• 제목/요약/키워드: Real world evidence

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Triffin Dilemma and International Monetary System : Evidence from Pooled Mean Group Estimation

  • Guan, Long-Fei;Lau, Wee-Yeap
    • The Journal of Asian Finance, Economics and Business
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    • 제5권2호
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    • pp.5-14
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    • 2018
  • This study is motivated based on concern from some renowned scholars and central bankers whom have raised the issue of the sustainability of the International Monetary System (IMS). Using the panel data set of four major international currencies, USD, JPY, EUR and GBP from 1973 to 2013 with Pooled Mean Group (PMG) estimator, to re-examine whether Triffin dilemma still exists through investigating the relationship between the reserve share, current account balance and real effective exchange rate. The evidence from the result indicates that Triffin dilemma exists only in the long run, and shows that in the long-run, current account balance is proportionate to the increased real effective exchange rate while varies inversely with the reserve shares. However, the estimation for the short-run is not significant to prove the existence of Triffin dilemma. In addition, we investigated the non-dollar panel sample and found that the international monetary system still suffers from Triffin dilemma even without the dollar. To overcome Triffin dilemma, immediate step such as having currency swap mechanism is recommended. In medium term, a multi-polar Monetary System is suggested, and in the longer time, a supranational currency will be used to replace all the currencies in the world.

무기체계 개발을 위한 RMF A&A의 실증에 관한 연구 (A Study on Proving RMF A&A in Real World for Weapon System Development)

  • 조광수;김승주
    • 정보보호학회논문지
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    • 제31권4호
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    • pp.817-839
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    • 2021
  • 소프트웨어를 안전하게 관리하기 위해 군은 RMF A&A(Risk Management Framework Assessment & Authorization) 표준에 따라 제품을 구매하고 관리한다. 해당 표준은 무기체계를 비롯한 군 IT 제품의 획득 체계에 관한 표준으로 제품에 대한 요구사항, 평가를 통한 구매, 유지보수를 다룬다. 해당 표준에 따르면 제품 개발활동에는 군에서 제시한 임무의 위험도가 반영되어야 한다. 즉, 개발사는 보안 내재화 및 공급망 보안을 통해 제시된 위험도를 완화하였고, RMF A&A의 보안 요구사항을 제대로 준수하였음을 입증하는 자료를 제출해야하고, 군에서는 개발사로부터 제출된 증거자료에 대한 평가를 통해 최종 획득 여부를 결정한다. 기존에 RMF A&A 실증 연구가 수행된 사례가 있다. 하지만, 해당 연구는 RMF A&A의 전체 단계가 아닌 일부분에 대해서만 다루고 있고, 해당 연구의 실증 사례가 대외비인 관계로 상세한 정보가 공개되지 않아 실제 산업 환경에 적용하는데 어려움이 있다. 이에 본 논문에서는 군의 위험도 측정 및 RMF A&A 관련 표준들을 분석하고, 이를 바탕으로 군 RMF A&A의 요구사항을 만족시킬 수 있는 증거자료 작성방안에 대해 제시한다. 또한, 제시한 방안을 실제 드론 시스템에 적용하여 작성된 평가 제출물이 RMF A&A의 요구사항에 부합한지 검증을 수행한다.

Long-Term Efficacy of Anti-Tumor Necrosis Factor Agents in Pediatric Luminal Crohn's Disease: A Systematic Review of Real-World Evidence Studies

  • Rheenen, Hanna van;Rheenen, Patrick Ferry van
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제23권2호
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    • pp.121-131
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    • 2020
  • Purpose: To determine the long-term efficacy of the anti-tumor necrosis factor (TNF) agents, infliximab (IFX) and adalimumab (ADA), in pediatric luminal Crohn's disease (CD) by performing a systematic literature review. Methods: An electronic search was performed in Medline, Embase, and the Cochrane Library from inception to September 26, 2019. Eligible studies were cohort studies with observation periods that exceeded 1 year. Studies that reported time-to-event analyses were included. Events were defined as discontinuation of anti-TNF therapy for secondary loss of response. We extracted the probabilities of continuing anti-TNF therapy 1, 2, and 3 years after initiation. Results: In total, 2,464 papers were screened, 94 were selected for full text review, and 13 studies (11 on IFX, 2 on ADA) met our eligibility criteria for inclusion. After 1 year, 83-97% of patients were still receiving IFX therapy. After 2 and 3 years the probability of continuing IFX therapy decreased to 67-91% and 61-85%, respectively. In total, 5 of the 11 studies subgrouped by concomitant medication consistently showed that the probabilities of continuing IFX therapy in patients with prolonged immunomodulator use were higher than those in patients on IFX monotherapy. Conclusion: This review of real-world evidence studies confirms the long-term therapeutic benefit of IFX therapy in diverse cohorts of children with luminal CD. Moreover, it supports the view that combination therapy with an immunomodulator prolongs the durability of IFX therapy in patients who previously failed to recover following first-line therapy. The limited number of time-to-event studies in patients on ADA prevented us from drawing definite conclusions about its long-term efficacy.

Do Real Interest Rate, Gross Domestic Savings and Net Exports Matter in Economic Growth? Evidence from Indonesia

  • SUJIANTO, Agus Eko;PANTAS, Pribawa E.;MASHUDI, Mashudi;PAMBUDI, Dwi Santosa;NARMADITYA, Bagus Shandy
    • The Journal of Asian Finance, Economics and Business
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    • 제7권11호
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    • pp.127-135
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    • 2020
  • This study aims to measure the effects of real interest rate (RIR), gross domestic savings (GDS), and net exports (EN) shocks on Indonesia's economic growth (EG). The focus on Indonesia is unique due to the abundant resources available in the nation, but they are unsuccessful in boosting economic growth. This study applied a quantitative method to comprehensively analyze the correlation between variables by employing Vector Autoregression Model (VAR) combined with Vector Error Correction Model (VECM). Various procedures are preformed: Augmented Dickey-Fuller test (ADF), Optimum Lag Test, Johansen Cointegration Test, Granger Causality Test, as well as Impulse Response Function (IRF) and Error Variance Decomposition Analysis (FEVD). The data were collected from the World Bank and the Asian Development Bank from 1986 to 2017. The findings of the study indicated that economic growth responded positively to real interest rate shocks, which implies that when the real interest rate experiences a shock (increase), the economy will be inclined to growth. While, economic growth responded negatively to gross domestic savings and net export shocks. Policymakers are expected to consider several matters, particularly the economic conditions at the time of formulating policy, so that the prediction effectiveness of a policy can be appropriately assessed.

Study to detect bond degradation in reinforced concrete beams using ultrasonic pulse velocity test method

  • Saleem, Muhammad
    • Structural Engineering and Mechanics
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    • 제64권4호
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    • pp.427-436
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    • 2017
  • Concrete technologists have used ultrasonic pulse velocity test for decades to evaluate the properties of concrete. However, the presented research work focuses on the use of ultrasonic pulse velocity test to study the degradation in steel-concrete bond subjected to increasing loading. A detailed experimental investigation was conducted by testing five identical beam specimens under increasing loading. The loading was increased from zero till failure in equal increments. From the experimentation, it was found that as the reinforced concrete beams were stressed from control unloaded condition till complete failure, the propagating ultrasonic wave velocity reduced. This reduction in wave velocity is attributed to the initiation, development, and propagation of internal cracking in the concrete surrounding the steel reinforcement. Using both direct and semidirect methods of testing, results of reduction in wave velocity with evidence of internal cracking at steel-concrete interface are presented. From the presented results and discussion, it can be concluded that the UPV test method can be successfully employed to identify zones of poor bonding along the length of reinforced concrete beam. The information gathered by such testing can be used by engineers for localizing repairs thereby leading to saving of time, labor and cost of repairs. Furthermore, the implementation strategy along with real-world challenges associated with the application of the proposed technique and area of future development have also been presented.

능숙도 중심의 대학 교양영어 교육을 위한 평가방안 연구 (An assessment model for proficiency oriented English instruction in college English)

  • 이종복
    • 영어어문교육
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    • 제8권2호
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    • pp.177-196
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    • 2003
  • The purpose of this study is to help teachers and program developers develop comprehensive and authentic assessment models with appropriate ways of using various kinds of assessment tools in college English instruction and assessment. Assessing by traditional discrete tests based on grammar and vocabulary cannot measure the authentic ability for language use in meaningful context in the real world. Currently, the trend in language assessment is changing to performance assessment. Increased use of performance assessments that involve language students in selecting and reflecting on their learning means that language teachers will have a wider range of evidence on which to judge whether students are becoming purposeful and are able to communicate as English users. Also, language programs focused on performance assessment are likely to instil in students authentic skills related to communication in the global world and enable them to evaluate what they learn from their English classes. In this study, the author investigated the theoretical background, the need of change, and several types of performance assessment.

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5-11세 소아에서 코로나19 백신의 효능 및 안전성에 대한 체계적 문헌고찰 (Efficacy and Safety of COVID-19 Vaccines in Children Aged 5 to 11 Years: A Systematic Review)

  • 최미영;유수연;정채림;최영준;최수한
    • Pediatric Infection and Vaccine
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    • 제29권1호
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    • pp.28-36
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    • 2022
  • 목적: 5-11세 소아에서 코로나19 백신의 효능과 안전성을 평가하기 위해서 체계적 문헌고찰을 시행하였다. 방법: 2022년 1월 4일까지 Ovid-MEDLINE 및 medRxiv를 검색하여 문헌을 선정하고 자료를 추출하였다. 근거 수준을 평가하기 위해 GRADE 도구를 사용하였다. 결과: 총 1,675 건의 연구가 일차적으로 검색되었고 최종적으로 5편의 연구가 포함되었다. 서로 다른 4개의 코로나19 백신(BNT162b2, mRNA-1273, CoronaVac, BBIBP-CorV)에 대한 무작위 대조군 연구 결과들은 5-11세 연령에서 각 백신의 양호한 면역원성과 안전성을 보여주었다. 미국에서 5-11세 소아 연령에서 BNT162b2 백신 접종 후 이상사례 모니터링 연구에서는 승인 전 임상시험을 통해 예상되었던 국소반응 및 전신반응이 보고되었으나 중대한 이상사례는 거의 보고되지 않았다. 결론: 5-11세 연령에서 코로나19 백신 접종에 대한 데이터는 제한적이다. 이 연령에서 코로나19 백신의 안전성과 효과에 대한 체계적인 평가를 위해 지속적이고 포괄적인 모니터링이 필요할 것으로 보인다.

중국의 제조물책임 관련법규와 사례연구 (The Product Liability Laws and Regulations of China and Case Study on Product Liability)

  • 허재창;한낙현
    • 무역상무연구
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    • 제25권
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    • pp.243-266
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    • 2005
  • Product liability is becoming a real issue to exporters, manufacturers world wide. The purpose of this study is to examine the product liability of Korean exporters, manufacturers, etc. under Product Liability Laws and Regulations of China. For this purpose, firstly we deal with the Product Liability Laws and Regulations of China. Secondly we analyze the case study concerning the Product Liability in China. From the analysis of case study, Korean exporters, manufacturers, etc. are required to pay close attention to the following : the correspondence of English with Chinese in the warning phrases, the possibility of application of strict global standard in case of existence of product liability, the proper treatment of evidence in the process of litigation, the application of strict liability and the shift of responsibility for evidence on to a defendant, the observance of procedures prescribed by the country in design and manufacture of the product, the manufacture of product to come up to country standard in quality, the consideration of diverse expression in the preparation of warning sign, the importance of quality control and inspection system in case of local procurement of parts and raw materials, Finally, this paper contributes to help the Korean Exporters, Manufacturers, etc. to build up the proper countermeasures regarding product liability under the product liability regulations of China.

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