• Title/Summary/Keyword: Read-across

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Existing test data for the Act on Registration & Evaluation, etc. of Chemical Substances

  • Choi, Bong-In;Ryu, Byung-Taek;Na, Suk-Hyun;Chung, Seon-Yong
    • Environmental Analysis Health and Toxicology
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    • v.30
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    • pp.17.1-17.6
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    • 2015
  • Objectives In this study, the possibility of using existing test data provided in Korea and elsewhere for the registration of chemical substances was examined. Data on 510 chemical substances that are among the first subject to registration under the "Act on the Registration and Evaluation, etc. of Chemical Substances (K-REACH)" were analyzed. Methods The possibility of using existing data from 16 reference databases was examined for 510 chemical substances notified in July 2015 as being subject to registration. Results Test data with the reliability required for the registration of chemical substances under the K-REACH constituted 48.4% of the required physicochemical characteristics, 6.5% of the required health hazards, and 9.4% of the required environmental hazards. Conclusions Some existing test data were not within the scope of this research, including data used for registration in the European Union (EU). Thus, considering that 350 of these 510 species are registered in EU Registration, Evaluation, Authorisation & Restriction of Chemicals, more test data may exist that can be utilized in addition to the data identified in this study. Furthermore, the K-REACH states that non-testing data (test results predicted through Read Across, Quantitative Structure-Activity Relationships) and the weight of evidence (test results predicted based on test data with low reliability) can also be utilized for registration data. Therefore, if methods for using such data were actively reviewed, it would be possible to reduce the cost of securing test data required for the registration of chemical substances.

An Efficient Logging Scheme based on Dynamic Block Allocation for Flash Memory-based DBMS (플래시 메모리 기반의 DBMS를 위한 동적 블록 할당에 기반한 효율적인 로깅 방법)

  • Ha, Ji-Hoon;Lee, Ki-Yong;Kim, Myoung-Ho
    • Journal of KIISE:Databases
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    • v.36 no.5
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    • pp.374-385
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    • 2009
  • Flash memory becomes increasingly popular as data storage for various devices because of its versatile features such as non-volatility, light weight, low power consumption, and shock resistance. Flash memory, however, has some distinct characteristics that make today's disk-based database technology unsuitable, such as no in-place update and the asymmetric speed of read and write operations. As a result, most traditional disk-based database systems may not provide the best attainable performance on flash memory. To maximize the database performance on flash memory, some approaches have been proposed where only the changes made to the database, i.e., logs, are written to another empty place that has born erased in advance. In this paper, we propose an efficient log management scheme for flash-based database systems. Unlike the previous approaches, the proposed approach stores logs in specially allocated blocks, called log blocks. By evenly distributing logs across log blocks, the proposed approach can significantly reduce the number of write and erase operations. Our performance evaluation shows that the proposed approaches can improve the overall system performance by reducing the number of write and erase operation compared to the previous ones.

Prediction of Genes Related to Positive Selection Using Whole-Genome Resequencing in Three Commercial Pig Breeds

  • Kim, HyoYoung;Caetano-Anolles, Kelsey;Seo, Minseok;Kwon, Young-jun;Cho, Seoae;Seo, Kangseok;Kim, Heebal
    • Genomics & Informatics
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    • v.13 no.4
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    • pp.137-145
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    • 2015
  • Selective sweep can cause genetic differentiation across populations, which allows for the identification of possible causative regions/genes underlying important traits. The pig has experienced a long history of allele frequency changes through artificial selection in the domestication process. We obtained an average of 329,482,871 sequence reads for 24 pigs from three pig breeds: Yorkshire (n = 5), Landrace (n = 13), and Duroc (n = 6). An average read depth of 11.7 was obtained using whole-genome resequencing on an Illumina HiSeq2000 platform. In this study, cross-population extended haplotype homozygosity and cross-population composite likelihood ratio tests were implemented to detect genes experiencing positive selection for the genome-wide resequencing data generated from three commercial pig breeds. In our results, 26, 7, and 14 genes from Yorkshire, Landrace, and Duroc, respectively were detected by two kinds of statistical tests. Significant evidence for positive selection was identified on genes ST6GALNAC2 and EPHX1 in Yorkshire, PARK2 in Landrace, and BMP6, SLA-DQA1, and PRKG1 in Duroc. These genes are reportedly relevant to lactation, reproduction, meat quality, and growth traits. To understand how these single nucleotide polymorphisms (SNPs) related positive selection affect protein function, we analyzed the effect of non-synonymous SNPs. Three SNPs (rs324509622, rs80931851, and rs80937718) in the SLA-DQA1 gene were significant in the enrichment tests, indicating strong evidence for positive selection in Duroc. Our analyses identified genes under positive selection for lactation, reproduction, and meat-quality and growth traits in Yorkshire, Landrace, and Duroc, respectively.

Development of a Path Generation and Tracking Algorithm for a Korean Auto-guidance Tillage Tractor

  • Han, Xiong-Zhe;Kim, Hak-Jin;Moon, Hee-Chang;Woo, Hoon-Je;Kim, Jung-Hun;Kim, Young-Joo
    • Journal of Biosystems Engineering
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    • v.38 no.1
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    • pp.1-8
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    • 2013
  • Purpose: Path planning and tracking algorithms applicable to various agricultural operations, such as tillage, planting, and spraying, are needed to generate steering angles for auto-guidance tractors to track a point ahead on the path. An optimal coverage path algorithm can enable a vehicle to effectively travel across a field by following a sequence of parallel paths with fixed spacing. This study proposes a path generation and tracking algorithm for an auto-guided Korean tractor with a tillage implement that generates a path with C-type turns and follows the generated path in a paddy field. A mathematical model was developed to generate a waypoint path for a tractor in a field. This waypoint path generation model was based on minimum tractor turning radius, waypoint intervals and LBOs (Limit of Boundary Offsets). At each location, the steering angle was calculated by comparing the waypoint angle and heading angle of the tractor. A path following program was developed with Labview-CVI to automatically read the waypoints and generate steering angles for the tractor to proceed to the next waypoint. A feasibility test of the developed program for real-time path tracking was performed with a mobile platform traveling on flat ground. The test results showed that the developed algorithm generated the desired path and steering angles with acceptable accuracy.

A 3D Memory System Allowing Multi-Access (다중접근을 허용하는 3차원 메모리 시스템)

  • 이형
    • Journal of KIISE:Computer Systems and Theory
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    • v.32 no.9
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    • pp.457-464
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    • 2005
  • In this paper a 3D memory system that allows 17 access types at an arbitrary position is introduced. The proposed memory system is based on two main functions: memory module assignment function and address assignment function. Based on them, the memory system supports 17 access types: 13 Lines, 3 Rectangles, and 1 Hexahedron. That is, the memory system allows simultaneous access to multiple data in any access types at an arbitrary position with a constant interval. In order to allow 17 access types the memory system consists of memory module selection circuitry, data routing circuitry for READ/WRITE, and address calculation/routing circuitry In the point of view of a developer and a programmer, the memory system proposed in this paper supports easy hardware extension according to the applications and both of them to deal with it as a logical three-dimensional away In addition, multiple data in various across types can be simultaneously accessed with a constant interval. Therefore, the memory system is suitable for building systems related to ,3D applications (e.g. volume rendering and volume clipping) and a frame buffer for multi-resolution.

Complete Genomic Characterization of Two Beet Soil-Borne Virus Isolates from Turkey: Implications of Comparative Analysis of Genome Sequences

  • Moradi, Zohreh;Maghdoori, Hossein;Nazifi, Ehsan;Mehrvar, Mohsen
    • The Plant Pathology Journal
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    • v.37 no.2
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    • pp.152-161
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    • 2021
  • Sugar beet (Beta vulgaris L.) is known as a key product for agriculture in several countries across the world. Beet soil-borne virus (BSBV) triggers substantial economic damages to sugar beet by reducing the quantity of the yield and quality of the beet sugars. We conducted the present study to report the complete genome sequences of two BSBV isolates in Turkey for the first time. The genome organization was identical to those previously established BSBV isolates. The tripartite genome of BSBV-TR1 and -TR3 comprised a 5,835-nucleotide (nt) RNA1, a 3,454-nt RNA2, and a 3,005-nt RNA3 segment. According to sequence identity analyses, Turkish isolates were most closely related to the BSBV isolate reported from Iran (97.83-98.77% nt identity). The BSBV isolates worldwide (n = 9) were phylogenetically classified into five (RNA-coat protein read through gene [CPRT], TGB1, and TGB2 segments), four (RNA-rep), or three (TGB3) lineages. In genetic analysis, the TGB3 revealed more genetic variability (Pi = 0.034) compared with other regions. Population selection analysis revealed that most of the codons were generally under negative selection or neutral evolution in the BSBV isolates studied. However, positive selection was detected at codon 135 in the TGB1, which could be an adaptation in order to facilitate the movement and overcome the host plant resistance genes. We expect that the information on genome properties and genetic variability of BSBV, particularly in TGB3, TGB1, and CPRT genes, assist in developing effective control measures in order to prevent severe losses and make amendments in management strategies.

Reading Speed Comparison: Paragraphs in Digital and Print Media (디지털 매체와 인쇄 매체에서의 문단 읽기 속도 비교)

  • Ko Eun Lee
    • Korean Journal of Cognitive Science
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    • v.34 no.4
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    • pp.299-314
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    • 2023
  • This study aimed to examine whether there are differences in reading performance between digital and print media by measuring reading speed of paragraphs on print materials and tablet PC. To investigate whether the physical characteristics of the media influence reading performance, the format of text was kept as similar as possible between print and digital media. We also compared conditions in which paragraphs consisted of either long or short sentences to explore if there were differential effects on reading performance based on sentence length across different media. Additionally, reading speed was analyzed based on reading span to investigate whether there were differences in reading performance according to participants' working memory capacity. As a result, reading speed was faster when reading print media compared to digital media. However, there was no difference in reading speed based on the length of sentences composing the paragraphs. Participants with a higher reading span exhibited faster reading speed compared to participants with a lower reading span. Moreover, participants with a higher reading span read paragraphs composed of long sentences faster on print media than on digital media. The findings of this study suggest that visual fatigue induced by tablet PCs and participants' working memory capacity may impact reading speed.

A Dream of Communal Society for Parts Without Parts: On Thomas More's Utopia (몫 없는 자들을 위한 공유사회의 꿈: 토머스 모어의 『유토피아』)

  • Lee, Myung-Ho
    • Cross-Cultural Studies
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    • v.45
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    • pp.295-324
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    • 2016
  • This essay attempts a contrapuntal reading of Thomas More's Utopia. Contrapunctual reading, proposed by Edward Said. attempts to make a text speak across temporal, cultural, and ideological boundaries to a topic of present. I examine two opposite readings of Utopia around 2011 by both pro- and anti-Occupy Wall Street positions. On the one hand, the opponents of Occupy find its limits as a utopian social movement echoing in the fictional character of Hythrodaeus and the alternative society verbally sketched by him in Book Two of Utopia. On the other, Occupy's advocates read More's text as embodying its radial possibility. However, each shares the tendency to denounce Book Two, praising Book One in which Hythrodaeus vehemently criticizes England; they read Hythrodaeus not as an utopian idealist but as a social critic. The Occupy, as a result, is seen here as having an ambivalent relationship to utopianism. I reinterpret the radical possibilities of Book Two criticized by both pro- and anti-Occupy invocations of Utopia. Book Two provides a utopian space in which the existing social contradictions are cancelled, revealing the limits of the three partial utopias proposed at the end of Book One. Following Louis Marin's argument, I argue, the "utopic" space does not lie in the so-called ideal society described in the text but in the inconsistencies between the text's description(discourse) and topography(map). In Book Two the existence of a king is described, yet his space is not found in the topography of utopia; likewise market is described as existing at the center of a city, yet its space is not found either. These inconsistencies create a neutral space in which the ideological contradictions of the text are cancelled, and the space opens up the possibility of communal society beyond modern sovereign power and capitalism I argue this utopian dream needs to be summoned once again in our time as a compelling alternative to the corporate, capitalist order.

A Prosodic Study of Korean Using a Large Database (대용량 데이터베이스를 이용한 한국어 운율 특성에 관한 연구)

  • Kim Jong-Jin;Lee Sook-Hyang
    • The Journal of the Acoustical Society of Korea
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    • v.24 no.2
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    • pp.117-126
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    • 2005
  • This study investigates the prosodic characteristics of Korean through the analysis of a large database. One female and one male speakers each read 650 sentences and they were segmentally and prosodically labeled. Statistical analyses were done on these utterances regarding the tonal pattern and the size of prosodic units, correlation between the size of higher level prosodic units and the number of lower level prosodic units. and the slope and F0 of the falling and rising contours of an accentual phrase. The results showed that the duration and the number of words and syllables of a prosodic unit were significantly different not only between speakers but also between its positions within a higher level prosodic nit. The munber of a prosodic unit showed a high correlation with the duration and the number of syllables of its higher level units. The slope of the falling contour within an accentual phrase was inversely Proportional to the number of its syllables. The slope was different depending on the first tone type of an accentual phrase, which could be explained with the F0 rising and the different amount of rising between tones when an accentual phrase starts with an H tone. The slope of the falling contour across an accentual phrase boundary showed a constant and larger value compared to one within an accentual phrase. The rising contours in the beginning and end of an accentual Phrase were similar in their slopes but they differ in the amount of F0 change : the former showed a larger amount of change. The slope of the rising contour which forms an accentual Phrase on its own was inversely Proportional to the number of its syllables.

Electrical Properties in $Pt/SrTiO_3/Pb_x(Zr_{0.52}, Ti_{0.48})O_3/SrTiO_3/Si$ Structure and the Role of $SrTiO_3$ Film as a Buffer Layer ($Pt/SrTiO_3/Pb_x(Zr_{0.52}, Ti_{0.48})O_3/SrTiO_3/Si$ 구조의 전기적 특성 분석 및 $SrTiO_3$박막의 완충층 역할에 관한 연구)

  • 김형찬;신동석;최인훈
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.11 no.6
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    • pp.436-441
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    • 1998
  • $Pt/SrTiO_3/Pb_x(Zr_{0.52}, Ti_{0.48})O_3/SrTiO_3/Si$ structure was prepared by rf-magnetron sputtering method for use in nondestructive read out ferroelectric RAM(NDRO-FEAM). PBx(Zr_{0.52}Ti_{0.48})O_3}$(PZT) and $SrTiO_3$(STO) films were deposited respectively at the temperatures of $300^{\circ}C and 500^{\circ}C$on p-Si(100) substrate. The role of the STO film as a buffer layer between the PZT film and the Si substrate was studied using X-ray diffraction (XRD), Auger electron spectroscopy (ASE), and scanning electron microscope(SEM). Structural analysis on the interfaces was carried out using a cross sectional transmission electron microscope(TEM). For PZT/Si structure, mostly Pb deficient pyrochlore phase was formed due to the serious diffusion of Pb into the Si substrate. On the other hand, for STO/PZT/STO/Si structure, the PZT film had perovskite phase and larger grain size with a little Pb interdiffusion. the interfaces of the PZT and the STO film, of the STO film and the interface layer and $SiO_2$, and of the $SiO_2$ and the Si substate had a good flatness. Across sectional TEM image showed the existence of an amorphous layer and $SiO_2$ with 7nm thickness between the STO film and the Si substrate. The electrical properties of MIFIS structure was characterized by C-V and I-V measurements. By 1MHz C-V characteristics Pt/STO(25nm)/PZT(160nm)/STO(25nm)/Si structure, memory window was about 1.2 V for and applied voltage of 5 V. Memory window increased by increasing the applied voltage and maximum voltage of memory window was 2 V for V applied. Memory window decreased by decreasing PZT film thickness to 110nm. Typical leakage current was abour $10{-8}$ A/cm for an applied voltage of 5 V.

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