically simulated to PWR type nuclear power plant. As a result of the test, the proposed model has shown good performance for detecting the specified instrument faults during normal plant conditions. Although the instrument fault detection sensitivity during plant accident conditions is lower than that during normal condition, the data-drive empirical model can be detected an instrument fault during early stage of plant accidents.

• Mycobiology
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• v.45 no.4
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• pp.362-369
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• 2017

We assessed the regulation of cryparin, a class II hydrophobin, using three representative mitogen-activated protein kinase (MAPK) pathways in Cryphonectria parasitica. Mutation of the CpSlt2 gene, an ortholog of yeast SLT2 in the cell wall integrity (CWI) pathway, resulted in a dramatic decrease in cryparin production. Similarly, a mutant of the CpBck1 gene, a MAP kinase kinase kinase gene in the CWI pathway, showed decreased cryparin production. Additionally, mutation of the cpmk1 gene, an ortholog of yeast HOG1, showed decreased cryparin production. However, mutation of the cpmk2 gene, an ortholog of yeast Kss1/Fus3, showed increased cryparin production. The easy-wet phenotype and accumulation of the cryparin transcript in corresponding mutants were consistent with the cryparin production results. In silico analysis of the promoter region of the cryparin gene revealed the presence of binding motifs related to downstream transcription factors of CWI, HOG1, and pheromone responsive pathways including MADS-box- and Ste12-binding domains. Real-time reverse transcriptase PCR analyses indicated that both CpRlm1, an ortholog of yeast RLM1 in the CWI pathway, and cpst12, an ortholog of yeast STE12 in the mating pathway, showed significantly reduced transcription levels in the mutant strains showing lower cryparin production in C. prasitica. However, the transcription of CpMcm1, an ortholog of yeast MCM1, did not correlate with that of the mutant strains showing downregulation of cryparin. These results indicate that three representative MAPK pathways played a role in regulating cryparin production. However, regulation varied depending on the MAPK pathways: the CWI and HOG1 pathways were stimulatory, whereas the pheromone-responsive MAPK was repressive.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.29 no.1
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• pp.5-16
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• 2019

Modern state-of-the-art military aviation assets are operated with independent embedded real-time operating systems(RTOS). These embedded systems are made with a high level of information assurance. However, once the systems are introduced and installed on individual platforms for sustaining operational employment, the systems are not actively managed and as a result the platforms become exposed to serious threats. In this paper, we analyzed vulnerability factors in the processing of mission planning data and maintenance-related data for fighter aircraft. We defined the method and form of cyber attacks that modulate air data using these vulnerabilities. We then proposed a detection module for integrity detection. The designed module can preemptively respond to potential cyber threats targeting high - value aviation assets by checking and preemptively responding to malware infection during flight data processing of fighter aircraft.

• Journal of Radiation Protection and Research
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• v.43 no.4
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• pp.154-159
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• 2018

Background: To prevent small leakage accidents, a real-time and direct detection system for small leaks with a detection limit below that of existing systems, e.g. $0.5gpm{\cdot}hr^{-1}$, is required. In this study, a small-size beta detector, which can be installed inside the reactor containment (CT) building and detect small leaks directly, was suggested and its feasibility was evaluated using MCNPX simulation. Materials and Methods: A target nuclide was selected through analysis of radiation from radionuclides in the reactor coolant system (RCS) and the spectrum was obtained via a silicon detector simulated in MCNPX. A window was designed to reduce the background signal caused by other nuclides. The sensitivity of the detector was also estimated, and its shielding designed for installation inside the reactor CT. Results and Discussion: The beta and gamma spectrum of the silicon detector showed a negligible gamma signal but it also contained an undesired peak at 0.22 MeV due to other nuclides, not the $^{16}N$ target nuclide. Window to remove the peak was derived as 0.4 mm for beryllium. The sensitivity of silicon beta detector with a beryllium window of 1.7 mm thickness was derived as $5.172{\times}10^{-6}{\mu}Ci{\cdot}cc^{-1}$. In addition, the specification of the shielding was evaluated through simulations, and the results showed that the integrity of the silicon detector can be maintained with lead shielding of 3 cm (<15 kg). This is a very small amount compared to the specifications of the lead shielding (600 kg) required for installation of $^{16}N$ gamma detector in inside reactor CT, it was determined that beta detector would have a distinct advantage in terms of miniaturization. Conclusion: The feasibility of the beta detector was evaluated for installation inside the reactor CT to detect small leaks below $0.5gpm{\cdot}hr^{-1}$. In future, the design will be optimized on specific data.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.05a
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• pp.571-573
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• 2014

In today's technology streaming service's QoS technologiey is an issue. On quality video streaming service there are some technical issues exist, such as buffering. This submission is "Adaptive dual-streaming system design" which is for the integrity of the data streaming that is sent to TCP and UDP for faster transmission of data to the stream. This system provides real-time incoming video encoding in bitrate of h.264-based H through a process based on the video footage of several server and client-to-TCP and UDP via Adaptive providing streaming services in a network environment. This is an unspecified number of buffers in a network environment and continued through the minimization of various streaming for playback of videos and multimedia will be utilized in the field.