• The Journal of Information Systems
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• v.31 no.1
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• pp.147-173
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• 2022

Purpose As the use of social network services has become common, it has become possible to freely communicate and establish relationships with other people anytime, anywhere for communication and information sharing. Influencers who have a strong influence on consumers' perceptions and attitudes through their own opinions and stories have appeared on various social media channels such as YouTube. Recently, companies utilize influencers with a large number of followers to check interactions with customers to understand customer attitudes and opinions about products in real time. Start-ups with insufficient resources need to quickly examine customer responses to reduce the probability of failure after product planning. The Lean process of creating an MVP and quickly confirming and learning the market response should be repeated over and over again. Findings In this paper, we try to suggest that the YouTube platform can play a sufficient role as a customer experiment space through examples. The case company is a company that has successfully commercialized products by continuously interacting with customers through the YouTube platform for the first four months of its founding. This paper is expected to be helpful in the experimental process for prospective founders and early founders to examine customer responses to reduce the probability of market failure before commercialization. Design/methodology/approach This paper analyzed the YouTube channel data of case companies based on the netnography methodology and presented the contents of the lean process management carried out in the experimental stage and the post-production stage through interview research.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.6
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• pp.850-858
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• 2022

To deploy Gate Recurrent Units (GRU) on resource-constrained embedded devices, this paper presents a reconfigurable FPGA-based GRU accelerator that enables structured compression. Firstly, a dense GRU model is significantly reduced in size by hybrid quantization and structured top-k pruning. Secondly, the energy consumption on external memory access is greatly reduced by the proposed reuse computing pattern. Finally, the accelerator can handle a structured sparse model that benefits from the algorithm-hardware co-design workflows. Moreover, inference tasks can be flexibly performed using all functional dimensions, sequence length, and number of layers. Implemented on the Intel DE1-SoC FPGA, the proposed accelerator achieves 45.01 GOPs in a structured sparse GRU network without batching. Compared to the implementation of CPU and GPU, low-cost FPGA accelerator achieves 57 and 30x improvements in latency, 300 and 23.44x improvements in energy efficiency, respectively. Thus, the proposed accelerator is utilized as an early study of real-time embedded applications, demonstrating the potential for further development in the future.

• Journal of Korean Neurosurgical Society
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• v.65 no.2
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• pp.236-244
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• 2022

Objective : To evaluate the interactions among differentially expressed autophagy and mitophagy markers in subarachnoid hemorrhage (SAH) patients with delayed cerebral ischemia (DCI). Methods : The expression data of autophagy and mitophagy-related makers in the cerebrospinal fluid (CSF) cells was analyzed by real-time reverse transcription-polymerase chain reaction and Western blotting. The markers included death-associated protein kinase (DAPK)-1, BCL2 interacting protein 3 like (BNIP3L), Bcl-1 antagonist X, phosphatase and tensin homolog-induced kinase (PINK), Unc-51 like autophagy activating kinase 1, nuclear dot protein 52, and p62. In silico functional analyses including gene ontology enrichment and the protein-protein interaction network were performed. Results : A total of 56 SAH patients were included and 22 (38.6%) of them experienced DCI. The DCI patients had significantly increased mRNA levels of DAPK1, BNIP3L, and PINK1, and increased expression of BECN1 compared to the non-DCI patients. The most enriched biological process was the positive regulation of autophagy, followed by the response to mitochondrial depolarization. The molecular functions ubiquitin-like protein ligase binding and ubiquitin-protein ligase binding were enriched. In the cluster of cellular components, Lewy bodies and the phagophore assembly site were enriched. BECN1 was the most connected gene among the differentially expressed markers related to autophagy and mitophagy in the development of DCI. Conclusion : Our study may provide novel insight into mitochondrial dysfunction in DCI pathogenesis.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.32 no.3
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• pp.547-554
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• 2022

Recently, the field of telemedicine is growing rapidly due to the COVID-19 pandemic. However, the cost of telemedicine services is relatively high, since cloud computing, video conferencing, and cyber security should be considered. Therefore, in this paper, we design and implement a cost-effective P2P-based telemedicine system. It is implemented using the widely used the open source computing platform, Raspberry Pi, and P2P network that frees users from security problems such as the privacy leakage by the central server and DDoS attacks resulting from the server/client architecture and enables trustworthy identifying connection system using SSL protocol. Also it enables users to check the other party's status including body temperature in real time by installing a thermal imaging camera using Raspberry Pi. This allows several medical diagnoses that requires visual aids. The proposed telemedicine system will popularize telemedicine service and meet the ever-increasing demand for telemedicine.

• Biomolecules & Therapeutics
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• v.30 no.3
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• pp.238-245
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• 2022

Previous reports have demonstrated that genetic mechanisms greatly mediate responses to drugs of abuse, including methamphetamine (METH). The circadian gene Period 2 (Per2) has been previously associated with differential responses towards METH in mice. While the behavioral consequences of eliminating Per2 have been illustrated previously, Per2 overexpression has not yet been comprehensively described; although, Per2-overexpressing (Per2 OE) mice previously showed reduced sensitivity towards METH-induced addiction-like behaviors. To further elucidate this distinct behavior of Per2 OE mice to METH, we identified possible candidate biomarkers by determining striatal differentially expressed genes (DEGs) in both drug-naïve and METH-treated Per2 OE mice relative to wild-type (WT), through RNA sequencing. Of the several DEGs in drug naïve Per2 OE mice, we identified six genes that were altered after repeated METH treatment in WT mice, but not in Per2 OE mice. These results, validated by quantitative real-time polymerase chain reaction, could suggest that the identified DEGs might underlie the previously reported weaker METH-induced responses of Per2 OE mice compared to WT. Gene network analysis also revealed that Asic3, Hba-a1, and Rnf17 are possibly associated with Per2 through physical interactions and predicted correlations, and might potentially participate in addiction. Inhibiting the functional protein of Asic3 prior to METH administration resulted in the partial reduction of METH-induced conditioned place preference in WT mice, supporting a possible involvement of Asic3 in METH-induced reward. Although encouraging further investigations, our findings suggest that these DEGs, including Asic3, may play significant roles in the lower sensitivity of Per2 OE mice to METH.

• Journal of Veterinary Science
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• v.23 no.4
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• pp.56.1-56.17
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• 2022

Background: At the therapeutic doses, diclofenac sodium (DFS) has few toxic side effects on mammals. On the other hand, DFS exhibits potent toxicity against birds and the mechanisms remain ambiguous. Objectives: This paper was designed to probe the toxicity of DFS exposure on the hepatic proteome of broiler chickens. Methods: Twenty 30-day-old broiler chickens were randomized evenly into two groups (n = 10). DFS was administered orally at 10mg/kg body weight in group A, while the chickens in group B were perfused with saline as a control. Histopathological observations, serum biochemical examinations, and quantitative real-time polymerase chain reaction were performed to assess the liver injury induced by DFS. Proteomics analysis of the liver samples was conducted using isobaric tags for relative and absolute quantification (iTRAQ) technology. Results: Ultimately, 201 differentially expressed proteins (DEPs) were obtained, of which 47 were up regulated, and 154 were down regulated. The Gene Ontology classification and Kyoto Encyclopedia of Genes and Genomes pathway analysis were conducted to screen target DEPs associated with DFS hepatotoxicity. The regulatory relationships between DEPs and signaling pathways were embodied via a protein-protein interaction network. The results showed that the DEPs enriched in multiple pathways, which might be related to the hepatotoxicity of DFS, were "protein processing in endoplasmic reticulum," "retinol metabolism," and "glycine, serine, and threonine metabolism." Conclusions: The hepatotoxicity of DFS on broiler chickens might be achieved by inducing the apoptosis of hepatocytes and affecting the metabolism of retinol and purine. The present study could provide molecular insights into the hepatotoxicity of DFS on broiler chickens.

• Journal of Biomedical Engineering Research
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• v.43 no.5
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• pp.361-368
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• 2022

The purpose of this study was to develop a hand rehabilitation training system for hemiplegic patients. We also tried to find out five hand postures (WF: Wrist Flexion, WE: Wrist Extension, BG: Ball Grip, HG: Hook Grip, RE: Rest) in real-time using multi-channel EMG-based deep learning. We performed a pre-processing method that converts to Spider Chart image data for the classification of hand movement from five test subjects (total 1,500 data sets) using Convolution Neural Networks (CNN) deep learning with an 8-channel armband. As a result of this study, the recognition accuracy was 92% for WF, 94% for WE, 76% for BG, 82% for HG, and 88% for RE. Also, ten physical therapists participated for the usability evaluation. The questionnaire consisted of 7 items of acceptance, interest, and satisfaction, and the mean and standard deviation were calculated by dividing each into a 5-point scale. As a result, high scores were obtained in immersion and interest in game (4.6±0.43), convenience of the device (4.9±0.30), and satisfaction after treatment (4.1±0.48). On the other hand, Conformity of intention for treatment (3.90±0.49) was relatively low. This is thought to be because the game play may be difficult depending on the degree of spasticity of the hemiplegic patient, and compensation may occur in patient with weakened target muscles. Therefore, it is necessary to develop a rehabilitation program suitable for the degree of disability of the patient.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.22 no.5
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• pp.17-22
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• 2022

In this paper, we design a lightweight embedded device that can support intelligent edge computing, and show that the device quickly detects an object in an image input from a camera device in real time. The proposed system can be applied to environments without pre-installed infrastructure, such as an intelligent video control system for industrial sites or military areas, or video security systems mounted on autonomous vehicles such as drones. The On-Device AI(Artificial intelligence) technology is increasingly required for the widespread application of intelligent vision recognition systems. Computing offloading from an image data acquisition device to a nearby edge device enables fast service with less network and system resources than AI services performed in the cloud. In addition, it is expected to be safely applied to various industries as it can reduce the attack surface vulnerable to various hacking attacks and minimize the disclosure of sensitive data.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.10
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• pp.1447-1452
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• 2022

Seoul Special City, one of the world's top 10 cities and Metro City, has traditional urban manufacturing industries such as printing, sewing, and mechanical metals. Small business owners in these manufacturing clusters have developed in the form of mutual assistance. Due to the nature of the agglomeration site, each process is handled by an individual company. It is difficult for relatively small business owners to prepare order processing services that provide real-time logistics movement information between processes. This paper collects and analyzes existing logistics data for smooth order and delivery of small business owners in package manufacturing and special printing fields We design an artificial intelligence Fulfillment Service Platform system with CRNN, k-NN, and ID3 Decision Tree Algorithm. Through this study, it is expected that it will greatly contribute to increasing sales and improving capabilities by allowing small business owners in integrated areas to use individual orders and delivery customized services through the Cloud network.

• International Journal of Advanced Culture Technology
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• v.10 no.3
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• pp.146-155
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• 2022

The purpose of this study is to investigate the recyclability of Shenlong in China using SWOT. The main analysis results are as follows. First, provided that the company's current capacity utilization rate is seriously insufficient, reducing staff is one among the effective ways. Second, Shenlong should open a web store to cater to young people's online shopping behavior, and further expand the brand visibility using national mainstream media and online shopping platforms like Taobao and JingDong to market Dongfeng Peugeot and Dongfeng Citroen on the whole network. Third, under the premise of maintaining the present best-selling models, Shenlong should appropriately reduce the amount of models, adjust the assembly capacity ratio of every model and every displacement in real time per the newest market trends, increase the agility of auto companies' production, and timely meet the wants of domestic consumers. Fourth, dual-brand coordination and channel integration are very necessary, and also the profitability and profitability of dealers are going to be further improved, thereby increasing sales. Fifth, target building new energy leading products of Shenlong, strive to attain the forefront of the industry within the sales of recent energy vehicles within 5 years, and gradually expand new energy vehicle products from passenger vehicles to passenger vehicles and commercial vehicles. Finally, the marketing field of Shenlong Automobile should achieve "three major changes", that is, change from a goal-driven type to a demand-driven type, cancel the bundling of outlet invoicing goals and delivery incentive tiers; start from basic capabilities, and set pragmatic and challenging goals; focus Channels, to realize following the activation of outlets, and single store sales increase.