• IMMUNE NETWORK
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• v.5 no.4
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• pp.205-214
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• 2005

Background: We examined global gene expression profiles of peripheral blood mononuclear cells (PBMCs) in patients with ulcerative colitis (DC), and tested whether the identified genes with the altered expression might be associated with susceptibility to UC. Methods: PBMCs from 8 UC and 8 normal healthy (NH) volunteers were collected, and total RNAs were subjected to the human 8.0K cDNA chip for the micro array analysis. Real time-PCR (RT-PCR) was performed to verify the results of micro array. One hundred forty UC patients and 300 NH controls were recruited for single nucleotide polymorphism (SNP) analysis. Results: Twenty-five immune function-related genes with over 2-fold expression were identified. Of these genes, two chemokines, namely, CXCL1 and CCL20, were selected because of their potential importance in the evocation of host innate and adaptive immunity. Four SNPs were identified in the promoter and coding regions of CXCL1, while there was no significant difference between all patients with UC and controls in their polymorphisms, except minor association at g.57A>G (rs2071425, p=0.02). On the other hand, among three novel and one known SNPs identified in the promoter region of CCL20, g. -1,706 G>A (p=0.000000055), g. -1,458 G>A (p=0.0048), and g. -962C>A (p=0.0006) were found to be significantly associated with the susceptibility of Uc. Conclusion: Altered gene expression in mononuclear cells may contribute to IBD pathogenesis. Although the findings need to be confirmed in other populations with larger numbers of patients, the current results demonstrated that polymorphisms in the promoter region of CCL20 are positively associated with the development of Uc.

• IMMUNE NETWORK
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• v.9 no.2
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• pp.64-73
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• 2009

Background: 15d-$PGJ_2$ has been known to act as an anti-inflammatory agent and has anti-hypertensive effects. As a result of these properties, we examined the effect of 15d-$PGJ_2$ on the LPS-induced IL-8/CXCL8 mRNA expression in VSMCs from SHR. Methods: Effect and action mechanism of 15d-$PGJ_2$ on the expression of LPS-induced IL-8/CXCL8 mRNA in VSMCs from SHR and WKY were examined by using real-time polymerase chain reaction, electrophoretic mobility shift assay for NF-${\kappa}B$ avtivity, Western blotting analysis for ERK and p38 phosphorylation and flow cytometry for NAD(P)H oxidase activity. Results: 15d-$PGJ_2$ decreased the expression of LPS-induced IL-8/CXCL8 mRNA in WKY VSMCs, but increased the expression of LPS-induced IL-8/CXCL8 mRNA in SHR VSMCs. The upregulatory effect of 15d-$PGJ_2$ in SHR VSMCs was mediated through PPAR${\gamma}$, and dependent on NF-${\kappa}B$ activation and ERK phosphorylation. However, inhibition of the p38 signaling pathway augmented the upregulatory effect of 15d-$PGJ_2$ on LPS-induced IL-8/CXCL8 mRNA. A NAD(P)H oxidase inhibitor inhibited the upregulatory effect of 15d-$PGJ_2$ on LPS-induced IL-8/CXCL8 mRNA expression in SHR VSMCs, and an increase in NAD(P)H oxidase activity was detected in SHR VSMCs treated with 15d-$PGJ_2$/LPS. Conclusion: Our results indicate that the upregulatory effect of 15d-$PGJ_2$ on LPS-induced IL-8/CXCL8 expression in SHR VSMCs is mediated through the PPAR${\gamma}$ and ERK pathway, and may be related to NAD(P)H oxidase activity. However, p38 inactivation may also play an important role in 15d-$PGJ_2$/LPS-induced IL-8/CXCL8 expression in SHR VSMCs.

• Journal of the Earthquake Engineering Society of Korea
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• v.16 no.1
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• pp.37-45
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• 2012

In an effort to further exploit the peak ground-motion acceleration (PGA) information per second available in real time by the enacted law, bracketed summations of the PGA per second ($BSPGA_k$) for 30 seconds based on the records with a rate of 100 samples were compared with the cumulative absolute velocity (CAV) and earthquake intensities based on a worldwide database of records from small-to-large earthquakes. The CAV, currently in use as an earthquake damage indicator for nuclear power plants due to its strong correlation with the earthquake intensity, has the disadvantage of requiring a massive amount of digital data with a rate of more than 100 samples per second. The comparative study shows that the $BSPGA_k$ is well correlated with the CAV over the wide range of strong ground-motion levels, which suggests that the $BSPGA_k$ is one of the new promising ground-motion parameters especially useful for rapid earthquake alert notifications through an earthquake monitoring network. Based on the domestic database of records from small-to-moderate earthquakes with felt reports, it is also observed that the $BSPGA_k$ is comparable to the CAV and better than the PGA in predicting the intensity by using the correlation relation.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.1
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• pp.71-78
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• 2018

Transportation is gradually changing into the era of V2X and autonomous cars. Accurate judgement of traffic conditions is an important indicator of route choice or autonomous driving. There are many ways to use probes car such as taxis, as a way to identify accurate traffic conditions. These methods may vary depending on the characteristics of the probe vehicle, and there is a problem with the cost. The V2X vehicle can solve these problems and collect traffic information in real time. If all vehicles are of V2X vehicle, these issues are expected to be resolved briefly. However, if the communication information of a V2X vehicle is represented by a traffic representative in a traffic with only V2X, the traffic information of some V2X vehicles will be able to collect traffic information. To accomplish this, a virtual network and transport were created and various scenarios were performed through SUMO simulations. It has been analyzed that 3-5 % of V2 vehicles are capable of representative the road traffic characteristics. In the future, various follow-up studies are planned.

• Journal of Digital Contents Society
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• v.15 no.4
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• pp.513-520
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• 2014

The Smart Grid is next-generation power system materialized Convergence and Integration of power technologies and Information Technologies. And this system is the next generation power system optimizing energy efficiency via real-time information exchanges grafting the information technologies upon present power networks which are web-net. The introduction of smart grid can be embodied for latitude, distributed and cooperated network by inter-active exchange of energy information between electrical power provider and consumer previous uni-directional electrical power supplement. Therefore in this paper, we proposed Convergence technologies - Smart power grid, Smart Place, Smart Renewable and Smart Electricity Service - to make smart-grid succeed via analyzing the datum. And we scoped on Convergence and Integration technologies, which could be used for smart-power-grid that is most important factor to replace previous power industries. And we brought out the expecting industrialize timing and interesting aspects and analyzed the result with survey of professional worker from institute, research center, power plant and business of power industries. And proposed the essential policies for the government and power-control-business companies based on the datum and survey output.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.12
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• pp.277-284
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• 2013

The analysis of phase synchronization characteristics from EEG signals is important for the understanding of information processing functionality in the brain network. In this paper, wavelet transformation(WT), Hilbert tansformation (HT), complex demodulation (CD) methods having time localization characteristics were applied to real evoked potential data and noise added simulation data with center frequencies corresponding to EEG bands for the estimation performance analysis of phase offset, phase changing point, and interband crosstalk. The WT is the best both in ${\delta}$, ${\theta}$, and ${\alpha}$ band signal decomposition, and in analyzing phase synchronization performance. The CD can be efficiently used in changing point detection under tolerant noise condition because of its abrupt performance degradation over noise endurance level. From experimental observations, the WT is the most suitable in phase synchronization application of EEG signal, and the CD can be affordable in restricted application such as changing point detection for higher bands than ${\delta}$. Particularly, WT and CD can be used to detect the changing instant of brain function by indirectly estimating the phase changing point.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.16 no.5
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• pp.39-48
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• 2016

One of the major trends of automotive networking architecture is the introduction of automotive Ethernet. Ethernet is already used in single automotive applications (e.g. to connect high-data-rate sources as video cameras), it is expected that the ongoing standardization at IEEE (IEEE802.3bw - 100BASE-T1, respectively IEEE P802.3bp - 1000BASE-T1) will lead to a much broader adoption in future. Those applications will not be limited to simple point-to-point connections, but may affect Electric/Electronic(EE) Architectures as a whole. It is agreed that IP based traffic via Ethernet could be secured by application of well-established IP security protocols (e.g., IPSec, TLS) combined with additional components like, e.g., automotive firewall or IDS. In the case of safety and real-time related applications on resource constraint devices, the IP based communication is not the favorite option to be used with complicated and performance demanding TLS or IPSec. Those applications will be foreseeable incorporate Layer-2 based communication protocols as, e.g., currently standardized at IEEE[13]. The present paper reflects the state-of-the-art communication concepts with respect to security and identifies architectural challenges and potential solutions for future Ethernet Switch-based EE-Architectures. It also gives an overview and provide insights into the ongoing security relevant standardization activities concerning automotive Ethernet. Furthermore, the properties of non-automotive Ethernet security mechanisms as, e.g., IEEE 802.1AE aka. MACsec or 802.1X Port-based Network Access Control, will be evaluated and the applicability for automotive applications will be assessed.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.16 no.5
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• pp.137-142
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• 2016

A two-step open system(TOS) was proposed to relay between a healing platform and a repository of personal health documents. TOS was designed by taking into consideration the pubsub service based on large scale connections to monitor a provider's access/request process for health documents in real time. TOS, however, uses WebSocket as a communication protocol in case of pubsub. Given the operational environment of low quality wireless networks for mobile devices that are user terminals in a healing platform, there is a need to add a messaging protocol to support QoS as well as a transmission protocol. As a light messaging protocol optimized for mobile devices, MQTT defines reliable messaging QoS to consider a wireless network situation of low speed/low quality. This study designed an MQTT protocol-based message broker to support QoS in case of large scale connections and pubsub by taking into consideration mobile devices that are user terminals in a healing platform. After designing a model between TOS and MQTT message broker, the study implemented a prototype based on the proposed design and compared it with its counterparts from previous studies based on the performance indicators in a load-test with the MQTT client tool.

• Journal of the Korea Society of Computer and Information
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• v.16 no.9
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• pp.131-143
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• 2011

Previous alerting service based on LBS was caused severe overload problem of server by using the method to confirm the location of each moving object on server. In this paper, by loading an App on smart moving object, we proposed a novel algorithm named ADAS(Active Disaster Alert Service) for accessing to the server site with oneself location information as needed and implemented the disaster alerting service system with visualization for user. In the proposed method, running App access to the server periodically with the present location coordinate gained from GPS module or network module and the ID of moving object. Then, the server compare the present location coordinate of moving object and the coordinates of disasters registered in DIDB and transmit the n NDIs existed in near distance orderly from the coordinate of present moving object to the client. The App compares the coordinate of present location for moving object and the coordinates of NDI is transmitted from server by real time and executes the service with classifying levels of alert into three steps such as danger, carefulness and safety. And new NDIs are gained by accessing DIDB on Server periodically during running App. Therefore, this will be become a novel method for reducing fundamentally the server overload problem in comparison with previous alerting service that the career of moving object is managed on server.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.41.1-41.1
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• 2018

We introduce a current status and future plans of Korea Microlensing Telescope Network (KMTNet) microlensing experiments, which include an observational strategy, pipeline, event-finder, and collaborations with Spitzer. The KMTNet experiments were initiated in 2015. From 2016, KMTNet observes 27 fields including 6 main fields and 21 subfields. In 2017, we have finished the DIA photometry for all 2016 and 2017 data. Thus, it is possible to do a real-time DIA photometry from 2018. The DIA photometric data is used for finding events from the KMTNet event-finder. The KMTNet event-finder has been improved relative to the previous version, which already found 857 events in 4 main fields of 2015. We have applied the improved version to all 2016 data. As a result, we find that 2597 events are found, and out of them, 265 are found in KMTNet-K2C9 overlapping fields. For increasing the detection efficiency of event-finder, we are working on filtering false events out by machine-learning method. In 2018, we plan to measure event detection efficiency of KMTNet by injecting fake events into the pipeline near the image level. Thanks to high-cadence observations, KMTNet found fruitful interesting events including exoplanets and brown dwarfs, which were not found by other groups. Masses of such exoplanets and brown dwarfs are measured from collaborations with Spitzer and other groups. Especially, KMTNet has been closely cooperating with Spitzer from 2015. Thus, KMTNet observes Spitzer fields. As a result, we could measure the microlens parallaxes for many events. Also, the automated KMTNet PySIS pipeline was developed before the 2017 Spitzer season and it played a very important role in selecting the Spitzer target. For the 2018 Spitzer season, we will improve the PySIS pipeline to obtain better photometric results.