• 제목/요약/키워드: Reabsorption

검색결과 185건 처리시간 0.02초

개의 신내혈류(腎內血流)에 미치는 Isoproterenol의 영향(影響) (Influence of Isoproterenol on Intra-renal Blood Flow in the Dog)

  • 박기동
    • 대한약리학회지
    • /
    • 제5권2호
    • /
    • pp.141-148
    • /
    • 1969
  • The direct effect of isoproterenol on renal function, when given intravenously, is usually obscured by its potent hypotensive action. To obviate the latter action, isoproterenol was infused directly into one renal artery of the dog, the other kidney serving as a control for the general action. And following results were obtained. In the first series of experiments, the directic action of isoproterenol was ascertained. $1.0\;{\mu}g/kg/min$. reduced on both kidneys the urine flow, clearances of PAH and creatinine, as well as the amount of sodium excreted, but the effect was weaker on the experimental side than on contralateral side. With $0.1\;{\mu}g/kg/min$., two cases among 6 experiments showed marked diuresis, two cases no apparent effect, and another two marked antidiuresis on the experimental kidney, whereas the contralateral kidney exhibited antidiuresis in all cases. Further reducing the dose unmasked the diuretic action on the ,experimental kidney. In another series, the effects of isoproterenol on the blood flow distribution within the kidney and on sodium concentration gradient within the kidney tissue were observed. $0.05\;{\mu}g/kg/min$ isoproterenol markedly increased the medullary plasma flow and slightly increased total renal plasma flow and glomerular filtration rate, along with concomitant increase in the amount of sodium excreted and osmolar clearance, and decrease in reabsorption of free water. Sodium concentration gradient markedly decreased in the experimental kidney, reaching 2/3 of the value observed in the contralateral kidney at the papilla. It is thus concluded that isoproterenol exerts a diuretic action, when infused directly into a renal artery, and the mechanism of the action rests on its hemodynamic action, substantiated as the increase in glomerular filtration and in the medullary blood flow, resulting in washout of hyperosmolality produced by the coutercurrent multiplier system.

  • PDF

쪽파 에탄올 추출물이 과당 유도 고혈압 백서의 신장 기능에 미치는 영향 (Effects of Ethanol-extract of Allium wageki on the Renal Function of Fructose-induced Hypertensive Rats)

  • 강대길;이안숙;이윤미;손은진;염기복;이호섭
    • 동의생리병리학회지
    • /
    • 제17권2호
    • /
    • pp.423-427
    • /
    • 2003
  • The present study was aimed to investigate whether ethanol-extract of Allium wageki has an ameliorative effect on the renal function in high fructose-diet induced hypertensive rats .. The urine osmolality (Uosmol) was decreased in rats with high fructose-diet (60%) during the whole experiment period without change of the urine volume (UV). The urinary excretion of sodium (UNaV) and chloride (UCIV) were decrease significantly in rats with fructose-induced hypertensive rats, whereas urinary excretion of potassium (UKV) was Increased. The creatinine clearance (Ccr) and solute-free water reabsorption were also decreased by treatment of fructose-rich diet. Among these renal functional parameters, Ccr was partially restored by the administration of ethanol-extract of Allium wageki. The Uosmol was also partially restored by the administration ethanol-extract of Allium wageki at the end of the experimental period. Taken together, ethanol-extract of Allium wageki has the ameliorative effect on glomerular filtration rate in rats with high fructose-diet induced hypertension.

음성 장애를 주소로 내원한 선천성 성대 격막 2예 (Two Cases of Congenital Laryngeal Web Presenting in Complaint of Hoarseness)

  • 문명기;채령;이상혁;진성민
    • 대한후두음성언어의학회지
    • /
    • 제25권2호
    • /
    • pp.99-103
    • /
    • 2014
  • A laryngeal web is connective tissue covered with epithelium stretching between both sides of the true vocal cords. Laryngeal webs were first reported by Fleischmann in 1882, and they cause upper airway obstruction and abnormalities of phonation. Congenital webs result from an arrest of reabsorption of the epithelium of the larynx at the tenth week of the fetus. The most common site of webbing is the anterior commissural glottic area, followed by other glottic areas and rarely subglottic or supraglottic areas. We have experienced two cases of congenital laryngeal webs. The webs were operated in two different methods. The first was excised under magnified vision through a laryngoscope, with a silastic keel secured between the raw surfaces of the separated mucosa. In the second case, the deepithelialized surfaces were exposed for a certain time length to mitomycin C to prevent postoperative webbing. We, hereby, report our experience of the diagnosis and management of two cases of a rare entity known as the congenital laryngeal web, and discuss the results with relevant studies.

  • PDF

Dopamine $D_2$ Receptor 차단제인 Raclopride의 신장작용 (Renal Action of Raclopride, a Dopamine $D_2$ Receptor Antagonist, in Dogs)

  • 고석태
    • 약학회지
    • /
    • 제45권6호
    • /
    • pp.683-693
    • /
    • 2001
  • This study was attempted to investigate the effect of raclopride, a dopamine $D_2$ receptor antagonist, on renal function in dog. Raclopride (70-220$\mu\textrm{g}$/kg), when given intravenously, Produced antidiuresis along with the decrease in free water clearance ( $C_{H_2O}$), urinary excretion of sodium and potassium ( $E_{Na}$ , $E_{K}$), partially decreased osmolar clearance ( $C_{osm}$) and increased reabsorption rates of sodium and potassium in renal tubules ( $R_{Na}$ , $R_{K}$). Raclopride administered into a renal artery did not influence on renal function in small doses (10 and 30$\mu\textrm{g}$/kg), whereas exhibited the decrease of urine volume (Vol) and $C_{H_2O}$ both in experimental and control kidney in much dose (100$\mu\textrm{g}$/kg), at this time, the decreased rates of both Vol. and $C_{H_2O}$) were more prominent in control kidney rather than that elicited in experimental kidney, and then only via was decreased in control kidney but increased in experimental kidney. Raclopride administered via carotid artery (30-200$\mu\textrm{g}$/kg) did not influence at all on renal function. Antidiuretic action induced by raclopride given intravenously was not affected by renal denervation. Raclopride given into carotid artery was little effect on renal function without relation to renal denervation. Above results suggest that raclopride produces antidiuresis by potentiation of antidiuretic hormone (ADH) action in blood without increase of ADH secretion in posterior pituitary gland, it is not related to renal nerve function in dogs.ogs.s.

  • PDF

수종 생약제가 신기능 및 신장 $Na^+-K^+$ ATPase에 미치는 영향 (Effect of Certain Herb Extracts on Renal Function and $Na^+-K^+$-ATPase in Rabbit Kidney)

  • 김인순;염윤희;이상복;조병헌;조규철
    • 대한약리학회지
    • /
    • 제16권1호
    • /
    • pp.51-56
    • /
    • 1980
  • Phytolaccae Radix (PR), Brunella Herba (BH), Akebiae Lignum (AL) and Atractylis Rhizoma (AR) are some of the diuretic agents used in Chinese medicine and folk remedy. Water or methanol extracts of them (100mg/kg) were intravenously injected to rabbits in order to re-evaluate the effects on renal function. PR water extract elicited moderate diuresis while water extracts of BH, AL and methanol extract of AR had antidiuretic effects. Influence of PR on renal hemodynamics and $Na^+-K^+$-ATPase activity in rabbit kidney were observed in vivo and in vitro. The results were as follows: 1) Clearances of inulin and p-aminohippuric acid increased significantly after 15 minutes following the administration of PR water extract, but Na+ reabsorption rate was not changed. 2) The increase of $Na^+-K^+$-ATPase activity in renal cortex, outer and inner medulla was observed at 15 minutes after PR water fraction was given intravenously, and the change was most prominent in cortical area. 3) More than 50% of decrease in $Na^+-K^+$-ATPase activity in renal tissues was observed with PR water fraction $(10^{-2}g/ml)$ in vitro experiments. However, the inhibition of $Na^+-K^+$-ATPase activity was reversed with lower concentrations $(10^{-4}g/ml,\;10^{-6}g/ml)$ of PR water fraction in outer and inner medullary zone. These results suggest the diuretic effect of PR is due to improved renal hemodynamics, and contradictory reults concerning $Na^+-K^+$-ATPase activity require further investigation.

  • PDF

단삼약침(丹蔘藥鍼)이 급성신부전(急性腎不全) 가토(家兎)의 신세뇨관(腎細尿管)에 미치는 영향(影響) (Effect of Salviae Radix herb-acupuncture on rabbits with Hg-induced acute renal failure)

  • 임춘우;서정철;윤현민;장경전;송춘호;안창범
    • Journal of Acupuncture Research
    • /
    • 제18권2호
    • /
    • pp.111-122
    • /
    • 2001
  • Objectives ; This study was undertaken to determine if Salviae Radix herb-acupuncture (SRA) exerts protective effect against alterations in membrane transport function in rabbits with mercury chloride (Hg)-induced acute renal failure. Methods and Results ; The administration of Hg at a subcutaneous single dose of 10mg/kg caused a reduction in GFR to 9.4% of the basal value and an increase in fractional Na+ excretion to 10-fold, indicating generation of acute renal failure. When animals were acupunctured with $0.5m{\ell}$ of SRA extract (0.1%) in both sides of Shinsu(BL23) for 7 days prod to Hg administration, such changes were significantly attenuated. The fractional excretion of glucose and phosphate was increased to approximately 132-fold and 7-fold, respectively, in rabbits treated with Hg alone, but the fractional excretion of glucose was increased to 26-fold and that of phosphate was not different from the basal value in SRA-pretreated rabbits. Uptakes of glucose and phosphate in purified isolated brush-border membrane and $Na^+-K^+$-ATPase activity in microsomal fraction were inhibited in rabbits treated with Hg alone, suggesting that impairment in proximal reabsorption of glucose and phosphate is resulted from a direct damage of membrane transport carriers and disruption of the normal $Na^+$ gradient. Conclusions ; Such changes were prevented by SRA. Uptakes of organic ions, PAH and TEA, in renal cortical slices were inhibited by the administration of Hg, which was prevented by SRA. Pretreatment of an antioxidant DPPD attenuated the increase in the fractional excretion of glucose and phosphate induced by the administration of Hg.

  • PDF

연근의 에탄올 추출물이 과당으로 유도된 고혈압 흰쥐의 혈압과 신장 기능에 미치는 효과 (Effects of Ethanol-Extract of Lotus Root on the Renal Function and Blood Pressure of Fructose-Induced Hypertensive Rats)

  • 박성혜;함태석;한종현
    • 동아시아식생활학회지
    • /
    • 제15권2호
    • /
    • pp.165-170
    • /
    • 2005
  • 연근의 에탄올 추출물이 과당 유도 고혈압 백서의 신장 기능에 미치는 영향을 관찰하고자 뇨량과 전해질 배설량, 혈장의 creatinine, creatinine 청소율, 자유-수분 재흡수량 등을 측정하였다. 그 결과 연근은 과당 유도 고혈압 백서에서 나타나는 전해질 배설량의 변화를 개선시키는 효과는 없는 것으로 나타났고 단지 삼투질 농도의 배설량에만 약간의 개선 효과를 보였다. 신장의 가장 중요한 기능중 하나는 여과 기능이고 이를 나타내는 지표는 사구체 여과율인데, 고혈압 백서에서 혈장내 creatinine 농도가 증가하였고, creatinie 청소율이 크게 억제되었으나 연근추출물 투여 후 사구체 여과율의 감소가 회복되었다. 그러므로 연근은 과당으로 유도된 고혈압 흰쥐의 사구체 여과율을 개선시키는 것으로 사료된다.

  • PDF

신갈나무 숲의 營養監類 循環 (Nutrienr cyclings in mongolian oak(quercus mongolica) forest)

  • Kwak, Young-Se;Kim, Joon-Ho
    • The Korean Journal of Ecology
    • /
    • 제15권1호
    • /
    • pp.35-46
    • /
    • 1992
  • To elucidate nutrient cyclings such as nitrogen, phosphorus and potassium in mongolian oak(quercus mongolica) forest, nutrient elements of precipitation, throughfall, outflow, soil, various plant organ and litter were determined at mt.nambyeongsan, pyeongchang-gun, gangwon province in central part of korean peninsula. Annual precipitation input, throughfall and outflow of nutrientswere 10.3, 8.6 and 4.2 kg/ha for the N, 0.11, 0.24 and 0.02 kg/ha for the Pand 1.3, 10.9 and 1.2 kg/ha for the K, respectively. Inseasonal changes of nutrient concentrations, N, P and Kconcentrations which were rich in young leaves decreased steadily until autumn and decreased abruptly during autumnal yellowing. The standing N, P and K concent were 565, 37 and 257 kg/ha for standing phytomass of overstory, 33, 3 and 18 kg/ha for understory, 132, 3.6 and 14 kg/ha for litter on ground including deadwood and 20, 752, 14 and 420 kg/ha for the soil, respectively. The amounts of annual uptake, reture and retain were 174.2, 57.2, 117.2 kg/ha for the N, 9.9, 3.5, 6.4 kg/ha for the P and 73.2, 30.3, 42.9 kg/ha for the K, respectively. Reabsorption efficiency, ratio of the nutrient amount reabsorbed into woody organs to that in the mature leaves before shedding, was 71%(or 99.8 kg/ha in the amount), 69%(or 5.1 kg/ha) and 57%(or 33.1% kg/ha) and recycling coeffciently made with which the large amount of nutrients is absorbed through roots during growing season(UPTAKE) and reasorbed from the leaves before shedding(RETAIN) but the small amount of nutrients is returned through litterfall(RETURN).

  • PDF

무마취 가토 신장기능에 미치는 Atrial Natriuretic Factor의 영향 (Effect of Atrial Natriuretic Factor on the Renal Function and Renin Release in Unanesthetized Rabbit)

  • 이준규;조경우
    • The Korean Journal of Physiology
    • /
    • 제20권1호
    • /
    • pp.103-124
    • /
    • 1986
  • Since it has been suggested that atrial receptor may be involved in the mechanism of extracellular volume regulation, it was shown that the granularity of atrial cardiocytes can be changed by water and salt depletion, and that an extract of cardiac atrial tissue, when injected intravenously into anesthetized rats, was shown to cause a large and rapid increase in renal excretion of sodium. Various natriuretic peptides were isolated and synthetized, and the effects were investigated by many workers. Most studies, however, have been carried out under anesthesia and there have teen some controversies over direct effect of the factor on the renal function. Therefore, it was attempted in this study to access the effects of an atrial extract and a synthetic natriuretic factor in unanesthetized rabbits. Intrarenal arterial infusion of atrial extract caused a rapid increase of urinary volume and excretion of sodium. Glomerular filtration rate and renal plasma flow were both increased with no change in filtration fraction. The ventricular extract produced no change in urinary excretion of electrolytes, nor in renal hemodynamics. Intrarenal infusion of synthetic atrial natriuretic factor caused increases of renal excretory rate of sodium, chloride and potassium, and $FE_{Na}$. Glomerular filtration rate, renal plasma flow increased. And free water clearance also increased. Accentuated excretory function correlated well with increased glomerular filtration rate and renal plasma flow during infusion and for 10 minutes following the cessation of the infusion. Renin secretion rate decreased during constant infusion of atrial natriuretic factor. However, no correlation was found with the changes in glomerular filtration rate, renal plasma flow, or urinary excretion of sodium. These results suggest that atrial extract or atrial natriuretic factor induces changes in renal hemodynamics, as in excretion of electrolytes either indirectly through hemodynamic changes or directly by inhibiting tubular reabsorption. At the same time, renin secretory function is affected by the factor possibly through an unknown mechanism.

  • PDF

Extracellular ATP Stimulates $Na^+\;and\;Cl^-$ Transport through the Activation of Multiple Purinergic Receptors on the Apical and Basolateral Membranes in M-1 Mouse Cortical Collecting Duct Cells

  • Jung, Jin-Sup;Hwang, Sook-Mi;Lee, Ryang-Hwa;Kang, Soo-Kyung;Woo, Jae-Suk;Kim, Yong-Keun
    • The Korean Journal of Physiology and Pharmacology
    • /
    • 제5권3호
    • /
    • pp.231-241
    • /
    • 2001
  • The mammalian cortical collecting duct (CCD) plays a major role in regulating renal NaCl reabsorption, which is important in $Na^+$ and $Cl^-$ homeostasis. The M-1 cell line, derived from the mouse cortical collecting duct, has been used as a mammalian model of the study on the electrolytes transport in CCD. M-1 cells were grown on collagen-coated permeable support and short circuit current $(I_{sc})$ was measured. M-1 cells developed amiloride-sensitive current $5{\sim}7$ days after seeding. Apical and basolateral addition of ATP induced increase in $I_{sc}$ in M-1 cells, which was partly retained in $Na^+-free$ or $Cl^--free$ solution, indicating that ATP increased $Na^+$ absorption and $Cl^-$ secretion in M-1 cells. $Cl^-$ secretion was mediated by the activation of apical cystic fibrosis transmembrane regulator (CFTR) chloride channels and $Ca^{2+}-activated$ chloride channels, but $Na^+$ absorption was not mediated by activation of epithelal sodium channel (ENaC). ATP increased cAMP content in M-1 cells. The RT-PCR analysis demonstrated that M-1 cells express $P2Y_2,\;P2X_3\;and\;P2Y_4$ receptors. These results showed that ATP regulates $Na^+$ and $Cl^-$ transports via multiple P2 purinoceptors on the apical and basolateral membranes in M-1 cells.

  • PDF