• Archives of Plastic Surgery
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• 제40권5호
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• pp.517-521
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• 2013

Background Diabetes is characterized by chronic hyperglycemia, which can increase reactive oxygen species (ROS) production by the mitochondrial electron transport chain. The formation of ROS induces oxidative stress and activates oxidative damage-inducing genes in cells. No research has been published on oxidative damage-related extracellular superoxide dismutase (EC-SOD) protein levels in human diabetic skin. We investigated the expression of EC-SOD in diabetic skin compared with normal skin tissue in vivo. Methods The expression of EC-SOD protein was evaluated by western blotting in 6 diabetic skin tissue samples and 6 normal skin samples. Immunohistochemical staining was also carried out to confirm the EC-SOD expression level in the 6 diabetic skin tissue samples. Results The western blotting showed significantly lower EC-SOD protein expression in the diabetic skin tissue than in the normal tissue. Immunohistochemical examination of EC-SOD protein expression supported the western blotting analysis. Conclusions Diabetic skin tissues express a relatively small amount of EC-SOD protein and may not be protected against oxidative stress. We believe that EC-SOD is related to the altered metabolic state in diabetic skin, which elevates ROS production.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.279-279
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• 2012

In order to estimate the average migration lengths of $H_3O^+$ ions in amorphous ice, we conducted experiments of reactive ion scattering (RIS), low energy sputtering (LES), and reflection absorption IR spectroscopy (RAIRS) with an ultra-high vacuum (UHV) chamber. Dopped water-ice films were grown on the clean surface of Ru single crystal and analyzed with RIS, LES and RAIRS methods. The population changes of probe molecules, which were buried at a controlled distance from the surface, were monitored by those methods so that we can mesure the migration efficiencies. From the measured efficiencies, we evaluated the average migration lengths. This result is expected to give the information about the dynamics of proton in water-ice film.

• 한국대기환경학회:학술대회논문집
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• 한국대기환경학회 2002년도 추계학술대회 논문집
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• pp.223-224
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• 2002

This study is motivated by the discrepancies found in previous studies that compared the observed photochemically reactive species in the marine boundary layer (MBL) with the model simulations. In particular, HCHO was underpredicted in PEM-Tropics (B) and overpredicted in TRACE-A, $H_2O$$_2$ overpredicted, $CH_3$OOH overpredicted, and $CH_3$OH significantly overpredicted (Thompson et al., 1993; Heikes et at., 1996; Davis et al., 1996; Jacob et al., 1996; Schultz et al., 1997; Suhre et al., 1998). (omitted)

• Annals of Clinical Neurophysiology
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• 제16권1호
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• pp.1-7
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• 2014

Iron is an important element for brain oxygen transport, myelination, DNA synthesis and neurotransmission. However, excessive iron can generate reactive oxygen species and contribute neurotoxicity. Although brain iron deposition is the natural process with normal aging, excessive iron accumulation is also observed in various neurological disorders such as neurodegeneration with brain iron accumulation, Parkinson's disease, Alzheimer's disease, multiple sclerosis, Friedreich ataxia, and others. Magnetic resonance image (MRI) is a useful method for detecting iron deposits in the brain. It can be a powerful tool for diagnosis and monitoring, while furthering our understanding of the role of iron in the pathophysiology of a disease. In this review, we will introduce the mechanism of iron toxicity and the basics of several iron-related MRI techniques. Also, we will summarize the previous results concerning the clinical application of such MR imagings in various neurological disorders.

• 한국세라믹학회지
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• 제35권11호
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• pp.1233-1239
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• 1998

Gas phase compositions of the hot filament-assisted diamond CVD reaction were analyzed by on-line quadrupole mass analysis(QMA) technique. D2 isotope experiments showed that methance molecules were decomposed into atomic state and then recombined in to acetylene during transport the probe line. Although acetylene or ethylene was supplied instead of methane similar gas compositions were obtained when filament temperature was above 1500$^{\circ}C$ Therefore this system could be assumed near thermal equilibrium state. Filament temperature and reaction pressure variation experiments exhibited the same tendency between acetylene concentration and diamond growth rate and these results implied that acetylene molecule played the role of the reactive species in the diamond CVD reaction.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제53권2호
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• pp.91-96
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• 2004

In darkroom condition, it was observed that a white picture pattern lasted several minutes leaves a recognizable trace in subsequent black background picture. Although this is not a serious problem for the most current public display or home TV applications, the image sticking should be minimized for future high quality multimedia display applications. In order to characterize this picture memory effect having relatively long time scale, spatially resolved luminance measurement and light waveform measurement have been performed. Pixels located at the outer boundary of white pattern previously displayed shows highest luminance. These cells also shows fastest ignition at the ramp up reset sequence. The luminance and ignition voltage differences between boundary cells and the other cells are increased with display duration and number of sustain-pulse. It is speculated that image sticking observed at the boundary cell is originated from the transport of charged particles and re-deposition of reactive species such as Mg, O provided from strong sustain discharge region.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 제38회 하계학술대회
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• pp.633-635
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• 2007

To cope with increasing power demand in metropolitan area, the power system in Korea has equipped with unit generator of large capacity, high density and uneven distribution, and transmission line of long distance, large capacity and high voltage. As the power system growing up enormous, it has become difficult to maintain the standard voltage in case of radical fluctuation of load or severe change of voltage by power system fault for its weakness of responsive characteristics although the power condenser has been installed to solve the unstability by lack of reactive power. Consequently, we review harmonic wave production and control characteristics to solve unstability problem of voltage in northern metropolitan, to reduce transmission restriction cost and to minimize load shedding by relocation of SVC (Static Var Compensator), which is highly effective for improvement of responsive characteristics for radical voltage fluctuation.

• 한국정보과학회논문지:정보통신
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• 제33권5호
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• pp.369-379
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• 2006

최근 기지국(Base Station)의 도움 없이 이동 단말기(Mobile Device) 간의 다중 무선 홉을 사용하여 송수신자 간의 데이타 전송을 가능하게 하는 Ad-hoc 통신망에 관한 연구가 활발히 진행되고 있다. 현재 인터넷 상에서 광범위하게 사용되고 있는 전송 규약인 TCP(Transmission Control Protocol)는 수동적인 혼잡 제어(Reactive Congestion Control)방식을 사용하여 망의 혼잡으로 인한 패킷 손실 발생 이전까지 혼잡 윈도우의 크기를 증가시킨다. 따라서 반복적인 혼잡과 그로 인한 패킷 손실로 인해 재전송을 반복하게 된다. 이와 같이 기존 TCP는 Ad-hoc 통신망에서 동작하는 이동 단말의 한정된 배터리 전원을 고려하지 않고 동작하기 때문에 이동 단말의 에너지를 불필요하게 낭비하는 문제를 가지게 된다. 본 논문은 Ad-hoc 통신망에서 이동 단말의 에너지 효율을 개선하기 위해 불필요한 재전송 방지 및 망상태에 따라 전송률을 적절하게 조절하는 새로운 혼잡 제어 기법인 TCP-New Veno를 제안하였다. 제안한 TCP-New Veno는 이동 단말의 에너지 효율 및 대역폭의 사용률(Utilization)을 향상시킬 있도록 설계되었다. 또한 ns-2 시뮬레이터를 이용한 실험을 통해 제안한 TCP-New Veno에 의해 이동 단말의 에너지 효율이 향상되었음을 확인하였다.

• 원예과학기술지
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• 제32권5호
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• pp.684-693
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• 2014

저온, 건조, 염과 같은 비생물적 스트레스는 식물의 생리적 형태적 변화와 수확량 감소를 초래한다. 이러한 이유로 식물체는 불리한 환경을 극복하기 위해 다양한 대사과정에 관련된 유전자들간의 복잡한 상호 관계를 조절함으로써 저항성을 획득한다. 본 연구는 배추에서 염 스트레스에 반응하는 유전자를 다각적으로 분석하기 위해 상호발현 네트워크를 구축하였다. 네트워크를 구축하기 위하여 배추를 염스트레스 조건 하에서 시간 경과에 따라 KBGP-24K 마이크로어레이 분석을 실시한 [BrEMD (Brassica rapa EST and Microarray Database)] 실험 결과를 수집하여 분석하였다. 구축된 네트워크 모델은 1,853개 node, 5,740개 edge, 및 142개 connected component(상관계수 > 0.85)로 구성되었다. 구축된 네트워크 분석 결과, ROS 신호 전달을 통한 N$Na^+$ 수송활성화와 proline 축적이 배추의 염 저항성 획득과 밀접한 연관이 있는 것으로 판단하였다.

• Journal of Microbiology and Biotechnology
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• 제28권12호
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• pp.1982-1991
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• 2018

Ethanol accumulation inhibited the growth of Saccharomyces cerevisiae during wine fermentation. Autophagy and the release of reactive oxygen species (ROS) were also induced under ethanol stress. However, the relation between autophagy and ethanol stress was still unclear. In this study, expression of the autophagy genes ATG1 and ATG8 and the production of ROS under ethanol treatment in yeast were measured. The results showed that ethanol stress very significantly induced expression of the ATG1 and ATG8 genes and the production of hydrogen peroxide ($H_2O_2$) and superoxide anion (${O_2}^{{\cdot}_-}$). Moreover, the atg1 and atg8 mutants aggregated more $H_2O_2$ and ${O_2}^{{\cdot}_-}$ than the wild-type yeast. In addition, inhibitors of the ROS scavenging enzyme induced expression of the ATG1 and ATG8 genes by increasing the levels of $H_2O_2$ and ${O_2}^{{\cdot}_-}$. In contrast, glutathione (GSH) and N-acetylcystine (NAC) decreased ATG1 and ATG8 expression by reducing $H_2O_2$ and ${O_2}^{{\cdot}_-}$ production. Rapamycin and 3-methyladenine also caused an obvious change in autophagy levels and simultaneously altered the release of $H_2O_2$ and ${O_2}^{{\cdot}_-}$. Finally, inhibitors of the mitochondrial electron transport chain (mtETC) increased the production of $H_2O_2$ and ${O_2}^{{\cdot}_-}$ and also promoted expression levels of the ATG1 and ATG8 genes. In conclusion, ethanol stress induced autophagy which was regulated by $H_2O_2$ and ${O_2}^{{\cdot}_-}$ derived from mtETC, and in turn, the autophagy contributed to the elimination $H_2O_2$ and ${O_2}^{{\cdot}_-}$.