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Effects of Kaempferol on Lippolysaccharide-induced Inflammation in Mouse Brain (Kaempferol이 LPS로 유도된 생쥐 중추신경계 염증에 미치는 영향)

  • Lee, Hung-Gi;Kim, Do-Hoon;Kim, Youn-Sub
    • The Korea Journal of Herbology
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    • v.30 no.1
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    • pp.77-84
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    • 2015
  • Objectives : Brain inflammation early activates the microglia and activated microglia secrete a variety of pro-inflammatory cytokines. Kaempferol, which is a flavonoid in Cuscutae Semen, shows a wide range of physiological activities, including neurons protection and anti-inflammatory actions through inhibition of pro-inflammatory mediators. The present study examined the modulatory effect of kaempferol on cytokines [tumor necrosis factor- alpha ($TNF-{\alpha}$), interleukin-1beta ($IL-1{\beta}$) and interleukin-6 (IL-6)] and cyclooxygenase-2 (COX-2) mRNA expression and microglia activation in the brain tissue of the mouse. Methods : Kaempferol was administered orally three doses of 10, 20 and 30 mg/kg respectively, once 1 hour before the lippolysaccharide(LPS) (3 mg/kg, i.p.) injection. Brain tissue was removed at 4 hours after LPS injection. Cytokines and COX-2 mRNA expression in the brain tissue was measured by the quantitative real-time polymerase chain reaction (PCR) method. Iba1 expression was calculated by western blotting method. Microglia was observed with immunohistochemistry. Immunohistochemistry stained microglia was analyzed by using ImageJ software. Results : Kaempferol 20 and 30 mg/kg was significantly attenuated the expression of $TNF-{\alpha}$, $IL-1{\beta}$ and IL-6 mRNA. Kaempfrol 10, 20 and 30 mg/kg significantly attenuated COX-2 mRNA expression in the brain tissue. Kaempferol 30 mg/kg significantly suppressed the increase of Iba1 protein expression by LPS. Kaempferol 30 mg/kg significantly decreased the number of microglia in the cerebral cortex and the number and cell size of microglia in the hypothalamic region and the area percentage of ionized calcium binding adaptor molecule 1(Iba1)-expressed microglia in the hippocampus. Conclusions : This results indicate that kaempferol plays an anti-inflammatory role in the brain.

Study of Surges in a Large-Diameter Subteranean Diversion Channel with Multiple Surge Tanks (대심도 지하관로 배수 시스템의 서어징 현상에 관한 연구)

  • Jeong, Gwang-Geun;Yeo, Un-Sik;An, Tae-Jin
    • Journal of Korea Water Resources Association
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    • v.31 no.6
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    • pp.757-768
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    • 1998
  • rate of outflow is equated to the total rate of flow, both the state equation and its linearized equation yield almost identical oscillations of water levels. This shows that effects of pipe resistance on the surges are small, and justifies a free oscillation analysis. Free oscillation equation has six eigen modes of different periods, including a rigid mode which is existed when the pumped rate of outflow differs from the total rate of inflow. The six modes constitute a variety of surges dependent on different inflow and outflow conditions. Presence of the rigid mode needs sophisticated pump operations adjusted to real flood inflows.

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IP Spoofing 대응 기능을 가진 방화벽 시스템 구현

  • 최석윤;김중규
    • Proceedings of the Korea Society for Industrial Systems Conference
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    • 1997.03a
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    • pp.163-181
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    • 1997
  • This dissertation provides a theroetic study on the network security in general , the firewall in particular . In fact, the firewall has been recognized as a very promising option to obtain the security in the real world network environment . The dissertation provides a thorough theoretic investigation on the various problems raised in the computer network, and also explores a methodology of the security against IP spoofing. Moreover, it investigates a systematic procedure to make analysis plans of the firewall configuration. Based on the above investigation and analysis , this dissertation provides two approaches to network security, which address a number of issues both at the network and at application level. At the network level. a new methdo is proposed which uses packet filtering based on the analysis of the counter plot about the screen router. On the other hand at the application level, a novel method is exlored which employs security software , Firewall-1, on Bastion host. To demonstrate the feasibility and the effectiveness of the proposed methodologes, a prototype implementation is made. The experiment result shows that the screen router employing the proposesed anti-IP spoofing method at the network level is effective enough for the system to remain secure without being invaded by any illegarl packets entering from external hackers. Meanwhile , at the application level. the proposed software approach employing Firewall -1 is proved to be robust enough to provent hackings from the outer point to point protocol connection. Theoretically, it is not possible to provide complete secuirty to the network system, because the network security involove a number of issues raised from low level network equipments form high level network protocol. The result in this dissertation provides a very promising solution to network security due to its high efficiency of the implementation and superb protectiveness from a variety of hacking.

Intranet을 위한 방화벽 시스템구현에 관한 연구

  • 최석윤;김중규
    • Journal of Korea Society of Industrial Information Systems
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    • v.2 no.1
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    • pp.103-123
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    • 1997
  • This dissertation provides a theoretic study on the network security in general , the firewall in particular. In fact the firewall has been recognized as a very promising option to obtain the security inthe real work network environment . The dissertation provides a throuth theoretic investigation on the various problems raised in the computer network, and also explores a methodology of the security against IP spoofing. Moreover, it investigates a systematic procddure to make analysis and plans of the firewall configuration . Based on the above investigation and analysis, this dissertation provides two approaches to network security , which address anumber of issuesboth at the network and at applicatino level. At the network level, a new method is proposed which uses packet filtering based on the analysis of the counter plot about the screen router.On the other hand, at the application level, a novel method is explored which employs secureity software. Firewall-1 , on Bastion host. To demonstrate the feasibililty and the effectiveness of the proposed methodologties , a prototype implementation is made The experiment result shows that the screen router employing the proposed anti-IP spoofing method at the network level is effective enough for the system to remain secure without being invaded by any illegal packets entering form external hackers. Meanwhile , at the application level, the proposed software approach employing Firewall-1 is proved to be robust enugh to prevent hackings from the outer point the point protocal connnection . Theoretically, it is not possible to provide complete security to the network system, because the network security involve a number of issues raised form low level network equipments form high level network protocol. The result inthis dissertation provides a very promising solution to network security due to its high efficiency of the implementation and superb protectiveness from a variety of hacking.

An Environment Information Management System for Cultivation in Agricultural Facilities using Augmented Reality (증강현실 기반 농업용 환경 정보 관리 시스템)

  • Kim, Min-ji;Kim, Jong-Ho;Koh, Jin-Gwang;Lee, Sung-Keun;Lee, Jae-Hak
    • The Journal of Bigdata
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    • v.3 no.2
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    • pp.113-121
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    • 2018
  • In this study, an augmented reality(AR)-based information management system for agricultural facility is proposed. Using a variety of sensed data transmitted by Lora-based wireless networks deployed at the agricultural facility, this system is capable of augmenting the sensed data and displaying them on the user's smartphone screen to provide visualized information to user. When users point their smartphone camera to the agricultural facility, the environment information collected from numerous sensors installed at the facility would be visualized and appear on the screen. Unlike traditional system which requires user to search a specific facility and then select sensor(s) to obtain the environment information, the proposed system shows the information on smartphone screen by augmenting it with real image captured by camera without doing a series of time-taking selection process. Since the way of acquiring information is through image or video, this system contributes to convenient monitoring and efficient management for agricultural facility.

Design and Implementation of a Power-Saving Management System using Intelligent Scheduler based on RFID/USN Technology (RFID/USN 기술 기반의 지능형 스케줄러를 이용한 절전관리 시스템 설계 및 구현)

  • Jeong, Kyu-Seuck;Choi, Sung-Chul;Jeong, Woo-Jeong;Kim, Tae-Ho;Kim, Jong-Heon;Seo, Dong-Min;Park, Yong-Hun;Yoo, Jae-Soo
    • The Journal of the Korea Contents Association
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    • v.9 no.12
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    • pp.64-76
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    • 2009
  • Recently, the ubiquitous environment and the practical technology associated with it become more popular topic along with the rapid development of wireless technologies. The necessity of the automated system based on the ubiquitous environment has been increasing when the concept of the ubiquitous is integrated into the fields of existing IT. Also, the necessity of formulating a power-saving plan on large buildings and public institutions is gathering strength because of a raise in exchange rates and high oil prices. In this paper, to efficiently manage the power consumption of the electronic machine such as electric lights, electric heaters, and air conditioners in a building, power-saving manage- ment system using RFID/USN technologies is proposed. Proposed system controls the electric machine and monitor it's condition by RFID and collects the real time information about the surrounding and the power consumption of the electric machine by USN. Especially, proposed system analyzes the real time information and supports the intelligent scheduler with the best power-saving. Finally, this paper shows the difference between proposed system and existing system and establishes thereality of our system through experiments in variety environments.

A study on the WTP estimates of green public buildings by the Contingent Valuation Method (조건부가치측정법(CVM)을 활용한 녹색 공공건축물 조성의 비용지불의사액 추정에 관한 연구)

  • Kim, Young-Hwan;Eo, Sang-Jin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.3
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    • pp.2249-2254
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    • 2015
  • Currently, green house gas(GHG) emissions in korea is aiming for a 30% reduction that it is compared to BAU by 2020. To this end, the government has proceed to a variety of reduction policies in GHG. In particular, GHG reduction effect in the public buildings is being a active discussion. It needs to reduce GHG for energy efficiency improvements in the way that public buildings are operated and maintained by public taxes. In this background, the purpose of this paper is to study environmental values judgement for non-market goods in the residents who use public buildings. The results of study are as follows; Respond to first suggested price was found the higher in price, the lower in willingness to pay(WTP). The result of second suggested price was as the same. Analysis of DBDC CVM revealed that income level shows a positive impact on WTP, but the other variables are irrelevant to WTP. Therefore, the citizen participation of the local population seems absolutely necessary to more effective GHG reduction of public sector in the future.

Standard Configuration for Interface of the Traffic Information Service using DSRC (DSRC를 이용한 교통정보서비스 인터페이스 표준 구성)

  • Kim, Kyoung-Hwan;Cho, Yung-Sung;Bae, Myoung-Hwan;Kim, Sang-Heon;Lee, Kyeong-Im
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.10 no.5
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    • pp.1-13
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    • 2011
  • Recently, a number of OBU(On Board Unit) have being spreaded since ETCS(Electronic Toll Collection System)using DSRC(Dedicated Short Range Communication) was installed in the tollgate of the whole country. Many R&D and commercialization related to ITS service using DSRC and OBU mentioned above are ongoing such as traffic information collection and provision and a signal control, and public traffic information and management and so on. Especially, there are many researches conducted(conducting) on traffic information collection and provision using communication between OBU and RSE. However, Standards for both DSRC application and traffic collection and provision are not established clearly yet. So we would like to suggest a method of traffic information collection and provision without changing of standard related to DSRC. This method is to put the traffic messages into the existing Action primitive for ETC, which is described on "Technical criterion IV of basic traffic information exchange" which was notified by Ministry of Land, Transport and Maritime Affairs. Proposed standard application method is applied both to RSE and OBE. It is the same system which ETCS used in highway, currently. We confirmed the efficiency and performance of the system through conducting a variety of driving test using 4 vehicles in real road condition. Result of the real road test shows the effectiveness and validity of this method with about 97% communication success rate and based on studying the cases of 3% communication failure, we can analyse the expected problems in traffic information collection and provision using this method.

A Study on Implementation Integrated Operation & Management System for Intermodal Connectivity Center (복합환승센터 통합운영시스템 구축방안에 관한 연구)

  • Kim, Sung-Eun;Lim, Jung-Sil;Moon, Young-Jun;Oh, Jae-Hak;Lee, Won-Young
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.10 no.4
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    • pp.24-35
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    • 2011
  • This paper demonstrates a methodology of integrated operation and management system for intermodal connectivity center (ICC), which is planning to be build up as a large scale public transit facilities for green growth strategy by the national government. The ICC needs to be capable of providing the integrated location based information for the public transit users in terms of collaborating a variety of transit modes and complex facility in a large scale center. Recently, the upcoming information and communication technologies enable to come up with real time information provision on nomadic and portable devices, i.e. smart phones and/or tablet PCs, as what the users actually need to get on demand. In order to provide the public transit users in ICC with the integrated information on their smart phones for example, the integrated operation and management system plays a key role to collect the data utilizing the wireless communication with real time location tracking and to manage them to be effective and operational sources for applicable personalized services. Thus, this paper defines a type of services, subsystems, and relevant technologies for the system integration so called a "Smart Garatagi Service" and shows a filed test demonstration case in the existing airport terminal, Gimpo Domestic.

Control Networks for Information Systems Development : Organizational and Agency Theory Perspectives (조직 이론과 대리 이론 관점에서 본 정보시스템 개발의 통제 네트워크에 관한 연구)

  • Hong, Sa-Neung
    • Journal of Intelligence and Information Systems
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    • v.18 no.1
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    • pp.71-90
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    • 2012
  • Although it has been studied for a long time in various disciplines, most of control theories remain being developed by analyzing relatively simple tasks. Even recent research on control of information systems development explains only a small part of control phenomena observed in the real world projects. This research focuses on identifying and analyzing the concepts and structures in order to make them useful for understanding and explaining control of information systems development comprehensively This investigation utilizes the complementary relationship between views on control from organizational and economic perspectives. A conceptual framework developed by integrating previous research on control allows us to analyze the development of information systems for control purposes. The results of discussion about control mechanisms and network can be used as guidelines for designing control systems in real projects. Analysis of control networks shows that control of development projects requires quite complex networks intertwining a variety of controllers and controlees. The results of this research are expected to contribute to correcting the unbalanced status of IS research which has emphasized too heavily on planning and implementation, and deepening and widening our understanding about controlling development projects. Practitioners can use the results as guidelines for designing control mechanisms and networks, and get alerted by them about the agency risks inherent in outsourced developments.