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Effects of Ethanol-extract of Allium wageki on the Renal Function of Fructose-induced Hypertensive Rats  

Kang Dae Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee An Sook (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee Yun Mi (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Sohn Eun Jin (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Yeum Kee Bok (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee Ho Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.2, 2003 , pp. 423-427 More about this Journal
Abstract
The present study was aimed to investigate whether ethanol-extract of Allium wageki has an ameliorative effect on the renal function in high fructose-diet induced hypertensive rats .. The urine osmolality (Uosmol) was decreased in rats with high fructose-diet (60%) during the whole experiment period without change of the urine volume (UV). The urinary excretion of sodium (UNaV) and chloride (UCIV) were decrease significantly in rats with fructose-induced hypertensive rats, whereas urinary excretion of potassium (UKV) was Increased. The creatinine clearance (Ccr) and solute-free water reabsorption were also decreased by treatment of fructose-rich diet. Among these renal functional parameters, Ccr was partially restored by the administration of ethanol-extract of Allium wageki. The Uosmol was also partially restored by the administration ethanol-extract of Allium wageki at the end of the experimental period. Taken together, ethanol-extract of Allium wageki has the ameliorative effect on glomerular filtration rate in rats with high fructose-diet induced hypertension.
Keywords
Allium wageki; urine osmolality; creatinine clearance; urine volume;
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Times Cited By KSCI : 1  (Citation Analysis)
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