Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Application of Iron Related Magnetic Resonance Imaging in the Neurological Disorders

신경계 질환에서 철 관련 자기공명영상 기법의 활용

  • Kim, Tae-Hyoung (Department of Neurology, Pusan National University Yangsan Hospital, Research Institute for Convergence of Biomedical Science and Technology) ;
  • Lee, Jae-Hyeok (Department of Neurology, Pusan National University Yangsan Hospital, Research Institute for Convergence of Biomedical Science and Technology)
  • 김태형 (양산부산대학교병원 신경과, 의생명연구소) ;
  • 이재혁 (양산부산대학교병원 신경과, 의생명연구소)
  • Received : 2014.06.05
  • Accepted : 2014.06.13
  • Published : 2014.06.30
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Abstract

Iron is an important element for brain oxygen transport, myelination, DNA synthesis and neurotransmission. However, excessive iron can generate reactive oxygen species and contribute neurotoxicity. Although brain iron deposition is the natural process with normal aging, excessive iron accumulation is also observed in various neurological disorders such as neurodegeneration with brain iron accumulation, Parkinson's disease, Alzheimer's disease, multiple sclerosis, Friedreich ataxia, and others. Magnetic resonance image (MRI) is a useful method for detecting iron deposits in the brain. It can be a powerful tool for diagnosis and monitoring, while furthering our understanding of the role of iron in the pathophysiology of a disease. In this review, we will introduce the mechanism of iron toxicity and the basics of several iron-related MRI techniques. Also, we will summarize the previous results concerning the clinical application of such MR imagings in various neurological disorders.

Keywords

References

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