• The Korean Journal of Physiology and Pharmacology
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• v.5 no.1
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• pp.87-92
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• 2001

Carbon monoxide (CO) binds to soluble guanylate cyclase to lead its activation and elicits smooth muscle relaxation. The vascular tissues have a high capacity to produce CO, since heme oxygenase-2 (HO-2) is constitutively expressed in endothelial and smooth muscle cells, and HO-1 can be greatly up-regulated by oxidative stress. Moreover, the substrate of HO, heme, is readily available for catalysis in vascular tissue. Although the activation of heme oxygenase pathway under various stress conditions may provide a defence mechanism in compromised tissues, the specific role of HO-1-derived CO in the control of aortic contractility still remains to be elucidated. The present study was done to determine the effect of HO-1 induction on the aortic contractility. Thus, the effects of incubation of aortic tissue with S-nitroso-N-acetylpenicillamine (SNAP) for 1 hr on the aortic contractile response to phenylephrine were studied. The preincubation with SNAP resulted in depression of the vasoconstrictor response to phenylephrine. This effect was restored by HO inhibitor or methylene blue but not by NOS inhibitor. The attenuation of vascular reactivity by preincubation with SNAP was also revealed in endothelium-free rings. $AlF4^--evoked$ contraction in control did not differ from that in SNP-treated group. These results suggest that increased production of CO was responsible for the reduction of the contractile response to phenylephrine in aortic ring preincubated with SNAP and this effect of SNAP was independent on endothelium.

• Nuclear Engineering and Technology
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• v.53 no.5
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• pp.1403-1415
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• 2021

The transient capability of a SP₃ based pin-wise core analysis code SPHINCS is developed and verified through the analyses of the C5G7-TD benchmark. Spatial discretization is done by the fine mesh finite difference method (FDM) within the framework of the coarse mesh finite difference (CMFD) formulation. Pin size fine meshes are used in the radial fine mesh kernels. The time derivatives of the odd moments in the time-dependent SP₃ equations are neglected. The pin homogenized group constants and Super Homogenization (SPH) factors generated from the 2D single assembly calculations at the unrodded and rodded conditions are used in the transient calculations via proper interpolation involving the approximate flux weighting method for the cases that involve control rod movement. The simplifications and approximations introduced in SPHINCS are assessed and verified by solving all the problems of C5G7-TD and then by comparing with the results of the direct whole core calculation code nTRACER. It is demonstrated that SPHINCS yields accurate solutions in the transient behaviors of core power and reactivity.

• Journal of the Korean Society of Systems Engineering
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• v.16 no.2
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• pp.1-15
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• 2020

Nuclear power plants in South Korea are operated to cover the baseload demand. Hence they are operated at 100% rated power and do not deploy power tracking control except for startup, shutdown, or during transients. However, as the contribution of renewable energy in the energy mix increases, load follow operation may be needed to cover the imbalance between consumption and production due to the intermittent nature of electricity produced from the conversion of wind or solar energy. Load follow operation may be quite challenging since the operators need to control the axial power distribution and core reactivity while simultaneously conducting the power maneuvering. In this paper, a systems engineering approach for multi-physics load follow simulation of APR1400 is performed. RELAP5/SCDAPSIM/MOD3.4/3DKIN multi-physics package is selected to simulate the Korean Advanced Power Reactor, APR1400, under load follow operation to reflect the impact of feedback signals on the system safety parameters. Furthermore, the systems engineering approach is adopted to identify the requirements, functions, and physical architecture to provide a set of verification and validation activities that guide this project development by linking each requirement to a validation or verification test with predefined success criteria.

• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.817-825
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• 2022

A recent benchmarking effort, under the auspices of the Organization for Economic Cooperation and Development (OECD) Nuclear Energy Agency (NEA), has been made to evaluate the current state of modeling and simulation tools available to model fluoride salt-cooled high temperature reactors (FHRs). The FHR benchmarking effort considered in this work consists of several cases evaluating the neutronic parameters of a 2D prismatic FHR fuel assembly model using the participants' choice of simulation tools. Benchmark participants blindly submitted results for comparison with overall good agreement, except for some which significantly differed on cases utilizing a molybdenum-bearing control rod. Participants utilizing more recently updated explicit isotopic cross sections had consistent results, whereas those using elemental molybdenum cross sections observed reactivity differences on the order of thousands of pcm relative to their peers. Through a series of supporting tests, the authors attribute the differences as being nuclear data driven from using older legacy elemental molybdenum cross sections. Quantitative analysis is conducted on the control rod to identify spectral, reaction rate, and cross section phenomena responsible for the observed differences. Results confirm the observed differences are attributable to the use of elemental cross sections which overestimate the reaction rates in strong resonance channels.

• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.781-789
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• 2022

KHNP had licensed Dynamic Control rod Reactivity Measurement (DCRM) method using detector current signals of PWRs in 2006. The method has been applied to all PWRs in Korea for about 15 years successfully. However, the original method was inapplicable to PWRs using low-sensitivity integral fission chamber as ex-core detectors because of their pulse pile-up and the nonlinearity of the mean-square voltage at low power region. Therefore, to overcome this disadvantage, a modified method, DCRM-EK, was developed using kinetics behavior after equilibrium condition where the pulse counts maintain the maximum value before pulse pile-up. Overall measurement, analysis procedure, and related computer codes were changed slightly to reflect the site test condition. The new method was applied to a total of 15 control rods of 1000 MWe and 1400 MWe PWRs in Korea with worths in the range of 200 pcm -1200 pcm. The results show the average difference of -0.4% and the maximum difference of 7.1% compared to the design values. Therefore, the new DCRM-EK will be applied to PWRs using low sensitivity integral fission chambers, and also can replace the original DCRM when the evaluation fails by big noises present in current or voltage signals of uncompensated/compensated ion chambers.

• Korean Journal of Veterinary Research
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• v.63 no.1
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• pp.2.1-2.7
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• 2023

Fenbendazole (FBZ) is a benzimidazole anthelmintic widely used to treat parasitic infections. The anticancer effect of FBZ has been recently highlighted leading to its consideration as a potential anticancer agent. Although previous studies have demonstrated the effect of FBZ on cancer cells, there is a paucity of studies on the effect of FBZ on lymphoma cells and normal immune cells. Herein, we investigated the effects of FBZ on a mouse lymphoma cell line, EL-4 cells, and spleen cells, using vincristine as a positive control. The cellular metabolic activity of EL-4 cells was decreased by FBZ, but that of the spleen cells was not decreased. Moreover, FBZ reduced the mitochondrial membrane potential and induced reactive oxygen species production in EL-4 cells, but not in spleen cells. FBZ induced G2/M phase arrest and increased the sub G0/G1 phase ratio, indicating apoptosis. Furthermore, compared to the control cells, the reactivity of spleen cells pretreated with FBZ to lipopolysaccharide was maintained. In summary, FBZ is cytotoxic to EL-4 cells, but not to spleen cells. This study provides experimental evidence that FBZ exerts an anticancer effect, and less cytotoxic effects and functional damage to normal spleen cells.

• Nuclear Engineering and Technology
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• v.24 no.2
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• pp.183-192
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• 1992

An advanced load-follow operation mode, Mode K, is presented for the Korean Standardized Nuclear Power Plants. The Mode K utilizes a heavy worth bank dedicated to axial shape control independent of the existing regulating banks. In Mode K, the heavy bank provides a wide range of axial shape control and a monotonic relationship between its motion and the axial shape change, which makes it easy to automate axial shape control. The achievement of full automatic reactor power control both for the reactivity and power shape would reduce the burden due to load-follow operation on the operator. Also, it can accommodate the frequen-cy control, which requires the plant to respond to the unexpected demand. The Mode K design concepts were tested using simulation responses of Yonggwang Units 3&4, the reference plants for the Korean Standardized Nuclear Power Plants. The results illustrate that the Mode K is an adequate operation mode to provide practical load-follow capabilities for the Korean Standardized Nuclear Power Plants.

• Nuclear Engineering and Technology
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• v.26 no.2
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• pp.197-204
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• 1994

In a PWR rod cluster control assembly(RCCA) for shutdown is released upon action of control rod drive mechanism and falls down through the guide thimble by its weight. Drop time and impact velocity of the RCCA are two key parameters with respect to reactivity insertion time and the mechanical integrity of fuel assembly. Therefore, the precise control of drop time and impact velocity is prerequisite to modifying the existing design features of the RCCA and guide thimble or newly designing them. During its falling down into the core, the RCCA is retarded by various forces acting on it such as fluid resistance caused by the RCCA movement, buoyance and mechanical friction caused by contacting inner surface of the guide thimble, etc. However, complicated coupling of the various forces makes it difficult to derive an analytical dynamic equation for the drop time and impact velocity. This paper deals with the development of a computer program containing an analytical dynamic equation applicable to the Korean Fuel Assembly(KOFA). The computer program is benchmarked with an available single control rod drop tests. Since the predicted values are in good agreement with the test results, the computer program developed in this paper can be employed to modify the exiting design features of the RCCA and guide thimble and to develope their new design features for advanced nuclear reactors.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.32 no.4
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• pp.129-136
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• 2021

Objectives: To investigate the relationship between brain structure and empathy in early adolescents with attention-deficit/hyperactivity disorder (ADHD). Methods: Nineteen early adolescents with ADHD and 20 healthy controls underwent 3T MRI. All the participants were assessed for different aspects of empathy using measures including the Interpersonal Reactivity Index and Empathy Quotient. Cortical thickness and subcortical structural volume based on T1-weighted scans were analyzed using FreeSurfer. Results: Cognitive empathy (t=-2.52, p=0.016) and perspective taking (t=-2.10, p=0.043) were impaired in the ADHD group compared with the control group. The cluster encompassing the left posterior insular, supramarginal, and transverse temporal cortices [cluster-wise p-value (CWP)=0.001], which are associated with emotional empathy, was significantly smaller in the ADHD group, and the volume of the left nucleus accumbens was greater than that of the control group (F=10.12, p=0.003, effect size=0.22). In the control group, the left superior temporal (CWP=0.002) and lingual cortical (CWP=0.035) thicknesses were positively associated with cognitive empathy, while the right amygdala volume was positively associated with empathic concern (Coef=14.26, t=3.92, p=0.001). However, there was no significant correlation between empathy and brain structure in the ADHD group. Conclusion: The ADHD group had a smaller volume of the cortical area associated with emotional empathy than the control group, and there was no brain region showing significant correlation with empathy, unlike in the control group.

• Journal of Food Hygiene and Safety
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• v.28 no.3
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• pp.195-201
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• 2013

In atherosclerosis, blood vessels become sensitive to vessel-constricting agents leading to reduced control in the event of abrupt blood pressure changes. Mulberry trees (Morus alba L., MA) have been claimed to contain various bioactive principles that could possibly prevent atherosclerosis development caused by high cholesterol consumption. In order to examine whether MA feeding can prevent the sensitization of blood vessels, MA leaves were fed to rats for 8 weeks and pressor responses to vasoconstricting agents were assessed. Animals were pithed before blood pressure assessments to eliminate reflex compensation in vessel responses. Feeding diets containing high levels of cholesterol led to potentiated pressor responses to sympathetic nerve stimulation, or to injection of norepinephrine, phenylephrine, angiotensin II and vasopressin in pithed rats. These potentiated pressor responses were prevented in rats fed MA leaf-containing diets at 2 or 10% levels. It was also examined in anesthetized non-pithed rats whether similar cholestrol-related sensitization and MA prevention could be observed. However, high cholesterol-induced sensitization in pressor responses were not observed, suggesting that destruction of central cardiovascular control by pithing must have revealed the sensitization responses. It was concluded that MA leaves seem to be active in preventing abnormal blood vessel reactivity caused by hypercholesterolemia.